Menée en Chine à partir de données d'entretiens auprès de 101 médecins et de 164 aidants de patients ayant survécu à un cancer pédiatrique, cette étude analyse les facteurs facilitant ou entravant l'accès aux soins de suite et aux programmes dédiés à l'après-cancer

Accessibility of and Barriers to Long-Term Follow-Up Care for Childhood Cancer Survivors

Cai, Jiaoyang ; Malone, Sara ; Bhakta, Nickhill ; Pui, Ching-Hon ; Chen, Jing ; Hu, Shaoyan ; Jiang, Hui ; Ju, Xiuli ; Zhou, Fen ; Hudson, Melissa M. ; Cheung, Yin Ting

Childhood cancer survivorship programs and long-term follow-up (LTFU) practices are inadequate in most regions of China.To understand the clinician and caregiver perceptions of LTFU care and to identify barriers to adherence to LTFU care in mainland China.This survey study had a 2-phase sequential mixed-methods approach, consisting of a cross-sectional survey followed by semistructured interviews. Participants included oncology clinicians recruited through an educational seminar on LTFU and [...]

Menée à partir de données portant sur 33 989 patientes ayant survécu à un cancer du sein et sur 157 609 témoins, cette étude analyse la survenue d'effets indésirables associés à une utilisation d'opioïdes

Opioid use and adverse health effects in breast cancer survivors

Haque, Reina ; Chen, Lie Hong ; Shi, Jiaxiao ; Gu, Zheng ; Brady-Rogers, Moira ; Chlebowski, Rowan T ; Hechter, Rulin C

Little information exists on adverse effects related to opioid use in breast cancer survivors following active cancer treatment, and no studies included an age-matched comparison group. Thus, we examined opioid use and risk of falls, fractures, lung problems, and cardiovascular events in breast cancer survivors in the years following active cancer treatment along with a comparison group.We conducted a longitudinal cohort study 33 989 breast cancer survivors and 157 609 age-matched women without [...]

Menée à partir de données de l'Assurance maladie coréenne portant sur 548 320 patients atteints d'un cancer (âge médian : 59 ans ; durée médiane de suivi : 7,3 ans), cette étude de cohorte analyse l'association entre des pratiques tabagiques et le risque d'insuffisance cardiaque en lien avec les traitements anticancéreux

Smoking Habits Following Cancer Diagnosis and Heart Failure

Lee, Hyeok-Hee ; Jiang, Changchuan ; Bhatt, Deepak L. ; Kim, Hyeon Chang ; Lee, Hokyou

Introduction: A previous study reported that changes in smoking habits after cancer diagnosis are associated with the risk of atherosclerotic cardiovascular disease.1 Heart failure (HF), given its different pathophysiologic characteristics and association with certain chemotherapeutics (eg, anthracyclines or antihuman epidermal growth factor receptor 2 [ERBB2; formerly HER2] agents), represents a distinct cardiovascular event among individuals with cancer. Methods: In this cohort study, we [...]

Menée aux Etats-Unis à partir de données 2000-2016 portant sur des patients atteints d'un cancer, cette étude de cohorte rétrospective estime l'excès de mortalité chez les patients infectés par le VIH (39 000 cas)

Excess Mortality in Persons with Concurrent HIV and Cancer Diagnoses: A Retrospective Cohort Study

Lee, Kamaria L. ; Sarovar, Varada ; Lam, Jennifer O. ; Leyden, Wendy A. ; Alexeeff, Stacey E. ; Lea, Alexandra N. ; Hechter, Rulin C. ; Hu, Haihong ; Marcus, Julia L. ; Yuan, Qing ; Kramer, Jennifer R. ; Lin, Lilie L. ; Chiao, Elizabeth Y. ; Towner, William J. ; Horberg, Michael A. ; Silverberg, Michael J.

Background: With extended lifespans for people with human immunodeficiency virus (PWH), there is a corresponding increased burden of chronic illnesses, including cancer. Our objective was to estimate the excess mortality among PWH with cancer compared with people without HIV (PWoH), accounting for the higher background mortality in the general PWH population. Methods: We identified 39,000 PWH and 387,767 demographically matched PWoH in three integrated healthcare systems from 2000 to 2016. We [...]

Menée aux Etats-Unis à partir de données portant sur 5 845 patientes ayant survécu à un cancer du sein et sur 160 162 témoins, cette étude analyse leur adhésion aux recommandations concernant la pratique d'une activité physique en fonction de critères ethniques et socioéconomiques

Racial, Ethnic, and Socioeconomic Disparities in Meeting Physical Activity Guidelines among Female Breast Cancer Survivors in the United States

Wojcik, Kaitlyn M. ; Wilson, Oliver W.A. ; Shiels, Meredith S. ; Sheppard, Vanessa B. ; Jayasekera, Jinani

Cancer survivors show low physical activity participation rates in the United States. However, there are limited national-level data on disparities in the prevalence of meeting physical activity guidelines among women with and without breast cancer. We aimed to evaluate national-level trends in meeting physical activity guidelines across demographic and socioeconomic characteristics of breast cancer survivors and women without cancer.Data for women ≥35 years of age with and without breast [...]

A partir d'une revue systématique de la littérature (16 articles, 1 948 patients), cette méta-analyse évalue l'effet d'une thérapie par la réminiscence sur la qualité de vie et sur les symptômes d'anxiété et de dépression des adultes atteints d'un cancer

The effectiveness of reminiscence therapy on anxiety, depression, and quality of life in adult cancer patients: a systematic review and meta-analysis

Bozkurt, Canan ; Erbay-Dalli, Öznur ; Yildirim, Yasemin

Purpose: To investigate the effectiveness of reminiscence therapy on anxiety, depression, and quality of life in adult cancer patients. Methods: This study is a systematic review and meta-analysis, including 16 randomized controlled trials (RCTs) and controlled clinical trials (CCTs), encompassing a total of 1948 participants. The sample sizes of the included studies ranged from 32 to 210, with results from 1852 participants being evaluated. Potential studies up to July 31, 2023, were searched [...]

A partir d'une revue systématique de la littérature publiée entre 1980 et 2023 (25 essais, 1 931 patients), cette méta-analyse évalue l'effet d'exercices d'aérobie sur les symptômes de dépression des patients atteints d'un cancer

Aerobic Physical Activity and Depression Among Patients With Cancer: A Systematic Review and Meta-Analysis

Kulchycki, Matthew ; Halder, Henry Ratul ; Askin, Nicole ; Rabbani, Rasheda ; Schulte, Fiona ; Jeyaraman, Maya M. ; Sung, Lillian ; Louis, Deepak ; Lix, Lisa ; Garland, Allan ; Mahar, Alyson L. ; Abou-Setta, Ahmed ; Oberoi, Sapna

Depression is prevalent among patients with cancer, affecting their quality of life and survival. Aerobic physical activity (APA) is an effective strategy for managing depression in the general population, but its effectiveness for reducing depressive symptoms among patients with cancer requires further study.To evaluate whether APA decreases depression severity in patients with cancer by synthesizing data from published randomized clinical trials (RCTs).Six databases (MEDLINE, Embase, Cochrane [...]

Menée à partir de données portant sur 53 patientes atteintes d'un cancer du sein, cette étude de cohorte prospective analyse l'effet d'une chimiothérapie de première ligne sur leurs déficiences cognitives et leur qualité de vie jusqu'à 2 à 3 ans après les traitements

Chemotherapy-induced cognitive impairment and its long-term development in patients with breast cancer: results from the observational CICARO study

Kerkmann, Anna ; Schinke, Christian ; Dordevic, Adam ; Kern, Johannes ; Bangemann, Nikola ; Finck, Josefine ; Blohmer, Jens-Uwe ; Ruprecht, Klemens ; Göpfert, Jens C ; Otto, Carolin ; Materne, Bianca ; Endres, Matthias ; Boehmerle, Wolfgang ; Huehnchen, Petra

Background: Chemotherapy-induced cognitive impairment (CICI) is a well-recognized side effect of breast cancer treatment. However, prospective long-term evaluations of CICI using standardized neuropsychological tests are scarce. Patients and Methods: This prospective longitudinal cohort study investigated cognitive dysfunction and its impact on quality of life and everyday functioning in patients with breast cancer receiving first-line chemotherapy compared to patients with breast cancer [...]

Menée aux Etats-Unis à partir de données portant sur 197 patients atteints d'un cancer et inclus dans des essais cliniques de phase précoce (âge médian : 63,4 ans), cette étude analyse l'association entre leurs difficultés financières et leur qualité de vie

Financial toxicity in early-phase cancer clinical trial participants

Durbin, Sienna M. ; Lundquist, Debra ; Pelletier, Andrea ; Petrillo, Laura A. ; Bame, Viola ; Turbini, Victoria ; Heldreth, Hope ; Lynch, Kaitlyn ; Boulanger, Mary ; Lam, Anh ; McIntyre, Casandra ; Ferrell, Betty R. ; Jimenez, Rachel ; Juric, Dejan ; Nipp, Ryan D.

Background: Little is known about financial toxicity in early-phase clinical trial (EP-CT) participants. This study sought to describe financial toxicity in EP-CT participants and assess associations with patient characteristics and patient-reported outcomes (PROs). Methods: Prospectively enrolled EP-CT participants from were followed from April 2021 through January 2023. Participants completed the Comprehensive Score for Financial Toxicity (<26 = financial toxicity) at time of treatment. [...]

Mené sur 438 patients atteints d'un cancer, cet essai prospectif évalue l'intérêt clinique et économique d'une intervention dirigée par le pharmacien puis validée par une équipe pluridisciplinaire en cancérologie afin de détecter les interactions médicamenteuses pouvant être rencontrées par les patients débutant un traitement anticancéreux

Clinical and economic impact of pharmacist interventions to identify drug-related problems in multidisciplinary cancer care: a prospective trial

Giraud, Jean-Stéphane ; Virginie, Korb-Savoldelli ; Germain, Perrin ; Anne, Jouinot ; Brigitte, Sabatier ; Rui, Batista ; Matthieu, Ribault ; Sixtine, De Percin ; Clémentine, Villeminey ; Margaux, Videau ; Benoit, Blanchet ; Francois, Goldwasser ; Albane, Degrassat-Theas ; Audrey, Thomas-Schoemann

Background: The prescription of antitumor drugs has often been associated with drug-related problems. Pretherapeutic multidisciplinary risk assessment programs including pharmaceutical care have been established to secure the initiation of injectable and oral antitumor therapies. This prospective cross-sectional double-center study evaluated the clinical and economic impact of the pharmacist in detecting drug-related problems in patients initiating antitumor therapies. Materials and Methods: [...]

Menée aux Pays-Bas, cette étude analyse le rapport coût-efficacité de protocoles utilisant des thérapies ciblées et des immunothérapies de façon séquentielle pour traiter des patients atteints d'un mélanome avec mutation BRAF et de stade avancé

Cost-effectiveness of treatment sequences for BRAF-mutant advanced melanoma in the Netherlands using a health economic model

Blommestein, Hedwig M. ; de Groot, Saskia ; Leeneman, Brenda ; Uyl- de Groot, Carin A. ; Haanen, John B. A. G. ; Wouters, Michel W. J. M. ; Aarts, Maureen J. B. ; van den Berkmortel, Franchette W. P. J. ; Blokx, Willeke A. M. ; Boers-Sonderen, Marye J. ; van den Eertwegh, Alfons J. M. ; de Groot, Jan Willem B. ; Hospers, Geke A. P. ; Kapiteijn, Ellen ; Van Not, Olivier J. ; van der Veldt, Astrid A. M. ; Suijkerbuijk, Karijn P. M. ; Franken, Margreet G.

Background: This study aims to evaluate the cost-effectiveness of treatment sequences for patients with advanced melanoma with a BRAF mutation in the Netherlands from a societal perspective. Methods: A semi-Markov model with a life-time horizon has been used to evaluate cost-effectiveness of 21 treatment sequences. Real-world data from the Dutch Melanoma Treatment Registry (DMTR) were used to estimate time to progression, next treatment and death. Utilities by health state as well as hospital [...]

Cet article présente un programme américain destiné à améliorer la qualité de vie des adolescents et jeunes adultes atteints d'un cancer

UNC AYA Cancer Program: Reach and Characteristics of Care

Stein, Jacob ; Wardell, Alexis ; Ritzwoller, Dawn M ; Swift, Catherine ; Matson, Melissa ; Winslow, Hannah C ; Muthukrishnan, Hrishika ; Waters, Austin R ; Haines, Emily R ; Lux, Lauren ; Smitherman, Andrew B

Cancer care organizations often struggle to adequately address the unique needs of AYA cancer patients, resulting in poorer outcomes compared to other age groups. Creation of AYA cancer programs serves to bridge this gap and improve quality of care for this population. We aimed to describe the evolution and impact of the University of North Carolina (UNC) at Chapel Hill’s AYA Cancer Program. To do so, we conducted a retrospective cohort study utilizing electronic health record (EHR) data [...]