Menée auprès de 205 patients atteints d'un carcinome épidermoïde de l'oesophage et 226 témoins, cette étude analyse l'association entre la concentration urinaire de 33 biomarqueurs d'exposition à la nicotine, aux hydrocarbures aromatiques polycycliques, aux composés organiques volatils et aux nitrosamines spécifiques du tabac et le risque de développer la maladie, en fonction du statut tabagique

Exposure to polycyclic aromatic hydrocarbons, volatile organic compounds, and tobacco-specific nitrosamines and incidence of esophageal cancer

Etemadi, Arash ; Poustchi, Hossein ; Chang, Cindy M ; Calafat, Antonia M ; Blount, Benjamin C ; Bhandari, Deepak ; Wang, Lanqing ; Roshandel, Gholamreza ; Alexandridis, Apostolos ; Botelho, Julianne Cook ; Xia, Baoyun ; Wang, Yuesong ; Sosnoff, Connie S ; Feng, Jun ; Nalini, Mahdi ; Khoshnia, Masoud ; Pourshams, Akram ; Sotoudeh, Masoud ; Gail, Mitchell H ; Dawsey, Sanford M ; Kamangar, Farin ; Boffetta, Paolo ; Brennan, Paul ; Abnet, Christian C ; Malekzadeh, Reza ; Freedman, Neal D

Studying carcinogens in tobacco and non-tobacco sources may be key to understanding the pathogenesis and geographic distribution of esophageal cancer.Golestan Cohort Study (GCS) has been conducted since 2004 in a region with high rates of esophageal squamous cell carcinoma (ESCC). For this nested study, the cases comprised of all incident cases by Jan 1, 2018; controls were matched to the case by age, sex, residence, time in cohort, and tobacco use. We measured urinary concentrations of 33 [...]

Menée en Norvège auprès de 4 250 personnes (durée de suivi : 125 090 personnes-années), cette étude analyse l'association entre une exposition professionnelle au feu, aux fumées ou au gaz d'échappement des moteurs diesel et le risque de cancer des voies urinaires (76 cas)

Occupational exposures of firefighting and urinary tract cancer risk among men in the Norwegian Fire Departments Cohort

Niki Marjerrison ; Tom K Grimsrud ; Johnni Hansen ; Jan Ivar Martinsen ; Karl-Christian Nordby ; Raymond Olsen ; Marit B Veierød ; Kristina Kjærheim

Objectives: Increased risks of bladder cancer and mesothelioma were the strongest evidence for the recent reclassification of firefighting as carcinogenic (Group 1) by the International Agency for Research on Cancer. Our study aim was to develop indicators for specific firefighting exposures and examine associations with urinary tract cancer (UTC), including bladder cancer. Methods: We developed indicators for exposure from employment at a fire department or in firefighting jobs, to fire and [...]

Menée en France à l'aide de données du registre national des cancers de l’enfant (RNCE) portant sur 40 196 témoins et 3 711 enfants atteints d'une leucémie aiguë diagnostiquée sur la période 2006-2013 (âge : moins de 15 ans), cette étude analyse l'association entre la proximité des vignes du lieu de résidence et le risque de développer la maladie

Association between Residential Proximity to Viticultural Areas and Childhood Acute Leukemia Risk in Mainland France: GEOCAP Case-Control Study, 2006–2013

Matthieu Mancini ; Denis Hémon ; Perrine de Crouy-Chanel ; Laurence Guldner ; Laure Faure ; Jacqueline Clavel ; Stéphanie Goujon

Background: Pesticide exposures are suspected of being a risk factor for several childhood cancers, particularly acute leukemia (AL). Most of the evidence is based on self-reported parental domestic use of pesticides, but some studies have also addressed associations with agricultural use of pesticides near the place of residence. Objectives: The objective of the study was to evaluate the risk of AL in children living close to vines, a crop subject to intensive pesticide use. Methods: Data were [...]

Menée à l'aide d'échantillons sanguins prélevés sur 88 témoins et 88 patients atteints d'un cancer de la thyroïde, cette étude analyse l'association entre les niveaux plasmatiques de substances per- et polyfluoroalkyles (PFAS) et le risque de développer la maladie

Per- and polyfluoroalkyl substances (PFAS) exposure and thyroid cancer risk

van Gerwen, Maaike ; Colicino, Elena ; Guan, Haibin ; Dolios, Georgia ; Nadkarni, Girish N. ; Vermeulen, Roel C. H. ; Wolff, Mary S. ; Arora, Manish ; Genden, Eric M. ; Petrick, Lauren M.

Background: Although per- and polyfluoroalkyl substances (PFAS) exposure is a potential contributor to the increasing thyroid cancer trend, limited studies have investigated the association between PFAS exposure and thyroid cancer in human populations. We therefore investigated associations between plasma PFAS levels and thyroid cancer diagnosis using a nested case-control study of patients with thyroid cancer with plasma samples collected at/before cancer diagnosis. Methods: 88 patients with [...]

Menée à l'aide de données portant sur 10 339 témoins et 3 510 patientes atteintes d'un cancer de l'ovaire, cette étude analyse l'association entre un traitement hormonal de la ménopause et le risque de développer la maladie, en fonction de l'origine ethnique

Menopausal hormone therapy use and risk of ovarian cancer by race: the ovarian cancer in women of African ancestry consortium

Petrick, Jessica L. ; Joslin, Charlotte E. ; Johnson, Courtney E. ; Camacho, T. Fabian ; Peres, Lauren C. ; Bandera, Elisa V. ; Barnard, Mollie E. ; Beeghly, Alicia ; Bethea, Traci N. ; Dempsey, Lauren F. ; Guertin, Kristin ; Harris, Holly R. ; Moorman, Patricia G. ; Myers, Evan R. ; Ochs-Balcom, Heather M. ; Rosenow, Will ; Setiawan, V. Wendy ; Wu, Anna H. ; Schildkraut, Joellen M. ; Rosenberg, Lynn

Background: Most studies examining post-menopausal menopausal hormone therapy (MHT) use and ovarian cancer risk have focused on White women and few have included Black women. Methods: We evaluated MHT use and ovarian cancer risk in Black (n = 800 cases, 1783 controls) and White women (n = 2710 cases, 8556 controls), using data from the Ovarian Cancer in Women of African Ancestry consortium. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2021 (134 études, 12 139 patients), cette méta-analyse évalue la prévalence mondiale du papillomavirus humain (HPV) et de la protéine p16INK4a chez les patients atteints d'un carcinome épidermoïde oropharyngé

Human papillomavirus and p16INK4a in oropharyngeal squamous cell carcinomas: A systematic review and meta-analysis

Lu, Yong ; Clifford, Gary M. ; Fairley, Christopher K. ; Grulich, Andrew E. ; Garland, Suzanne M. ; Xiao, Fei ; Wang, Yuan ; Zou, Huachun

We intended to update human papillomavirus (HPV) prevalence and p16INK4a positivity in oropharyngeal squamous cell carcinomars (SCC), and calculate HPV attributable fraction (AF) for oropharyngeal SCC by geographic region. We searched Medline, Embase, and the Cochrane Library to identify published studies of HPV prevalence and p16INK4a positivity alone or together in oropharyngeal SCC before December 28, 2021. Studies that reported type-specific HPV DNA prevalence using broad-spectrum PCR-based [...]

Menée à l'aide de données de la "UK Biobank" portant sur 431 861 personnes (âge : 38-73 ans ; 46 % d'hommes ; durée médiane de suivi : 10,7 ans), cette étude analyse l'association entre l'utilisation d'un téléphone mobile et le risque de cancer (25 localisations) en fonction du sexe

Mobile phone use and risks of overall and 25 site-specific cancers: a prospective study from the UK Biobank Study

Zhang, Yanjun ; Zhang, Yuanyuan ; Ye, Ziliang ; Yang, Sisi ; Liu, Mengyi ; Wu, Qimeng ; Zhou, Chun ; He, Panpan ; Gan, Xiaoqin ; Qin, Xianhui

Background: The association between mobile phone use and incident cancers remains uncertain. We aimed to investigate the relationships of mobile phone use with incident overall and 25 site-specific cancers in men and women. Methods: 431,861 participants aged 38-73 years without prior cancers were included from the UK Biobank. Of these, 46.7% were male. Participants who used a mobile phone at least once per week to make or receive calls were defined as mobile phone users. The study outcomes were [...]

Menée à l'aide de modèles de prédiction du risque et de données sur le régulome entier portant sur 6 723 témoins et 8 275 patients atteints d'un adénocarcinome canalaire du pancréas, cette étude analyse l'association entre l'accessibilité de la chromatine et le risque de développer la maladie

Regulome-wide association study identifies genetically driven accessible regions associated with pancreatic cancer risk

Liu, Shuai ; Zhong, Hua ; Zhu, Jingjing ; Wu, Yong ; Deng, Youping ; Wu, Lang

Genome-wide association studies (GWAS) have identified two dozen genetic variants that are associated with the risk of pancreatic ductal adenocarcinoma (PDAC), a deadly malignancy. However, a majority of these variants are located in noncoding regions of the genome, which limits the translation of GWAS findings into clinical applications. The regulome-wide association study (RWAS) is a recently developed method for identifying TF binding-induced accessibility regions for diseases. However, [...]

Menée en Chine sur la période 2014-2018 auprès de 638 patients atteints d'un cancer colorectal de stade précoce, cette étude analyse l'association entre un syndrome métabolique et l'âge de survenue de la maladie

Association between metabolic syndrome and early-stage colorectal cancer

Zhang, Chenchen ; Zhang, Liting ; Tian, Yan ; Guan, Bingxin ; Li, Shuai

Background: Accumulating studies have suggested metabolic syndrome (MetS) contributed to colorectal cancer (CRC) development. However, advanced CRC might decrease the detection proportion of MetS due to chronic malnutrition, we included patients with early-stage CRC to examine the associations among MetS, onset age, and different tumorigenesis pathways of CRC. Methods: We conducted a retrospective study that included 638 patients with early-stage CRC from January 2014 to December 2018. Patient [...]