Menée au Portugal, au Brésil et aux Etats-Unis auprès de 118 patients atteints d'un cancer et âgés de 8 à 18 ans, cette étude analyse l'association entre la douleur pendant l'hospitalisation, la qualité du sommeil et la qualité de vie

Pain, sleep patterns and health-related quality of life in paediatric patients with cancer

Nunes, Michelle Darezzo Rodrigues ; Nascimento, Lucila Castanheira ; Fernandes, Ananda Maria ; Batalha, Luis ; De Campos, Catarina ; Gonçalves, Ana ; Leite, Ana Carolina Andrade Biaggi ; Alvarenga, Willyane de Andrade ; de Lima, Regina Aparecida Garcia ; Jacob, Eufemia

Purpose : To compare sleep and health-related quality of life (HRQOL) in children and adolescents with cancer who had pain, with those who had no pain during hospitalisation. Method : A prospective comparative study was used to collect data from paediatric oncology units in three countries (Portugal, Brazil, USA). Participants (n = 118; 8–18 years) completed the Quality of Life Inventory (PedsQL) Cancer module, which includes a pain subscale, and wore a wrist actigraph for at least 72 hr. [...]

Menée en France à partir de données portant sur 318 patientes ayant survécu à un cancer épithélial de l'ovaire et sur 318 témoins, cette étude analyse la fatigue, les symptômes psychiques et physiques, et la qualité de vie plus de 3 ans après la fin des traitements de première ligne (durée moyenne de suivi : 6 ans)

Long-term fatigue and quality of life among epithelial ovarian cancer survivors: A GINECO case/control VIVROVAIRE I Study

Ahmed-Lecheheb, D ; Joly, F ; Savoye, A M ; Kurtz, J E ; Alexandre, J ; Follana, P ; Delecroix, V ; Dohollou, N ; Roemer-Becuwe, C ; De Rauglaudre, G ; Lortholary, A ; Prulhiere, K ; Gernier, F ; Lesoin, A ; Zannetti, A ; N’Guyen, S ; Trager-Maury, S ; Chauvenet, L ; Abadie Lacourtoisie, S ; Gompel, A ; Lhommé, C ; Pautier, P ; Floquet, A ; Kalbacher, E ; Clarisse, B ; Grellard, J M ; Heutte, N ; Berton-Rigaud, D ; Tredan, O ; Fabbro, M

Background : Few data are available on long-term fatigue (LTF) and quality-of-life (QoL) among epithelial ovarian cancer survivors (EOCS). In this case-control study, we compared LTF, symptoms and several QoL domains in EOCS relapse-free ≥3 years after first-line treatment and age-matched healthy women. Patients and Methods : EOCS were recruited from 25 cooperative GINECO centers in France. Controls were randomly selected from the electoral rolls. All participants completed validated [...]

Menée à partir des données du registre danois des cancers portant sur 458 646 patients ayant survécu à un cancer diagnostiqué entre 1997 et 2014 (âge moyen : 69 ans), et sur 2 121 567 témoins, cette étude analyse le risque à long terme de maladies somatiques nécessitant une hospitalisation

Long-term Somatic Disease Risk in Adult Danish Cancer Survivors

Kjaer, Trille Kristina ; Andersen, Elisabeth Anne Wreford ; Winther, Jeanette Falck ; Bidstrup, Pernille Envold ; Borre, Michael ; Møller, Henrik ; Larsen, Signe Benzon ; Johansen, Christoffer ; Dalton, Susanne Oksbjerg

Importance : Long-term health effects of cancer in adult survivors are a major concern; however, it is difficult to differentiate between the consequences of cancer and cancer treatment and those of normal aging or comorbidity. Objectives : To provide an overview and investigate the temporal pattern of hospitalizations for medically verified incident somatic disease in adult survivors compared with cancer-free comparison people, taking into consideration pretreatment comorbidity and the [...]

Menée au Canada à partir de données sur la période 1983-2012, cette étude présente une projection de l'incidence des cancers sur la période 2013-2042, en fonction du sexe et pour cinq localisations (poumon, colon-rectum, vessie, sein et prostate)

The future burden of cancer in Canada: Long-term cancer incidence projections 2013–2042

Poirier, Abbey E. ; Ruan, Yibing ; Walter, Stephen D. ; Franco, Eduardo L. ; Villeneuve, Paul J. ; King, Will D. ; Volesky, Karena D. ; O’Sullivan, Dylan E. ; Friedenreich, Christine M. ; Brenner, Darren R.

Background : Cancer is the leading cause of death in Canada and the estimated annual spending associated with cancer is approximately $7.5 billion. Projecting the future burden of cancer in Canada is essential for health planning and evaluation. We aimed to estimate the future incidence of cancer in Canada to 2042. Methods : Age-sex-region-specific cancer incidence data were obtained for the years 1983-2012 and cancer incidence was projected from 2013 to 2042 for the top five cancer sites. The [...]

Menée au Portugal à partir de données portant sur 187 patients atteints d'un myélome multiple diagnostiqué et/ou traité entre 2012 et 2015, cette étude rétrospective analyse, en fonction de la catégorie d'âge (inférieure ou supérieure à 65 ans), la survie sans progression et la survie globale, en lien avec les traitements reçus et l'utilisation des soins et des services de santé

Real-world treatment patterns, resource use and cost burden of multiple myeloma in Portugal

Antunes, Luís ; Rocha-Gonçalves, Francisco ; Chacim, Sérgio ; Lefèvre, Cinira ; Pereira, Marta ; Pereira, Sónia ; Zagorska, Aleksandra ; Bento, Maria José

Objective : We provide a real-world overview of multiple myeloma (MM) treatment patterns, outcomes and healthcare resource use (HRU) in Portugal. Methods : Data were collected retrospectively from consecutive patients diagnosed/treated at the Portuguese Oncology Institute of Porto (IPO-Porto) between 2012 and 2015. Primary objectives were progression-free survival (PFS) and overall survival (OS), with treatment patterns and HRU secondary. Analysis was by line of therapy (LOT), and post hoc by [...]

Menée en Allemagne par entretien auprès de 100 patients atteints d'un myélome (âge médian : 70 ans), cette étude analyse leur adhésion à un traitement par immunomodulateurs

High adherence of patients with multiple myeloma who receive treatment with immunomodulatory drugs (IMIDS) in hematology/oncology group practices in Germany

Feiten, Stefan ; Chakupurakal, Geothy ; Feustel, Hans Peter ; Maasberg, Michael ; Otremba, Burkhard ; Ehscheidt, Peter ; Hensel, Manfred ; Hansen, Richard ; Weide, Rudolf

Purpose : Immunomodulatory drugs (IMIDS) have changed the treatment and outcome of patients suffering from multiple myeloma. However, with the oral administration adherence becomes an issue. Since there is no “gold standard” in measuring adherence, we assessed the adherence of myeloma patients with the help of different data sources. Methods : All patients who have been receiving IMIDS for at least 3 months were eligible. Computer assisted personal interviews of patients and, if possible, their [...]

Menée à partir des données du registre danois des cancers du poumon portant sur 2 985 patients atteints d'un cancer du poumon de stade I diagnostiqué entre 2011 et 2014, cette étude analyse les traitements reçus (curatifs, palliatifs, ou absence de traitement) et leur effet sur la mortalité à 1 an

Treatment, no treatment and early death in Danish stage I lung cancer patients

Christensen, Niels Lyhne ; Dalton, Susanne ; Ravn, Jesper ; Christensen, Jane ; Jakobsen, Erik ; Rasmussen, Torben Riis

Background : Stage I lung cancer is curable with surgery as the treatment of choice. Other effective and curative treatments exist. Nevertheless, some patients only receive palliative treatment and some receive no treatment at all. Materials and Methods : Using the Danish Lung Cancer Registry (DLCR), we assessed treatment distribution for a population-based Danish cohort of stage I lung cancer patients diagnosed from 2011-2014. We assessed one-year mortality according to treatment. Furthermore, [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2018 (23 articles), cette étude analyse la situation professionnelle de patients ayant survécu à un cancer du poumon

Lung cancer survivors and employment: a systematic review

Vayr, Flora ; Savall, Frédéric ; Bigay-Game, Laurence ; Soulat, Jean-Marc ; Chouaid, Christos ; Herin, Fabrice

Background : The aim of this systematic review is to identify, in a comprehensive manner, the impact of lung cancer on the employment status of survivors. Methods : The Preferred Reported Items for Systematic Reviews and Meta-analyses (PRISMA) statement was used as a formal guideline. The systematic review includes scientific papers published between January 2000 and October 2018. The search strategy queried the database MEDLINE. Inclusion criteria comprised: [ 1 ] inclusion of patients [...]

Menée en Suède à partir de données portant sur 39 671 patients atteints d'un cancer du poumon non à petites cellules diagnostiqué entre 2002 et 2016, cette étude analyse l'association entre le niveau socioéconomique du patient, sa prise en charge médicale (du diagnostic aux traitements) et la mortalité spécifique et toutes causes confondues

Educational level and management and outcomes in non-small cell lung cancer. A nationwide population-based study

Willén, Linda ; Berglund, Anders ; Bergstrom, Stefan ; Bergqvist, Michael ; Öjdahl-Bodén, Anna ; Wagenius, Gunnar ; Lambe, Mats

Objectives: We examined associations between educational level and clinical presentation, patterns of management and mortality in patients with non-small cell lung cancer (NSCLC) in Sweden, a country with a National Health Care System. Materials and Methods: We identified 39,671 patients with a NSCLC diagnosis 2002-2016 in Lung Cancer Data Base Sweden (LCBaSe), a population-based research database. In analyses adjusted for comorbidity and other prognostic factors, odds Ratios (OR) and hazard [...]

Menée au Canada à partir de données portant sur 676 125 patients atteints d'une tumeur solide diagnostiquée entre 1997 et 2014, cette étude analyse l'association entre une utilisation de services psychiatriques (services d'urgence, admission hospitalière, traitement ambulatoire) avant le diagnostic de cancer et la mortalité par cancer et toutes causes confondues

The impact of psychiatric utilisation prior to cancer diagnosis on survival of solid organ malignancies

Klaassen, Zachary ; Wallis, Christopher J. D. ; Goldberg, Hanan ; Chandrasekar, Thenappan ; Sayyid, Rashid K. ; Williams, Stephen B. ; Moses, Kelvin A. ; Terris, Martha K. ; Nam, Robert K. ; Urbach, David ; Austin, Peter C. ; Kurdyak, Paul ; Kulkarni, Girish S.

Background : Among patients with cancer, prior research suggests that patients with mental illness may have reduced survival. The objective was to assess the impact of psychiatric utilisation (PU) prior to cancer diagnosis on survival outcomes. Methods : All residents of Ontario diagnosed with one of the top 10 malignancies (1997–2014) were included. The primary exposure was psychiatric utilisation gradient (PUG) score in 5 years prior to cancer: 0: none, 1: outpatient, 2: emergency department, [...]

Menée en Allemagne auprès de 307 patients atteints de divers types de cancer (69 % atteints d'un cancer de stade avancé), cette étude analyse les caractéristiques démographiques, médicales et psychologiques associées à l'acceptation de la mort

Characterizing death acceptance among patients with cancer

Philipp, Rebecca ; Mehnert, Anja ; Lo, Chris ; Müller, Volkmar ; Reck, Martin ; Vehling, Sigrun

Objective : Death acceptance may indicate positive adaptation in cancer patients. Little is known about what characterizes patients with different levels of death acceptance or its impact on psychological distress. We aimed to broaden the understanding of death acceptance by exploring associated demographic, medical, and psychological characteristics. Methods : At baseline, we studied 307 mixed cancer patients attending the University Cancer Center Hamburg and a specialized lung cancer center [...]

Menée en Chine auprès de 190 et 169 patients atteints d'un carcinome du rhinopharynx, cette étude transversale analyse les symptômes d'une détresse psychologique et les troubles de l'humeur associés

Characteristics of symptom distress in Chinese nasopharyngeal carcinoma patients and its relation to mood disturbance: A cross-sectional study

Chen, Yu ; Chen, Weichen ; Yang, Yuan ; Zhao, Yang ; Yang, Xueling

Objective : To evaluate the psychometric properties of a modified Chinese version of the Symptom Distress Scale (SDS), to explore symptom distress and its association with mood disturbance and factors that related to levels of symptom distress and mood disturbance. Methods : A cross-sectional, correlation design was adopted. A convenience sample of 190 nasopharyngeal carcinoma (NPC) patients was recruited from a Cancer Center in Guangzhou, China, with 169 patients completing the study. Results [...]

Menée dans un contexte américain à partir de données portant sur 1 374 patients atteints d'un lymphome diffus à grandes cellules B récidivant après une chimiothérapie de première ligne de type R-CHOP, cette étude analyse les coûts associés à l'utilisation des soins après la récidive et aux traitements de deuxième ligne

Direct Costs Associated with Relapsed Diffuse Large B-Cell Lymphoma Therapies

Purdum, Anna ; Tieu, Ryan ; Reddy, Sheila R. ; Broder, Michael S.

Background : About one third of patients with diffuse large B‐cell lymphoma (DLBCL) relapse after receiving first‐line (1L) treatment of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP). Relapsed patients may then be eligible for second‐line (2L) therapy. The study's objective was to examine health care use and costs among treated patients with DLBCL receiving 2L therapy versus those without relapse. Materials and Methods : We analyzed Truven Health MarketScan® [...]

Menée aux Etats-Unis auprès de 114 patients atteints d'un cancer du poumon de stade précoce (âge moyen : 70 ans), cette étude analyse, dans le cadre du processus de prise de décision thérapeutique, leurs préférences concernant une radiothérapie stéréotaxique et une résection chirurgicale

Understanding patients' values and preferences regarding early stage lung cancer treatment decision making

Sullivan, Donald R. ; Eden, Karen B. ; Dieckmann, Nathan F. ; Golde, Sara E. ; Vranas, Kelly C. ; Nugent, Shannon M. ; Slato, Christopher G.

Introduction : With advances in treatments among patients with lung cancer, it is increasingly important to understand patients’ values and preferences to facilitate shared decision making. Methods : Prospective, multicenter study of patients with treated stage I lung cancer at time of study participation which occurred 4–6 months after treatment. Value clarification and discrete choice methods were used to elicit participants’ values and treatment preferences regarding stereotactic body [...]