A partir d'une revue systématique de la littérature (18 études), cette méta-analyse évalue la prévalence et la sévérité d'une fatigue chez des travailleurs ayant survécu à un cancer

Prevalence, severity, and risk factors of cancer-related fatigue among working cancer survivors: a systematic review and meta-analysis

Matsunaga, Masaaki ; He, Yupeng ; Khine, May Thet ; Shi, Xuliang ; Okegawa, Ryusei ; Li, Yuanying ; Yatsuya, Hiroshi ; Ota, Atsuhiko

Purpose: The aim of this study is to evaluate the prevalence, severity, and risk factors of cancer-related fatigue among currently working cancer survivors. Methods: We searched the PubMed, Embase, Scopus, CINAHL, Cochrane Library, and ICHUSHI databases. The risk of bias was evaluated independently using the Risk of Bias Assessment Tool for Non-randomized Studies (RoBANS). A meta-analysis was conducted to determine the prevalence, severity, and related factors associated with cancer-related [...]

Mené sur 264 patients atteints d'un cancer (sein, gastro-intestinal) traité par capécitabine, cet essai randomisé de phase III évalue l'efficacité du diclofénac sous forme topique pour prévenir un syndrome mains-pieds lié au traitement anticancéreux

Topical Diclofenac for Prevention of Capecitabine-Associated Hand-Foot Syndrome: A Double-Blind Randomized Controlled Trial

Akhil Santhosh ; Atul Sharma ; Sameer Bakhshi ; Akash Kumar ; Vinod Sharma ; Prabhat Singh Malik ; Raja Pramanik ; Ajay Gogia ; Chandra Prakash Prasad ; Tushar Sehgal ; Sneha Gund ; Arundhathi Dev ; Winson Y. Cheung ; R.M. Pandey ; Saran Kumar ; Ishaan Gupta ; Atul Batra ; on behalf of the D-TORCH Trial Investigators

PURPOSE: Hand-foot syndrome (HFS) is a dose-limiting side effect of capecitabine. Celecoxib prevents HFS by inhibiting cyclooxygenase-2 (COX-2) that is upregulated because of the underlying associated inflammation. However, systemic side effects of celecoxib have limited routine prescription. Topical diclofenac inhibits COX-2 locally with minimal risk of systemic adverse events. Therefore, we conducted this study to assess the efficacy of topical diclofenac in the prevention of [...]

Menée à partir de données des registres néerlandais des cancers portant sur 2 456 adolescents et jeunes adultes ayant survécu à un cancer (âge : 18-39 ans), cette étude analyse l'effet de la maladie, 3 à 5 ans après le diagnostic, sur leur situation professionnelle et sur celle de leur partenaire de vie

Employment outcomes of adolescent and young adult (AYA) cancer survivors and their partners: A Dutch population-based study

Dankers, Polle W. ; Janssen, Silvie H. M. ; van Eenbergen, Mies ; Siflinger, Bettina M. ; van der Graaf, Winette T. A. ; Husson, Olga

Background: The aim of this population-based registry study was to examine the impact of cancer on employment outcomes in adolescent and young adult (AYA) survivors and their partners and associated sociodemographic and clinical characteristics. Methods: A total of 2456 AYA cancer patients, diagnosed in 2013 and aged 18 through 39 years old, were selected from the Netherlands Cancer Registry and linked to employment data from Statistics Netherlands, from which 1252 partners of AYAs could be [...]

Menée à l'aide des données d'une enquête réalisée en Angleterre auprès de 28 393 adultes fumeurs, cette étude analyse l'évolution de la perception des effets nocifs des cigarettes électroniques par rapport aux cigarettes de tabac depuis 2014

Trends in Harm Perceptions of E-Cigarettes vs Cigarettes Among Adults Who Smoke in England, 2014-2023

Jackson, Sarah E. ; Tattan-Birch, Harry ; East, Katherine ; Cox, Sharon ; Shahab, Lion ; Brown, Jamie

Electronic cigarettes (e-cigarettes) are less harmful to users than combustible cigarettes. However, public health and media reporting have often overstated the potential risks of e-cigarettes, and inaccurate perceptions of the harms of vaping relative to smoking are pervasive.To examine time trends in harm perceptions of e-cigarettes compared with combustible cigarettes among adults who smoke.This nationally representative monthly cross-sectional survey study was conducted from November 2014 [...]

Menée à partir des données d'une enquête réalisée dans 129 pays entre 1999 et 2020, cette étude analyse l'évolution de la susceptibilité des jeunes au tabagisme ainsi que les facteurs associés

Smoking Susceptibility and Trends Among Nonsmoking Adolescents: An International Study

Liu, Huaqing ; Qi, Qi ; Duan, Ying ; Cui, Yan ; Chen, Yan ; Zhou, Chengchao

Smoking susceptibility is defined as a lack of firm decision against smoking, usually starts in the preparation and/or initiation stages of smoking behavior, and is a strong predictor of smoking experimentation during adolescence. However, the recent global prevalence and trends in smoking susceptibility among adolescents are not well documented. This study assessed global smoking susceptibility and secular trends among nonsmoking adolescents.Smoking susceptibility was analyzed using the most [...]

Menée aux Etats-Unis à partir de données 2014-2016 portant sur 85 396 patients atteints d'un cancer du poumon traité par chirurgie, cette étude analyse l'association entre la qualité du traitement chirurgical mesurée à l'aide d'un indicateur (taux de mortalité à 90 jours) et la survie à 5 ans

Association Between Surgical Quality and Long-Term Survival in Lung Cancer

Lee, James D. ; Zheng, Richard ; Okusanya, Olugbenga ; Evans, Nathaniel R., III ; Grenda, Tyler R.

Objectives: There are significant variations in both perioperative and long-term outcomes after lung cancer resection. While perioperative outcomes are often used as comparative measures of quality, they are unreliable, and their association with long-term outcomes remain unclear. In this context, we evaluated whether historical perioperative mortality after lung cancer resection is associated with 5-year survival. Patients and Methods: The National Cancer Database (NCDB) was queried to [...]

Mené en Chine sur 160 aidants d'adolescents ou jeunes adultes atteints d'un cancer, cet essai randomisé évalue l'intérêt d'une intervention psycho-pédagogique dispensée par messagerie instantanée pour diminuer leurs symptômes d'anxiété et de dépression et améliorer leur qualité de vie

A Mobile Instant Messaging–Delivered Psychoeducational Intervention for Cancer Caregivers: A Randomized Clinical Trial

Cheng, Qinqin ; Ng, Marques Shek Nam ; Choi, Kai Chow ; Chen, Yongyi ; Liu, Gaoming ; So, Winnie Kwok Wei

Importance : Psychoeducational interventions (PEIs), which provide both information and emotional and psychosocial support, may address the unmet needs of the caregivers of adolescent and young adult patients with cancer. Objective : To explore the effects of an instant messaging–delivered PEI on anxiety, depression, quality of life (QOL), and coping and determine whether the intervention reduces caregivers’ unmet needs. Design, Setting, and Participants : This randomized clinical trial using [...]

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2023 (12 revues incluant plus de 90 études), cette méta-analyse évalue la prévalence d'un syndrome d'épuisement professionnel chez les professionnels de santé en cancérologie

The prevalence of burnout in oncology professionals: an overview of systematic reviews with meta-analyses including more than 90 distinct studies

Martinez-Calderon, Javier ; Infante-Cano, Marta ; Casuso-Holgado, María Jesús ; García-Muñoz, Cristina

Purpose: This overview of reviews aimed to summarize the prevalence of burnout and the dimensions of burnout (emotional exhaustion, depersonalization, and personal accomplishment) in oncology professionals around the world. Methods: The CINAHL, Embase, PsycINFO, and PubMed databases were searched from inception to September 13, 2023. AMSTAR 2 was used to assess the quality of reviews. The overlap between reviews was calculated. Results: Twelve reviews were included. Overall, reviews showed that [...]

Menée à partir de données 1995-2020 portant sur 131 médicaments anticancéreux autorisés par l'"Agence européenne des médicaments" pour 166 indications, cette étude de cohorte rétrospective analyse les avantages de ces médicaments et les revenus générés

Added benefit and revenues of oncology drugs approved by the European Medicines Agency between 1995 and 2020: retrospective cohort study

Francine Brinkhuis ; Wim G Goettsch ; Aukje K Mantel-Teeuwisse ; Lourens T Bloem

Objectives : To evaluate the added benefit and revenues of oncology drugs, explore their association, and investigate potential discrepancies between added benefit and revenues across different approval pathways of the European Medicines Agency (EMA). Design: Retrospective cohort study. Setting :Oncology drugs and their indications approved by the EMA between 1995 and 2020. Main outcome measures : Added benefit was evaluated using ratings published by seven organisations: health technology [...]

Menée au Danemark à partir de données 2014-2021 portant sur 6 698 patients admis aux urgences sans signe ou symptôme spécifiques de cancer, cette étude de cohorte rétrospective analyse la proportion de patients diagnostiqués ultérieurement avec un cancer

Risk of cancer and serious disease in Danish patients with urgent referral for serious non-specific symptoms and signs of cancer in Funen 2014–2021

Grønnemose, Rasmus Birkholm ; Hansen, Per Syrak ; Worsøe Laursen, Søren ; Gerke, Oke ; Kjellberg, Jakob ; Lykkegaard, Jesper ; Thye-Rønn, Clara ; Høilund-Carlsen, Poul Flemming ; Thye-Rønn, Peter

Background: In 2011, as the first European country, Denmark introduced the non-organ-specific cancer patient pathway (CPP) for patients presenting with non-specific symptoms and signs of cancer (NSSC). The proportion of patients with cancer over time is unknown. Methods: A retrospective cohort study of all patients with a NSSC-CPP investigational course in the province of Funen to the Diagnostic Centre in Svendborg from 2014 to 2021 was performed to evaluate the proportion of patients with [...]

Menée en France à partir de données portant sur 340 patientes décédées d'un cancer du sein métastatique, cette étude multicentrique analyse leur admission dans une unité de soins palliatifs et l'intensité des soins dans les 3 mois précédant le décès

Palliative care interventions and end-of-life care for patients with metastatic breast cancer: a multicentre analysis

Lucchi, Elisabeth ; Berger, Frederique ; Milder, Maude ; Commer, Jean-Marie ; Morin, Sophie ; Capodano, Geraldine ; Thomaso, Muriel ; Fogliarini, Anne ; Bremaud, Nathalie ; Henry, Aline ; Mastroianni, Bénédicte ; Chvetzoff, Gisele ; Bouleuc, Carole

Background: The aim of this study was to describe the implementation of integrated palliative care (PC) and the intensity of care in the last 3 months before death for patients with metastatic breast cancer. Materials and Methods: We conducted a multicentric study of all adult patients with metastatic breast cancer who died over a 4-month period. Complete data were collected and checked from clinical records, including PC interventions and criteria regarding EOL care aggressiveness. Results: A [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2023, cette étude analyse la qualité des recommandations concernant la nutrition des patients atteints d'un cancer colorectal

Clinical practice guidelines for the nutrition of colorectal cancer patients: a systematic review

Chang, Cheng ; Sun, Jiao ; Zhao, Xiaosu ; Chen, Si ; Song, Dongpo ; Wang, Lijie ; Yang, Yang ; Huang, Ruling ; Zhang, Haijia ; Du, Jing

Purpose: The aim of this study is to rigorously assess the methodological quality of published clinical practice guidelines (CPGs) related to nutrition among colorectal cancer patients, to compile consensus recommendations, and to evaluate the quality of the included CPGs. Methods: The systematic search covered eight electronic databases, two relevant professional association websites, and six guideline websites from their inception up to January 22, 2023. The methodological quality of the [...]