Sleep and risk of pancreatic cancer in the UK Biobank
Menée à l'aide de données de la "UK Biobank" portant sur 475 286 personnes (durée de suivi : 14 ans), cette étude analyse l'association entre des caractéristiques du sommeil, le travail posté et le risque d'adénocarcinome canalaire du pancréas (1 079 cas)
Résumé en anglais
Background: Light at night, which may cause circadian disruption, is a potential pancreatic cancer risk factor. However, evidence from related exposures such as poor sleep health and shift work remains inconclusive and sparsely investigated.
Methods: We evaluated associations between self-reported typical sleep duration, chronotype, shift work, insomnia symptoms, snoring, and daytime sleeping and pancreatic ductal adenocarcinomas (PDAC) incidence among 475,286 United Kingdom (UK) Biobank participants. We used Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) adjusting for age, sex, body mass index, smoking status, duration, and frequency, alcohol intake, diabetes status, race, and employment/shift work.
Results: Over 14 years of follow-up, 1,079 adults were diagnosed with PDAC. There were no associations observed between sleep characteristics, including sleep duration (<7 vs. 7-<9 hours; HR: 1.03, 95% CI 0.90-1.19; ≥9 hours; HR: 1.00 [0.81-1.24]), evening chronotype (“definitely” an evening person vs. “definitely” a morning person; HR: 0.99 [0.77-1.29]), shift work, insomnia symptoms, snoring, or daytime sleep and PDAC risk.
Conclusions: Self-reported typical sleep characteristics and shift work were not associated with PDAC risk.
Impact: Considering the role of light at night and shift work in circadian disruption and cancer risk, it is plausible that poor sleep health among a general population may be related to cancer risk through similar sleep and circadian disrupting processes. This work may suggest that typical sleep characteristics and shift work are not associated with PDAC, though additional work is needed to confirm these findings.
