A partir d'une revue de la littérature, cette étude analyse les effets d'une radiothérapie pelvienne sur les tissus érectiles féminins et sur les troubles de la sexualité chez les patientes atteintes d'un cancer

Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review

Marshall, Deborah C. ; Tarras, Elizabeth S. ; Ali, Ayesha ; Bloom, Julie ; Torres, Mylin A. ; Kahn, Jenna M.

Sexual function is a vital aspect of human health and is recognized as a critical component of cancer survivorship. Understanding and evaluating the impacts of radiotherapy on female sexual function requires precise knowledge of the organs involved in sexual function and the relationship between radiotherapy exposure and sexual tissue function. Although substantial evidence exists describing the impact of radiotherapy on male erectile tissues and related clinical sexual outcomes, there is very [...]

A partir d'une revue systématique de la littérature (9 études), cette étude analyse l'effet de la pratique d'une activité physique sur la fatigue chez des enfants, adolescents et jeunes adultes ayant survécu à un cancer pédiatrique

Effect of physical activity on fatigue in childhood cancer survivors: a systematic review

Moberg, Libby ; Fritch, Jordan ; Westmark, Danielle ; Mina, Daniel Santa ; Krause, Crystal ; Bilek, Laura ; Acquazzino, Melissa

Purpose : Many children, adolescents, and young adult survivors of childhood cancer experience fatigue following cancer treatment. Physical activity has been shown to be effective in improving cancer-related fatigue in adult survivors, but there is a lack of evidence on its effect in childhood cancer survivors. In addition, there are no guidelines for treatment of fatigue in childhood cancer survivors. The purpose of this study was to examine the existing literature on the effect of physical [...]

Mené sur 32 patientes atteintes d'un cancer du sein, cet essai randomisé évalue l'efficacité d'une thérapie par photobiomodulation pour prévenir une neuropathie périphérique induite par la chimiothérapie

The use of photobiomodulation therapy for the prevention of chemotherapy-induced peripheral neuropathy: a randomized, placebo-controlled pilot trial (NEUROLASER trial)

Joy, Lodewijckx ; Jolien, Robijns ; Marithé, Claes ; Stijn, Evens ; Laura, Swinnen ; Hilde, Lenders ; Sandra, Bortels ; Wendy, Nassen ; Ruth, Hilkens ; Liesbeth, Raymakers ; Sylvana, Snoekx ; Sylvia, Hermans ; Jeroen, Mebis

Purpose : The purpose of this study was to investigate the effectiveness of photobiomodulation (PBM) therapy for the prevention of chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer patients. Methods : A prospective, randomized placebo-controlled pilot trial (NEUROLASER) was set up with 32 breast cancer patients who underwent chemotherapy (ClinicalTrials.gov; NCT03391271). Patients were randomized to receive PBM (n = 16) or placebo treatments (n = 16) (2 × /week) during their [...]

Mené en Espagne sur 60 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'intérêt, du point de vue de l'état de santé physique, de la fatigue liée à la maladie, des symptômes de dépression et de la qualité de vie, d'un programme d'entraînement de résistance supervisé pendant 12 semaines et combiné à de l'activité physique à domicile

Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors: the EFICAN randomized controlled trial

Soriano-Maldonado, Alberto ; Díez-Fernández, David M. ; Esteban-Simón, Alba ; Rodríguez-Pérez, Manuel A. ; Artés-Rodríguez, Eva ; Casimiro-Artés, Miguel A. ; Moreno-Martos, Herminia ; Toro-de-Federico, Antonio ; Hachem-Salas, Nur ; Bartholdy, Cecilie ; Henriksen, Marius ; Casimiro-Andújar, Antonio J.

Purpose : This study assessed the effects of 12-week supervised resistance training combined with home-based physical activity on physical fitness, cancer-related fatigue, depressive symptoms, health-related quality of life (HRQoL), and life satisfaction in female breast cancer survivors. Methods : A parallel-group, outcome assessor-blinded, randomized controlled trial included 60 female breast cancer survivors who had completed their core treatments within the previous 10 years. Through [...]

Menée dans l'Etat du Texas à partir de données portant sur 13 925 patients atteints d'un cancer hépatocellulaire (7 622 cas de cancer de stade localisé et 6 303 cas de stade avancé), cette étude analyse l'impact du niveau socioéconomique du voisinage sur l'association entre l'origine ethnique et le stade de la maladie au diagnostic

Mediating effects of neighborhood-level socioeconomic deprivation on the association between race/ethnicity and advanced hepatocellular carcinoma

Oluyomi, Abiodun O. ; Mohammadi, Kusha A. ; El-Serag, Hashem B. ; Thrift, Aaron P.

Background: Racial/ethnic minorities are more likely than non-Hispanic whites (NHW) to be diagnosed with advanced stage hepatocellular carcinoma (HCC). We examined the role of neighborhood disadvantage as a mediator of the association between race/ethnicity and HCC stage at diagnosis. Methods: We used data from HCC cases diagnosed in Texas from 2007-2015. HCC cases were classified as local versus regional/advanced stage. A mediation model approach was used to estimate the average direct effect, [...]

Menée aux Etats-Unis sur la période 2019-2020 par questionnaire auprès de 20 818 patients ayant survécu à un cancer, cette étude analyse les changements de comportement tabagique au cours de la prise en charge de la maladie

Changes in cigarette smoking behavior in cancer survivors during diagnosis and treatment

Jose, Thulasee ; Schroeder, Darrell R ; Warner, David O

Continued cigarette smoking is a critical determinant of outcome in oncology patients, but how the separate events of cancer diagnosis, cancer treatment, and completion of treatment affect smoking behavior in cancer survivors is unknown. This study described such changes, hypothesizing that they would be more pronounced for smoking-related cancers.The Cancer Patient Tobacco Use Questionnaire (CTUQ) was sent to every cancer patient ≥ 18 years old scheduled for outpatient visits at the Mayo [...]

Menée aux Etats-Unis à partir de données portant sur 1 304 498 patients atteints d'un cancer traité par chirurgie entre 2004 et 2015 (16 localisations de tumeur solide), cette étude de cohorte rétrospective analyse l'association entre le nombre de ganglions lymphatiques atteints et la mortalité

Quantitative Nodal Burden and Mortality across Solid Cancers

Nguyen, Anthony T ; Luu, Michael ; Nguyen, Vina P ; Lu, Diana J ; Shiao, Stephen L ; Kamrava, Mitchell ; Atkins, Katelyn M ; Mita, Alain C ; Scher, Kevin S ; Spratt, Daniel E ; Faries, Mark B ; Daskivich, Timothy J ; Lin, De-Chen ; Chen, Michelle M ; Mallen-St. Clair, Jon ; Sandler, Howard M ; Ho, Allen S ; Zumsteg, Zachary S

Background : Nodal staging systems vary substantially across solid tumors, implying significant heterogeneity in the behavior of nodal variables in various contexts. We hypothesized, in contradiction to this, that metastatic lymph node (LN) number is a universal and dominant predictor of outcome across solid tumors. Methods : Retrospective cohort analysis of 1,304,498 patients in the National Cancer Database undergoing surgery between 2004–2015 across 16 solid cancer sites. Multivariable Cox [...]

Menée auprès de 60 jeunes patients ayant survécu à un cancer (âge médian : 21 ans), cette étude analyse l'association entre une diminution de la masse musculaire (composante de la fragilité) et la qualité de vie

Frail young adult cancer survivors experience poor health-related quality of life

Pranikoff, Sarah ; Ayer Miller, Vanessa L. ; Heiling, Hillary ; Deal, Allison M. ; Valle, Carmina G. ; Williams, Grant R. ; Muss, Hyman B. ; Nichols, Hazel B. ; Smitherman, Andrew B.

Background: Young adult cancer survivors experience frailty and decreased muscle mass at rates equivalent to much older noncancer populations, which indicate accelerated aging. Although frailty and low muscle mass can be identified in survivors, their implications for health-related quality of life are not well understood. Methods: Through a cross-sectional analysis of young adult cancer survivors, frailty was assessed with the Fried frailty phenotype and skeletal muscle mass in relation to [...]

Menée à partir de données portant sur 160 patients atteints de mélanomes primitifs multiples et sur 160 patients atteints d'un mélanome primitif unique (âge moyen : 47 ans ; 43,8 % d'hommes), cette étude compare la survie globale, la survie sans récidive et les schémas métastatiques de ces 2 populations

Poorer survival outcomes in patients with multiple versus single primary melanoma

Karapetyan, Lilit ; Yang, Xi ; Knight, Andrew D. ; Huang, Ziyu ; Wang, Hong ; Sander, Cindy A. ; Minnier, Christopher P. ; Wilson, Melissa ; Li, Aofei ; Karunamurthy, Arivarasan ; Storkus, Walter J. ; Kirkwood, John M.

Background: Given equivocal results related to overall survival (OS) for patients with multiple primary melanomas (MPMs) compared with those with single primary melanomas (SPMs) in previous reports, the authors sought to determine whether OS differs between these 2 cohorts in their center using their UPCI-96-99 database. Secondary aims were to assess the differences in recurrence-free survival (RFS). In a subset of patients, transcriptomic profiling of peripheral blood mononuclear cells (PBMCs) [...]

Menée à partir des données des registres américains des cancers portant sur 841 975 patientes atteintes d'un cancer du sein de stade précoce diagnostiqué entre 2000 et 2017, cette étude analyse les disparités ethniques (9 origines ethniques étudiées) dans le stade au diagnostic et dans la survie, par sous-type moléculaire

A contemporary analysis of racial and ethnic disparities in diagnosis of early stage breast cancer and stage-specific survival by molecular subtype

Primm, Kristin M. ; Zhao, Hui ; Hernandez, Daphne C. ; Chang, Shine

Background: Prior studies of breast cancer disparities have focused primarily on differences between Black and White women, yet contemporary patterns of disparity for other groups are not well understood. We examine breast cancer disparities by stage at diagnosis across nine racial and ethnic groups. Methods: The SEER 18 registries identified 841,975 women diagnosed with breast cancer from 2000 to 2017. Joinpoint models assessed trends in diagnosis stage and survival. Multivariable logistic [...]

Menée aux Pays-Bas à partir de données portant sur 379 patients ayant survécu à un cancer, cette étude de cohorte longitudinale analyse l'évolution des facteurs associés à des troubles cognitifs, 6, 12 et 18 mois après leur retour au travail

Trajectories of cognitive symptoms and associated factors in cancer survivors after return to work: an 18-month longitudinal cohort study

Ehrenstein, Johanna K. ; van Zon, Sander K. R. ; Duijts, Saskia F. A. ; Stewart, Roy E. ; Almansa, Josué ; Amick, Benjamin C. ; Schagen, Sanne B. ; Bültmann, Ute

Purpose : Cognitive symptoms affect cancer survivors’ functioning at work. To date, cognitive symptoms trajectories in working cancer survivors and the factors associated with these trajectories have not been examined. Methods : Data from a heterogeneous group of working cancer survivors (n = 379) of the longitudinal “Work-Life-after-Cancer” study, linked with Netherlands Cancer Registry data, were used. The Cognitive Symptom Checklist-Work was administered at baseline (within the first 3 [...]

Menée en Norvège par questionnaire auprès de 2 803 patientes ayant survécu à un cancer du sein de stade I à III diagnostiqué en 2011 ou 2012 (âge lors du diagnostic : 20-65 ans ; 1 361 répondantes), cette étude analyse les facteurs associés aux changements de leur situation professionnelle, 8 ans après le diagnostic

Work status changes and associated factors in a nationwide sample of Norwegian long-term breast cancer survivors

Bøhn, Synne-Kristin Hoffart ; Vandraas, K. F. ; Kiserud, C. E. ; Dahl, A. A. ; Thorsen, L. ; Ewertz, M. ; Lie, H. C. ; Falk, R. ; Reinertsen, K. V.

Purpose : The study aims to describe work status at diagnosis and 8 years post-diagnosis in a nationwide sample of breast cancer survivors (BCSs), and investigate associated and self-reported factors of reduced work status. Methods : Women aged 20–65 years when diagnosed with stage I–III breast cancer (BC) in 2011 or 2012 were invited to participate in a questionnaire study in 2019 (n = 2803), of whom 49% (n = 1361) responded. For this sub-study, we included 974 BCSs below the legal retirement [...]

Menée à partir de données portant sur 541 patients atteints d'un cancer et inclus dans un essai randomisé (âge : égal ou supérieur à 70 ans), cette étude analyse l'effet, sur les fonctions physiques du patient, de la communication entre oncologue et patient vis-à-vis des problèmes liés à l'âge

Association of Oncologist-Patient Communication With Functional Status and Physical Performance in Older Adults: A Secondary Analysis of a Cluster Randomized Clinical Trial

Jensen-Battaglia, Marielle ; Lei, Lianlian ; Xu, Huiwen ; Kehoe, Lee ; Patil, Amita ; Loh, Kah Poh ; Ramsdale, Erika ; Magnuson, Allison ; Kleckner, Amber S. ; Wildes, Tanya M. ; Lin, Po-Ju ; Mustian, Karen M. ; Giri, Gilbert ; Whitehead, Mary ; Bearden, James, III ; Burnette, Brian L. ; Geer, Jodi ; Mohile, Supriya G. ; Dunne, Richard F.

Importance : The functional status and physical performance of older adults with cancer are underassessed and undertreated despite the high prevalence of impaired functional status and physical performance in this population and their associations with chemotherapy-induced toxic effects and mortality. Objective : To examine the association between providing oncologists with a geriatric assessment (GA) summary with recommendations and having oncologist-patient conversations about functional and [...]