Menée à partir de données australiennes 2001-2019, cette étude analyse l'association entre l'augmentation de la température liée au changement climatique et l'incidence du cancer du foie

Long-Term Effect of Temperature Increase on Liver Cancer in Australia: A Bayesian Spatial Analysis

Ting Gan ; Hilary Bambrick ; Yumin Li ; Kristie L. Ebi ; Wenbiao Hu

Background: While some evidence has potentially linked climate change to carcinogenic factors, the long-term effect of climate change on liver cancer risk largely remains unclear. Objectives: Our objective is to evaluate the long-term relationship between temperature increase and liver cancer incidence in Australia. Methods: We mapped the spatial distribution of liver cancer incidence from 2001 to 2019 in Australia. A Bayesian spatial conditional autoregressive (CAR) model was used to estimate [...]

Menée à partir de données danoises, cette étude analyse l'association entre une épilespsie chez la mère ou l'enfant, une utilisation de médicaments anticonvulsifs pendant la grossesse et le risque de cancer chez l'enfant

Danish population based study of familial epilepsy and childhood cancer

Platamone, Corbin C. ; Deng, Chuanjie ; Mazumder, Rajarshi ; Ritz, Beate ; Olsen, Jorn ; Hansen, Johnni ; Saechao, Chai ; Heck, Julia E.

Results from studies investigating the association between maternal or child epilepsy, use of anticonvulsants in pregnancy, and childhood cancer are inconsistent and at times contradictory. Linking Danish national databases, we obtained epilepsy and childhood cancer diagnoses, and anticonvulsant use data. We estimated adjusted odds ratios of all or specific childhood cancers in relation to maternal or child epilepsy and anticonvulsant therapies using conditional logistic regression. Maternal [...]

Menée à partir de données des registres américains des cancers portant sur 174  916 patients atteints d'un cancer primitif de la thyroïde, cette étude analyse l'association entre un traitement par rayonnements et le risque de cancer cutané non kératinocytaire (865 cas dont 790 mélanomes)

Development of Melanoma and Other Nonkeratinocyte Skin Cancers After Thyroid Cancer Radiation

Rezaei, Shawheen J. ; Chen, Michael L. ; Kim, Jiyeong ; John, Esther M. ; Sunwoo, John B. ; Linos, Eleni

Thyroid cancer and skin cancer are commonly diagnosed cancers in the US. Prior research has suggested a link between papillary thyroid cancer and malignant melanoma via common pathogenic variants. Unlike nonmelanoma skin cancers, the evidence for a relationship between melanoma and exposure to ionizing radiation is sparse. Although radioactive iodine therapy for thyroid cancer is thought to be associated with subsequent solid organ and hematologic tumors, the association has rarely been [...]

Menée auprès de 644 personnes ayant réalisé une coloscopie de dépistage, cette étude analyse l'association entre l'heure des repas et le risque d'adénome colorectal

Association of late eating with colorectal adenomas: a cross-sectional study

Adnan, Darbaz ; Khoshaba, Edena R. ; Abel-Reheem, Mostafa ; Trinh, Jonathan Q. ; Cao, Yin ; Bishehsari, Faraz

Purpose: Colorectal cancer (CRC) is linked to lifestyle exposures. However, changes in the CRC rates among younger populations remain poorly understood and suggest the existence of yet unidentified factor(s) that may contribute to colon carcinogenesis. Here, we investigated the potential role of time of eating in the risk of pre-cancerous colonic neoplasms (tubular adenoma: TA). Methods: We enrolled 663 participants undergoing screening colonoscopies. Data on food timing, dietary intake, [...]

Menée à partir de données de la "UK Biobank" portant sur 234 102 personnes, cette étude analyse l'association entre le score "Life's Essential 8" (LE8) évaluant la santé cardiovasculaire et le risque de cancer du pancréas

Life's Essential 8, genetic susceptibility, and risk of incident pancreatic cancer: A prospective cohort study

Wu, Zhuo ; Zeng, Liangtang ; Fang, Zhou ; Yuan, Yuan ; Zhou, Yu ; Chen, Rufu

The association between the American Heart Association (AHA) Life's Essential 8 (LE8) and the risk of pancreatic cancer (PC) remains unclear. Our goal was to assess the relationships between LE8, genetic susceptibility, and PC risk. This cohort consisted of 234,102 participants from the UK Biobank. The components of LE8 include diet, nicotine exposure, sleep, physical activity, blood glucose, body mass index, blood lipids, and blood pressure. LE8 is classified into three categories: low [...]

Menée auprès de 8 156 personnes, cette étude analyse l'association entre le stress oxydatif systémique, évalué par un système de score, et le risque de cancer par localisation

Relationship between oxidative balance score and prostate cancer: a cross-sectional study of NHANES, 1999–2010

Li, Han ; Zhang, Zhipeng ; Liu, Shengjie ; Liu, Ming ; Wang, Miao ; Wang, Xuan

Objective: Few studies have examined the relationship between systemic oxidative stress and prostate cancer (PCa) risk. This study aimed to explore potential correlations between PCa and oxidative balance score (OBS), which measures systemic oxidative stress. Design: A cross-sectional study. Setting: The National Health and Nutrition Examination Survey. Participants: A total of 8156 individuals were included in this study. Primary and secondary outcome measures: Weighted logistic regression [...]

Menée à l'aide de données portant sur 304 959 adultes et 1 794 patients atteints d'un cancer colorectal, cette étude analyse l'association entre la charge allostatique et le risque de développer la maladie ou la mortalité toutes causes confondues

Allostatic Load, Genetic Susceptibility, Incidence Risk, and All-cause Mortality of Colorectal Cancer

Zhao, Jianhui ; Xue, Erxu ; Zhou, Siyun ; Zhang, Meng ; Sun, Jing ; Tan, Yuqian ; Li, Xue

Allostatic load (AL) reflects the cumulative burden of chronic stress throughout life, potentially influencing the onset and prognosis of cancer. However, the associations between AL, colorectal cancer (CRC) risk and all-cause mortality in patients with CRC remain unclear.We analyzed the association between AL and CRC risk in 304,959 adults and all-cause mortality in 1,794 patients with CRC from the UK Biobank, using Cox proportional hazards regression models.Compared to the AL level in the [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données pangénomiques portant sur 177 833 personnes en Asie de l'Est, cette étude analyse l'association entre la densité minérale osseuse et le risque de cancer du sein

A causal relationship between bone mineral density and breast cancer risk: a mendelian randomization study based on east Asian population

Cheng, Ziyang ; Xu, Hui ; Wang, Xin ; Teng, Tao ; Li, Bin ; Cao, Zhong ; Li, Zhichao ; Zhang, Jiayi ; Xuan, Jin ; Zhang, Fengyi ; Chen, Yaxin ; Li, Yujie ; Wang, Wenbo

Background: Breast cancer (BC) poses significant burdens on women globally. While past research suggests a potential link between bone mineral density (BMD) and BC risk, findings remain inconsistent. Our study aims to elucidate the causal relationship between BMD and BC in East Asians using bidirectional Mendelian randomization (MR). Methods: Genetic association data for bone mineral density T-scores (BMD-T) and Z-scores (BMD-Z) (Sample size = 92,615) and BC from two different sources (Sample [...]

Menée à partir de données de séquençage à haut-débit de l'ADN de 48 patients atteints d'un cancer thyroïdien familial non médullaire (FNMTC), cette étude recherche et identifie des variants constitutionnels de 94 gènes associés à la prédisposition héréditaire de la maladie y compris parmi des gènes impliqués dans la réparation de l'ADN

Identification of novel candidate predisposing genes in familial nonmedullary thyroid carcinoma implicating DNA damage repair pathways

Pires, Carolina ; Marques, Inês J. ; Saramago, Ana ; Moura, Margarida M. ; Pojo, Marta ; Cabrera, Rafael ; Santos, Catarina ; Rosário, Francisco ; Lousa, Diana ; Vicente, João B. ; Bandeiras, Tiago M. ; Teixeira, Manuel R. ; Leite, Valeriano ; Cavaco, Branca M.

The genetic basis of nonsyndromic familial nonmedullary thyroid carcinoma (FNMTC) is still poorly understood, as the susceptibility genes identified so far only account for a small percentage of the genetic burden. Recently, germline mutations in DNA repair-related genes have been reported in cases with thyroid cancer. In order to clarify the genetic basis of FNMTC, 94 genes involved in hereditary cancer predisposition, including DNA repair genes, were analyzed in 48 probands from FNMTC [...]