Menée aux Etats-Unis à partir des données d'une enquête réalisée en 2020 par le "National Cancer Institute" auprès de 2 906 adultes, cette étude analyse la relation entre la consommation d'alcool et la connaissance du risque de cancer associé

Alcohol and cancer risk beliefs as correlates of alcohol consumption status

Rohde, Jacob A. ; Klein, William M. P. ; D'Angelo, Heather

Alcohol consumption increases risk for several cancer types including liver, esophageal, colorectal, and breast. Alcohol consumption is a leading modifiable cancer risk factor, accounting for 5.6% of incident cancers in the U.S., and over 50% of U.S. adults report past 30-day drinking. Yet awareness of the link between alcohol and cancer remains low and varies by alcoholic beverage type. This study examined whether awareness of alcohol as a cancer risk factor was associated with alcohol [...]

Menée à partir de données 2015-2018 d'un registre portant sur 5 116 fumeurs de tabac et/ou utilisateurs de cigarettes électroniques, cette étude analyse les facteurs associés à une abstinence d'un mois

Factors associated with smoking cessation in exclusive smokers and dual users of e-cigarette and conventional cigarettes from CDTnet registry

Valter, Rémi ; Guyonvarch, Ophélie ; Allagbe, Ingrid ; Le Faou, Anne-Laurence

Dual use of electronic cigarettes and conventional cigarettes may be a transitional state towards cigarette smoking cessation. However, maintaining dual use may increase tobacco-related consequences as smoking behavior persists. The aim of our study was to describe characteristics of dual users and explore factors associated with their one-month abstinence in comparison to exclusive smokers in French smoking cessation services (SCS). We retrospectively studied 5116 smokers registered in a [...]

Menée notamment à partir de données de la "UK Biobank" et de la cohorte "TriNetX" portant au total sur 1 785 491 personnes, cette étude analyse l'association entre une utilisation de statines et le risque de carcinome hépatocellulaire (472 cas)

Association of Statin Use With Risk of Liver Disease, Hepatocellular Carcinoma, and Liver-Related Mortality

Vell, Mara Sophie ; Loomba, Rohit ; Krishnan, Arunkumar ; Wangensteen, Kirk J. ; Trebicka, Jonel ; Creasy, Kate Townsend ; Trautwein, Christian ; Scorletti, Eleonora ; Seeling, Katharina Sophie ; Hehl, Leonida ; Rendel, Miriam Daphne ; Zandvakili, Inuk ; Li, Tang ; Chen, Jinbo ; Vujkovic, Marijana ; Alqahtani, Saleh ; Rader, Daniel James ; Schneider, Kai Markus ; Schneider, Carolin Victoria

Given the burden of chronic liver disease on the health care system, more information on the hepatoprotective association of statins in the general population is needed.To examine whether regular statin use is associated with a reduction in liver disease, particularly hepatocellular carcinoma (HCC) and liver-related deaths, in the general population.This cohort study used data from the UK Biobank (UKB) (individuals aged 37-73 years) collected from baseline (2006-2010) to the end of follow-up in [...]

Menée à l'aide de données de la "UK Biobank" portant sur 18 453 adultes (durée médiane de suivi : 8,8 ans), cette étude analyse l'association entre le taux sérique de 25-hydroxyvitamine D et le risque de cancer colorectal (284 cas) chez les adultes atteints de diabète de type 2

Serum 25-hydroxyvitamin D concentrations and colorectal cancer incidence in adults with type 2 diabetes

Ren, Jiao-Jiao ; Li, Zhi-Hao ; Zhong, Wen-Fang ; Chen, Pei-Liang ; Huang, Qing-Mei ; Wang, Xiao-Meng ; Gao, Ping-Ming ; Mao, Chen

Background: To examine the association of serum 25-hydroxyvitamin D (25[OH]D) with colorectal cancer (CRC) risk in adults with type 2 diabetes (T2D). Methods: Using UK Biobank data, this study included 18,453 adults with T2D. Serum 25(OH)D concentrations were determined by the chemiluminescent immunoassay method. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for CRC outcomes. Results: During a median follow-up of 8.8 years, there [...]

Mené aux Etats-Unis sur 201 enfants âgés de 9 à 11 ans, cet essai multicentrique de phase II évalue la stabilité des anticorps spécifiques au papillomavirus humain (HPV16/18) 24 mois après l'administration d'une dose unique d'un vaccin nonavalent contre le HPV

HPV16/18 Antibody Responses After a Single Dose of Nonavalent HPV Vaccine

Zeng, Yi ; Moscicki, Anna-Barbara ; Woo, Heide ; Hsu, Chiu-Hsieh ; Kemp, Troy J. ; Pinto, Ligia A. ; Szabo, Eva ; Dimond, Eileen ; Bauman, Julie ; Sahasrabuddhe, Vikrant V. ; Chow, H-H Sherry

A single dose of human papillomavirus (HPV) vaccine would simplify logistics and reduce costs of vaccination programs worldwide. We conducted a phase IIa trial to determine the stability of HPV type-specific antibody responses after a single dose of the nonavalent HPV vaccine, Gardasil9.Two hundred-and-one healthy 9 to 11-year-old girls and boys were enrolled at 2 centers in the United States to receive a prime dose of the nonavalent vaccine at baseline, a delayed dose at month 24, and an [...]

Menée aux Etats-Unis auprès de 1 629 fumeurs ou vapoteurs, cette étude évalue l'impact de 28 messages d'avertissement sanitaire concernant l'utilisation de la cigarette électronique

Optimising messages and images for e-cigarette warnings

Allison J Lazard ; Mohammad Ebrahimi Kalan ; Sydney Nicolla ; Marissa G Hall ; Kurt M Ribisl ; Jennifer Mendel Sheldon ; Callie Whitesell ; Tara L Queen ; Noel T Brewer

Background: The US Food and Drug Administration (FDA) requires electronic cigarettes (e-cigarettes) to have a single addiction warning, but many other health harms are associated with vaping and warnings grow stale over time. We aimed to develop new warning messages and images to discourage e-cigarette use. Methods: Participants were 1629 US adults who vaped or smoked. We randomised each participant to evaluate 7 of 28 messages on newly developed warning themes (metals exposure, DNA mutation, [...]

Mené aux Etats-Unis entre 2019 et 2022 sur 392 Afro-Américains fumant quotidiennement (âge moyen : 53 ans ; 57 % de femmes), cet essai randomisé évalue l'efficacité, du point de vue de l'abstinence en semaine 26, de différentes pharmacothérapies de sevrage tabagique

Multiple Pharmacotherapy Adaptations for Smoking Cessation Based on Treatment Response in Black Adults Who Smoke: A Randomized Clinical Trial

Nollen, Nicole L. ; Ahluwalia, Jasjit S. ; Mayo, Matthew S. ; Ellerbeck, Edward F. ; Leavens, Eleanor L. S. ; Salzman, Gary ; Shanks, Denton ; Woodward, Jennifer ; Greiner, K. Allen ; Cox, Lisa Sanderson

Adapting to different smoking cessation medications when an individual has not stopped smoking has shown promise, but efficacy has not been tested in racial and ethnic minority individuals who smoke and tend to have less success in quitting and bear a disproportionate share of tobacco-related morbidity and mortality.To evaluate efficacy of multiple smoking cessation pharmacotherapy adaptations based on treatment response in Black adults who smoke daily.This randomized clinical trial of adapted [...]