Mené sur 187 patients atteints d'un cancer et présentant une cachexie (poumon non à petites cellules, pancréas, côlon-rectum), cet essai randomisé de phase II évalue l'efficacité, du point de vue de l'évolution du poids à 12 semaines, du ponségromab (un anticorps inhibant la cytokine GDF-15)

Ponsegromab for the Treatment of Cancer Cachexia

John D. Groarke ; Jeffrey Crawford ; Susie M. Collins ; Shannon Lubaczewski ; Eric J. Roeland ; Tateaki Naito ; Andrew E. Hendifar ; Marie Fallon ; Koichi Takayama ; Timothy Asmis ; Richard F. Dunne ; Isik Karahanoglu ; Carrie A. Northcott ; Magdalena A. Harrington ; Michelle Rossulek ; Ruolun Qiu ; Aditi R. Saxena

Background: Cachexia is a common complication of cancer and is associated with an increased risk of death. The level of growth differentiation factor 15 (GDF-15), a circulating cytokine, is elevated in cancer cachexia. In a small, open-label, phase 1b study involving patients with cancer cachexia, ponsegromab, a humanized monoclonal antibody inhibiting GDF-15, was associated with improved weight, appetite, and physical activity, along with suppressed serum GDF-15 levels. Methods: In this phase [...]

Mené sur 187 patients atteints d'un cancer et présentant une cachexie (poumon non à petites cellules, pancréas, côlon-rectum), cet essai randomisé de phase II évalue l'efficacité, du point de vue de l'évolution du poids à 12 semaines, du ponségromab (un anticorps inhibant la cytokine GDF-15)

NEJM at ESMO — Ponsegromab in Cancer Cachexia

Eric J. Rubin ; Oladapo O. Yeku ; Stephen Morrissey

In this audio interview, Editor-in-Chief Eric Rubin and NEJM Evidence Associate Editor Oladapo Yeku discuss research being presented at the 2024 European Society of Medical Oncology annual meeting.

Ce dossier thématique fait le point sur la sexualité des patients atteints d'un cancer hématologique ou ayant survécu à la maladie

Sexual health-related psychological and emotional life after allogeneic haematopoietic stem-cell transplantation

Alsuliman, Tamim ; Alasadi, Lugien ; Polomeni, Alice ; Capes, Antoine ; Peric, Zinaida ; Linke, Andrea ; Schoemans, Helene ; Malard, Florent ; Chalandon, Yves ; Mohty, Mohamad

Sexual health is important for the quality of life of patients who have received haematopoietic stem-cell transplantation (HSCT). Sexual dysfunction and couple dissatisfaction can seriously affect a patient's recovery and treatment process. However, this aspect of post-transplantation recovery is still usually neglected in clinical practice. In this Series paper, we aim to elucidate the emotional and psychosocial factors affecting the sexual function in these patients, with a special focus on [...]

Ce dossier thématique fait le point sur la sexualité des patients atteints d'un cancer hématologique ou ayant survécu à la maladie

Sexually transmitted infections in the context of haematological malignancies

Alsuliman, Tamim ; Musiu, Paolo ; Stocker, Nicolas ; Desnica, Lana ; El-Cheikh, Jean ; Sestili, Simona ; Srour, Micha ; Marjanovic, Zora ; Alrstom, Ali

Sexually transmitted infections (STIs) are a difficult health challenge for immunocompromised patients. Patients treated for several haematological malignancies have further compromised immune systems. Furthermore, many chemotherapies, alone or associated with haematopoietic stem-cell transplantation, make the body's natural barriers extremely fragile. STIs can negatively impact both patient morbidity and mortality. In this Series paper, we discuss Chlamydia trachomatis, Neisseria gonorrhoeae, [...]

Ce dossier thématique fait le point sur la sexualité des patients atteints d'un cancer hématologique ou ayant survécu à la maladie

Sexual health and emotional wellbeing of adolescent and young adult survivors of haematological malignancies

Alsuliman, Tamim ; Rojas, Reyes María Martín ; Basha, Ahmad Ali ; Musiu, Paolo ; Magro, Léonardo ; Testi, Anna Maria ; Mohty, Mohamad

This Comment is linked to The Lancet Haematology Series on Sexual Health in Patients with Haematological Malignancies; we discuss sexual and emotional life for patients with haematological malignancies elsewhere in our Series. Cancer, the side effects of cancer therapies, and changes in body image are often traumatic long-term events for cancer survivors (ie, individuals no longer being treated for cancer and considered to have no active disease), especially for adolescent and young adult (AYA) [...]

Ce dossier thématique fait le point sur la sexualité des patients atteints d'un cancer hématologique ou ayant survécu à la maladie

Sexual health and emotional wellbeing of patients with haematological malignancies: general review

Alsuliman, Tamim ; Rojas, Reyes María Martín ; Moukalled, Nour ; Brissot, Eolia ; Quarez-Blaise, Laurence ; Marjanovic, Zora ; Blaise, Didier ; Murphy, Danielle ; Logue, Melissa ; Savani, Bipin N. ; Mohty, Mohamad

Sexual health is an important aspect of a person's life. Many patients and haematologists believe that intimacy and sexuality issues are substantial during cancer treatment. The haematological cancer disease, diagnosis, shock of the announcement, treatment, and follow-up appointments, can all have negative effects on the quality of life of patients, their partners, other family members, and friends. Addressing the intimate aspects of patients' lives not only enhances their wellbeing but also [...]

Ce dossier thématique fait le point sur la sexualité des patients atteints d'un cancer hématologique ou ayant survécu à la maladie

Let's talk about sex and haematopoietic stem-cell transplantation

Linke, Andrea ; del Castillo, Jacqueline ; Scheffel, Kirsti ; Feenstra, Peter ; Manninen, Riikka-Leena

When diagnosed with a life-threatening disease, the last thing you want to talk about is sex. Wrong. Sexual health is crucial to wellbeing and quality of life. Yet, in our experience, sex remains a taboo topic in haematology and is rarely discussed openly.

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Education and Information to Improve Adherence to Screening for Breast, Colorectal, and Cervical Cancer—Lessons Learned during the COVID-19 Pandemic

Gabriele, Raimondo ; Campagnol, Monica ; Sapienza, Paolo ; Borrelli, Valeria ; Di Marzo, Luca ; Sterpetti, Antonio V.

The objective of this study was to determine the correlation between adherence to cancer screening programs and earlier diagnosis of the 14 most common types of cancers in the adult population, before and during the COVID-19 pandemic. National data concerning number of admissions and operations in Italy for adult patients admitted with oncologic problems during the COVID-19 pandemic (2020 to 2022) and in the pre-pandemic period (2015 to 2019) were analyzed. We selected 14 types of cancer that [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

The COVID-19 pandemic and associated declines in cancer incidence by race/ethnicity and census-tract level SES, rurality, and persistent poverty status

Liu, Benmei ; Yu, Mandi ; Byrne, Jeffrey ; Cronin, Katheen A. ; Feuer, Eric J.

Background: The COVID-19 pandemic had a significant impact on cancer screening and treatment, particularly in 2020. However, no single study has comprehensively analyzed its effects on cancer incidence and disparities among groups such as race/ethnicity, socioeconomic status (SES), persistent poverty (PP), and rurality. Methods: Utilizing the recent data from the United States National Cancer Institute's Surveillance, Epidemiology, and End Results Program, we calculated delay- and age-adjusted [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Impact of the COVID-19 pandemic on treatment of patients with acute myeloid leukaemia in India

Philip, Chepsy ; Selvarajan, Sushil ; Nayak, Lingaraj ; Jain, Hasmukh ; Kulkarni, Uday ; Samuel, Prasanna ; Agrawal, Narendra ; Kayal, Smita ; Mishra, Kundan ; Pavitra, D. S. ; Jayachandran, P. K. ; Bala, Stalin Chowdary ; Raghavan, Vineetha ; Paul, Mobin ; Singh, Jagdeep ; Sreeraj, V. ; Mujumdar, Swaratika ; Nayak, Akshatha ; Prakash, Om ; Barath, U. ; Dharmaraj, Aravind ; Rajendra, Akhil ; Thorat, Jayashree ; Bagal, Bhausaheb ; Abraham, Aby ; Bhurani, Dinesh ; Ganesan, Prasanth ; Sengar, Manju ; Mathews, Vikram

During the COVID-19 pandemic, our findings highlight changes in AML management strategies in India. There was a decrease in overall patient registrations, particularly at large referral centers, while smaller centers saw an increase, reflecting a shift towards more localized care. This shift was accompanied by a rise in the use of hypomethylating agents (HMAs). Despite these changes, survival outcomes remained comparable to pre-pandemic levels, likely due to improved infection control measures [...]

Mené sur 120 aidants de patients atteints d'une tumeur cérébrale primitive, cet essai randomisé évalue l'intérêt d'une intervention psychosociale pour réduire leurs symptômes d'anxiété et de dépression

NeuroCARE: A Randomized Controlled Trial of a Psychological Intervention for Caregivers of Patients With Primary Malignant Brain Tumors

Deborah A. Forst ; Alyx F. Podgurski ; Sumita M. Strander ; Jessica D. Whitman ; Shibani Datta ; Kedie Pintro ; Nora K. Horick ; Kelcie D. Willis ; Timothy S. Sannes ; Joseph A. Greer ; Areej El-Jawahri ; Jamie M. Jacobs ; Jennifer S. Temel

Purpose: Caregivers of patients with primary malignant brain tumors (PMBT) experience significant psychological distress. We assessed the effect of a psychological intervention (NeuroCARE) on anxiety symptoms among PMBT caregivers. Methods: We conducted a randomized trial of NeuroCARE versus usual care in PMBT caregivers with elevated anxiety (Generalized Anxiety Disorder-7 score ≥5) within 6 months of the patient's diagnosis. NeuroCARE was developed for PMBT caregivers and consists of six [...]

Mené sur 120 aidants de patients atteints d'une tumeur cérébrale primitive, cet essai randomisé évalue l'intérêt d'une intervention psychosociale pour réduire leurs symptômes d'anxiété et de dépression

Caring for the Family Caregiver in Oncology

Liv Mendelsohn ; Rinat Nissim ; Breffni Hannon

Across all health care settings, the crucial role played by family caregivers (FCs) is often overlooked. FCs are defined as relatives, friends, or neighbors who provide unpaid patient care, assisting with physically, emotionally, and socially demanding tasks.1 With medical advancements that have extended the lives of many patients with cancer and with most cancer care now being delivered in outpatient settings, the responsibilities placed on FCs have become increasingly complex and prolonged. [...]