Disparity in checkpoint inhibitor utilization among commercially insured adult patients with metastatic lung cancer
Menée aux Etats-Unis à partir de données portant sur 17 022 patients atteints d'un cancer métastatique du poumon diagnostiqué entre 2015 et 2020 et bénéficiant d'une assurance maladie privée, cette étude analyse les disparités dans l'utilisation d'inhibiteurs de points de contrôle immunitaires
Résumé en anglais
Background : There is a lack of evidence from nationwide sample on the disparity of initiating immune checkpoint inhibitors (ICIs) after metastatic lung cancer diagnosis.
Methods : We identified metastatic lung cancer patients diagnosed between 2015 and 2020 from a large nationwide commercial claims database. We analyzed the time from metastatic lung cancer diagnosis to ICI therapy using Cox proportional hazard models. Independent variables included county-level measures (quintiles of percentage of racialized population, quintiles of percentage of population below poverty, urbanity, and density of medical oncologists) and patient characteristics (age, sex, Charlson comorbidity index, Medicare Advantage, and year of diagnosis). All tests were two-sided.
Results : A total of 17,022 patients were included. Counties with a larger proportion of racialized population appeared to be more urban, have a greater percentage of its residents in poverty, and have a higher density of medical oncologists. In Cox analysis, the adjusted hazard ratio of the second, third, fourth, and highest quintile of percentage of racialized population were 0.89 (95% confidence interval [CI]: 0.82-0.98), 0.85 (95% CI: 0.78-0.93), 0.78 (95% CI: 0.71-0.86), and 0.71 (95% CI: 0.62-0.81), respectively, compared to counties in the lowest quintile. The slower ICI therapy initiation was driven by counties with the highest percentage of Hispanic population and other non-Black racialized groups.
Conclusions : Commercially insured patients with metastatic lung cancer who lived in counties with greater percentage of racialized population had slower initiation of ICI therapy after lung cancer diagnosis, despite greater density of oncologists in their neighborhood.
