Clonal Hematopoiesis of Indeterminate Potential and Risk of Death from COVID-19

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Résumé en anglais

Clonal hematopoiesis is an age-related phenomenon in which a clonal population of blood cells emerges and is often detected by the presence of a mutation present in a peripheral blood sample. Clonal hematopoiesis of indeterminate potential (CHIP) is a subtype of clonal hematopoiesis found in individuals without a hematologic malignancy in which a somatic pathogenic mutation in a gene mutated in myeloid neoplasia is present in at least 2% of the sequenced blood DNA (termed variant allele fraction, or VAF).1,2 CHIP is associated with increased mortality and risk of adverse outcomes including cardiovascular and pulmonary disease (COPD).3-5 These associations, which are largely driven by CHIP clones with VAF greater than 0.1, are thought to arise from augmentation of inflammasome-mediated IL-1ß and IL-6 production by mutant macrophages.