A partir d'une revue systématique de la littérature publiée jusqu'en mai 2022 (20 études, 11 315 patients), cette méta-analyse évalue l'association entre le type de viande consommée et le risque de cancer du pancréas

The association between red, processed and white meat consumption and risk of pancreatic cancer: a meta-analysis of prospective cohort studies

Kim, Youngyo

Purpose: The association between meat consumption and the risk of pancreatic cancer has not been comprehensively investigated by different types of meat. The current study was conducted to evaluate this association. Methods: PubMed and Web of Science databases were used to search for prospective cohort studies on meat consumption and pancreatic cancer risk through May 2022. A meta-analysis was performed using random-effects models to combine study-specific relative risks (RR). The quality of [...]

Menée en Nouvelle-Ecosse auprès de 8 501 témoins et 2 315 patients atteints d'un cancer (poumon, sein ou voies urinaires), cette étude analyse l'association entre une exposition à la pollution atmosphérique liée à la circulation et le risque de développer la maladie

Traffic-related air pollution and risk of lung, breast and urinary tract cancer in Halifax, Nova Scotia

Dummer, Trevor J. B. ; Yu, Xing ; Cui, Yunsong ; Nauta, Laura ; Saint-Jacques, Nathalie ; Magee, Molly Sweeney ; Rainham, Daniel G. C.

Objectives: We assessed the association of traffic-related air pollution (TRAP) with the incidence of lung, breast and urinary tract cancer in Halifax, Nova Scotia. Methods: Our case-control study included 2315 cancers and 8501 age-sex matched controls. Land-use regression was used to estimated TRAP concentrations. Logistic regression was used to assess cancer risk in relation to TRAP, adjusting for community social and material deprivation. Results: There was no association between the risk of [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2022 (35 articles), cette étude analyse l'association entre une exposition à l'arsenic et le risque de cancer digestif

Carcinogenic effect of arsenic in digestive cancers: a systematic review

Kasmi, Sophie ; Moser, Laureline ; Gonvers, Stéphanie ; Dormond, Olivier ; Demartines, Nicolas ; Labgaa, Ismail

Background: The carcinogenic effect of arsenic (As) has been documented in lung, bladder and skin cancers but remains unclear for digestive cancers, although metabolic pathways of As and recent data suggest that it may be an important determinant in these malignancies as well. Objective: This study aimed to systematically review the available literature investigating the potential association between As and digestive cancers. Methods: An extensive search was conducted in Medline Ovid SP, [...]

Menée en Corée auprès de 5 265 590 personnes ayant participé à un dépistage national sur la période 2009-2012 (âge : 20-39 ans), cette étude analyse l'association entre une stéatose hépatique non alcoolique et le risque de survenue précoce d'un cancer digestif (oe

Increased Risk of Young-Onset Digestive Tract Cancers Among Young Adults Age 20-39 Years With Nonalcoholic Fatty Liver Disease: A Nationwide Cohort Study

Joo-Hyun Park ; Jung Yong Hong ; Jay J. Shen ; Kyungdo Han ; Joon Oh Park ; Young Suk Park ; Ho Yeong Lim

PURPOSE: Although the incidence of young-onset digestive tract cancers is increasing worldwide, their risk factors remain largely unknown. We investigated the association between nonalcoholic fatty liver disease (NAFLD) and young-onset digestive tract cancers. PATIENTS AND METHODS: This nationwide cohort study included 5,265,590 individuals age 20-39 years who underwent national health screening under the Korean National Health Insurance Service between 2009 and 2012. The fatty liver index was [...]

Cette étude analyse le risque de carcinome épidermoïde du sein après une reconstruction par implant pour un cancer du sein non épidermoïde

Risk of Squamous Cell Carcinoma of the Breast Following Postmastectomy Implant Reconstruction in Women With Breast Cancer and Carcinoma in Situ

Kinslow, Connor J. ; Yu, James B. ; DeStephano, David M. ; Kachnic, Lisa A. ; Cheng, Simon K. ; Neugut, Alfred I. ; Horowitz, David P.

The US Food and Drug Administration issued a safety communication on September 8, 2022, about reports of squamous cell carcinoma (SCC) and various lymphomas of the breast associated with breast implants. These malignant tumors were distinct from breast implant–associated anaplastic large cell lymphoma (BIA-ALCL), which is the subject of a black box warning on all saline- and silicone gel–filled breast implants since 2020. While BIA-ALCL has been almost exclusively associated with textured [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2022 (127 études, 231 737 patients), cette méta-analyse évalue l'association entre le groupe sanguin et le risque de cancer (20 localisations)

Epidemiological and genetic evidence for the relationship between ABO blood group and human cancer

Cui, Huijie ; Qu, Yang ; Zhang, Li ; Zhang, Wenqiang ; Yan, Peijing ; Yang, Chao ; Zhang, Min ; Bai, Ye ; Tang, Mingshuang ; Wang, Yutong ; Chen, Lin ; Xiao, Chenghan ; Zou, Yanqiu ; Liu, Yunjie ; Zhang, Ling ; Yang, Yanfang ; Yao, Yuqin ; Li, Jiayuan ; Liu, Zhenmi ; Yang, Chunxia ; Jiang, Xia ; Zhang, Ben

To comprehensively evaluate the etiological role of ABO blood group in human cancer, we conducted a large-scale meta-analysis of 127 publications totaling 20 million participants including 231 737 patients of 20 cancers, supplemented by genetic evidence. Effects of A, AB and B groups on cancer risk were investigated by respectively comparing with O group and their combined counterparts, and subgroup analysis by ethnicity was conducted for O-referent models. For cancer categories, A group [...]

Menée en Finlande à l'aide de données de registres et auprès de 54 753 membres de la famille de 5 562 patientes atteintes d'un cancer du sein diagnostiqué avant l'âge de 40 ans sur la période 1970-2012, cette étude analyse leur risque de développer un cancer autre qu'un cancer du sein

Familial aggregation of early-onset cancers in early-onset breast cancer families

Rantala, Jasmiina N. J. ; Heikkinen, Sanna M. M. ; Hirvonen, Elli M. ; Tanskanen, Tomas ; Malila, Nea K. ; Pitkäniemi, Janne M.

The risk of early-onset (EO) breast cancer is known to be increased in relatives of EO breast cancer patients, but less is known about the familial risk of other EO cancers. We assessed familial risks of EO cancers (aged ≤40 years) other than breast cancer in 54 753 relatives of 5562 women with EO breast cancer (probands) by using a population-based cohort from Finland. Standardized incidence ratios (SIRs) and 95% confidence intervals (CI) were estimated by using gender-, age- and [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 1,6 million de témoins et 562 871 patients atteints d'un cancer (67 localisations), cette étude analyse l'association entre les niveaux d'acides gras polyinsaturés et le risque de développer la maladie

The association between genetically elevated polyunsaturated fatty acids and risk of cancer

Tintle, Nathan ; Rice, Terri ; Cheng, Iona ; Jenkins, Mark ; Gallinger, Steve ; Cornish, Alex J. ; Sud, Amit ; Vijayakrishnan, Jayaram ; Wrensch, Margaret ; Johansson, Mattias ; Norman, Aaron D. ; Klein, Alison ; Clay-Gilmour, Alyssa ; Franke, Andre ; Ardisson Korat, Andres V. ; Wheeler, Bill ; Nilsson, Björn ; Smith, Caren ; Heng, Chew-Kiat ; Song, Ci ; Riadi, David ; Claus, Elizabeth B. ; Ellinghaus, Eva ; Ostroumova, Evgenia ; Hosnijeh, ; de Vathaire, Florent ; Cugliari, Giovanni ; Matullo, Giuseppe ; Oi-Lin Ng, Irene ; Passow, Jeanette E. ; Foo, Jia Nee ; Han, Jiali ; Liu, Jianjun ; Barnholtz-Sloan, Jill ; Schildkraut, Joellen M. ; Maris, John ; Wiemels, Joseph L. ; Hemminki, Kari ; Yang, Keming ; Kiemeney, Lambertus A. ; Wu, Lang ; Amundadottir, Laufey ; Stern, Marc-Henri ; Boutron, Marie-Christine ; Iles, Mark Martin ; Purdue, Mark P. ; Stanulla, Martin ; Bondy, Melissa ; Gaudet, Mia ; Mobuchon, Lenha ; Camp, Nicola J. ; Sham, Pak Chung ; Guénel, Pascal ; Brennan, Paul ; Taylor, Philip R. ; Ostrom, Quinn ; Stolzenberg-Solomon, Rachael ; Dorajoo, Rajkumar ; Houlston, Richard ; Jenkins, Robert B. ; Diskin, Sharon ; Berndt, Sonja I. ; Tsavachidis, Spiridon ; Channock, Stephen J. ; Harrison, Tabitha ; Galesloot, Tessel ; Gyllensten, Ulf ; Joseph, Vijai ; Shi, Y. ; Yang, Wenjian ; Lin, Yi ; Van Den Eeden, Stephen K. ; Haycock, Philip C. ; Borges, Maria Carolina ; Burrows, Kimberley ; Lemaitre, Rozenn N. ; Burgess, Stephen ; Khankari, Nikhil K. ; Tsilidis, Konstantinos K. ; Gaunt, Tom R. ; Hemani, Gibran ; Zheng, Jie ; Truong, Thérèse ; Birmann, Brenda M. ; Omara, Tracy ; Spurdle, Amanda B. ; Iles, Mark M. ; Law, Matthew H. ; Slager, Susan L. ; Saberi Hosnijeh, Fatemeh ; Mariosa, Daniela ; Cotterchio, Michelle ; Cerhan, James R. ; Peters, Ulrike ; Enroth, Stefan ; Gharahkhani, Puya ; Le Marchand, Loic ; Williams, Ann C. ; Block, Robert C. ; Amos, Christopher I. ; Hung, Rayjean J. ; Zheng, Wei ; Gunter, Marc J. ; Smith, George Davey ; Relton, Caroline ; Martin, Richard M.

Background: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain. Methods: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European and East Asian ancestry individuals. We defined the primary exposure as PUFA desaturase activity, proxied by rs174546 at the FADS locus. Secondary exposures were defined as omega 3 and omega 6 PUFAs that could be proxied by genetic [...]