Menée auprès de 98 265 participants à l'essai "the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial" (durée moyenne de suivi : 8,86 ans), cette étude analyse l'association entre une consommation d'aliments ultra-transformés et le risque de cancer du pancréas (387 cas)

Ultra-processed food consumption and the risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Zhong, Guo-Chao ; Zhu, Qian ; Cai, Dong ; Hu, Jie-Jun ; Dai, Xin ; Gong, Jian-Ping ; Sun, Wei-Ping

Whether ultra-processed food consumption is associated with the risk of pancreatic cancer has not been determined. We performed a prospective study to fill this gap. A population-based cohort of 98265 American adults was identified from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Ultra-processed foods were defined by the NOVA classification. Cox regression was used to estimate hazard ratios (HRs) for pancreatic cancer incidence. Subgroup analysis was performed to [...]

Menée en Chine auprès de 657 témoins et 373 patientes atteintes d'un cancer du sein diagnostiqué sur la période 2012-2016, cette étude analyse l'association entre une exposition aux substances perfluoroalkylées (PFAS) et le risque de développer la maladie

Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population

Li, Xuejun ; Song, Fengju ; Liu, Xiaotu ; Shan, Anqi ; Huang, Yubei ; Yang, Zhengjun ; Li, Haixin ; Yang, Qiaoyun ; Yu, Yue ; Zheng, Hong ; Cao, Xu-Chen ; Chen, Da ; Chen, Ke-Xin ; Chen, Xi ; Tang, Nai-jun

Background: Perfluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Recent studies have implicated exposure to PFASs as a risk factor for breast cancer in Europe and America. Little is known about the role of PFASs with respect to breast cancer in the Chinese population. Methods: Participants who were initially diagnosed with breast cancer at Tianjin Medical University Cancer Institute and Hospital between 2012 [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de la "UK Biobank" et de la "FinnGen" portant au total sur 19 590 patients atteints d'un cancer digestif (oesophage, estomac, foie, voies biliaires, pancréas et colon-rectum), cette étude analyse l'association entre le chronotype et le risque de développer la maladie

Morning Chronotype and Digestive Tract Cancers: Mendelian Randomization Study

Chen, Jie ; Larsson, Susanna C. ; Kar, Siddhartha ; Burgess, Stephen ; Li, Xue ; Yuan, Shuai ; Vithayathil, Mathew ; Mason, Amy M. ; Titova, Olga E.

Morning chronotype has been associated with a reduced risk of prostate and breast cancer. However, few studies have examined whether chronotype is associated with digestive tract cancer risk. We conducted a Mendelian randomization (MR) study to assess the associations of chronotype with major digestive tract cancers. A total of 317 independent genetic variants associated with chronotype at the genome-wide significance level (P<5×10-8) were used as instrumental variables from a genome-wide [...]

Menée au Danemark et à Taïwan auprès de 8 580 personnes atteintes d'un cancer et 2 237 361 témoins, cette étude analyse l'association entre un diabète maternel (type 2 ou gestationnel) et le risque de cancer chez l'enfant

Maternal diabetes and childhood cancer risks in offspring: two population-based studies

Huang, Xiwen ; Hansen, Johnni ; Lee, Pei-Chen ; Wu, Chia-Kai ; Federman, Noah ; Arah, Onyebuchi A. ; Li, Chung-Yi ; Olsen, Jorn ; Ritz, Beate ; Heck, Julia E.

Background: The effect of maternal diabetes on childhood cancer has not been widely studied. Methods: We examined this in two population-based studies in Denmark (N = 6420 cancer cases, 160,484 controls) and Taiwan (N = 2160 cancer cases, 2,076,877 non-cases) using logistic regression and Cox proportional hazard regression adjusted for birth year, child’s sex, maternal age and birth order. Results: Gestational diabetes in Denmark [odds ratio (OR) = 0.98, 95% confidence interval (CI): 0.71–1.35] [...]