Menée aux Etats-Unis à partir de données portant sur 400 aidants de patients atteints d'un cancer, cette étude analyse les caractéristiques d'un outil permettant de détecter leur détresse psychologique, d'identifier leurs besoins en soins de support et de les orienter vers les ressources adaptées

CancerSupportSourceTM-Caregiver: Development of a Distress Screening Measure for Cancer Caregivers

Zaleta, Alexandra K. ; Miller, Melissa F. ; Fortune, Erica E. ; Olson, Julie S. ; Rogers, Kimberly Papay ; Hendershot, Kelly ; Ash-Lee, Susan

Objective: Given the substantial demands of cancer caregiving, practical and psychometrically sound tools to evaluate distress among cancer caregivers are needed. CancerSupportSourceTM-Caregiver is a distress screening, referral, and support program designed to identify the unmet needs of cancer caregivers and link caregivers to desired resources and support. This study refined and finalized the CSS-Caregiver screening measure and examined its psychometric properties. Methods: Using an analytic [...]

Menée auprès de 4 068 patients atteins d'un cancer traité par chirurgie, cette étude de cohorte prospective analyse l'effet de la réduction de la durée des traitements par opioïdes prescrits après un traitement chirurgical sur l'utilisation chronique d'opioïdes

Postoperative Restrictive Opioid Protocols and Durable Changes in Opioid Prescribing and Chronic Opioid Use

Zsiros, Emese ; Ricciuti, Jason ; Gallo, Steven ; Argentieri, Deanna ; Attwood, Kristopher ; Ji, Wenyan ; Hutson, Alan ; Visco, Paul ; Coffey, Devon ; Riebandt, Grazyna ; Mark, Jaron ; Varghese, Aaron ; Hess, Suzanne M. ; Furlani, Thomas ; Fabiano, Andrew ; Hennon, Mark ; Yendamuri, Sai ; Kauffman, Eric C. ; Wooten, Kimberly E. ; Hicks, Wesley L., Jr ; Young, Jessica ; Takabe, Kazuaki ; Odunsi, Kunle ; Case, Amy A. ; Segal, Brahm H. ; Johnson, Candace S. ; Kuvshinoff, Boris, II ; Nurkin, Steven ; Paragh, Gyorgy ; de Leon-Casasola, Oscar

Importance : Changes in postsurgical opioid prescribing practices may help reduce chronic opioid use in surgical patients. Objective : To investigate whether postsurgical acute pain across different surgical subspecialties can be managed effectively after hospital discharge with an opioid supply of 3 or fewer days and whether this reduction in prescribed opioids is associated with reduced new, persistent opioid use. Design, Setting, and Participants : In this prospective cohort study with a [...]

Mené sur 193 patients atteints d'une maladie chronique du greffon contre l'hôte, cet essai de phase III évalue l'efficacité, du point de vue du taux de réponse en semaine 48, et la toxicité de l'ajout de l'ibrutinib à la prednisone

Ibrutinib for First-Line Treatment of Chronic Graft-Versus-Host Disease: Results From the Randomized Phase III iNTEGRATE Study

David Bernard Miklos ; Mohammad Abu Zaid ; Julian P. Cooney ; Jörn C. Albring ; Mary Flowers ; Alan P. Skarbnik ; Ibrahim Yakoub-Agha ; Bor-Sheng Ko ; Benedetto Bruno ; Edmund K. Waller ; Jean Yared ; Sang Kyun Sohn ; Claude-Eric Bulabois ; Takanori Teshima ; David Jacobsohn ; Hildegard Greinix ; Ahmad Mokatrin ; Yihua Lee ; Justin T. Wahlstrom ; Lori Styles ; Gérard Socié

PURPOSE: To present primary and final analyses from the randomized, double-blind, placebo-controlled, phase III iNTEGRATE study, which evaluated the safety and efficacy of ibrutinib with prednisone in previously untreated patients with chronic graft-versus-host disease (cGVHD). METHODS: Patients (age ≥ 12 years) with newly diagnosed moderate or severe cGVHD, requiring systemic corticosteroid therapy, and with no prior systemic treatment for cGVHD were randomly assigned 1:1 to receive ibrutinib [...]

Menée aux Etats-Unis à partir de données du système de santé militaire et de données des registres des cancers portant respectivement sur 5 379 et 21 516 patients atteints d'un cancer de la prostate de stade avancé, cette étude analyse la survie à 5 ans en fonction du régime de santé

Five-year survival of patients with late-stage prostate cancer: comparison of the Military Health System and the U.S. general population

Lin, Jie ; Nousome, Darryl ; Jiang, Jiji ; Chesnut, Gregory T. ; Shriver, Craig D. ; Zhu, Kangmin

Background: While the 5-year survival rate for local and regional prostate cancer is nearly 100%, it decreases dramatically for advanced tumours. Accessibility to health care is an important factor for cancer prognosis. The U.S. Military Health System (MHS) provides universal health care to its beneficiaries, reducing financial barriers to medical care. However, whether the universal care translates into improved survival among patients with advanced prostate cancer in the MHS is unknown. In [...]

Menée dans 17 pays d'Europe et en Israël à partir de données portant sur 6 238 patients ayant survécu à un cancer et sur 60 961 témoins (âge : supérieur ou égal à 50 ans), cette étude transversale analyse leurs fonctions pyschosociales et leur qualité de vie

The impact of cancer on psychosocial function and quality of life: A cross-sectional study in 18 pan-European countries

Bazilainsky, Svetlana ; Cohen, Miri ; Holtmaat, Karen ; Erlich, Brach ; Verdonck-de Leeuw, Irma M.

Background: To improve psychosocial cancer care in Europe, more information is needed on psychosocial function and quality of life (QoL) among cancer patients in European countries. Aims: To investigate differences in psychosocial function between cancer survivors and the general population in Europe, in relation to national economic status and personal factors. Method: Data were from the Survey of Health, Ageing and Retirement in Europe (Wave 6). Main outcomes were psychosocial functioning: [...]

Menée aux Etats-Unis par enquête auprès de 9 303 participants, cette étude analyse l'association entre des troubles psychiques et des perceptions négatives concernant le cancer

Relationship between mental health disorder symptoms and negative cancer perceptions among U.S. adults

Fwelo, Pierre ; Adzrago, David ; Adekunle, Ayooluwatomiwa D. ; Adekunle, Toluwani E. ; Akinlo, Ambrose ; Perkinson, William B.

Purpose: Although much emphasis has been placed on the impact of ambiguity on cognitive processes, the impact of mental health disorder symptoms and racial/ethnic disparities in cancer perception of fatalism and ambiguity remains less explored. This study explored the association between mental health disorder symptoms and negative cancer perceptions. Also, we assessed differences in these outcomes within mental health disorder symptoms and racial/ethnic subgroups to investigate the association [...]

Menée au Danemark et en Suède auprès de 546 321 conjoints de patients atteints d'un cancer et de 2 731 574 témoins, cette étude de cohorte analyse la présence et l'évolution de leurs troubles psychiatriques

Risk of Psychiatric Disorders Among Spouses of Patients With Cancer in Denmark and Sweden

Hu, Kejia ; Liu, Qianwei ; László, Krisztina D. ; Wei, Dang ; Yang, Fen ; Fall, Katja ; Adami, Hans-Olov ; Ye, Weimin ; Valdimarsdóttir, Unnur A. ; Li, Jiong ; Fang, Fang

Importance : There is emerging evidence that spouses of patients with cancer may have a higher prevalence of mental illness, but these studies have been limited by pre-post designs, focus on a single mental illness, and short follow-up periods. Objectives :To assess the overall burden of psychiatric disorders among spouses of patients with cancer vs spouses of individuals without cancer and to describe possible changes in this burden over time. Design, Setting, and Participants : This [...]

Menée aux Etats-Unis à partir de données portant sur 1 473 patients atteints d'un cancer, cette étude analyse l'association entre des problèmes financiers, une utilisation de substances psychoactives, la santé psychique et la qualité de vie

Association of financial worry with substance use, mental health, and quality of life in cancer patients

Jones, Salene M. W. ; Ton, Mimi ; Heffner, Jaimee L. ; Malen, Rachel C. ; Cohen, Stacey A. ; Newcomb, Polly A.

Purpose: Financial worry is an under-appreciated negative effect of cancer. The relationship of financial worry and health behaviors in cancer is poorly characterized and has important clinical implications. This study examined the association of financial worry with substance misuse, mood, and quality of life. Methods: People with cancer (n = 1473; 6 to 20 months after diagnosis) were recruited from a SEER cancer registry in the Pacific Northwest. Participants completed an online survey [...]

Menée en Belgique à partir des données 2004-2017 du registre des cancers portant sur 125 692 patients, cette étude analyse l'association entre les coûts des médicaments anticancéreux, leur remboursement (pour 12 indications de cancer) et l'évolution de la survie globale

Belgian observational survival data (incidence years 2004-2017) and expenditure for innovative oncology drugs in twelve cancer indications

Neyt, Mattias ; Devos, Carl ; Thiry, Nancy ; Silversmit, Geert ; De Gendt, Cindy ; Van Damme, Nancy ; Castanares-Zapatero, Diego ; Hulstaert, Frank ; Verleye, Leen

Background: The Food and Drug Administration (FDA) and European Medicines Agency (EMA) typically approve market access for cancer drugs based on surrogate endpoints, which do not always translate into the substantiated improvements in outcomes that matter most to patients, i.e. survival and quality of life (QoL). These drugs often also have a high price tag. We assessed whether there was an increase in cancer drug expenditure for a broad selection of indications and whether this correlates with [...]

Mené sur 32 patientes ayant survécu à un cancer gynécologique, cet essai randomisé évalue l'intérêt d'une intervention destinée à améliorer la communication patient-médecin sur la santé sexuelle

Starting the Conversation: randomized pilot trial of an intervention to promote effective clinical communication about sexual health for gynecologic cancer survivors

Reese, Jennifer Barsky ; Bober, Sharon L. ; Sorice, Kristen A. ; Handorf, Elizabeth ; Chu, Christina S. ; Middleton, Danny ; McIlhenny, Sarah ; El-Jawahri, Areej

Purpose: Gynecologic cancer survivors often hesitate to raise sexual health concerns with their clinicians. We pilot tested Starting the Conversation (STC), a theory-guided intervention aimed at facilitating survivors’ clinical communication about sexual health. Methods: Survivors (N = 32) were randomized 2:1 to STC (23-min video and accompanying workbook grounded in social cognitive theory that provides information and skills training for communicating with providers about sexual concerns, and [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2022 (24 articles), cette étude analyse l'impact, sur le choix thérapeutique, d'outils d'aide à la décision pour les patients atteints d'un cancer localisé de la prostate

Examining the effectiveness and implementation of patient treatment decision-aid tools for men with localised prostate cancer: A systematic review

Todio, Elizabeth ; Sharp, Jessica ; Morrow, April ; Taylor, Natalie ; Schofield, Penelope ; Mazariego, Carolyn

Objective: Men diagnosed with localised prostate cancer (LPC) often face a difficult process deciding on a treatment choice that suits their personal preferences. This systematic review examines the impact of patient treatment decision-aids (DAs) on decisional outcomes and treatment choice for men diagnosed with LPC. Our secondary aim was to examine how DAs have been implemented into routine clinical practice. Methods: A systematic search was conducted up to June 2022 using the following [...]