Menée à l'aide des données d'un essai randomisé portant sur 739 personnes (âge moyen : 51 ans ; 47,2 % de femmes), cette étude analyse la réussite du sevrage tabagique en fonction de la volonté d'arrêter de fumer exprimée avant le traitement par substitut nicotinique

Desire to Quit Smoking, Opt-Out Tobacco Treatment, and Cessation: A Secondary Analysis of a Randomized Clinical Trial

Gajewski, Byron ; Faseru, Babalola ; Richter, Kimber P.

A randomized clinical trial (RCT) demonstrated that opt-out treatment achieved higher verified quit rates (22%) than opt-in treatment (16%) 1 month after randomization. When people who smoke have a higher desire to quit before treatment, they have a higher rate of smoking cessation. Understanding how individuals respond to different smoking cessation treatment approaches could guide clinical personalized decision-making. We wanted to know if the opt-out effect was diminished if the participant [...]

Menée à l'aide de données de la "UK Biobank" portant sur 86 252 personnes (durée médiane de suivi : 5,3 ans ; 56 % de femmes), cette étude analyse l'association entre les horaires d'activité physique diurne et le risque de cancer colorectal (529 cas)

Diurnal timing of physical activity and risk of colorectal cancer in the UK Biobank

Stein, Michael J. ; Baurecht, Hansjörg ; Bohmann, Patricia ; Fervers, Beatrice ; Fontvieille, Emma ; Freisling, Heinz ; Friedenreich, Christine M. ; Konzok, Julian ; Peruchet-Noray, Laia ; Sedlmeier, Anja M. ; Leitzmann, Michael F. ; Weber, Andrea

Background: Physical activity reduces colorectal cancer risk, yet the diurnal timing of physical activity in colorectal cancer etiology remains unclear. Methods: This study used 24-h accelerometry time series from UK Biobank participants aged 42 to 79 years to derive circadian physical activity patterns using functional principal component analysis. Multivariable Cox proportional hazard models were used to examine associations with colorectal cancer risk. Results: Among 86,252 participants (56% [...]

Menée à l'aide d'une revue de la littérature et d'entretiens, cette étude identifie les facteurs facilitant et entravant la vaccination des adolescents contre le papillomavirus humain puis évalue la nécessité d'une intervention pour soutenir la prise de décision des parents hésitants

Developing films to support vaccine-hesitant, ethnically diverse parents’ decision-making about the human papillomavirus (HPV) vaccine: a codesign study

Fisher, Harriet ; Denford, Sarah ; Chantler, Tracey ; Audrey, Suzanne ; Finn, Adam ; Hajinur, Huda ; Hickman, Matthew ; Mounier-Jack, Sandra ; Roderick, Marion ; Tucker, Leanne ; Yates, Julie ; Mohamed, Asha

Objective: To illustrate an evidence-, theory- and person-based approach to codesign the COMMUNICATE films that support parental decision-making about the human papillomavirus (HPV) vaccine for their teenagers. Design: Codesign study. Setting: Localities covered by two immunisation teams in London and the south-west of England. Methods: The intervention planning phase involved combining evidence from a literature review with qualitative interview data to identify barriers and facilitators to [...]