Menée en Australie auprès de 9 785 patients ayant survécu à un premier cancer (durée moyenne de suivi : 7,3 ans), cette étude analyse le risque de second cancer primitif lié au tabagisme

Pre-diagnostic cigarette smoking and risk of second primary cancer: The Melbourne Collaborative Cohort Study

Phua, Zhi Jing ; MacInnis, Robert J. ; Hodge, Allison M. ; Lynch, Brigid M. ; Hopper, John L. ; Smith-Warner, Stephanie A. ; Giles, Graham G. ; Milne, Roger L. ; Jayasekara, Harindra

Enhanced survival following a diagnosis of cancer has led to a steep rise in the number of individuals diagnosed with a second primary cancer. We examined the association between pre-cancer cigarette smoking and risk of second cancer in 9785 participants diagnosed with first invasive cancer after enrolment in the Melbourne Collaborative Cohort Study. Follow-up was from date of first invasive cancer until diagnosis of second primary invasive cancer, death, or 31 July 2019, whichever came first. [...]

Menée à l'aide de données de la cohorte européenne "EPIC" portant sur 450 107 personnes (durée moyenne de suivi : 14,1 ans), cette étude analyse le rôle de facteurs de risque modifiables dans la cancérogenèse de l'intestin grêle (160 cas)

Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Ersoy Guller, Zeynep ; Harewood, Rhea N. ; Weiderpass, Elisabete ; Huybrechts, Inge ; Jenab, Mazda ; Huerta, José María ; Sánchez, María-José ; Jakszyn, Paula ; Amiano, Pilar ; Ardanaz, Eva ; Agnoli, Claudia ; Tumino, Rosario ; Palli, Domenico ; Skeie, Guri ; Manjer, Jonas ; Papier, Keren ; Tjønneland, Anne ; Eriksen, Anne Kirstine ; Schulze, Matthias B. ; Kaaks, Rudolf ; Katzke, Verena ; Bergmann, Manuela M. ; Riboli, Elio ; Gunter, Marc J. ; Cross, Amanda J.

Purpose: The incidence of small intestinal cancer (SIC) is increasing, however, its aetiology remains unclear due to a lack of data from large-scale prospective cohorts. We examined modifiable risk factors in relation to SIC overall and by histological subtype. Methods: We analysed 450,107 participants enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. Cox proportional hazards models were used to estimate univariable and multivariable hazard ratios (HRs) and [...]

Menée à partir de données portant sur 21 192 participants de la cohorte "the Prostate, Lung, Colorectal, and Ovarian Cancer screening", cette étude analyse l'association entre des habitudes alimentaires et le risque d'adénome colorectal

Associations of Dietary Patterns with Colorectal Adenomas in the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Cohort

Nepal, Sushma ; Aslani, Zahra ; Shi, Ni ; Tabung, Fred K.

Background: Most Colorectal cancers arise from adenomas, and though insulinemic and inflammatory dietary patterns have been associated with colorectal cancer risk, these dietary patterns have not been studied in relation to adenoma risk. Methods: Using data from 21,192 participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer screening cohort, we calculated the Empirical Dietary Index for Hyperinsulinemia (EDIH), Empirical Dietary Inflammatory Pattern (EDIP) and overall dietary [...]

Menée à partir de données portant sur 4 812 Estoniens ayant participé aux travaux de nettoyage des zones contaminées près de la centrale de Tchernobyl sur la période 1986-1991, cette étude identifie des facteurs associés au risque de cancer (687 cas)

Cancer incidence among Chernobyl cleanup workers from Estonia: A 34-year follow-up

Rahu, Kaja ; Rahu, Mati ; Auvinen, Anssi ; Zeeb, Hajo ; Boice Jr, John D.

From 1986 to 1991, 4831 men from Estonia were sent to clean up radioactively contaminated areas near Chernobyl (Chornobyl). Their cancer incidence during 1986 to 2019 was compared to that of the male population of Estonia. The cohort of cleanup workers was linked to national population and cancer registers based on unique personal identification numbers. Nineteen (0.4%) workers could not be traced. A total of 4812 men contributing 120 770 person-years of follow-up were eligible for the [...]

Menée auprès de 2 517 926 hommes vétérans de la guerre du Vietnam, cette étude analyse l'association entre une exposition à l'agent orange et le risque de cancer de la vessie (50 781 cas)

Exposure to Agent Orange and Risk of Bladder Cancer Among US Veterans

Williams, Stephen B. ; Janes, Jessica L. ; Howard, Lauren E. ; Yang, Ruixin ; De Hoedt, Amanda M. ; Baillargeon, Jacques G. ; Kuo, Yong-Fang ; Tyler, Douglas S. ; Terris, Martha K. ; Freedland, Stephen J.

To date, limited data exist regarding the association between Agent Orange and bladder cancer, and the Institute of Medicine concluded that the association between exposure to Agent Orange and bladder cancer outcomes is an area of needed research.To examine the association between bladder cancer risk and exposure to Agent Orange among male Vietnam veterans.This nationwide Veterans Affairs (VA) retrospective cohort study assesses the association between exposure to Agent Orange and bladder [...]

Menée à partir des données de cinq études du projet "StoP" portant sur 6 517 témoins et 1 889 patients atteints d'un cancer de l'estomac, cette étude analyse l'association entre une utilisation d'inhibiteurs de la pompe à protons et le risque de développer la maladie

Intake of Proton-Pump Inhibitors and Gastric Cancer Within the Stomach cancer Pooling (StoP) Project

Sassano, Michele ; Mariani, Marco ; Pelucchi, Claudio ; Lunet, Nuno ; Morais, Samantha ; Martin, Vicente ; Moreno, Víctor ; Curado, Maria Paula. ; Dias-Neto, Emmanuel ; Leja, Marcis ; Gašenko, Evita ; La Vecchia, Carlo ; Boccia, Stefania ; Pastorino, Roberta

Background: A potential association between proton-pump inhibitors (PPIs) and gastric cancer (GC) remains undefined. Thus, we aimed to evaluate such association within the Stomach cancer Pooling (StoP) Project. Methods: Data from five case-control studies of the StoP Project were included (1,889 cases, 6,517 controls). We assessed the impact of different exposure definitions, specifically any reported use of PPIs and exposure definitions based on the duration of PPI intake. Additionally, we [...]

Menée à partir de données suédoises 2006-2016 portant sur 236 388 témoins et 60 110 patients atteints d'un cancer de la prostate, cette étude analyse l'association entre une thérapie anti-androgénique et le risque de cancer colorectal

Risk of colorectal adenocarcinoma in men receiving androgen deprivation therapy for prostate cancer; a nationwide cohort study

Shore, Richard ; Zhang, Ji ; Ye, Weimin ; Stattin, Pär ; Lindblad, Mats

Purpose: To assess whether androgens play a role in explaining the sex related differences in the incidence of colorectal cancer (CRC). Methods: A nationwide matched cohort study was conducted employing the Prostate Cancer data Base Sweden (PCBaSe) 4.0 during the study period 2006–2016. Prostate cancer (PC) patients receiving androgen deprivation therapy (ADT) were treated as exposed. Prostate cancer-free men from the general population were randomly selected and matched to the index case by [...]

Menée auprès de 3 602 patientes ayant eu un cancer du sein (durée médiane de suivi : 9,6 ans), cette étude évalue le risque de cancer du sein controlatéral associé au traitement par radiothérapie chez les patientes porteuses d'un variant pathogène BRCA1/2, en fonction de l'âge au diagnostic (avant ou après 40 ans)

Contralateral breast cancer risk in irradiated breast cancer patients with a germline-BRCA1/2 pathogenic variant

van Barele, Mark ; Akdeniz, Delal ; Heemskerk-Gerritsen, Bernadette A M ; Genepso ; Andrieu, Nadine ; Nogues, Catherine ; HEBON ; van Asperen, Christi J ; Wevers, Marijke ; Ausems, Margreet G E M ; de Bock, Geertruida H ; Dommering, Charlotte J ; Gómez-García, Encarnacion B ; van Leeuwen, Flora E ; Mooij, Thea M ; EMBRACE ; Easton, Douglas F ; Antoniou, Antonis C ; Evans, D Gareth ; Izatt, Louise ; Tischkowitz, Marc ; Frost, Debra ; Brewer, Carole ; Olah, Edit ; Simard, Jacques ; Singer, Christian F ; Thomassen, Mads ; Kast, Karin ; Rhiem, Kerstin ; Engel, Christoph ; de la Hoya, Miguel ; Foretova, Lenka ; Jakubowska, Anna ; Jager, Agnes ; Sattler, Margriet G A ; Schmidt, Marjanka K ; Hooning, Maartje J ; IBCCS

Radiation-induced secondary breast cancer may be a concern after radiotherapy for primary breast cancer (PBC), especially in young germline (g)BRCA-associated breast cancer patients with already high contralateral breast cancer (CBC) risk and potentially increased genetic susceptibility to radiation.To investigate whether adjuvant radiotherapy for PBC increases the risk of CBC in gBRCA1/2-associated BC patients.gBRCA1/2 pathogenic variant carriers diagnosed with PBC were selected from the [...]

Menée auprès de 6 380 témoins et 552 patients pédiatriques présentant des tumeurs germinales malignes, cette étude analyse l'association entre des malformations congénitales et le risque de développer la maladie selon le sexe, le type de malformation et des caractéristiques de la tumeur

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site

Schraw, Jeremy M. ; Sok, Pagna ; Desrosiers, Tania A. ; Janitz, Amanda E. ; Langlois, Peter H. ; Canfield, Mark A. ; Frazier, A. Lindsay ; Plon, Sharon E. ; Lupo, Philip J. ; Poynter, Jenny N.

Background: Studies have reported increased rates of birth defects among children with germ cell tumors (GCTs). However, few studies have evaluated associations by sex, type of defect, or tumor characteristics. Methods: Birth defect–GCT associations were evaluated among pediatric patients (N = 552) with GCTs enrolled in the Germ Cell Tumor Epidemiology Study and population-based controls (N = 6380) without cancer from the Genetic Overlap Between Anomalies and Cancer in Kids Study. The odds [...]

Menée à partir de données de registres portant sur les femmes nées au Danemark entre le 1er janvier 1940 et le 31 décembre 1993 (durée médiane de suivi : 26 ans), cette étude analyse l'association entre un syndrome des ovaires polykystiques et le risque de cancer épithélial de l'ovaire (6 490 cas) ou de tumeur de l'ovaire à la limite de la malignité (2 990 cas)

Risk of epithelial ovarian tumors among women with polycystic ovary syndrome: A nationwide population-based cohort study

Frandsen, Clarissa L. B. ; Svendsen, Pernille F. ; Nøhr, Bugge ; Viuff, Jakob H. ; Maltesen, Thomas ; Kjær, Susanne K. ; Jensen, Allan

An association between polycystic ovary syndrome (PCOS) and epithelial ovarian tumors is biologically plausible as conditions inherent to PCOS such as excessive androgenic hormones, reproductive factors and obesity are also risk factors for these hormone-sensitive tumors. However, previous studies have showed conflicting results and have various methodological limitations. This population-based cohort study investigates the association between PCOS and epithelial ovarian tumors and includes all [...]

Menée à l'aide de données portant sur 11 362 témoins et 8 027 patients atteints d'un cancer du pancréas, cette étude analyse l'association entre le statut des gènes FUT2 (déterminant le statut de sécréteur) et FUT3 (déterminant les antigènes de Lewis) et le risque de développer la maladie

Relationship between ABO blood group alleles and pancreatic cancer is modulated by secretor (FUT2) genotype, but not Lewis antigen (FUT3) genotype

Kim, Jihye ; Yuan, Chen ; Amundadottir, Laufey T. ; Wolpin, Brian M. ; Klein, Alison P. ; Risch, Harvey A. ; Kraft, Peter

Background: In western populations, Pancreatic Ductal Adenocarcinoma (PDAC) risk has been found to be greater among individuals with non-O blood types than those with O blood type. However, the association has not been fully evaluated with respect to FUT2 (determining secretor status) and FUT3 (determining Lewis antigens) status, two biologically important genes in the expression of ABO blood groups with PDAC. Methods: We examined interactions in data from 8,027 cases and 11,362 controls in [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données d'études sur le génome entier portant sur 12 525 témoins et 9 253 patients atteints d'un cancer du pancréas, cette étude analyse l'association entre une prédisposition à la stéatose hépatique non alcoolique et le risque de cancer du pancréas

Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization

King, Sontoria D. ; Veliginti, Swathi ; Brouwers, Martijn C G J. ; Ren, Zhewen ; Zheng, Wei ; Setiawan, Veronica Wendy. ; Wilkens, Lynne R. ; Shu, Xiao-Ou ; Arslan, Alan A. ; Beane Freeman, Laura E. ; Bracci, Paige M. ; Canzian, Federico ; Du, Mengmeng ; Gallinger, Steven J. ; Giles, Graham G. ; Goodman, Phyllis J. ; Haiman, Christopher A. ; Kogevinas, Manolis ; Kooperberg, Charles ; Le Marchand, Loic ; Neale, Rachel E. ; Visvanathan, Kala ; White, Emily ; Albanes, Demetrius ; Andreotti, Gabriella ; Babic, Ana ; Berndt, Sonja I. ; Brais, Lauren K. ; Brennan, Paul ; Buring, Julie E. ; Rabe, Kari G. ; Bamlet, William R. ; Chanock, Stephen J. ; Fuchs, Charles S. ; Gaziano, J. Michael ; Giovannucci, Edward L. ; Hackert, Thilo ; Hassan, Manal M. ; Katzke, Verena ; Kurtz, Robert C. ; Lee, I-Min ; Malats, Nuria ; Murphy, Neil ; Oberg, Ann L. ; Orlow, Irene ; Porta, Miquel ; Real, Francisco X. ; Rothman, Nathaniel ; Sesso, Howard D. ; Silverman, Debra T. ; Thompson, Ian M. ; Wactawski-Wende, Jean ; Wang, Xiaoliang ; Wentzensen, Nicolas ; Yu, Herbert ; Zeleniuch-Jacquotte, Anne ; Yu, Kai ; Wolpin, Brian M. ; Duell, Eric J. ; Li, Donghui ; Hung, Rayjean J. ; Perdomo, Sandra ; McCullough, Marjorie L. ; Freedman, Neal D. ; Patel, Alpa V. ; Peters, Ulrike ; Riboli, Elio ; Sund, Malin ; Tjønneland, Anne ; Zhong, Jun ; Van Den Eeden, Stephen K. ; Kraft, Peter ; Risch, Harvey A. ; Amundadottir, Laufey T. ; Klein, Alison P. ; Stolzenberg-Solomon, Rachael Z. ; Antwi, Samuel O.

Background: There are conflicting data on whether nonalcoholic fatty liver disease (NAFLD) is associated with susceptibility to pancreatic cancer (PC). Using Mendelian randomization (MR), we investigated the relationship between genetic predisposition to NAFLD and risk for PC. Methods: Data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium (PanScan; cases n=5090, controls n=8733) and the Pancreatic Cancer Case Control Consortium (PanC4; cases n=4,163, controls [...]

Menée auprès de 5 284 hommes (âge moyen : 57,6 ans), cette étude analyse l'association entre une fibrose hépatique et le risque de cancer de la prostate (726 cas) ainsi que la mortalité, en fonction de l'origine ethnique

Liver fibrosis scores and prostate cancer risk and mortality in the Atherosclerosis Risk in Communities (ARIC) Study

Wang, Anqi ; Lazo, Mariana ; Lu, Jiayun ; Couper, David J. ; Prizment, Anna E. ; Vitolins, Mara Z. ; Denmeade, Samuel R. ; Joshu, Corinne E. ; Platz, Elizabeth A.

Subclinical liver impairment due to fibrosis could influence the development and detectability of prostate cancer. To investigate the association between liver fibrosis and prostate cancer incidence and mortality, we included 5,284 men (mean age: 57.6 years, 20.1% Black) without cancer or liver disease at Visit 2 in Atherosclerosis Risk in Communities study. Liver fibrosis was assessed using the aspartate aminotransferase to platelet ratio index (APRI), fibrosis 4 index (FIB-4), and [...]

Menée aux Etats-Unis à l'aide de données portant sur 27 800 témoins et 556 patients atteints d'un sarcome d'Ewing diagnostiqué sur la période 1988-2015, cette étude analyse l'association entre des caractéristiques périnatales et le risque de développer la maladie

Birth characteristics and risk of Ewing sarcoma

Wiemels, Joseph L. ; Wang, Rong ; Feng, Qianxi ; Yee, Amy C. ; Morimoto, Libby M. ; Metayer, Catherine ; Ma, Xiaomei

Purpose: The incidence of Ewing sarcoma varies according to race and ethnicity, and genetic susceptibility is known to affect disease risk. Apart from these factors, the etiology of Ewing sarcoma is largely unknown. Methods: We compared the birth characteristics of a population-based series of 556 Ewing sarcoma cases born in California in 1978–2015 and diagnosed in 1988–2015 with those of 27,800 controls selected from statewide birth records and frequency-matched to cases on the year of birth, [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2023 (51 études, 2 238 patientes), cette méta-analyse évalue l'association entre un méningiome et le risque de cancer du sein

The Association Between Meningioma and Breast Cancer: A Systematic Review and Meta-analysis

Degeneffe, Aurélie ; De Maertelaer, Viviane ; De Witte, Olivier ; Lefranc, Florence

A potential relationship between meningioma and breast cancer was suggested 70 years ago. However, to date, no conclusive evidence is available on this topic.To provide a comprehensive review of the literature on the association of meningioma with breast cancer, supported by a meta-analysis.A systematic PubMed search was performed up to April 2023 to identify articles on the association of meningioma with breast cancer. The following key words were used strategically: meningioma, breast cancer, [...]

Menée en Nouvelle-Angleterre auprès de 897 témoins et 616 patients atteints d'un carcinome urothélial, cette étude analyse l'association entre le pH urinaire et le risque de développer la maladie

Urine pH and Risk of Bladder Cancer in Northern New England

Fischer, Alexander H. ; Wong, Jason YY. ; Baris, Dalsu ; Koutros, Stella ; Karagas, Margaret R. ; Schwenn, Molly ; Johnson, Alison ; Alguacil, Juan ; Silverman, Debra T. ; Rothman, Nathaniel

Background: Acidic urine pH is associated with rapid hydrolysis of N-glucuronide conjugates of aromatic amines into metabolites that may undergo metabolism in the bladder lumen to form mutagenic DNA adducts. We previously reported that consistently acidic urine was associated with increased bladder cancer risk in a hospital-based case-control study in Spain. Here, we conducted a separate study in northern New England to replicate these findings. Methods: In a large, population-based [...]

Menée à partir de données de 3 consortia en génétique portant au total sur 41 499 témoins et 31 318 patients atteints d'un cancer colorectal, cette étude sur le génome entier analyse l'influence de certains gènes sur l'association entre le diabète et le risque de cancer colorectal

Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses

Dimou, Niki ; Kim, Andre E. ; Flanagan, Orlagh ; Murphy, Neil ; Díez-Obrero, Virginia ; Shcherbina, Anna ; Aglago, Elom K. ; Bouras, Emmanouil ; Campbell, Peter T. ; Casey, Graham ; Gallinger, steven ; Gruber, Stephen B. ; Jenkins, Mark A. ; Lin, Yi ; Moreno, Víctor ; Ruiz-Narvaez, Edward ; Stern, Mariana C. ; Tian, Yu ; Tsilidis, Kostas K. ; Arndt, Volker ; Barry, Elizabeth L. ; Baurley, James W. ; Berndt, Sonja I. ; Bézieau, Stéphane ; Bien, Stephanie A. ; Bishop, D. Timothy ; Brenner, Hermann ; Budiarto, Arif ; Carreras-Torres, Robert ; Cenggoro, Tjeng Wawan ; Chan, Andrew T. ; Chang-Claude, Jenny ; Chanock, Stephen J. ; Chen, Xuechen ; Conti, David V. ; Dampier, Christopher H. ; Devall, Matthew ; Drew, David A. ; Figueiredo, Jane C. ; Giles, Graham G. ; Gsur, Andrea ; Harrison, Tabitha A. ; Hidaka, Akihisa ; Hoffmeister, Michael ; Huyghe, Jeroen R. ; Jordahl, Kristina ; Kawaguchi, Eric ; Keku, Temitope O. ; Larsson, Susanna C. ; Le Marchand, Loic ; Lewinger, Juan Pablo ; Li, Li ; Mahesworo, Bharuno ; Morrison, John ; Newcomb, Polly A. ; Newton, Christina C. ; Obón-Santacana, Mireia ; Ose, Jennifer ; Pai, Rish K. ; Palmer, Julie R. ; Papadimitriou, Nikos ; Pardamean, Bens ; Peoples, Anita R. ; Pharoah, Paul D. P. ; Platz, Elizabeth A. ; Potter, John D. ; Rennert, Gad ; Scacheri, Peter C. ; Schoen, Robert E. ; Su, Yu-Ru ; Tangen, Catherine M. ; Thibodeau, Stephen N. ; Thomas, Duncan C. ; Ulrich, Cornelia M. ; Um, Caroline Y. ; van Duijnhoven, Fränzel J. B. ; Visvanathan, Kala ; Vodicka, Pavel ; Vodickova, Ludmila ; White, Emily ; Wolk, Alicja ; Woods, Michael O. ; Qu, Conghui ; Kundaje, Anshul ; Hsu, Li ; Gauderman, W. James ; Gunter, Marc J. ; Peters, Ulrike

Background: Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis. Methods: We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction [...]

Menée à l'aide de la méthode DEPTH (DEPendency of association on the number of Top Hits) et de données portant sur 13 973 témoins et 14 600 patients atteints d'un cancer colorectal, cette étude identifie de nouvelles régions de susceptibilité à la maladie, non identifiées par les méthodes conventionnelles d'analyse sur le génome entier

Using DEPendency of association on the number of Top Hits (DEPTH) as a complementary tool to identify novel colorectal cancer susceptibility loci

Lai, John ; Wong, Chi Kuen ; Schmidt, Daniel F. ; Kapuscinski, Miroslaw K. ; Alpen, Karen ; Maclnnis, Robert J. ; Buchanan, Daniel D. ; Win, Aung K. ; Figueiredo, Jane C. ; Chan, Andrew T. ; Harrison, Tabitha A. ; Hoffmeister, Michael ; White, Emily ; Le Marchand, Loic ; Pai, Rish K. ; Peters, Ulrike ; Hopper, John L. ; Jenkins, Mark A. ; Makalic, Enes

Background: DEPendency of association on the number of Top Hits (DEPTH) is an approach to identify candidate susceptibility regions by considering the risk signals from overlapping groups of sequential variants across the genome. Methods: We conducted a DEPTH analysis using a sliding window of 200 SNPs to colorectal cancer (CRC) data from the Colon Cancer Family Registry (CCFR) (5,735 cases and 3,688 controls), and GECCO (8,865 cases and 10,285 controls) studies. A DEPTH score >1 was used to [...]