Menée à l'aide d'une méthode de randomisation mendélienne et de données multicentriques européennes, cette étude analyse l'association entre une exposition au tabagisme passif et le risque de développer une maladie affectant les systèmes cardiovasculaire, respiratoire, immunitaire, endocrinien et nerveux

Assessing causality between second-hand smoking and potentially associated diseases in multiple systems: A two-sample Mendelian randomization study

Wang, Shilin ; Yang, Peiwen ; Liu, Hao ; Wang, Zhiwen ; Hu, Poyi ; Ye, Ping ; Xia, Jiahong ; Chen, Shu

The global disease burden may be exacerbated by exposure to passive smoking (SHS), with the workplace being a primary location for such exposure. Numerous epidemiological studies have identified SHS as a risk factor for diseases affecting various systems, including cardiovascular, respiratory, immune, endocrine, and nervous systems. The conventional observational study has certain methodological constraints which can be circumvented through a Mendelian randomization (MR) study. Our MR study [...]

Menée aux Etats-Unis auprès de 1 381 témoins et 1 812 patientes atteintes d'un cancer du sein diagnostiqué sur la période 2010-2015 (âge : moins de 50 ans), cette étude analyse l'association entre la consommation d'alcool au cours de la vie et le risque de survenue précoce de la maladie

Lifetime alcohol consumption patterns and young-onset breast cancer by subtype among Non-Hispanic Black and White women in the Young Women’s Health History Study

Hirko, Kelly A. ; Lucas, Darek R. ; Pathak, Dorothy R. ; Hamilton, Ann S. ; Post, Lydia M. ; Ihenacho, Ugonna ; Carnegie, Nicole Bohme ; Houang, Richard T. ; Schwartz, Kendra ; Velie, Ellen M.

Purpose: The role of alcohol in young-onset breast cancer (YOBC) is unclear. We examined associations between lifetime alcohol consumption and YOBC in the Young Women’s Health History Study, a population-based case–control study of breast cancer among Non-Hispanic Black and White women < 50 years of age. Methods: Breast cancer cases (n = 1,812) were diagnosed in the Metropolitan Detroit and Los Angeles County SEER registry areas, 2010–2015. Controls (n = 1,381) were identified through [...]

Menée sur la période 1999-2018 auprès de 860 témoins et 215 patientes atteintes d'un cancer du col de l'utérus (âge : au moins 30 ans), cette étude analyse l'association entre des apports alimentaires et le risque de développer la maladie

Diet-Related Risk Factors for Cervical Cancer: Data from National Health and Nutrition Examination Survey 1999–2018

Xu, Ling ; Tan, Yao ; Xiang, Ping ; Luo, Yu ; Peng, Jia ; Xiao, Hong ; Liu, FuChun

Diverse dietary constituents, encompassing both macro- and micronutrient intakes, have established connections with various cancers, though their specific roles in cervical cancer remain unclear. This study explores dietary intake correlations among women aged 30 yrs and above diagnosed with cervical cancer (n?=?215), contrasted with women without (n?=?860). These populations were selected from the 1999?2018?cycle of the National Health and Nutrition Examination Survey. The research implemented [...]

Menée à l'aide d'une base de données taïwanaise portant sur 2 267 186 dyades mère-enfant (durée moyenne de suivi : 8 ans), cette étude analyse l'association entre des infections maternelles, une prise d'antibiotiques pendant la grossesse et le risque de cancer infantile

Maternal medically diagnosed infection and antibiotic prescription during pregnancy and risk of childhood cancer: A population-based cohort study in Taiwan, 2004 to 2015

Sirirungreung, Anupong ; Lee, Pei-Chen ; Hu, Ya-Hui ; Liew, Zeyan ; Ritz, Beate ; Heck, Julia E.

While associations between maternal infections during pregnancy and childhood leukemia in offspring have been extensively studied, the evidence for other types of childhood cancers is limited. Additionally, antibiotic exposure during pregnancy could potentially increase the risk of childhood cancers. Our study investigates associations between maternal infections and antibiotic prescriptions during pregnancy and the risk of childhood cancer in Taiwan. We conducted a population-based cohort [...]

A partir d'une revue systématique de la littérature publiée entre 1990 et 2022 (21 études, 837 patients), cette méta-analyse évalue la prévalence du virus d'Epstein-Barr chez des patients atteints d'un lymphome gastrique primitif (de type MALT ou diffus à grandes cellules B)

Estimating the prevalence of Epstein–Barr virus in primary gastric lymphoma: a systematic review and meta-analysis

Hirabayashi, Mayo ; Traverse-Glehen, Alexandra ; Combes, Jean-Damien ; Clifford, Gary M. ; de Martel, Catherine

The stomach is a common site for extranodal non-Hodgkin’s lymphoma. While Helicobacter pylori (H. pylori) is the main established risk factor for primary gastric lymphoma, a fraction could be aetiologically associated with Epstein–Barr virus (EBV), a known haematolymphoid carcinogen. We systematically searched five databases from 1 January 1990 until 31 May 2022 for studies reporting EBV prevalence in gastric lymphoma tumour tissue by in-situ hybridisation (ISH) for EBV-encoded small RNA [...]

Menée auprès de 537 témoins et 476 patients atteints d'un carcinome rhinopharyngé et n'ayant pas reçu de traitement, cette étude analyse l'association entre le mycobiome de la cavité buccale et le risque de développer la maladie

Oral fungal profiling and risk of nasopharyngeal carcinoma: a population-based case-control study

Chen, Yufeng ; Li, Wanxin ; Chang, Ellen T. ; Debelius, Justine W. ; Manoharan, Lokeshwaran ; Zheng, Yuming ; Li, Yancheng ; Huang, Guangwu ; Adami, Hans-Olov ; Knight, Rob ; Cai, Yonglin ; Zhang, Zhe ; Ye, Weimin

Background: Dysbiosis of the oral mycobiome has been linked to some diseases, including cancers. However, the role of oral fungal communities in nasopharyngeal carcinoma (NPC) carcinogenesis has not previously been investigated. Methods: We characterized the oral salivary fungal mycobiome in 476 untreated incident NPC patients and 537 population-based controls using fungal internal transcribed spacer (ITS)-2 sequencing. The relationship between oral fungal mycobiome and the risk of NPC was [...]

A partir d'une revue systématique de la littérature publiée entre 1975 et 2022 (83 articles), cette étude analyse l'association entre la dose de radiothérapie reçue et le risque de tumeur du système nerveux central chez des patients ayant survécu à un cancer pédiatrique

Risk of Subsequent Neoplasms in Childhood Cancer Survivors After Radiation Therapy: A Comprehensive PENTEC Review

Casey, Dana L. ; Vogelius, Ivan R. ; Brodin, N. Patrik ; Roberts, Kenneth B. ; Avanzo, Michele ; Moni, Janaki ; Owens, Constance ; Ronckers, Cecile M. ; Constine, Louis S. ; Bentzen, Soren M. ; Olch, Arthur

Purpose: A Pediatric Normal Tissue Effects in the Clinic (PENTEC) analysis of published investigations of central nervous system (CNS) subsequent neoplasms (SNs), subsequent sarcomas, and subsequent lung cancers in childhood cancer survivors who received radiation therapy (RT) was performed to estimate the effect of RT dose on the risk of SNs and the modification of this risk by host and treatment factors. Methods and Materials: A systematic literature review was performed to identify data [...]

Menée au Japon à partir de données portant sur 104 062 enfants, cette étude analyse l'association entre une exposition professionnelle des parents à des anticancéreux, des anesthésiques et/ou des rayonnements ionisants et le risque de leucémie ou de tumeur cérébrale chez l'enfant avant 3 ans

Pediatric leukemia and maternal occupational exposure to anticancer drugs: The Japan Environment and Children's Study

Yamamoto, Shunsuke ; Sanefuji, Masafumi ; Suzuki, Maya ; Sonoda, Yuri ; Hamada, Norio ; Kato, Wakako ; Ono, Hiroaki ; Oba, Utako ; Nakashima, Kentaro ; Ochiai, Masayuki ; Kusuhara, Koichi ; Koga, Yuhki ; Ohga, Shouichi

Occupational exposure to medical agents and ionizing radiation has been suggested as a possible risk factor for childhood cancer. However, the relationship between such exposure and pediatric malignancies has not yet been comprehensively studied. This cohort study aimed to investigate the association between parental occupational exposure to hazardous medical agents or ionizing radiation and the risk of childhood cancer in offspring. Data from a large birth cohort in Japan, which included [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 10 742 Suédois, cette étude pangénomique analyse l'association entre les niveaux plasmatiques de ghréline et le risque de cancer gastrointestinal

Genome-Wide Association and Two-Sample Mendelian Randomization Analyses of Plasma Ghrelin and Gastrointestinal Cancer Risk

Larsson, Susanna C. ; Höijer, Jonas ; Sun, Jing ; Li, Xue ; Burgess, Stephen ; Michaelsson, Karl

Background: Observational studies have suggested that the gut hormone ghrelin is an early marker of future risk of developing gastrointestinal cancer. However, whether ghrelin is a causal risk factor remains unclear. We conducted a genome-wide association study (GWAS) of plasma ghrelin and used Mendelian randomization (MR) to investigate the possible causal association between ghrelin and gastrointestinal cancer risk. Methods: Genetic variants associated with plasma ghrelin were identified in a [...]

Menée à l'aide de données de 2 études californiennes portant sur 2 765 témoins et 2 692 patients pédiatriques atteints d'une leucémie lymphoblastique aiguë, cette étude analyse l'association entre une exposition maternelle au tabac pendant la grossesse et le risque de développer la maladie chez l'enfant et identifie ainsi de nouveaux gènes impliqués dans la leucémogenèse

Gene-environment analyses reveal novel genetic candidates with prenatal tobacco exposure in relation to risk for childhood acute lymphoblastic leukemia

Zhong, Charlie ; Li, Shaobo ; Arroyo, Katti ; Morimoto, Libby M. ; De Smith, Adam J. ; Metayer, Catherine ; Ma, Xiaomei ; Kogan, Scott C. ; Gauderman, W James. ; Wiemels, Joseph L.

Background: Associations between maternal tobacco exposure during pregnancy and childhood acute lymphoblastic leukemia (ALL) have yielded mixed results. This may be due to biases in self-reported smoking or other differences in individual level risk factors. We utilized a biological marker of maternal tobacco exposure to evaluate the association between maternal tobacco exposure during pregnancy, genetics, and subsequent childhood ALL risk in two large population-based studies of childhood ALL [...]