Menée à l'aide de données de la "UK Biobank" et par questionnaire auprès de 14 058 témoins et 4 686 patients atteints d'un cancer colorectal (durée médiane de suivi : 12,4 ans), cette étude identifie des facteurs génétiques influençant l'association entre l'alimentation et le risque de développer la maladie

Genome-Wide Interaction Study of Dietary Intake and Colorectal Cancer Risk in the UK Biobank

Hoang, Tung ; Cho, Sooyoung ; Choi, Ji-Yeob ; Kang, Daehee ; Shin, Aesun

Candidate gene analysis approaches have shown that colorectal cancer (CRC) risk attributable to diet may differ according to genotype. A genome-wide approach further allows for the exploration of underlying pathways for associations between diet and CRC risk across the genome.To identify genetic variants that modify diet-CRC associations and to further explore the underlying pathways in the cause of CRC.This nested case-control study used data on White British participants from the prospective [...]

Menée à l'aide de données de la "UK Biobank" portant sur 475 286 personnes (durée de suivi : 14 ans), cette étude analyse l'association entre des caractéristiques du sommeil, le travail posté et le risque d'adénocarcinome canalaire du pancréas (1 079 cas)

Sleep and risk of pancreatic cancer in the UK Biobank

Freeman, Joshua R. ; Saint-Maurice, Pedro F. ; Zhang, Ting ; Matthews, Charles E. ; Stolzenberg-Solomon, Rachael Z.

Background: Light at night, which may cause circadian disruption, is a potential pancreatic cancer risk factor. However, evidence from related exposures such as poor sleep health and shift work remains inconclusive and sparsely investigated. Methods: We evaluated associations between self-reported typical sleep duration, chronotype, shift work, insomnia symptoms, snoring, and daytime sleeping and pancreatic ductal adenocarcinomas (PDAC) incidence among 475,286 United Kingdom (UK) Biobank [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2023 (11 articles), cette méta-analyse évalue l'association entre une exposition aux substances per- et polyfluoroalkyles (PFAS) et le risque de cancer du sein

Exposure to Per- and Polyfluoroalkyl Substances and Breast Cancer Risk: A Systematic Review and Meta-analysis of Epidemiologic Studies

Chang, Che-Jung ; Ish, Jennifer L ; Chang, Vicky C ; Daniel, Meklit ; Jones, Rena R ; White, Alexandra J

We synthesized the epidemiologic evidence on the associations between per- and polyfluoroalkyl substances (PFAS) exposure and breast cancer risk. Our systematic review and meta-analysis included 18 and 11 articles, respectively, covering studies up to February 2023. The summary relative risks (RR) estimated by random-effects meta-analyses did not support an association between PFAS and overall breast cancer risk (e.g., a natural log (ln)-unit increase in serum/plasma concentrations [ng/mL] for [...]

Menée à l'aide d'échantillons sanguins prélevés chez 150 témoins et 156 patientes atteintes d'un cancer de l'endomètre, cette étude analyse l'association entre l'activité oestrogénique liée aux polluants environnementaux et le risque de développer la maladie

Total Effective Xenoestrogen Burden in Serum Samples and Risk of Endometrial Cancer in the Spanish Screenwide Case–Control Study

Laura Costas ; Jon Frias-Gomez ; Francisco M. Peinado ; Jose Manuel Molina-Molina ; Paula Peremiquel-Trillas ; Sonia Paytubi ; Marta Crous-Bou ; Javier de Francisco ; Victor Caño ; Yolanda Benavente ; Beatriz Pelegrina ; José Manuel Martínez ; Marta Pineda ; Joan Brunet ; Xavier Matias-Guiu ; Silvia de Sanjosé ; Jordi Ponce ; Nicolás Olea ; Laia Alemany ; Mariana F. Fernández

BACKGROUND: Endometrial cancer is a hormone-dependent cancer, and estrogens play a relevant role in its etiology. However, little is known about the effects of environmental pollutants that act as xenoestrogens or that influence estrogenic activity through different pathways. OBJECTIVE: We aimed to assess the relationship between the combined estrogenic activity of mixtures of xenoestrogens present in serum samples andthe risk of endometrial cancer in the Screenwide case–control study. METHODS: [...]

Menée aux Etats-Unis auprès de 120 témoins et 20 patients atteints d'une maladie lymphoproliférative traitée par immunothérapie à base de lymphocytes CAR-T ciblant CD19 (âge médian : 67 ans ; 60 % de femmes), cette étude identifie des facteurs de risque de néoplasme myéloïde lié au traitement

Features and Factors Associated With Myeloid Neoplasms After Chimeric Antigen Receptor T-Cell Therapy

Gurney, Mark ; Baranwal, Anmol ; Rosenthal, Allison ; Kharfan-Dabaja, Mohamed A. ; Kenderian, Saad S. ; Lin, Yi ; Shah, Mithun Vinod

Impressive clinical trial outcomes led to US Food and Drug Administration approval of chimeric antigen receptor T-cell therapy (CART) targeting CD19 for B-cell lymphoproliferative disorders (LPDs) and B-cell maturation antigen for multiple myeloma (MM). The most common CART toxic effect, immune effector cell–associated hematotoxicity (ICAHT), generally resolves by month 3. Myeloid neoplasms occurring after CART (post-CART MN) are also recognized outcomes but with short latency. To inform [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données du "Breast Cancer Association Consortium" portant sur 96 201 témoins et 118 474 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre l'utilisation de médicaments antihypertenseurs et le risque de développer la maladie

Antihypertensive drug targets and breast cancer risk: a two-sample Mendelian randomization study

Zheng, Guoqiao ; Chattopadhyay, Subhayan ; Sundquist, Jan ; Sundquist, Kristina ; Ji, Jianguang

Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental variables to proxy changes in gene expressions of antihypertensive medication targets to interrogate this. Genetic instruments for expression of antihypertensive drug target genes were identified with expression quantitative trait loci in blood, which should be associated with systolic [...]

Menée à partir de données de l'Assurance maladie taïwanaise portant sur 756 547 patients atteints de diabète de type 2 (durée médiane de suivi : 8,8 ans), cette étude analyse l'association entre les complications générées par la maladie, la durée de ce diabète et le risque de cancer (70 218 cas)

Severity of Complications and Duration of Type 2 Diabetes and the Risk of Cancer: A Population-based Study

Hu, Yu-Wen ; Yeh, Chiu-Mei ; Liu, Chia-Jen ; Chen, Tzeng-Ji ; Huang, Nicole ; Chou, Yiing-Jenq

Background: The literature on the association between diabetes severity and cancer risk is limited and inconclusive. The study aimed to evaluate the association between the adapted Diabetes Complications Severity Index (aDCSI) and the duration of type 2 diabetes and cancer risk. Methods: Patients aged 20 years or older with newly diagnosed type 2 diabetes between January 1, 2007 and December 31, 2011 were identified from Taiwan National Health Insurance claims data. Standardized incidence [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données pangénomiques, cette étude analyse l'association entre 731 immunophénotypes et le risque de cancer du poumon

Assessing the causal relationship between 731 immunophenotypes and the risk of lung cancer: a bidirectional mendelian randomization study

Xu, Ming ; Li, Chengkai ; Xiang, Liyan ; Chen, Siyue ; Chen, Lin ; Ling, Gongxia ; Hu, Yanqing ; Yang, Lan ; Yuan, Xiang ; Xia, Xiaodong ; Zhang, Hailin

Background: Previous studies have observed a link between immunophenotypes and lung cancer, both of which are closely associated with genetic factors. However, the causal relationship between them remains unclear. Methods: Bidirectional Mendelian randomization (MR) was performed on publicly available genome-wide association study (GWAS) summary statistics to analyze the causal relationships between 731 immunophenotypes and lung cancer. Sensitivity analyses were conducted to verify the [...]

Menée à partir de données de la cohorte américaine "the Health Professionals Follow-Up Study" portant sur 19 889 hommes, cette étude analyse l'association entre le poids de naissance et le risque de cancer agressif de la prostate (2 520 cas)

A prospective study of birth weight and prostate cancer risk and mortality in the Health Professionals Follow-up Study

Liu, Qinran ; Zhang, Yiwen ; Vaselkiv, Jane B. ; Mucci, Lorelei A. ; Giovannucci, Edward L. ; Platz, Elizabeth A. ; Sutcliffe, Siobhan

Background: Previous studies have observed inconsistent associations between birth weight and aggressive prostate cancer risk. This study aimed to prospectively analyse this association in the Health Professionals Follow-up Study (HPFS). Methods: Birth weight was self-reported in 1994, and prostate cancer diagnoses were assessed biennially through January 2017 and confirmed by medical record review. Multivariable Cox proportional hazards regression was used to evaluate the association between [...]

Menée à l'aide de données de la cohorte européenne "EPIC" portant sur 1 591 témoins et 1 591 patients atteints d'un cancer colorectal (55 % de femmes), cette étude analyse l'association entre la concentration sanguine de 97 métabolites lipidiques (acylcarnitines, glycérophospholipides et sphingolipides) et le risque de développer la maladie

Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Harewood, Rhea ; Rothwell, Joseph A. ; Besevic, Jelena ; Viallon, Vivian ; Achaintre, David ; Gicquiau, Audrey ; Rinaldi, Sabina ; Wedekind, Roland ; Prehn, Cornelia ; Adamski, Jerzy ; Schmidt, Julie A. ; Jacobs, Inarie ; Tjønneland, Anne ; Olsen, Anja ; Severi, Gianluca ; Kaaks, Rudolf ; Katzke, Verena ; Schulze, Matthias B. ; Prada, Marcela ; Masala, Giovanna ; Agnoli, Claudia ; Panico, Salvatore ; Sacerdote, Carlotta ; Jakszyn, Paula Gabriela ; Sánchez, María-José ; Castilla, Jesús ; Chirlaque, María-Dolores ; Atxega, Amaia Aizpurua ; Van Guelpen, Bethany ; Heath, Alicia K. ; Papier, Keren ; Tong, Tammy Y. N. ; Summers, Scott A. ; Playdon, Mary ; Cross, Amanda J. ; Keski-Rahkonen, Pekka ; Chajès, Veronique ; Murphy, Neil ; Gunter, Marc J.

Background: Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods: In a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. Circulating lipids were [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données pangénomiques du "GECCO", de l'étude "CORECT", du registre "CCFR" et de la "UK Biobank" portant au total sur 65 829 témoins et 6 176 patients atteints d'un cancer colorectal de survenue précoce, cette méta-analyse identifie des facteurs génétiques ou liés au mode de vie associés à la maladie

Genome-wide association study and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer

Laskar, R. S. ; Qu, C. ; Huyghe, J. R. ; Harrison, T. ; Hayes, R. B. ; Cao, Y. ; Campbell, P. T. ; Steinfelder, R. ; Talukdar, F. R. ; Brenner, H. ; Ogino, S. ; Brendt, S. ; Bishop, D. T. ; Buchanan, D. D. ; Chan, A. T. ; Cotterchio, M. ; Gruber, S. B. ; Gsur, A. ; Van Guelpen, B. ; Jenkins, M. A. ; Keku, T. O. ; Lynch, B. M. ; Le Marchand, L. ; Martin, R. M. ; McCarthy, K. ; Moreno, V. ; Pearlman, R. ; Song, M. ; Tsilidis, K. K. ; Vodicka, P. ; Woods, M. O. ; Wu, K. ; Hsu, L. ; Gunter, M. J. ; Peters, U. ; Murphy, N.

Background: The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally; however, the causes underlying this trend are largely unknown. Colorectal cancer (CRC) has strong genetic and environmental determinants, yet common genetic variants and causal modifiable risk factors underlying EOCRC are unknown. We conducted the first EOCRC-specific genome-wide association study (GWAS) and Mendelian randomization analyses to explore germline genetic and causal [...]

Menée à partir de données chinoises portant sur 1 465 témoins et 1 596 patients atteints d'un adénome colorectal, cette étude analyse l'association entre l'indice triglycéride-glucose et le risque de développer la maladie ou le risque de récidive

Association of the triglyceride-glucose index with the occurrence and recurrence of colorectal adenomas: a retrospective study from China

Li, Jiaoyan ; Chen, Jingfeng ; Liu, Haoshuang ; Yan, Su ; Wang, Youxiang ; Xing, Miao ; Ding, Suying

Background: Resection of colorectal adenoma (CRA) prevents colorectal cancer; however, recurrence is common. We aimed to assess the association of the triglyceride-glucose (TyG) index with CRA occurrence and recurrence. Methods: Data from 3392 participants at a hospital in China from 2020 to 2022 were analyzed. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). A restricted cubic spline was used to fit TyG index dose‒response curves to recurrent [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données du "FinnGen consortium" portant sur 14 824 personnes d'origine européenne, cette étude analyse l'association entre le niveau sanguin de certaines cytokines et le risque de cancer colorectal

Exploring causal correlations between circulating levels of cytokines and colorectal cancer risk: A Mendelian randomization analysis

Meng, Cong ; Sun, Liting ; Shi, Jinyao ; Li, Yang ; Gao, Jiale ; Liu, Yishan ; Wei, Pengyu ; Yang, Zhengyang ; Yao, Hongwei ; Zhang, Zhongtao

Colorectal cancer has the highest mortality rate of all digestive system diseases. Considering the debate about cytokines and biases that exist in traditional observational study designs, we performed a two-sample Mendelian randomization (MR) analysis to explore the association of circulating cytokines with CRC risk. In this study, we used cytokine genetic variants from a recently published genome-wide association study (GWAS) including 14,824 European-ancestry participants. Summary-level data [...]

Menée à partir de données du "Breast Cancer Association Consortium" portant sur 91 477 témoins et 106 278 patientes atteintes d'un cancer du sein, cette étude sur le génome et le transcriptome entiers identifie 88 loci de 235 gènes associés au risque de développer la maladie (5 sous-types tumoraux)

Multi-tissue transcriptome-wide association studies identified 235 genes for intrinsic subtypes of breast cancer

Li, James L ; McClellan, Julian C ; Zhang, Haoyu ; Gao, Guimin ; Huo, Dezheng

Although genome-wide association studies (GWAS) of breast cancer (BC) identified common variants which differ between intrinsic subtypes, genes through which these variants act to impact BC risk have not been fully established. Transcriptome-wide association studies (TWAS) have identified genes associated with overall BC risk, but subtype-specific differences are largely unknown.We performed two multi-tissue TWASs for each BC intrinsic subtype including an expression-based approach that [...]