Breast Cancer in Users of Levonorgestrel-Releasing Intrauterine Systems

Menée au Danemark auprès de femmes âgées d'au moins 30 ans et non ménopausées, cette étude analyse l'association entre l'utilisation de dispositifs contraceptifs intra-utérins libérant du lévonorgestrel et le risque de cancer du sein

Résumé en anglais

Use of levonorgestrel-releasing intrauterine systems (LNG-IUSs) has been increasing. LNG-IUS use constitutes the preferred hormonal contraception among Danish premenopausal women older than 30 years. However, whether use of an LNG-IUS is associated with breast cancer risk remains unclear. Increased breast cancer risk was found in users of LNG-IUSs, but that study was not designed to address duration of continuous use. Also, previous studies have not adequately accounted for other hormonal contraceptive use. This study assessed breast cancer risk with continuous use of an LNG-IUS, accounting for other hormonal exposures.