Menée à l'aide de données portant sur 26 348 personnes, cette étude analyse l'association entre la pratique, pendant l'adolescence (12-17 ans) ou au début de l'âge adulte (25-34 ans), d'une activité physique de loisir d'intensité modérée à vigoureuse et le risque de cancer du sein avant 40 ans (2 502 cas)

Physical activity during adolescence and early adulthood and breast cancer risk before age 40 years

Kehm, Rebecca D. ; Genkinger, Jeanine M. ; Knight, Julia A. ; Maclnnis, Robert J. ; Liao, Yuyan ; Li, Shuai ; Weideman, Prue C. ; Chung, Wendy K. ; Kurian, Allison W. ; Colonna, Sarah V. ; Andrulis, Irene L. ; Buys, Saundra S. ; Daly, Mary B. ; John, Esther M. ; Hopper, John L. ; Terry, Mary Beth

Background: Breast cancer (BC) incidence is increasing in women under age 40 years, underscoring the need for research on BC risk factors for younger women. Methods: We used data from an international family cohort (n=26,348) to examine whether recreational physical activity (RPA) during adolescence and early adulthood are associated with BC risk before age 40. The cohort includes 2,502 women diagnosed with BC before age 40, including 2,408 diagnosed before study enrollment (68% within 5 years [...]

Menée à partir de données portant sur 707 personnes (âge : 50-74 ans ; 51 % de femmes) ainsi qu'à l'aide des données d'une étude portant sur 621 témoins et 621 patientes atteintes d'un cancer du sein après la ménopause, cette étude analyse l'association entre l'activité physique, des métabolites sériques et le risque de cancer du sein

Physical activity, metabolites, and breast cancer associations

Watts, Eleanor L ; Moore, Steven C ; Abar, Leila ; Hong, Hyokyoung G ; Saint-Maurice, Pedro F ; O'Connell, Caitlin ; Matthews, Charles E ; Loftfield, Erikka

The effects of usual physical activity on physiology and disease prevention are not fully understood. We examined the associations between physical activity, metabolites, and breast cancer risk.Physical activity levels were assessed using doubly labeled water, accelerometers, and 24-hr recalls in the IDATA study (N = 707 participants, ages 50-74 years, 51% women), with 1-6 assessments over 12 months and two blood sample collections. Partial Spearman correlations were used to estimate [...]

Menée à partir de données portant sur 1 636 056 patients atteints de diabète de type 2 (durée de suivi : 5 ans), cette étude analyse l'association entre l'utilisation d'un traitement par agonistes des récepteurs du GLP-1 et le risque de cancer du pancréas en fonction de l'obésité et du statut tabagique

GLP-1 receptor agonists and pancreatic cancer risk: target trial emulation using real-world data

Wang, Lindsey ; Wang, QuanQiu ; Li, Li ; Kaelber, David C ; Xu, Rong

Data on the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on pancreatic cancer incidence are limited and inconsistent. Here we evaluate the association of GLP-1RAs, alone and in combinations, with incident pancreatic cancer risk in a real-world population, stratified by obesity and smoking status.This retrospective cohort included patients with T2DM who were prescribed GLP-1RAs or other non-GLP-1RA anti-diabetes medications between January 2013 and March 2019 and had no prior [...]

Menée en Caroline du Nord auprès de 326 345 enfants, cette étude identifie des facteurs associés à une couverture vaccinale contre le papillomavirus humain plus faible en milieu rural

Identifying measures for understanding and addressing county-level disparities in adolescent HPV vaccination coverage in North Carolina

Grabert, Brigid K. ; McKeithen, Mary Catharine. ; Trogdon, Justin G. ; Spees, Lisa P. ; Wheeler, Stephanie B. ; Myers, Jenny K. ; Spencer, Jennifer C. ; Gilkey, Melissa B.

Background: HPV vaccination coverage is characterized by geographic disparities in the US, with national studies finding lower coverage in rural versus nonrural areas. To direct quality improvement efforts in North Carolina, we sought to understand how different rurality measures characterize these disparities. Methods: We used separate negative binomial regression models to test associations between 5 dichotomized county-level rurality measures and HPV vaccination coverage (≥1 dose) among [...]