Menée à partir des données 1999-2019 de l'étude "the SUN project" portant sur 10 930 femmes (âge moyen : 35,2 ans ; durée médiane de suivi : 12,1 ans), cette étude analyse l'association entre la qualité de différents régimes alimentaires pauvres en graisse et le risque de cancer du sein (150 cas), en fonction du statut ménopausique

Associations between an overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a Mediterranean cohort: the SUN project

Aguilera- Buenosvinos, I. ; Martínez-González, M. Á ; Zazpe, I. ; Romanos-Nanclares, A. ; Sanchez-Bayona, R. ; Toledo, E.

Objective: Dietary patterns may have a greater influence on human health than individual foods or nutrients and they are also of substantial interest in the field of breast cancer prevention. Beyond the adequate balance of macronutrients, evidence shows that the quality of macronutrient sources may play an important role in health outcomes. We sought to examine the relationship between a healthful and an unhealthful low-fat dietary pattern in relation to breast cancer. Methods: We used an [...]

A l'aide notamment d'une revue systématique de la littérature publiée entre 2000 et 2021 (33 articles), cette méta-analyse évalue le risque de cancer lié aux infrastructures de quartier

Neighborhood infrastructure-related risk factors and non-communicable diseases: a systematic meta-review

Zhang, Yuyang ; Liu, Ningrui ; Li, Yan ; Long, Ying ; Baumgartner, Jill ; Adamkiewicz, Gary ; Bhalla, Kavi ; Rodriguez, Judith ; Gemmell, Emily

Background: With rapid urbanization, the urban environment, especially the neighborhood environment, has received increasing global attention. However, a comprehensive overview of the association between neighborhood risk factors and human health remains unclear due to the large number of neighborhood risk factor–human health outcome pairs. Method: On the basis of a whole year of panel discussions, we first obtained a list of 5 neighborhood domains, containing 33 uniformly defined neighborhood [...]

Menée dans 2 Etats indiens auprès de 166 témoins et 214 patients atteints d'un cancer de la vésicule biliaire (âge : 30-69 ans ; 73,4 % de femmes), cette étude analyse l'association entre les niveaux d'arsenic dans les eaux souterraines et le risque de développer la maladie

Chronic Exposure to Drinking Water Arsenic and Gallbladder Cancer Risk: Preliminary Evidence from Endemic Regions of India

Shridhar, Krithiga ; Krishnatreya, Manigreeva ; Sarkar, Soumyajit ; Kumar, Ranjit ; Kondal, Dimple ; Kuriakose, Steena ; RS, Vinutha ; Singh, Amulya K. ; Kataki, Amal Chandra. ; Ghosh, Ashok ; Mukherjee, Abhijit ; Prabhakaran, D ; Mondal, Debapriya ; Prabhakaran, Poornima ; Dhillon, Preet K.

BACKGROUND: Evidence linking arsenic in drinking water to digestive tract cancers is limited. We evaluated the association between arsenic levels in groundwater and gallbladder cancer (GBC) risk in a case-control study (2019-2021) of long-term residents (≥10years) in two arsenic-impacted and high-GBC risk states of India– Assam and Bihar. METHODS: We recruited men and women aged 30-69 years from hospitals (73.4% women), with newly diagnosed, biopsy-confirmed GBC (N=214) and unrelated controls [...]

Menée à partir de données 1991-2016 portant sur 1 096 greffes de cellules hématopoïétiques chez des patients atteints de drépanocytose, cette étude analyse le risque de cancer secondaire associé à ces greffes (22 cas)

Secondary Neoplasms After Hematopoietic Cell Transplant for Sickle Cell Disease

Mary Eapen ; Ruta Brazauskas ; David A. Williams ; Mark C. Walters ; Andrew St Martin ; Benjamin L. Jacobs ; Joseph H. Antin ; Kira Bona ; Sonali Chaudhury ; Victoria H. Coleman-Cowger ; Nancy L. DiFronzo ; Erica B. Esrick ; Joshua J. Field ; Courtney D. Fitzhugh ; Julie Kanter ; Neena Kapoor ; Donald B. Kohn ; Lakshmanan Krishnamurti ; Wendy B. London ; Michael A. Pulsipher ; Sohel Talib ; Alexis A. Thompson ; Edmund K. Waller ; Ted Wun ; Mary M. Horowitz

PURPOSE: To report the incidence and risk factors for secondary neoplasm after transplantation for sickle cell disease. METHODS: Included are 1,096 transplants for sickle cell disease between 1991 and 2016. There were 22 secondary neoplasms. Types included leukemia/myelodysplastic syndrome (MDS; n = 15) and solid tumor (n = 7). Fine-Gray regression models examined for risk factors for leukemia/MDS and any secondary neoplasm. RESULTS: The 10-year incidence of leukemia/MDS was 1.7% (95% CI, 0.90 [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 2 échantillons de patients et sur des variants de 1 136 gènes liés aux mitochondries, cette étude analyse l'association entre un dysfonctionnement mitochondrial et le risque de cancer (18 localisations) puis identifie des gènes candidats

Mitochondrial related genome-wide Mendelian randomization identifies putatively causal genes for multiple cancer types

Li, Yanni ; Sundquist, Kristina ; Zhang, Naiqi ; Wang, Xiao ; Sundquist, Jan ; Memon, Ashfaque A.

Background: Mitochondrial dysfunction is a hallmark of cancer. However, it is unclear whether it is a cause of cancer. This two-sample Mendelian randomization (MR) analyses, uses genetic instruments to proxy the exposure of mitochondrial dysfunction and cancer summary statistics as outcomes, allowing for causal inferences. Methods: Summary statistics from 18 common cancers (2107–491,974 participants), gene expression, DNA methylation and protein expression quantitative trait loci (eQTL, mQTL [...]

Menée à l'aide d'une méthode de randomisation mendélienne et des données de 2 études d'association sur le génome entier portant sur 578 647 personnes, cette étude analyse l'association entre une obésité infantile et le risque de cancer colorectal

Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study

Papadimitriou, Nikos ; Bull, Caroline J. ; Jenab, Mazda ; Hughes, David J. ; Bell, Joshua A. ; Sanderson, Eleanor ; Timpson, Nicholas J. ; Smith, George Davey ; Albanes, Demetrius ; Campbell, Peter T. ; Küry, Sébastien ; Le Marchand, Loic ; Ulrich, Cornelia M. ; Visvanathan, Kala ; Figueiredo, Jane C. ; Newcomb, Polly A. ; Pai, Rish K. ; Peters, Ulrike ; Tsilidis, Kostas K. ; Boer, Jolanda M. A. ; Vincent, Emma E. ; Mariosa, Daniela ; Gunter, Marc J. ; Richardson, Tom G. ; Murphy, Neil

Background: Observational studies have linked childhood obesity with elevated risk of colorectal cancer; however, it is unclear if this association is causal or independent from the effects of obesity in adulthood on colorectal cancer risk. Methods: We conducted Mendelian randomization (MR) analyses to investigate potential causal relationships between self-perceived body size (thinner, plumper, or about average) in early life (age 10) and measured body mass index in adulthood (mean age 56.5) [...]

Menée auprès de 15 104 patientes ayant survécu à un cancer du sein invasif traité par chirurgie ipsilatérale, cette étude analyse le risque de cancer du sein controlatéral chez les femmes présentant des variants pathogènes constitutionnels au niveau des gènes ATM, BRCA1, BRCA2, CHEK2 ou PALB2

Contralateral Breast Cancer Risk Among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2

Siddhartha Yadav ; Nicholas J. Boddicker ; Jie Na ; Eric C. Polley ; Chunling Hu ; Steven N. Hart ; Rohan D. Gnanaolivu ; Nicole Larson ; Susan Holtegaard ; Huaizhi Huang ; Carolyn A. Dunn ; Lauren R. Teras ; Alpa V. Patel ; James V. Lacey ; Susan L. Neuhausen ; Elena Martinez ; Christopher Haiman ; Fei Chen ; Kathryn J. Ruddy ; Janet E. Olson ; Esther M. John ; Allison W. Kurian ; Dale P. Sandler ; Katie M. O'Brien ; Jack A. Taylor ; Clarice R. Weinberg ; Hoda Anton-Culver ; Argyrios Ziogas ; Gary Zirpoli ; David E. Goldgar ; Julie R. Palmer ; Susan M. Domchek ; Jeffrey N. Weitzel ; Katherine L. Nathanson ; Peter Kraft ; Fergus J. Couch

PURPOSE: To estimate the risk of contralateral breast cancer (CBC) among women with germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2. METHODS: The study population included 15,104 prospectively followed women within the CARRIERS study treated with ipsilateral surgery for invasive breast cancer. The risk of CBC was estimated for PV carriers in each gene compared with women without PVs in a multivariate proportional hazard regression analysis accounting for the competing [...]