A partir de revues systématiques de la littérature publiée jusqu'au 31 mai 2022, cette méta-analyse évalue l'association entre le tabagisme et 36 maladies dont le cancer

Health effects associated with smoking: a Burden of Proof study

Dai, Xiaochen ; Gil, Gabriela F. ; Reitsma, Marissa B. ; Ahmad, Noah S. ; Anderson, Jason A. ; Bisignano, Catherine ; Carr, Sinclair ; Feldman, Rachel ; Hay, Simon I. ; He, Jiawei ; Iannucci, Vincent ; Lawlor, Hilary R. ; Malloy, Matthew J. ; Marczak, Laurie B. ; McLaughlin, Susan A. ; Morikawa, Larissa ; Mullany, Erin C. ; Nicholson, Sneha I. ; O’Connell, Erin M. ; Okereke, Chukwuma ; Sorensen, Reed J. D. ; Whisnant, Joanna ; Aravkin, Aleksandr Y. ; Zheng, Peng ; Murray, Christopher J. L. ; Gakidou, Emmanuela

As a leading behavioral risk factor for numerous health outcomes, smoking is a major ongoing public health challenge. Although evidence on the health effects of smoking has been widely reported, few attempts have evaluated the dose–response relationship between smoking and a diverse range of health outcomes systematically and comprehensively. In the present study, we re-estimated the dose–response relationships between current smoking and 36 health outcomes by conducting systematic reviews up [...]

Menée à partir des données internationales de 10 études portant au total sur 9 626 témoins et 9229 patients atteints d'un lymphome non hodgkinien, cette étude analyse l'association entre une utilisation professionnelle d'herbicides et le risque de développer la maladie

Herbicide use in farming and other jobs in relation to non-Hodgkin’s lymphoma (NHL) risk

De Roos, Anneclaire J ; Fritschi, Lin ; Ward, Mary H ; Monnereau, Alain ; Hofmann, Jonathan ; Bernstein, Leslie ; Bhatti, Parveen ; Benavente Moreno, Yolanda ; Benke, Geza ; Casabonne, Delphine ; Clavel, Jacqueline ; Cocco, Pierluigi ; Huynh, Tran ; 't Mannetje, Andrea ; Miligi, Lucia ; Piro, Sara ; Rothman, Nathaniel ; Schinasi, Leah H ; Vajdic, Claire M ; Wang, Sophia S ; Zhang, Yawei ; Slager, Susan L ; Cerhan, James R

Objectives: Given mixed evidence for carcinogenicity of current-use herbicides, we studied the relationship between occupational herbicide use and risk of non-Hodgkin’s lymphoma (NHL) in a large, pooled study. Methods: We pooled data from 10 case-control studies participating in the International Lymphoma Epidemiology Consortium, including 9229 cases and 9626 controls from North America, the European Union and Australia. Herbicide use was coded from self-report or by expert assessment in the [...]

Menée à l'aide de données européennes portant sur 199 719 personnes, cette étude analyse l'association entre une exposition à long terme à la pollution de l'air (dioxyde d'azote, particules fines PM2.5, carbone, ozone) et le risque de cancer du sein (9 659 cas)

Breast cancer incidence in relation to long-term low-level exposure to air pollution in the ELAPSE pooled cohort

Hvidtfeldt, Ulla Arthur. ; Chen, Jie ; Rodopoulou, Sophia ; Strak, Maciej ; de Hoogh, Kees ; Andersen, Zorana J. ; Bellander, Tom ; Brandt, Jørgen ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hertel, Ole ; Hoffmann, Barbara H. ; Katsouyanni, Klea ; Ketzel, Matthias ; Brynedal, Boel ; Leander, Karin ; Ljungman, Petter L. S. ; Magnusson, Patrik K. E. ; Nagel, Gabriele ; Pershagen, Göran ; Rizzuto, Debora ; Boutron-Ruault, Marie-Christine ; Samoli, Evangelia ; So, Rina ; Stafoggia, Massimo ; Tjønneland, Anne ; Vermeulen, Roel ; Verschuren, W. M. Monique ; Weinmayr, Gudrun ; Wolf, Kathrin ; Zhang, Jiawei ; Zitt, Emanuel ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole

Background: Established risk factors for breast cancer include genetic disposition, reproductive factors, hormone therapy, and lifestyle-related factors such as alcohol consumption, physical inactivity, smoking, and obesity. More recently a role of environmental exposures, including air pollution, has also been suggested. The aim of this study, was to investigate the relationship between long-term air pollution exposure and breast cancer incidence. Methods: We conducted a pooled analysis among [...]

Menée auprès d'une cohorte de 97 677 femmes ménopausées, cette étude analyse l'association entre la lumière extérieure nocturne et le risque de cancer de l'endomètre (991 cas)

Outdoor light at night and risk of endometrial cancer in the NIH-AARP diet and health study

Medgyesi, Danielle N. ; Trabert, Britton ; Fisher, Jared A. ; Xiao, Qian ; James, Peter ; White, Alexandra J. ; Madrigal, Jessica M. ; Jones, Rena R.

Purpose: Outdoor light at night (LAN) can result in circadian disruption and hormone dysregulation and is a suspected risk factor for some cancers. Our study is the first to evaluate the association between LAN and risk of endometrial cancer, a malignancy with known relationship to circulating estrogen levels. Methods: We linked enrollment addresses (1996) for 97,677 postmenopausal women in the prospective NIH-AARP cohort to satellite imagery of nighttime radiance to estimate LAN exposure. [...]

Menée aux Etats-Unis auprès de 58 227 participants, cette étude analyse l'association entre une utilisation d'anti-inflammatoires non stéroïdiens et le risque de mélanome, en fonction de l'exposition aux rayons UV ambiants et de la sensibilité individuelle au soleil

Use of Nonsteroidal Anti-Inflammatory Drugs and Incidence of Melanoma in the United States Radiologic Technologists Study

Mai, Jim Z. ; Kitahara, Cari M. ; Sargen, Michael R. ; Little, Mark P. ; Alexander, Bruce H. ; Linet, Martha S. ; Tucker, Margaret A. ; Cahoon, Elizabeth K.

Although NSAIDs have been associated with both reduced and increased cutaneous melanoma risk, few studies have examined these associations by ultraviolet radiation (UVR) or personal sun-sensitivity. We examined the associations between NSAID use and first primary invasive cutaneous melanoma among 58,227 non-Hispanic white participants in the United States Radiologic Technologists cohort study. Poisson regression was used to calculate rate ratios (RR) and 95% likelihood-based confidence [...]

Menée en France, en Suède et en Italie auprès de 8 475 patientes ayant survécu à un cancer de la thyroïde traité sur la période 1934-2005 (âge moyen au diagnostic : 45 ans ; durée médiane de suivi : 12,7 ans), cette étude analyse le risque de cancer du sein associé au traitement par l'iode 131 (335 cas)

Breast cancer risk among thyroid cancer survivors and the role of I-131 treatment

Tran, Thi-Van-Trinh ; Rubino, Carole ; Allodji, Rodrigue ; Andruccioli, Milena ; Bardet, Stephane ; Diallo, Ibrahima ; Dottorini, Massimo ; Garsi, Jérome ; Hall, Per ; Henry-Amar, Michel ; Lamart, Stephanie ; Le Thai, Françoise ; Lönn, Stefan ; Ricard, Marcel ; Schvartz, Claire ; Schlumberger, Martin ; Journy, Neige ; de Vathaire, Florent

Background: Female thyroid cancer survivors are more likely to have a higher risk of breast cancer compared to the general population, and the underlying causes are yet to be understood. The potential role of I-131 treatment on this association remains controversial. Methods: We pooled individual data of women who were treated for differentiated thyroid cancer from 1934 to 2005 in France, Italy and Sweden. Standardized incidence ratios (SIRs) for breast cancer were estimated by comparison with [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données 2003-2008 de la "BioBank Japan" portant sur 158 284 personnes, cette étude sur le génome entier évalue l'association entre l'indice de masse corporelle et le risque de cancer de l'estomac (6 563 cas) ou de l'oesophage (1 300 cas)

Association of Body Mass Index and the Risk of Gastro-Esophageal Cancer: A Mendelian Randomization Study in a Japanese Population

Zang, Zhaoping ; Shao, Yi ; Nakyeyune, Rena ; Shen, Yi ; Niu, Chen ; Zhu, Lingyan ; Ruan, Xiaoli ; Wei, Tong ; Wei, Ping ; Liu, Fen

There are growing concerns that body mass index (BMI) is related to cancer risk at various anatomical sites, including the upper gastrointestinal tract, and the existence of a causal relationship remains unclear. The Mendelian randomization (MR) method uses instrumental genetic variables of risk factors to explore whether a causal relationship exists while preventing confounding. In our study, genome-wide association study (GWAS) data from the BioBank Japan (BBJ) project were used. Genetic [...]

Menée au Danemark auprès de 189 609 femmes participant au dépistage organisé sur la période 2012-2017 (âge : 50-69 ans ; durée de suivi : 1 067 282 personnes-années), cette étude analyse l'association entre la densité mammaire et le risque de cancer du sein (4 110 cas)

Breast Density and Risk of Breast Cancer

Lynge, Elsebeth ; Vjeborg, Ilse ; Lillholm, Martin ; Nielsen, Mads ; Napolitano, George ; von Euler-Chelpin, My

Early studies reported a 4-6-fold risk of breast cancer between women with extremely dense and fatty breasts. As most early studies were case-control studies, we took advantage of a population-based screening program to study density and breast cancer incidence in a cohort design. In the Capital Region, Denmark, woman aged 50-69 are invited to screening biennially. Women screened November 2012 - December 2017 were included, and classified by BI-RADS density code, version 4, at first screen [...]