Menée à partir de données portant sur 327 patientes ayant survécu à un cancer du sein, cette étude analyse l'association entre la pratique d'une activité physique, l'indice de masse corporelle et la sévérité des symptômes (douleur, fatigue, dépression)

Breast cancer survivors with pain: an examination of the relationships between body mass index, physical activity, and symptom burden

Dorfman, Caroline S. ; Fisher, Hannah M. ; Thomas, Samantha ; Kelleher, Sarah A. ; Winger, Joseph G. ; Mitchell, Nia S. ; Miller, Shannon N. ; Somers, Tamara J.

Purpose: Overweight and obesity are common for breast cancer survivors and associated with high symptom burden (i.e., pain, fatigue, depressive symptoms). Physical activity may protect breast cancer survivors with higher body mass indexes (BMI) from increased symptoms. However, the role of physical activity in buffering the relationship between higher BMI and greater symptoms is unclear. Methods: Baseline data from a randomized trial investigating Pain Coping Skills Training among breast cancer [...]

Menée en Norvège par questionnaire auprès de 1 353 patientes ayant survécu à un cancer du sein de stade I à III et âgées de 20 à 65 ans, cette étude identifie les facteurs associés à la présence de symptômes à long terme et à leur sévérité

Burden of late effects in a nationwide sample of long-term breast cancer survivors

Smedsland, Solveig K. ; Falk, Ragnhild S. ; Reinertsen, Kristin V. ; Kiserud, Cecilie E. ; Brekke, Mette ; Bøhn, Synne H. ; Dahl, Alv A. ; Vandraas, Kathrine F.

Background: Long-term breast cancer survivors (BCSs) may experience several late effects (LEs) simultaneously. This study aimed to identify subgroups of 8-year BCSs with higher burden of LEs who could benefit from closer survivorship care, explore variables associated with higher symptom burden, and describe how symptom burden may affect general functioning. Methods: All Norwegian women aged 20 to 65 years when diagnosed with stage I-III breast cancer in 2011 and 2012 were invited (n = 2803). [...]

Menée au Japon, cette étude présente, pour la période 2020-2050, des projections de la prévalence de certains cancers (22 localisations)

Cancer prevalence projections in Japan and decomposition analysis of changes in cancer burden, 2020-2050: A statistical modelling study

Nguyen, Phuong The. ; Hori, Megumi ; Matsuda, Tomohiro ; Katanoda, Kota

Background: We provide comprehensive sex-stratified projections of cancer prevalence for 22 cancer sites in Japan from 2020 to 2050. Methods: Using a scenario-based approach, we projected cancer prevalence by combining projected incidence cases and survival probabilities. Age-specific incidences were forecasted using age-period-cohort models, while survival rates were estimated using a period-analysis approach and multiple parametric survival models. To understand changes in cancer prevalence, [...]

Menée aux Etats-Unis à partir de données portant sur 30 039 patients atteints d'un cancer traité par chirurgie (âge médian : 67 ans ; 97,8 % d'hommes), cette étude de cohorte rétrospective analyse le taux de thromboembolie veineuse post-opératoire et l'adhésion des patients à une prophylaxie pharmacologique

Venous Thromboembolism Chemoprophylaxis Adherence Rates After Major Cancer Surgery

Logan, Charles D. ; Hudnall, Matthew T. ; Schlick, Cary Jo R. ; French, Dustin D. ; Bartle, Brian ; Vitello, Dominic ; Patel, Hiten D. ; Woldanski, Lauren M. ; Abbott, Daniel E. ; Merkow, Ryan P. ; Odell, David D. ; Bentrem, David J.

Importance : Venous thromboembolism (VTE) represents a major source of preventable morbidity and mortality and is a leading cause of death in the US after cancer surgery. Previous research demonstrated variability in VTE chemoprophylaxis prescribing, although it is unknown how these rates compare with performance in the Veterans Health Administration (VHA). Objective : To determine VTE rates after cancer surgery, as well as rates of inpatient and outpatient (posthospital discharge) [...]

Menée au Royaume-Uni à partir de données portant sur 2 751 patients atteints d'un cancer du poumon non à petites cellules (646 fumeurs au moment du diagnostic), cette étude multicentrique analyse l'impact d'un sevrage tabagique sur la survie à 2 ans

Quitting smoking improves two-year survival after a diagnosis of non-small cell lung cancer

Gemine, Rachel E. ; Davies, Gareth ; Lanyon, Kirsty ; Rees, Sarah ; Campbell, Ian ; Lewis, Keir E.

Background: Smoking at diagnosis is associated with worse survival in lung cancer but the effects of quitting smoking on survival remain unclear. Methods: In a UK multi-centre study (NCT01192256) we followed all 2751 patients with newly diagnosed non-small cell lung cancer (NSCLC) for up to 2 years or until death as part of the observational trial. Patients were offered smoking cessation advice and treatments according to national guidelines and local services. Smoking status was verified by [...]

Menée en Suède à partir de données 2008-2020 portant sur 11 382 patients atteints d'un cancer de la prostate de stade métastatique de novo (âge médian : 74 ans), cette étude de cohorte analyse l'évolution de la survie en lien avec une utilisation d'une thérapie par doublet (doublet de chimiothérapie, ou thérapie anti-androgénique combinée à un inhibiteur de la voie de signalisation des récepteurs androgéniques)

Survival Trend in Individuals With De Novo Metastatic Prostate Cancer After the Introduction of Doublet Therapy

Corsini, Christian ; Garmo, Hans ; Orrason, Andri Wilberg ; Gedeborg, Rolf ; Stattin, Pär ; Westerberg, Marcus

Importance : Recently, life-prolonging treatments for patients with advanced prostate cancer have been introduced in clinical practice. Objective : To investigate if the introduction of doublet therapy is associated with changes in survival on a population-basis. Design, Setting, and Participants : This nationwide population-based cohort study used data from the Prostate Cancer data Base Sweden from 2008 to 2020. Men registered with de novo metastatic castration-sensitive prostate cancer [...]

Menée à partir de données portant sur 1 098 patients atteints d'un cancer colorectal de stade I à III, cette étude de cohorte analyse l'association entre un mode de vie sain (statut tabagique, activité physique, adhésion à un régime de type méditerranéen), l'indice de masse corporelle et la survie sans récidive ainsi que la survie globale

Combined associations of a healthy lifestyle and body mass index with colorectal cancer recurrence and survival: a cohort study

Barot, Shabane ; Rantanen, Petri ; Nordenvall, Caroline ; Lindforss, Ulrik ; Hallqvist Everhov, Åsa ; Larsson, Susanna C. ; Lindblom, Annika ; Liljegren, Annelie

Purpose: Colorectal cancer (CRC) risk is associated with modifiable lifestyle factors including smoking, physical inactivity, Western diet, and excess body weight. The impact of lifestyle factors on survival is less known. A cohort study was conducted to investigate the combined effects of a healthy lifestyle and body mass index on prognosis following CRC diagnosis. Methods: Treatment and follow-up data were collected from the patient files of 1098 participants from the Colorectal cancer [...]

Menée auprès de 4 117 patients atteints d'une tumeur des cellules germinales, cette étude analyse la survie sans progression et la survie globale en fonction du stade au diagnostic (tumeur récidivante de stade I ou métastatique de novo)

Outcomes of relapsed clinical stage I versus de novo metastatic testicular cancer patients: an analysis of the IGCCCG Update database

Lauritsen, Jakob ; Sauvé, Nicolas ; Tryakin, Alexey ; Jiang, Di Maria ; Huddart, Robert ; Heng, Daniel Y. C. ; Terbuch, Angelika ; Winquist, Eric ; Chovanec, Michal ; Hentrich, Marcus ; Fankhauser, Christian D. ; Shamash, Jonathan ; del Muro, Xavier Garcia ; Vaughn, David ; Heidenreich, Axel ; Sternberg, Cora N. ; Sweeney, Christopher ; Necchi, Andrea ; Bokemeyer, Carsten ; Bandak, Mikkel ; Jandari, Abolghassem ; Collette, Laurence ; Gillessen, Silke ; Beyer, Joerg ; Daugaard, Gedske

Background: Active surveillance after orchiectomy is the preferred management in clinical stage I (CSI) germ-cell tumours (GCT) associated with a 15 to 30% relapse rate. Patients and methods: In the IGCCCG Update database, we compared the outcomes of gonadal disseminated GCT relapsing from initial CSI to outcomes of patients with de novo metastatic GCT. Results: A total of 1014 seminoma (Sem) [298 (29.4%) relapsed from CSI, 716 (70.6%) de novo] and 3103 non-seminoma (NSem) [626 (20.2%) relapsed [...]

Menée en Suède à partir de données portant sur 20 177 patientes atteintes d'un cancer du col de l'utérus diagnostiqué entre 1978 et 2018 (âge moyen : 53,4 ans), cette étude analyse l'association entre la présence de troubles psychiques antérieure au diagnostic de cancer et la mortalité spécifique ou toutes causes confondues

Overall and Cervical Cancer Survival in Patients With and Without Mental Disorders

Herweijer, Eva ; Wang, Jiangrong ; Hu, Kejia ; Valdimarsdóttir, Unnur A. ; Adami, Hans-Olov ; Sparén, Pär ; Sundström, Karin ; Fang, Fang

Importance : Individuals with a mental disorder experience substantial health disparity and are less likely to participate in cervical screening and human papillomavirus vaccination. Additionally, this population may benefit less from tertiary cancer prevention. Objective : To compare clinical characteristics and survival patterns between patients with cervical cancer with and without a preexisting diagnosis of a mental disorder at the time of cervical cancer diagnosis. Design, Setting, and [...]

Menée auprès de 130 dyades constituées de patients atteints d'un cancer colorectal et de leur aidant, cette étude identifie les facteurs associés à un stress post-traumatique pendant les 2 années qui suivent le diagnostic de cancer

Correlates of posttraumatic stress in cancer patients and their family caregivers across two years following diagnosis

Mitchell, Hannah-Rose ; Antoni, Michael H. ; Shaffer, Kelly M. ; Kim, Youngmee

Objective: To examine risk-factors of cancer-related PTSS in the 2-years post-diagnosis in adult colorectal cancer patients and caregivers. Methods: Patients with colorectal cancer and their caregivers (N = 130 dyads) self-reported sociodemographic, psychosocial, and medical factors at diagnosis/treatment initiation (T1), at 1- (T2), and 2-year (T3) post-diagnosis. Cancer-related PTSS were assessed, and path analysis examined associations between proposed correlates and PTSS. Results: Among [...]

Menée en Espagne à partir de données portant sur 841 patients atteints d'un cancer de stade avancé, cette étude multicentrique prospective analyse l'effet de stratégies pour affronter la maladie sur la détresse psychologique associée au sentiment d'incertitude généré par la maladie

Coping strategies as mediators of uncertainty and psychological distress in patients with advanced cancer

Obispo, Berta ; Cruz-Castellanos, Patricia ; Fernández-Montes, Ana ; Coca-Membribes, Sara ; Rogado, Jacobo ; Antoñanzas, Mónica ; Castillo-Trujillo, Oscar A. ; López-Ceballos, Helena ; Rodríguez-González, Adán ; Jiménez-Fonseca, Paula ; Calderon, Caterina

Purpose: Uncertainty in the context of advanced cancer diagnosis often incurs significant psychological distress. The aims were to evaluate the incidence of psychological distress upon diagnosis of advanced cancer and to analyze whether the relationship between illness uncertainty and psychological distress can be mediated by coping strategies. Methods: A multicenter, prospective, cross-sectional study was conducted in 15 medical oncology departments across Spain. Individuals with unresectable [...]

A partir d'une revue systématique de la littérature (62 articles), cette méta-analyse identifie des facteurs associés au bien-être psychique des patients atteints d'un cancer de la prostate

Prognostic factors for mental wellbeing in prostate cancer: A systematic review and meta-analysis

Vyas, Neel ; Brunckhorst, Oliver ; Fanshawe, Jack B. ; Stewart, Robert ; Dasgupta, Prokar ; Ahmed, Kamran

Objectives: To evaluate the evidence base for patient, oncological, and treatment prognostic factors associated with multiple mental wellbeing outcomes in prostate cancer patients. Methods: We performed a literature search of MEDLINE, EMBASE, and CINAHL databases including studies evaluating patient, oncological, or treatment factors against one of five mental wellbeing outcomes; depression, anxiety, fear of cancer recurrence, masculinity, and body image perception. Data synthesis included a [...]

Mené en Inde sur 245 patientes atteintes d'un cancer du sein de stade précoce (âge médian : 48 ans), cet essai randomisé évalue l'efficacité, du point de vue du conflit décisionnel mesuré par un système de score, d'un outil d'aide à la décision thérapeutique (chirurgie conservatrice ou mastectomie)

Effectiveness of a Decision Aid Plus Standard Care in Surgical Management Among Patients With Early Breast Cancer: A Randomized Clinical Trial

Joshi, Shalaka ; Ramarajan, Lakshmi ; Ramarajan, Naresh ; Lee, Serenity S. ; Deshpande, Ojas ; Fernandes, Elizabeth ; Engineer, Mitchelle ; Srivastava, Gitika ; Vanmali, Vaibhav ; Kannan, Sadhana ; Hawaldar, Rohini ; Nair, Nita ; Parmar, Vani ; Thakkar, Purvi ; Chitkara, Garvit ; Gupta, Sudeep ; Badwe, Rajendra

Importance : Patients with early breast cancer must choose between undergoing breast conservation surgery or mastectomy. This decision is often difficult as there are trade-offs between breast conservation and adverse effects, and women with higher decisional conflict have a harder time choosing the therapy that suits their preferences. Objective : To study the impact of a decision aid with a patient preference assessment tool for surgical decision-making on patients’ decisional conflict scale [...]