Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

COVID-19 Vaccine–Related Beliefs and Behaviors Among Patients With and Survivors of Hematologic Malignancies

Jesper Akesson ; Elisa S. Weiss ; Maria Sae-Hau ; Gabriela Gracia ; Marialanna Lee ; Lucy Culp ; Brian Connell ; Steve Butterfield ; Rena M. Conti

PURPOSE:Patients with and survivors of hematologic malignancies are particularly vulnerable to COVID-19 disease and complications. This study examined patients' vaccination attitudes and behaviors and their correlates. METHODS:A two-wave survey was fielded in December 2020 and June 2021 among hematologic malignancy patients and survivors (N = 2,272). Demographic characteristics, intent to get vaccinated, vaccination status, attitudes toward vaccination, and level of trust in specific sources of [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Assessing Unique Risk Factors for COVID-19 Complications Among Cancer Patients: A Multi-ethnic Cohort Study

Borno, Hala T. ; Kim, Mi-Ok ; Tolstykh, Irina ; Lin, Amy ; Hong, Julian C. ; Yousefi, Sasha ; Zhang, Sylvia ; McKay, Rana R. ; Harismendy, Olivier ; Razavi, Pedram ; Cinar, Pelin ; Rugo, Hope ; Koshkin, Vadim S. ; Rabow, Maya ; Wang, Christine ; Bailey, Adina ; Small, Eric J.

A myriad of organ-specific complications have been observed with COVID-19. While racial/ethnic minorities have been disproportionately burdened by this disease, our understanding of the unique risk factors for complications among a diverse population of cancer patients remains limited. This is a multi-institutional, multi-ethnic cohort study evaluating COVID-19 complications among cancer patients. Patients with an invasive cancer diagnosis and confirmed SARS-CoV-2 infection were identified from [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Impact of the Nutritional Status on Clinical Outcomes of Patients with Coronavirus Disease Undergoing Cancer Treatment

Crisóstomo, Rebeca Prado ; Silva, Ana Carolina Leão ; Murahara, Erika Yuri Hirose ; Roberto, Thais Giovaninni ; Pescuma, Janilene Medeiros da Silva ; Custódio, Amanda Guimarães Castro ; Rodrigues, Ana Lúcia Chalhoub Chediac ; Severine, Ariane Nadolskis ; Ortega, Tainá Teixeira

Coronavirus disease (COVID-19) is a critical and potentially fatal condition. The nutritional status affects the evolution and clinical outcome throughout the disease course among factors influencing the patient prognosis. In patients with cancer, the Patient-Generated Subjective Global Assessment (PG-SGA) is the preferred instrument for assessing the nutritional status. The aim of this retrospective cross-sectional study was to evaluate the impact of the nutritional status on the clinical [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Incident Cancer Detection During Multiple Waves of COVID-19: The Tsunami After the Earthquake

Fu, Rui ; Sutradhar, Rinku ; Li, Qing ; Hanna, Timothy P. ; Chan, Kelvin K.W. ; Irish, Jonathan C. ; Coburn, Natalie ; Hallet, Julie ; Dare, Anna ; Singh, Simron ; Parmar, Ambica ; Earle, Craig C. ; Lapointe-Shaw, Lauren ; Krzyzanowska, Monika K. ; Finelli, Antonio ; Louie, Alexander V. ; Look Hong, Nicole J. ; Witterick, Ian J. ; Mahar, Alyson ; Gomez, David ; McIsaac, Daniel I. ; Enepekides, Danny ; Urbach, David R. ; Eskander, Antoine

As of August 29, 2022, COVID-19 has infected more than 601 million people worldwide, with the death toll exceeding 6.4 million. However, some of the devastating consequences of COVID-19 are only now emerging. Non–COVID-19 care, including cancer care, has been disrupted. Notably, cancer detection has declined dramatically.1 Cancer types that depend heavily on routine screening for early detection were most impacted, because screening programs were suspended for months.2 Delayed cancer diagnosis [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

The impact of the first 2 years of the COVID-19 pandemic on breast cancer diagnoses: a population-based study in England

Gathani, Toral ; Dodwell, David ; Horgan, Kieran

Cancer services were seriously disrupted during the COVID-19 pandemic. Using publicly available data for England, we show that breast cancer diagnoses decreased substantially in the first year of the pandemic, but have recovered to at least pre-pandemic levels. Long term follow-up is needed to assess the impact on outcomes. The impact of the coronavirus disease 2019 (COVID-19) pandemic was significant with three ‘stay at home’ orders of varying durations issued in England in March 2020, [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Factors Associated with COVID‑19 Vaccine Uptake Among Adolescents and Young Adults Recently Diagnosed with Cancer

Gary Kwok ; Samantha Reese ; Sanjana Dugad ; Kristine A. Donovan ; Jennifer Tsui ; Olle Jane Z. Sahler ; Kristine Levonyan-Radloff ; Marie E. Barnett ; Sharon Manne ; Pamela Ohman-Strickland ; and Katie A. Devine

Adolescents and young adults (AYAs) recently diagnosed with cancer are medically vulnerable but little is known about vaccine uptake/intent in this group. AYAs reported on their COVID-19 vaccine uptake/intent. Logistic regression models examined factors associated with vaccine uptake. Higher education (adjusted odds ratio [aOR] = 1.9, 95% confidence interval [CI]: 1.0–3.5) and knowing someone diagnosed with COVID-19 (aOR = 7.2, 95% CI: 1.6–33.5) were associated with increased vaccine uptake. [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

SARS-CoV-2 Vaccine Immunogenicity in Patients with Gastrointestinal Cancer Receiving Systemic Anti-Cancer Therapy

Lau, David K ; Aresu, Maria ; Planche, Timothy ; Tran, Amina ; Lazaro-Alcausi, Retchel ; Duncan, Julie ; Kidd, Shannon ; Cromarty, Susan ; Begum, Ruwaida ; Rana, Isma ; Li, Su ; Mohamed, Ali Abdulnabi ; Monahan, Irene ; Clark, David J ; Eckersley, Nicholas ; Staines, Henry M ; Groppelli, Elisabetta ; Krishna, Sanjeev ; Mayora-Neto, Martin ; Temperton, Nigel ; Fribbens, Charlotte ; Watkins, David ; Starling, Naureen ; Chau, Ian ; Cunningham, David ; Rao, Sheela

Introduction Patients with gastrointestinal (GI) cancers have an increased risk of serious complications and death from SARS-CoV-2 infection. The immunogenicity of vaccines in patients with GI cancers receiving anti-cancer therapies is unclear. We conducted a prospective study to evaluate the prevalence of neutralizing antibodies in a cohort of GI cancer patients receiving chemotherapy following SARS-CoV-2 vaccination. Materials and Methods Between September 2020 and April 2021, patients with [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Immunogenicity and safety of COVID-19 vaccine in lung cancer patients receiving anticancer treatment: A prospective multicenter cohort study

Nakashima, Kei ; Ishida, Masayuki ; Matsui, Hiroki ; Yoshida, Chihiro ; Nagai, Tatsuya ; Shiraga, Minoru ; Nakaoka, Hiroshi ; Otsuka, Yoshihito ; Nakagama, Yu ; Kaku, Natsuko ; Nitahara, Yuko ; Kido, Yasutoshi ; Hirota, Yoshio

This study assessed the immunogenicity and safety of the BNT162b2 mRNA vaccine in lung cancer patients receiving anticancer treatment. We enrolled lung cancer patients receiving anticancer treatment and non-cancer patients; all participants were fully vaccinated with the BNT162b2 vaccine. Blood samples were collected before the first and second vaccinations and 4?±?1?weeks after the second vaccination. Anti-severe respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein S1 subunit [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Impact of COVID-19 on Head and Neck Cancer Advancement Measured by Increasing Numbers of Urgent Dyspnea Cases - What Could Be Improved in the Event of Subsequent Pandemics?

Pietruszewska, Wioletta ; Burduk, Paweł ; Rosiak, Oskar ; Podlawska, Paulina ; Zakrzewski, Bartosz ; Barańska, Magda ; Kowalczyk, Magdalena ; Piątkowski, Jakub ; Śmigielski, Grzegorz ; Solarz, Paweł ; Staszak, Marta ; Wierzbicka, Małgorzata ; Mikaszewski, Bogusław

The COVID-19 pandemic has altered all aspects of the healthcare system’s organization and impacted patients with head and neck cancer (HNC) who have experienced delayed diagnosis and treatment. The pandemic resulted in the admission of patients with severe dyspnea and a need for tracheotomy due to extremely advanced HNC. This study’s objective was to evaluate the clinical characteristics of two multi-center cohorts, “pre-COVID-19” and “COVID-19”, of HNC patients admitted as emergencies for [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Impact of the COVID-19 Pandemic on Cancer Staging: An Analysis of Patients With Breast Cancer From a Community Practice in Brazil

Cristiano A.A. Resende ; Heloísa M. Fernandes Cruz ; Matheus Costa e Silva ; Rafael D. Paes ; Rodrigo Dienstmann ; Carlos H.E. Barrios ; Aline C. Goncalves ; Fanny G.A. Cascelli ; Andreza K.B.A. Souto ; Leandro C. Oliveira ; Tomás Reinert ; Diocesio A.P. Andrade ; Mauro P. Passos ; Eduardo C. Millen ; Felipe Zerwes ; Paulo L. Moraes ; Bruno L. Ferrari ; Max S. Mano

PURPOSE : A nationwide lockdown was enforced in Brazil starting in March 2020 because of the COVID-19 pandemic when cancer screening activities were reduced. In this study, we evaluated the impact of the COVID-19 pandemic on breast cancer (BC) diagnosis. METHODS : We extracted data from the medical records of patients age older than 18 years who were diagnosed with BC and started treatment or follow-up in private oncology institutions in Brazil between 2018 and 2021. The primary objective was [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

The Effect of Dexamethasone Treatment on COVID-19 Prognosis in Cancer Patients

Souan, Lina ; Al-Khairy, Zienab ; Al-Binni, Maysaa’ Adnan ; Battah, Abdelkader ; Sughayer, Maher A.

Background: Dexamethasone is used to treat cancer, relieve chemotherapy-induced nausea and vomiting, enhance cancer patients’ appetites, and treat COVID-19 patients. There is little evidence of the impact of a dexamethasone treatment plan on the severity of COVID-19 infections in cancer patients. This study explores whether dexamethasone treatment plan influences the severity of COVID-19 in dexamethasone-treated cancer patients. Methods: The medical records of 108 cancer patients receiving [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Understanding the experiences of lung cancer patients during the COVID-19 pandemic: a qualitative interview study

Taylor, Sally ; Stanworth, Melissa ; Eastwood, Charlotte ; Gomes, Fabio ; Khatoon, Binish ; Yorke, Janelle

Purpose:The study explores experiences of lung cancer patients during COVID-19 and considers how changes to care delivery and personal lives affected patient needs. Methods: Semi-structured telephone interviews were conducted to explore experiences of lung cancer patients during COVID-19. Interviews were audio-recorded, transcribed verbatim and analysed thematically. Interview participants were purposively selected based on age, gender, treatment status, timing of diagnosis (pre/post first [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Impact and Recovery from COVID-19–Related Disruptions in Colorectal Cancer Screening and Care in the US: A Scenario Analysis

van den Puttelaar, Rosita ; Lansdorp-Vogelaar, Iris ; Hahn, Anne I. ; Rutter, Carolyn M. ; Levin, Theodore R. ; Zauber, Ann G. ; Meester, Reinier G.S.

Background: Many colorectal cancer–related procedures were suspended during the COVID-19 pandemic. In this study, we predict the impact of resulting delays in screening (colonoscopy, FIT, and sigmoidoscopy) and diagnosis on colorectal cancer–related outcomes, and compare different recovery scenarios. Methods: Using the MISCAN-Colon model, we simulated the US population and evaluated different impact and recovery scenarios. Scenarios were defined by the duration and severity of the disruption [...]

Menée dans 31 pays européens à partir de données portant sur 135 847 enfants et adolescents atteints d'un cancer diagnostiqué entre 2000 et 2013 (âge : 0-14 ans), cette étude estime la survie à long terme (5 et 15 ans) et la proportion de patients pédiatriques guéris

Long-term survival and cure fraction estimates for childhood cancer in Europe (EUROCARE-6): results from a population-based study

Botta, Laura ; Gatta, Gemma ; Capocaccia, Riccardo ; Stiller, Charles ; Canete, Adela ; Dal Maso, Luigino ; Innos, Kaire ; Mihor, Ana ; Erdmann, Friederike ; Spix, Claudia ; Lacour, Brigitte ; Marcos-Gragera, Rafael ; Murray, Deirdre ; Rossi, Silvia ; Hackl, Monika ; van Eycken, Elizabeth ; Van Damme, Nancy ; Valerianova, Zdravka ; Sekerija, Mario ; Scoutellas, Vasos ; Demetriou, Anna ; Dušek, Ladislav ; Krejci, Denisa ; Storm, Hans ; Mägi, Margit ; Paapsi, Keiu ; Malila, Nea ; Pitkäniemi, Janne ; Jooste, Valérie ; Clavel, Jacqueline ; Poulalhon, Claire ; Désandes, Emmanuel ; Monnereau, Alain ; Katalinic, Alexander ; Petridou, Eleni ; Markozannes, Georgios ; Garami, Miklos ; Birgisson, Helgi ; Walsh, Paul M. ; Mazzoleni, Guido ; Vittadello, Fabio ; Cuccaro, Francesco ; Galasso, Rocco ; Sampietro, Giuseppe ; Rosso, Stefano ; Gasparotto, Cinzia ; Maifredi, Giovanni ; Ferrante, Margherita ; Torrisi, Antonina ; Sutera Sardo, Antonella ; Gambino, Maria Letizia ; Lanzoni, Monica ; Ballotari, Paola ; Giacomazzi, Erica ; Ferretti, Stefano ; Caldarella, Adele ; Manneschi, Gianfranco ; Sant, Milena ; Baili, Paolo ; Berrino, Franco ; Trama, Annalisa ; Lillini, Roberto ; Bernasconi, Alice ; Bonfarnuzzo, Simone ; Vener, Claudia ; Didonè, Fabio ; Lasalvia, Paolo ; Del Monego, Giulia ; Buratti, Lucia ; Serraino, Diego ; Taborelli, Martina ; De Angelis, Roberta ; Demuru, Elena ; Di Benedetto, Corrado ; Santaquilani, Mariano ; Venanzi, Serenella ; Tallon, Marco ; Boni, Luca ; Iacovacci, Silvia ; Russo, Antonio Giampiero ; Gervasi, Federico ; Spagnoli, Gianbattista ; Cavalieri D'Oro, Luca ; Fusco, Mario ; Vitale, Maria Francesca ; Usala, Mario ; Vitale, Francesco ; Michiara, Maria ; Chiranda, Giorgio ; Sacerdote, Carlotta ; Maule, Milena ; Cascone, Giuseppe ; Spata, Eugenia ; Mangone, Lucia ; Falcini, Fabio ; Cavallo, Rossella ; Piras, Daniela ; Dinaro, Ylenia ; Castaing, Marine ; Fanetti, Anna Clara ; Minerba, Sante ; Candela, Giuseppina ; Scuderi, Tiziana ; Rizzello, Roberto Vito ; Stracci, Fabrizio ; Tagliabue, Giovanna ; Rugge, Massimo ; Brustolin, Angelita ; Pildava, Santa ; Smailyte, Giedre ; Azzopardi, Miriam ; Johannesen, Tom Børge ; Didkowska, Joanna ; Wojciechowska, Urszula ; Bielska-Lasota, Magdalena ; Pais, Ana ; Ferreira, Ana Maria ; Bento, Maria José ; Miranda, Ana ; Safaei Diba, Chakameh ; Zadnik, Vesna ; Zagar, Tina ; Sánchez-Contador Escudero, Carmen ; Franch Sureda, Paula ; Lopez de Munain, Arantza ; De-La-Cruz, Marta ; Rojas, Marìa Dolores ; Aleman, Araceli ; Vizcaino, Ana ; Almela, Fernando ; Sanvisens, Arantza ; Sánchez, María José ; Chirlaque, María Dolores ; Sánchez-Gil, Antonia ; Guevara, Marcela ; Ardanaz, Eva ; Cañete-Nieto, Adela ; Peris-Bonet, Rafael ; Galceran, Jaume ; Carulla, Marià ; Kuehni, Claudia ; Redmond, Shelagh ; Visser, Otto ; Karim-Kos, Henrike ; Stevens, Sarah ; Gavin, Anna ; Morrison, David ; Huws, Dyfed Wyn

Background : The EUROCARE-5 study revealed disparities in childhood cancer survival among European countries, giving rise to important initiatives across Europe to reduce the gap. Extending its representativeness through increased coverage of eastern European countries, the EUROCARE-6 study aimed to update survival progress across countries and years of diagnosis and provide new analytical perspectives on estimates of long-term survival and the cured fraction of patients with childhood cancer. [...]

Menée dans 31 pays européens à partir de données portant sur 135 847 enfants et adolescents atteints d'un cancer diagnostiqué entre 2000 et 2013 (âge : 0-14 ans), cette étude estime la survie à long terme (5 et 15 ans) et la proportion de patients pédiatriques guéris

Cancer research in Europe: a focus on children and young people

Vassal, Gilles ; Pearson, Andrew D. J.

We commend Mark Lawler and colleagues 1 for their call for the strategic expansion of cancer research in Europe towards a more patient-centred and data-driven agenda. Cancer occurs in all ages and 35 000 children and young people (aged 0–25 years) are diagnosed each year in Europe. As a result of clinical research, integration of care and research, and academic cooperative groups linking clinical with basic and translational research during the past 50 years, 5-year survival for cancer has now [...]

Menée à partir de données portant sur 676 enfants atteints d'une leucémie lymphoïde aiguë (durée médiane de suivi : 7,9 mois), cette étude analyse l'association entre l'indice de masse corporelle mesuré pendant le traitement d'entretien et le risque de récidive de la maladie

Body mass index during maintenance therapy and relapse risk in children with acute lymphoblastic leukemia: A Children's Oncology Group report

Wadhwa, Aman ; Chen, Yanjun ; Hageman, Lindsey ; Hoppmann, Anna L. ; Angiolillo, Anne ; Dickens, David S. ; Lew, Glen ; Neglia, Joseph P. ; Ravindranath, Yaddanapudi ; Ritchey, A. Kim ; Termuhlen, Amanda ; Wong, F. Lennie ; Landier, Wendy ; Bhatia, Smita

Background : Obesity at diagnosis of childhood acute lymphoblastic leukemia (ALL) is associated with greater risk of relapse; whether this association extends to obesity during maintenance is unstudied. Methods : This study used data from AALL03N1 to calculate median body mass index (BMI) for 676 children over 6 consecutive months during maintenance therapy; BMI percentile (BMI%ile) were operationalized as normal/underweight (<85%ile), overweight/obese (85%–98%ile), and extreme obesity [...]

Menée à partir de données portant sur 676 enfants atteints d'une leucémie lymphoïde aiguë (durée médiane de suivi : 7,9 mois), cette étude analyse l'association entre l'indice de masse corporelle mesuré pendant le traitement d'entretien et le risque de récidive de la maladie

From soup to nuts: Obesity impairs chemotherapy during early and late phases of acute lymphoblastic leukemia treatment

Orgel, Etan ; Mittelman, Steve D.

Obesity during chemotherapy is associated with increased relapse and worse survival from acute lymphoblastic leukemia—a finding now extended from the first to the final days of therapy. Patients with obesity constitute a group at higher risk for poorer outcomes who urgently require new interventions targeting the multiple underlying biologic and systematic mechanisms.

Cet article met en avant les enjeux liés à la recherche sur le cancer en Europe

European Groundshot—addressing Europe's cancer research challenges: a Lancet Oncology Commission

Lawler, Mark ; Davies, Lynne ; Oberst, Simon ; Oliver, Kathy ; Eggermont, Alexander ; Schmutz, Anna ; La Vecchia, Carlo ; Allemani, Claudia ; Lievens, Yolande ; Naredi, Peter ; Cufer, Tanja ; Aggarwal, Ajay ; Aapro, Matti ; Apostolidis, Kathi ; Baird, Anne-Marie ; Cardoso, Fatima ; Charalambous, Andreas ; Coleman, Michel P. ; Costa, Alberto ; Crul, Mirjam ; Dégi, Csaba L. ; Di Nicolantonio, Federica ; Erdem, Sema ; Geanta, Marius ; Geissler, Jan ; Jassem, Jacek ; Jagielska, Beata ; Jönsson, Bengt ; Kelly, Daniel ; Kelm, Olaf ; Kolarova, Teodora ; Kutluk, Tezer ; Lewison, Grant ; Meunier, Françoise ; Pelouchova, Jana ; Philip, Thierry ; Price, Richard ; Rau, Beate ; Rubio, Isabel T. ; Selby, Peter ; Južnič Sotlar, Maja ; Spurrier-Bernard, Gilliosa ; van Hoeve, Jolanda C. ; Vrdoljak, Eduard ; Westerhuis, Willien ; Wojciechowska, Urszula ; Sullivan, Richard

Cancer research is a crucial pillar for countries to deliver more affordable, higher quality, and more equitable cancer care. Patients treated in research-active hospitals have better outcomes than patients who are not treated in these settings. However, cancer in Europe is at a crossroads. Cancer was already a leading cause of premature death before the COVID-19 pandemic, and the disastrous effects of the pandemic on early diagnosis and treatment will probably set back cancer outcomes in [...]

Cet article met en avant les enjeux liés à la recherche sur le cancer en Europe

The impact of GDPR on data sharing for European cancer research

Lawlor, Rita T.

The European Groundshot—addressing Europe's cancer research challenges: a Lancet Oncology Commission by Mark Lawler and colleagues, 1 which addresses Europe's cancer research challenges, has outlined how collaborative research is vital to ensure rapid improvement in cancer care from early diagnosis to precise application of therapies. Data sharing ensures research robustness, adequate datasets for statistically significant results, economies of scales and cost-effective approaches through data [...]

Cet article met en avant les enjeux liés à la recherche sur le cancer en Europe

Groundshot: a pan-European, patient-centred, and data-driven approach to tackling cancer

Costa, Márcia ; Collingridge, David

In 2017, inspired by the US Cancer Moonshot initiative, The Lancet Oncology published a Commission on cancer research priorities in the USA. Writing in a Comment reflecting on this Commission from a European perspective, Fortunato Ciardiello and Josep Tabernero remarked, “as scientists and doctors working in Europe, we…believe that The Lancet Oncology Commission presents research priorities that must also be discussed within the European Union (EU)...[because]…large disparities in national [...]