A partir d'une revue systématique de la littérature publiée entre 2018 et 2022 (5 essais randomisés), cette étude présente les recommandations actualisées de l'"American Sociéty of Clinical Oncology" concernant la prévention et la prise en charge d'une thromboembolie veineuse chez les patients atteints d'un cancer

Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Guideline Update

Nigel S. Key ; Alok A. Khorana ; Nicole M. Kuderer ; Kari Bohlke ; Agnes Y.Y. Lee ; Juan I. Arcelus ; Sandra L. Wong ; Edward P. Balaban ; Christopher R. Flowers ; Leigh E. Gates ; Ajay K. Kakkar ; Margaret A. Tempero ; Shilpi Gupta ; Gary H. Lyman ; Anna Falanga

PURPOSE: To conduct an update of the ASCO venous thromboembolism (VTE) guideline. METHODS: After publication of potentially practice-changing clinical trials, identified through ASCO's signals approach to updating, an updated systematic review was performed for two guideline questions: perioperative thromboprophylaxis and treatment of VTE. PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) published between November 1, 2018, and June 6, 2022. RESULTS: Five [...]

Mené sur 32 patientes atteintes d'un cancer du sein, cet essai randomisé évalue l'intérêt, pour prendre en charge une alopécie induite par la chimiothérapie et accélérer la repousse des cheveux, d'une thérapie par photobiomodulation

The use of photobiomodulation therapy for the management of chemotherapy-induced alopecia: a randomized, controlled trial (HAIRLASER trial)

Lodewijckx, Joy ; Robijns, Jolien ; Claes, Marithé ; Pierson, Maud ; Lenaerts, Melissa ; Mebis, Jeroen

Purpose: The purpose of this trial was to evaluate if photobiomodulation (PBM) can accelerate hair regrowth after chemotherapy in breast cancer patients and if this is correlated with a better quality of life (QoL). Methods: A randomized controlled trial with breast cancer patients that underwent an anthracycline and taxane-containing chemotherapy regimen was set up at the Jessa Hospital (Hasselt, Belgium). Patients were randomized into the control group (no intervention) or the PBM group [...]

A partir d'une revue systématique de la littérature (21 publications), cette étude analyse l'intérêt d'interventions destinées à améliorer la sexualité chez des hommes atteints d'un cancer de l'appareil génito-urinaire et chez leur partenaire de vie

Experiences of sexual well-being interventions in males affected by genitourinary cancers and their partners: an integrative systematic review

Schubach, Kathryn ; Niyonsenga, Theo ; Turner, Murray ; Paterson, Catherine

Purpose: Sexual well-being has been identified as an unmet supportive care need among many individuals with genitourinary (GU) cancers. Little is known about the experiences of using sexual well-being interventions among men and their partners. Methods: This review was reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and followed a systematic review protocol. Data extraction and methodological quality appraisal were performed, and a narrative [...]

Menée en France par enquête auprès de 371 patients ayant survécu 5 ans à un cancer du poumon, cette étude identifie les facteurs associés à leur qualité de vie en fonction de leur catégorie d'âge (âge supérieur ou inférieur à 70 ans)

Quality of life in older French long-term lung cancer survivors: VICAN5 national survey

Couderc, Anne-Laure ; Bouhnik, Anne-Deborah ; Rey, Dominique ; Bendiane, Marc-Karim ; Greillier, Laurent ; Nouguerède, Emilie ; Pille, Ariane ; Montegut, Coline ; Rousseau, Frédérique ; Villani, Patrick ; Mancini, Julien

Objectives: This study aimed to describe quality of life (QoL) five years after diagnosis, in a representative sample of lung cancer (LC) survivors, to compare the QoL of survivors aged 70 years or older with that of younger ones, and to identify factors associated with poorer long-term QoL in both age groups. Materials and Methods: Our study sample consists of all individuals with a LC diagnosed between January 2010 and December 2011, who participated in the French national survey VICAN 5. [...]

Menée à partir de données portant sur 4 748 patients ayant survécu à un cancer du testicule traité entre 1976 et 2007 (durée médiane de suivi : 16 ans), cette étude de cohorte multicentrique identifie les facteurs associés au risque de maladie cardiovasculaire puis évalue l'impact de ces maladies sur leur qualité de vie (272 cas de maladie cardiovasculaire)

Cardiovascular Disease in Testicular Cancer Survivors: Identification of Risk Factors and Impact on Quality of Life

Sjoukje Lubberts ; Harmke J. Groot ; Ronald de Wit ; Sasja Mulder ; Johannes A. Witjes ; J. Martijn Kerst ; Gerard Groenewegen ; Joop D. Lefrandt ; Flora E. van Leeuwen ; Janine Nuver ; Michael Schaapveld ; Jourik A. Gietema

PURPOSE: Testicular cancer (TC) treatment is clearly associated with cardiovascular morbidity and mortality. To enable development of preventive strategies for cardiovascular disease (CVD), we assessed cardiometabolic risk factors and quality of life (QoL) in TC survivors. METHODS: Incidence of coronary artery disease, myocardial infarction, and heart failure after TC treatment was assessed in a multicenter cohort comprising 4,748 patients treated at the age of 12-50 years between 1976 and [...]

Menée aux Etats-Unis à partir de données 2018-2020, cette étude estime le nombre de décès par cancer en fonction de l'origine ethnique

Cancer mortality rates by racial/ethnic groups in the United States, 2018–2020

Haque, Anika T ; Berrington de Gonzalez, Amy ; Chen, Yingxi ; Haozous, Emily A ; Inoue-Choi, Maki ; Lawrence, Wayne R ; McGee-Avila, Jennifer K ; Nápoles, Anna M ; Pérez-Stable, Eliseo J ; Taparra, Kekoa ; Vo, Jacqueline B ; Freedman, Neal D ; Shiels, Meredith S

Background: Starting in 2018, national death certificates included a new racial classification system that accounts for multiple-race decedents and separates Native Hawaiian and Pacific Islander (NHPI) individuals from Asian individuals. We estimated cancer death rates across updated racial/ethnic categories, sex, and age. Methods: Age-standardized U.S. cancer mortality rates and rate ratios from 2018-2020 among ≥20-year-olds were estimated with national death certificate data by [...]

Menée en Belgique sur la période 2004-2017, cette étude analyse l'incidence des cancers primitifs multiples puis évalue le risque de second cancer et la survie relative

The epidemiology of multiple primary cancers in Belgium (2004–2017): Incidence, proportion, risk, stage and impact on relative survival estimates

Macq, Gilles ; Silversmit, Geert ; Verdoodt, Freija ; van Eycken, Liesbet

Background: As both life expectancy and cancer survival improve, the incidence of multiple primary cancer has augmented and is expected to further increase. This study describes for the first time the epidemiology of multiple invasive tumours in Belgium. Methods: This nationwide study, based on all cancers diagnosed between 2004 and 2017 in Belgium, describes the proportion of multiple primary cancer, its evolution over time, the impact of inclusion or exclusion of multiple primary cancer on [...]

Menée aux Etats-Unis dans un contexte de vie réelle à partir de données portant sur 2 715 patients atteints d'un cancer du poumon non à petites cellules de stade avancé avec mutation G12C au niveau du gène KRAS et présentant ou non une mutation au niveau des gènes STK11 et/ou KEAP1, cette étude analyse l'association entre la présence de ces mutations et la survie globale en fonction des traitements reçus (chimiothérapie et immunothérapie en monothérapie ou en combinaison)

Overall survival in patients with advanced non-small cell lung cancer with KRAS G12C mutation with or without STK11 and/or KEAP1 mutations in a real-world setting

Julian, Cristina ; Pal, Navdeep ; Gershon, Anda ; Evangelista, Marie ; Purkey, Hans ; Lambert, Peter ; Shi, Zhen ; Zhang, Qing

Background: KRAS mutations occur frequently in advanced non-small cell lung cancer (aNSCLC); the G12C mutation is the most prevalent. Alterations in STK11 or KEAP1 commonly co-occur with KRAS mutations in aNSCLC. Using real-world data, we assessed the effect of KRAS G12C mutation with or without STK11 and/or KEAP1 mutations on overall survival (OS) in patients with aNSCLC receiving cancer immunotherapy (CIT), chemotherapy, or both in first line (1L) and second line (2L). Methods: Patients [...]

Menée à Hong Kong à partir de données portant sur 13 537 patients atteints d'un cancer de la prostate traité par thérapie anti-androgénique entre 1993 et 2021, cette étude de cohorte rétrospective analyse l'évolution de l'incidence d'événements cardiovasculaires indésirables

Temporal trends in cardiovascular burden among patients with prostate cancer receiving androgen deprivation therapy: a population-based cohort study

Chan, Jeffrey Shi Kai ; Satti, Danish Iltaf ; Lee, Yan Hiu Athena ; Hui, Jeremy Man Ho ; Dee, Edward Christopher ; Ng, Kenrick ; Liu, Kang ; Tse, Gary ; Ng, Chi Fai

Background: Although androgen deprivation therapy (ADT) is associated with cardiovascular risks, the extent and temporal trends of cardiovascular burden amongst patients with prostate cancer receiving ADT are unclear. Methods: This retrospective cohort study analyzed adults with PCa receiving ADT between 1993–2021 in Hong Kong, with follow-up until 31/9/2021 for the primary outcome of major adverse cardiovascular events (MACE; composite of cardiovascular mortality, myocardial infarction, [...]

Menée à partir de données 1995-2019 du registre taïwanais des cancers, cette étude analyse l'évolution de l'incidence du cancer de la thyroïde

Trends in thyroid cancer burden in Taiwan over two decades

Cheng, Sheena Yi-Hsin ; Hsu, Yi-Chiung ; Cheng, Shih-Ping

Purpose: Thyroid cancer incidence has increased over recent decades with considerable geographic variations in incidence patterns. Here, we analyzed temporal trends in the incidence and mortality rates of thyroid cancer in Taiwan. Methods: We obtained age-standardized rates at a national level using data from the Taiwan Cancer Registry annual reports from 1995 to 2019. Trends in age-standardized rates were characterized by joinpoint regression analysis. Results: The age-standardized incidence [...]

Menée en Chine, cette étude analyse l'évolution, sur la période 2006-2016, de l'incidence du cancer du col de l'utérus et de la mortalité associée puis présente des projections jusqu'en 2030 par tranche d'âge et par zone géographique (zone rurale et zone urbaine)

Trend in Cervical Cancer Incidence and Mortality Rates in China, 2006–2030: A Bayesian Age-Period-Cohort Modeling Study

Yuan, Meiwen ; Zhao, Xuelian ; Wang, Honghao ; Hu, Shangying ; Zhao, Fanghui

Background: There are no studies extrapolating the incidence and mortality of cervical cancer in China by comparing incidence and deaths pattern between geographic and age groups. Methods: We applied age-period-cohort models to assess region-level trends in incidence and mortality from 2006 to 2016, with piecewise linear regression in a Bayesian framework to predict these trends to 2030. Results: Between 2006 and 2016, age-standardized incidence rates (ASIR) for females aged 15 to 84 years [...]

Mené sur des patients atteints d'un cancer et souffrant de troubles dépressifs sévères, cet essai non randomisé évalue l'intérêt de la psilocybine (un hallucinogène, agoniste au niveau du récepteur 5-HT2A) pour traiter leur dépression

Assessment of Psilocybin Therapy for Patients With Cancer and Major Depression Disorder

Agrawal, Manish ; Emanuel, Ezekiel ; Richards, Brian ; Richards, William ; Roddy, Kim ; Thambi, Paul

About 15% of patients with cancer experience major depression, which is associated with lower treatment adherence and reduced quality of life. Yet, oncologists often feel inadequate to address mental health issues, and many treatments have limited success in treating depression.Psilocybin is a 5-HT2A receptor agonist with success in reducing a variety of psychiatric symptoms while using 2 therapists per patient. To create a scalable, rapidly effective depression treatment, this nonrandomized [...]

A partir d'une revue systématique de la littérature publiée entre 2013 et 2021 (17 revues systématiques ou méta-analyses), cette étude présente les recommandations actualisées de l'"American Society of Clinical Oncology" concernant la prise en charge de l'anxiété et de la dépression chez des adultes ayant survécu à un cancer

Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update

Barbara L. Andersen ; Christina Lacchetti ; Kimlin Ashing ; Jonathan S. Berek ; Barry S. Berman ; Sage Bolte ; Don S. Dizon ; Barbara Given ; Larissa Nekhlyudov ; William Pirl ; Annette L. Stanton ; Julia H. Rowland

PURPOSE: To update the American Society of Clinical Oncology guideline on the management of anxiety and depression in adult cancer survivors. METHODS: A multidisciplinary expert panel convened to update the guideline. A systematic review of evidence published from 2013-2021 was conducted. RESULTS: The evidence base consisted of 17 systematic reviews ± meta analyses (nine for psychosocial interventions, four for physical exercise, three for mindfulness-based stress reduction [MBSR], and one for [...]

Menée aux Etats-Unis auprès de 29 dyades constituées de patients atteints d'un cancer et de leur aidant, cette étude identifie les facteurs associés au risque de symptômes neuropsychologiques chez les aidants

Predictors of psychoneurological symptoms in cancer caregivers over time: Role of caregiving burden, stress, and patient symptoms

Litzelman, Kristin ; Berghoff, Ashley ; Stevens, Jen ; Kwekkeboom, Kris

Purpose: In cancer patients, stress is associated with a psychoneurologic (PN) symptom cluster of depressed mood, anxiety, pain, fatigue, and sleep disturbance. The stress of caregiving may trigger similar symptoms among caregivers and warrants investigation. The purpose of this analysis was to characterize correlates of PN symptom burden in cancer caregivers. Methods: Cancer patient-caregiver dyads (n = 29) provided eight weekly symptom reports using a web-based survey. Primary and secondary [...]

Menée aux Pays-Bas à partir de données portant sur 1 797 adultes ayant survécu à un cancer pédiatrique (âge moyen : 35,4 ans), cette étude identifie les facteurs associés à leur santé psychique

Psychosocial outcomes in long-term Dutch adult survivors of childhood cancer: The DCCSS-LATER 2 psycho-oncology study

Maas, Anne ; Maurice-Stam, Heleen ; Kremer, Leontien C. M. ; van der Aa-van Delden, Alied ; van Dulmen-den Broeder, Eline ; Tissing, Wim J. E. ; Loonen, Jacqueline J. ; van der Pal, Helena J. H. ; de Vries, Andrica C. H. ; van den Heuvel-Eibrink, Marry M. ; Ronckers, Cecile ; Neggers, Sebastian ; Bresters, Dorine ; Louwerens, Marloes ; van der Heiden-van der Loo, Margriet ; van Gorp, Marloes ; Grootenhuis, Martha ; Dutch LATER Study Group

Background : This study compares a comprehensive range of psychosocial outcomes of adult childhood cancer survivors (CCS) to general population-based references and identifies sociodemographic and medical risk factors. Methods : CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963–2001) part 2 (attained age ≥18 years, diagnosed <18 years, ≥5 years since diagnosis) completed the Rosenberg Self-Esteem Scale, Hospital Anxiety and Depression Scale, Distress [...]

A partir d'une revue systématique de la littérature (9 études), cette étude analyse les facteurs entravant l'accès aux traitements anticancéreux chez des patients souffrant de troubles psychiques sévères antérieurs au diagnostic de cancer

Barriers in cancer trajectories of patients with pre-existing severe mental disorders—A systematic review

Terese Myhre Bentson, ; Louise E. Fløe, ; Josefine M. Bruun, ; Jesper Grau Eriksen, ; Søren Paaske Johnsen, ; Poul Videbech, ; Trine Brogaard, ; Pernille Andreassen, ; Anna Mygind, ; Kirstine B. Bøndergaard

Background : Patients with pre-existing severe mental disorders are significantly less likely to receive guideline-recommended cancer treatment and seems to have a significantly lower rate of cancer survival compared to patients with cancer without mental disorders. Aim: To perform a systematic review on barriers at patient-, provider- and system-levels in cancer trajectories of patients with pre-existing severe mental disorders. Method: A systematic review was performed following the PRISMA [...]

Menée aux Etats-Unis à partir de données portant sur 6 054 patientes atteintes d'un cancer primitif invasif du sein diagnostiqué entre 2007 et 2011 (âge : supérieur ou égal à 20 ans), cette étude analyse l'impact d'une dépression sur l'adhésion aux traitements recommandés et sur la survie

Influence of depression on breast cancer treatment and survival: A Kentucky population-based study

Lei, Feitong ; Vanderpool, Robin C. ; McLouth, Laurie E. ; Romond, Edward H. ; Chen, Quan ; Durbin, Eric B. ; Tucker, Thomas C. ; Tai, Eric ; Huang, Bin

Background: Depression is common among breast cancer patients and can affect concordance with guideline-recommended treatment plans. Yet, the impact of depression on cancer treatment and survival is understudied, particularly in relation to the timing of the depression diagnosis. Methods: The Kentucky Cancer Registry data was used to identify female patients diagnosed with primary invasive breast cancer who were 20 years of age or older in 2007–2011. Patients were classified as having no [...]

Cette étude passe en revue les articles évaluant les difficultés financières des patients atteints traités pour un cancer et de leur famille puis présente des pistes de réflexion pour réduire ces difficultés

Financial Toxicity in Cancer Care: Implications for Clinical Care and Potential Practice Solutions

Hiba M. Khan ; Scott Ramsey ; Veena Shankaran

Patients with cancer face an array of financial consequences as a result of their diagnosis and treatment, collectively referred to as financial toxicity (FT). In the past 10 years, the body of literature on this subject has grown tremendously, with a recent focus on interventions and mitigation strategies. In this review, we will briefly summarize the FT literature, focusing on the contributing factors and downstream consequences on patient outcomes. In addition, we will put FT into context [...]

Menée en Allemagne par questionnaire auprès de 153 oncologues, cette étude transversale analyse l'association entre leur anxiété personnelle vis-à-vis de la mort et leurs stratégies de communication sur la fin de vie avec leurs patients atteints d'un cancer de stade avancé

Association between oncologists' death anxiety and their end-of-life communication with advanced cancer patients

Harnischfeger, Nele ; Rath, Hilke M. ; Alt-Epping, Bernd ; Brand, Hannah ; Haller, Karl ; Letsch, Anne ; Rieder, Nicola ; Thuss-Patience, Peter ; Bokemeyer, Carsten ; Oechsle, Karin ; Bergelt, Corinna

Objective : Early and open communication of palliative care (PC) and end-of-life (EoL)-related issues in advanced cancer care is not only recommended by guidelines, but also preferred by the majority of patients. However, oncologists tend to avoid timely addressing these issues. We investigated the role of oncologists' personal death anxiety in the rare occurrence of PC/EoL conversations. Methods : We conducted a multicenter cross-sectional study assessing oncologists' strengths and [...]