Mené aux Etats-Unis entre 2015 et 2020 sur 21 442 personnes âgées d'au moins 60 ans (durée médiane de suivi : 3,6 ans), cet essai randomisé analyse le rôle, dans la prévention des cancers, d'une supplémentation en vitamines et minéraux

Multivitamins in the prevention of cancer and cardiovascular disease: The COSMOS randomized clinical trial

Sesso, Howard D ; Rist, Pamela M ; Aragaki, Aaron K ; Rautiainen, Susanne ; Johnson, Lisa G ; Friedenberg, Georgina ; Copeland, Trisha ; Clar, Allison ; Mora, Samia ; Moorthy, M Vinayaga ; Sarkissian, Ara ; Wactawski-Wende, Jean ; Tinker, Lesley F ; Carrick, William R ; Anderson, Garnet L ; Manson, JoAnn E ; for the COSMOS Research Group

Although older adults commonly take multivitamin-multimineral (MVM) supplements to promote health, evidence on use of daily MVMs on invasive cancer is limited.The study objective was to determine if a daily MVM decreases total invasive cancer among older adults.We performed a randomized, double-blind, placebo-controlled, two-by-two factorial trial of a daily MVM and cocoa extract for prevention of cancer and cardiovascular disease (CVD) among 21,442 U.S. adults (12,666 women aged ≥ 65 years and [...]

Menée à l'aide de lignées cellulaires humaines et murines de cancer de la prostate, cette étude met en évidence le rôle prépondérant du delta-tocotriénol (une forme de vitamine E) dans la prévention du cancer de la prostate

Delta-Tocotrienol is the Most Potent Vitamin E Form in Inhibiting Prostate Cancer Cell Growth and Inhibits Prostate Carcinogenesis in Ptenp−/− Mice

Wang, Hong ; Yan, William ; Sun, Yuhai ; Yang, Chung S.

Vitamin E compounds, consisting of α, β, γ, and δ forms of tocopherols and tocotrienols, display different cancer preventive activities in experimental models. Tocotrienols may have higher potential for clinical use due to their lower effective doses in laboratory studies. However, most studies on tocotrienols have been carried out using cancer cell lines. Strong data from animal studies may encourage the use of tocotrienols for human cancer prevention research. To examine the cancer inhibitory [...]

Menée aux Etats-Unis à partir de données 2001-2017, cette étude analyse l'association entre le statut vaccinal contre le papillomavirus humain (HPV) et le risque de cancer lié au HPV (carcinome oropharyngé, anal, vulvaire, vaginal, cervical et pénien ; 657 317 cas), en fonction du sexe et de l'origine ethnique

Trends in Human Papillomavirus–Associated Cancers, Demographic Characteristics, and Vaccinations in the US, 2001-2017

Liao, Cheng-I. ; Francoeur, Alex Andrea ; Kapp, Daniel S. ; Caesar, Michelle Ann P. ; Huh, Warner K. ; Chan, John K.

Nearly 45 000 human papillomavirus (HPV)-associated cancers are diagnosed annually in the US. The HPV vaccine has been approved since 2006, but information on the association between vaccination and the incidence of HPV-attributable cancers is unclear.To evaluate the potential association of screening and vaccination on the trends of HPV-associated cancers.A retrospective, population-based cross-sectional study was conducted using data on HPV-associated (oropharyngeal squamous cell carcinoma [...]