Menée à partir de données vietnamiennes portant sur 2 995 témoins et 3 758 patients atteints d'un cancer, cette étude analyse l'association entre l'apport en vitamine B12 et le risque de développer la maladie

Vitamin B12 Intake and Cancer Risk: Findings from a Case-Control Study in Vietnam

Le, Ngoan Tran ; Pham, Yen Thi-Hai ; Lu, Y. Thanh ; Le, Linh Thuy ; Huynh, Nhi Yen Ngoc ; Dao, Hang Viet ; Nguyen, Dai Duc ; Demanelis, Kathryn ; Ha, Toan H. ; Kuchipudi, Suresh V. ; Luu, Hung N.

There is inconclusive evidence on the role of dietary intake of vitamin B12 in cancer. We evaluated the association between vitamin B12 intake and cancer risk in a hospital-based case-control study, comprising 3,758 cancer cases and 2,995 controls in Vietnam. Vitamin B12 intake was derived from the validated food frequency questionnaire. Unconditional logistic regression model was used to calculate the odds ratios (ORs), and respective 95% confidence intervals (CIs) for the association between [...]

Menée à partir de données de l'étude "the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial" portant sur 101 688 personnes (durée médiane de suivi : 9,4 ans), cette étude analyse l'association entre la consommation d'aliments ultra-transformés et l'incidence du carcinome à cellules rénales (410 cas) ainsi que la mortalité spécifique (230 décès)

Ultra-processed food consumption and renal cell carcinoma incidence and mortality: results from a large prospective cohort

Li, Ya-Dong ; Fu, Yong-Xin ; Gong, Le-Lan ; Xie, Ting ; Tan, Wei ; Huang, Hao ; Zeng, Sheng-Jie ; Liu, Chuan ; Ren, Zheng-Ju

Background: Growing evidence shows that ultra-processed food consumption is associated with the risk of cancer. However, prospective evidence is limited on renal cell carcinoma (RCC) incidence and mortality. In this study, we aimed to examine the association of ultra-processed food consumption and RCC incidence and mortality in a large cohort of US adults. Methods: A population-based cohort of 101,688 participants were included from the Prostate, Lung, Colorectal and Ovarian Cancer Screening [...]

Menée à partir de données des cohortes américaines "the Nurses' Health Studies" (durée de suivi : jusqu'à 30 ans), cette étude analyse l'association entre une consommation d'aspartame et le risque de cancer du sein (10 814 cas)

Consumption of aspartame and risk of breast cancer in the Nurses’ Health Studies

Romanos-Nanclares, Andrea ; Schernhammer, Eva ; Willett, Walter C ; Holmes, Michelle D ; Chen, Wendy Y ; Eliassen, A Heather

Debate persists regarding the potential carcinogenicity of aspartame as suggested by experimental studies. Therefore, we prospectively evaluated whether aspartame consumption is associated with breast cancer risk in the Nurses’ Health Study (NHS) and Nurses’ Health study II (NHSII). We used Cox models to calculate HRs and 95% CIs. During up to 30 years of follow-up with 4-yearly assessments of intake, we documented 10,814 invasive breast cancer cases. Overall, there was no association between [...]

Menée à partir de données suisses 1990-2016 portant sur 3 137 patients atteints d'un cancer hématologique pédiatrique (âge : 0-15 ans), cette étude analyse l'association entre une exposition résidentielle aux ultra-violets solaires et le risque de développer la maladie

Residential exposure to solar ultraviolet radiation and risk of childhood hematological malignancies in Switzerland: A census-based cohort study

Coste, Astrid ; Kreis, Christian ; Backes, Claudine ; Bulliard, Jean-Luc ; Folly, Christophe ; Brack, Eva ; Renella, Raffaele ; Vernez, David ; Spycher, Ben D. ; for the SNC study group

Still little is known about possible environmental risk factors of childhood hematological malignancies (CHM). Previous studies suggest that ultraviolet radiation (UVR) exposure is associated with a lower risk of acute lymphoblastic leukemia (ALL) in children. We investigated the association between solar UVR exposure and risk of CHM in Switzerland, a country with greatly varying topography and weather conditions. We included all resident children aged 0–15 years from the Swiss National Cohort [...]

Menée au Danemark auprès de femmes âgées d'au moins 30 ans et non ménopausées, cette étude analyse l'association entre l'utilisation de dispositifs contraceptifs intra-utérins libérant du lévonorgestrel et le risque de cancer du sein

Breast Cancer in Users of Levonorgestrel-Releasing Intrauterine Systems

Mørch, Lina Steinrud ; Meaidi, Amani ; Corn, Giulia ; Hargreave, Marie ; Wessel Skovlund, Charlotte

Use of levonorgestrel-releasing intrauterine systems (LNG-IUSs) has been increasing. LNG-IUS use constitutes the preferred hormonal contraception among Danish premenopausal women older than 30 years. However, whether use of an LNG-IUS is associated with breast cancer risk remains unclear. Increased breast cancer risk was found in users of LNG-IUSs, but that study was not designed to address duration of continuous use. Also, previous studies have not adequately accounted for other hormonal [...]

A partir d'une revue systématique de la littérature publiée entre janvier 2017 et juin 2024 (35 articles), cette étude analyse l'association entre une consommation de cannabis et le risque de cancer par localisation

Cancer risk and legalisation of access to cannabis in the USA: overview of the evidence

Nargis, Nigar ; Westmaas, J. Lee ; Orr, Eva ; Alqahtani, Mohammed M. ; Choudhury, Parichoy Pal ; Islami, Farhad ; Jemal, Ahmedin

Cannabis in the USA is transitioning from a nationwide illegal status to liberalisation for medicinal or recreational use across different jurisdictions. As the acceptability and accessibility of cannabis continue to grow, updated knowledge on the cancer risk from recreational cannabis use is necessary to inform recommendations by public health organisations, policy makers, and clinical practitioners. We reviewed the evidence to date. Our umbrella review of current global epidemiological [...]

Menée à partir de données de la "UK Biobank" portant sur 253 138 personnes (durée moyenne de suivi : 12,9 ans), cette étude analyse l'association entre les niveaux plasmatiques d'oméga-3 et d'oméga-6 et l’incidence du cancer (19 localisations, 29 838 cas)

Associations of plasma omega-6 and omega-3 fatty acids with overall and 19 site-specific cancers: A population-based cohort study in UK Biobank

Zhang, Yuchen ; Sun, Yitang ; Song, Suhang ; Khankari, Nikhil K. ; Brenna, J. Thomas ; Shen, Ye ; Ye, Kaixiong

Previous epidemiological studies on the associations between polyunsaturated fatty acids (PUFAs) and cancer incidence have been inconsistent. We investigated the associations of plasma omega-3 and omega-6 PUFAs with the incidence of overall and 19 site-specific cancers in a large prospective cohort. 253,138 eligible UK Biobank participants were included in our study. With a mean follow-up of 12.9 years, 29,838 participants were diagnosed with cancer. The plasma levels of omega-3 and omega-6 [...]

Menée à l'aide des données d'une étude canadienne portant sur 707 témoins et 363 patientes atteintes d'un cancer de l'ovaire et âgées d'au moins 50 ans, cette étude analyse l'association entre l'adiposité au cours de la vie et le risque de développer la maladie

Body fatness across the adult life course and ovarian cancer risk

Ritonja, Jennifer A. ; Madathil, Sreenath ; Nicolau, Belinda ; L’Espérance, Kevin ; Ho, Vikki ; Abrahamowicz, Michal ; Koushik, Anita

Excess body fatness in late adulthood has been observed to increase ovarian cancer risk, but the association is relatively weak. Body fatness can change over time, and timing may differently influence risk. We used a life course epidemiology approach to identify whether the relation between body fatness and ovarian cancer risk is best described by a critical period, accumulation or sensitive period hypothesis. In a population-based case-control study of ovarian cancer in Montreal, Canada [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données génétiques, cette étude analyse le rôle d'une exposition à long terme aux oestrogènes, évaluée par la mesure de la densité minérale osseuse du col du fémur et du rachis lombaire, dans le développement d'un cancer épithélial de l’ovaire

Exploring estrogen-related mechanisms in ovarian carcinogenesis: association between bone mineral density and ovarian cancer risk in a multivariable Mendelian randomization study

Tuesley, Karen M. ; Webb, Penelope M. ; Protani, Melinda M. ; Donovan, Peter ; Jordan, Susan J. ; Dixon-Suen, Suzanne

Background: Estrogen may play a role in epithelial ovarian cancer (EOC) carcinogenesis, with effects varying by EOC histotype. Measuring women’s long-term exposure to estrogen is difficult, but bone mineral density (BMD) may be a reasonable proxy of longer-term exposure. We examined this relationship by assessing the association between genetic predisposition for higher BMD and risk of EOC by histotype. Methods: We used Mendelian randomization (MR) to assess associations between genetic markers [...]

Menée auprès de 6 058 662 adultes sans diabète ni cancer (durée médiane de suivi : 6,4 ans), cette étude analyse l'association entre des évolutions du statut du prédiabète (hyperglycémie) et le risque de cancer de la vésicule biliaire (1 349 cas)

Prediabetes persistence or remission and subsequent risk of gallbladder cancer: a nationwide cohort study

Park, Joo-Hyun ; Hong, Jung Yong ; Han, Kyungdo ; Park, Young Suk ; Park, Joon Oh ; Lim, Ho Yeong ; Shen, Jay J.

Background & Aims: Hyperglycemia is associated with an increased risk of gallbladder cancer (GBC), potentially by inhibiting gallbladder motility and inducing prolonged cholestasis. Although intermediate hyperglycemia (or prediabetes) is highly reversible, evidence is lacking about whether prediabetes persistence or remission is associated with an altered GBC risk. Methods: This nationwide cohort study included 6,058,662 adults without diabetes or cancer who underwent national health [...]