Menée en Norvège à partir de données portant sur 730 patients atteints d'un cancer du poumon non à petites cellules de stade avancé, cette étude analyse l'évolution de leurs symptômes et de leur qualité de vie durant leur dernière année de vie

Trajectory of health-related quality of life during the last year of life in patients with advanced non-small–cell lung cancer

Kristensen, Are ; Grønberg, Bjørn Henning ; Fløtten, Øystein ; Kaasa, Stein ; Solheim, Tora Skeidsvoll

Background : The aims of this study were to assess the trajectory of health-related quality of life (HRQOL) during the last year of life in patients with advanced non-small–cell lung cancer (NSCLC) and to explore when and to what degree deterioration of symptoms and physical functioning accelerate towards the end of life. Methods : Data from two RCTs of first-line chemotherapy in advanced NSCLC was analyzed. HRQOL was assessed repeatedly using the EORTC QLQ-C30 and LC13. Changes in HRQOL scores [...]

Menée aux Etats-Unis à partir de données portant sur 8 962 patients atteints d'un cholangiocarcinome intrahépatique diagnostiqué entre 2000 et 2018, cette étude analyse la survie et les causes de décès (7 335 décès dont 4 832 décès par cholangiocarcinome)

Survival and Causes of Death among Patients with Intrahepatic cholangiocarcinoma in the United State from 2000 to 2018

Elgenidy, Anas ; Afifi, Ahmed M. ; Jalal, Prasun K.

Background: Intrahepatic cholangiocarcinoma (ICCA) has shown a substantial increase in mortality globally. On the contrary, perihilar cholangiocarcinoma and distal cholangiocarcinoma have been decreasing. We aim to evaluate the causes of death after ICCA diagnosis. Methods: We studied 8,962 ICCA patients diagnosed between 2000 and 2018 in the United States. The standardized mortality ratio (SMR) for each cause of death was calculated. We used R software version 3.5 to perform Kaplan-Meier [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2022 (22 interventions), cette étude analyse l'utilisation d'entretiens motivationnels pour améliorer les comportements de santé (activité physique, nutrition)

Motivational interviewing interventions aiming to improve health behaviors among cancer survivors: a systematic scoping review

Seven, Memnun ; Reid, Allecia ; Abban, Sabriye ; Madziar, Camilla ; Faro, Jamie M.

Purpose : The scoping review aimed to map out the literature on the utilization of motivational interviewing (MI) to improve health behaviors (i.e., physical activity, nutrition) in adult cancer survivors. Methods : This scoping review was conducted following the methods and protocol outlined by the Joanna Briggs Institute Methods Manual. Five databases, including PubMed, CINAHL, Web of Science, and SPORTDiscus, were searched in February 2022 to identify MI interventions to improve health [...]

Menée au Canada à partir de données portant sur 535 patients atteints d'un cancer du poumon non à petites cellules de stade précoce ayant été réséqué, cette étude de cohorte rétrospective analyse la présence de mutations du gène EGFR, les traitements reçus, le taux de récidive et la survie

EGFR Mutation Prevalence, Real-world Treatment Patterns, and Outcomes among Patients with Resected, Early-stage, Non-small Cell Lung Cancer in Canada

Sara Kuruvilla, M. ; Liu, Geoffrey ; Syed, Iqra ; Gwadry-Sridhar, Femida ; Sheffield, Brandon S. ; Rakibuz-Zaman, Muhammad ; Liu, Linda ; Sachdeva, Robin ; Pencz, Alec ; Zhan, Luna ; Hueniken, Katrina ; Patel, Devalben ; Balaratnam, Karmugi ; Khan, Khaleeq ; Grant, Benjamin ; Noy, Shawna ; Singh, Karan ; Moldaver, Daniel ; Kate Shanahan, Mary ; Cheema, Parneet K.

Objectives : The ADAURA trial demonstrated the benefit of adjuvant osimertinib among patients with resected, early-stage, epidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC). To understand the potential population impact, it is critical to deduce the prevalence, management, and outcomes of this patient population in the real-world setting before use of adjuvant osimertinib. Materials and Methods : Using PALEOS (Pan-cAnadian Lung cancEr Observational Study) data [...]

Menée aux Etats-Unis à partir de données portant sur 666 patients atteints d'un cancer du rectum (255 femmes et 411 hommes), cette étude rétrospective analyse l'effet de l'âge sur le choix des traitements, la survenue de complications post-opératoires et la survie

The impact of age on rectal cancer treatment, complications and survival

Høydahl, Øystein ; Edna, Tom-Harald ; Xanthoulis, Athanasios ; Lydersen, Stian ; Endreseth, Birger Henning

Background : The number of older patients with rectal cancer is increasing. Treatment outcome discrepancies persist, despite similar treatment guidelines. To offer the oldest patients optimal individually adjusted care, further knowledge is needed regarding treatment strategy and outcome. The present study aimed to evaluate treatment, postoperative complications, and survival in older patients treated for rectal cancer. Methods : This retrospective study included all 666 patients (n=255 [...]

Menée dans l'Etat de Californie sur la période 1988-2019, cette étude analyse l'association entre des facteurs sociodémographiques et la survie chez des patients atteints d'un cancer de l'ouraque

Association of Sociodemographic Characteristics With Survival Among Patients With Urachal Cancer in California From 1988 to 2019

Benjamin, David J. ; Shrestha, Anshu ; Fellman, Dimitra ; Cress, Rosemary D. ; Kalebasty, Arash Rezazadeh

Urachal cancer is a rare genitourinary malignant neoplasm that arises from the remnant of the embryological structure between the bladder and allantois. It has been considered an extremely aggressive neoplasm, with a median overall survival (OS) ranging between 12 and 24 months among patients with locally advanced and metastatic disease. Surgery is the preferred treatment for localized and regional disease, and chemotherapy and/or immunotherapy are recommended for metastatic disease. We [...]

Menée aux Pays-Bas par questionnaire auprès de 150 parents et proches de patients décédés d'un cancer de stade avancé, cette étude prospective longitudinale analyse les facteurs associés à leur état émotionnel pendant le deuil

Emotional functioning during bereavement after the death of patients with advanced cancer and associated factors

Ham, Laurien ; Fransen, Heidi P ; van Roij, Janneke ; van den Borne, Ben ; Creemers, Geert Jan ; Hendriks, Mathijs P ; Kuip, Evelien ; van Laarhoven, Hanneke WM ; van Leeuwen, Lobke ; van der Padt – Pruijsten, Annemieke ; Smilde, Tineke ; Stellingwerf, Margriet ; van Zuylen, Lia ; van de Poll – Franse, Lonneke ; Raijmakers, Natasja JH

Objective : The death of a loved one is considered to be the most stressful of all life events. However, the impact of bereavement on quality of life varies between individuals. The aim of our study was to assess emotional functioning, which is a domain of quality of life, of bereaved relatives after the death of their loved one and its associated factors. Method : A prospective, longitudinal, multicenter, observational study on quality of care and quality of life of patients with advanced [...]

Menée aux Etats-Unis à partir de données portant sur 2 049 patients atteints d'un cancer (âge moyen : 68,1 ans), cette étude analyse l'association entre leur situation professionnelle, des difficultés financières, l'adhésion aux traitements et des symptômes de dépression et d'anxiété

Financial Worry in People with Cancer: Relationship to Employment and Outcomes

Jones, Salene M. W.

Background : People with cancer experience financial hardship. Most previous research has focused on material financial burden rather than financial worry. This study investigated employment predictors of financial worry and examined outcomes potentially affected by financial worry. Methods : Data from the 2018 National Health Interview Study was used and limited to people diagnosed with cancer and having complete data on relevant variables (n=2049). Preliminary analyses indicated three [...]

Menée en Chine à partir de données portant sur 2 930 patient atteints d'un cancer de stade avancé ne présentant pas de symptômes majeurs de dépression, cette étude analyse les facteurs associés à des idées suicidaires

Suicidal Ideation in Advanced Cancer Patients without Major Depressive Disorder

Tang, Lili ; He, Yi ; Pang, Ying ; Su, Zhongge ; Zhou, Yuhe ; Wang, Yu ; Lu, Yongkui ; Jiang, Yu ; Han, Xinkun ; Song, Lihua ; Wang, Liping ; Li, Zimeng ; Lv, Xiaojun ; Wang, Yan ; Yao, Juntao ; Liu, Xiaohong ; Zhou, Xiaoyi ; He, Shuangzhi ; Zhang, Yening ; Song, Lili ; Li, Jinjiang ; Wang, Bingmei

Introduction : Major depressive disorder (MDD) is associated with an increased risk of suicide and suicide attempt among cancer patients. However, we do not know how many cancer patients without MDD have suicidal ideation (SI). Objectives : This study aimed to investigate the prevalence, characteristics and correlated factors of SI among advanced cancer patients without MDD. Methods : This is a multi-center, cross-sectional study based on an electronic patient-reported outcome (ePRO) systems in [...]

Menée à partir de données portant sur 1 772 patients atteints d'un cancer de la prostate traité par prostatectomie radicale, cette étude identifie les facteurs associés à leur perception d'eux-mêmes

Cancer-related self-perception in men affected by prostate cancer after radical prostatectomy

Jahnen, Matthias ; Lehner, Luisa ; Meissner, Valentin H. ; Andreas Dinkel, ; Schiele, Stefan ; Schulwitz, Helga ; Gschwend, Jurgen E. ; Herkommer, Kathleen

Purpose : To identify factors associated with cancer-related self-perception after being affected by prostate cancer (PCa) and radical prostatectomy. Subjects and methods : Men affected by PCa and radical prostatectomy were asked to choose one of 5 cancer-related identities (“patient,” “victim,” “someone who has had cancer,” “cancer survivor,” and “cancer conqueror”). Associations with clinical data, functional outcome (continence and sexual activity), and psychological factors were assessed. [...]

Menée aux Etats-Unis à partir de données portant sur 360 patientes ménopausées atteintes d'un cancer du sein de stade précoce, cette étude de cohorte analyse l'évolution de leurs symptômes neuropsychologiques en lien avec une utilisation d'anastrozole

Trajectories of neuropsychological symptom burden in postmenopausal women prescribed anastrozole for early-stage breast cancer

McCall, Maura K. ; Sereika, Susan M. ; Snader, Stephanie ; Lavanchy, Alexa ; Rosenzweig, Margaret Q. ; Conley, Yvette P. ; Beumer, Jan H. ; Bender, Catherine M.

Purpose : Aromatase inhibitors (AIs) prolong survival for postmenopausal women with hormone receptor-positive breast cancer (HR + BC) but also burden patients with symptoms, a major reason for suboptimal AI adherence. This study characterizes inter-relationships among symptom measures; describes neuropsychological symptom burden trajectories; and identifies trajectory group membership predictors for postmenopausal women prescribed anastrozole for HR + BC. Methods : This study utilized [...]

Menée en Australie par enquête auprès de 116 patients atteints d'un gliome de haut grade, cette étude de cohorte prospective analyse l'évolution de l'intensité de leur détresse psychologique, avant la chimioradiothérapie et 3 et 6 mois après, puis évalue leurs besoins en soins de support

Brain cancer patients’ levels of distress and supportive care needs over time

Halkett, Georgia ; Lobb, Elizabeth ; Spilsbury, Katrina ; Dhillon, Haryana ; Nowak, Anna

Purpose : This study aimed to describe patient self-reported distress over time and how this was associated with wellbeing, and supportive care needs over a six-month period from commencing chemoradiotherapy for high grade glioma (HGG). Methods : In this prospective cohort study, participants completed surveys at three time points: before chemoradiotherapy, at three and six months. These included Distress Thermometer, Functional Assessment of Cancer/Brain Cancer Treatment-general [...]

Menée dans un contexte américain à partir de données portant sur un total de 199 344 patients atteints d'un cancer (105 255 cas de cancer du sein, 23 571 cas de cancer colorectal, 11 321 cas de cancer du poumon et 59 197 cas de cancer de la prostate), cette étude de cohorte présente une estimation des coûts restant à la charge des patients bénéficiant d'une assurance santé privée, pendant la première année suivant le diagnostic de la maladie

Costs Around the First Year of Diagnosis for 4 Common Cancers Among the Privately Insured

Shih, Ya-Chen Tina ; Xu, Ying ; Bradley, Cathy ; Giordano, Sharon H ; Yao, James ; Yabroff, K Robin

Background : We estimated trends in total and out-of-pocket (OOP) costs around the first year of diagnosis for privately insured nonelderly adult cancer patients. Methods : We constructed incident cohorts of breast, colorectal, lung, and prostate cancer patients diagnosed between 2009 and 2016 using claims data from the Health Care Cost Institute. We identified cancer-related surgery, intravenous (IV) systemic therapy, and radiation and calculated associated total and OOP costs (in 2020 US [...]