A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2017 (4 études de cohorte incluant 2 041 689 participants et 5 études cas-témoins incluant 1 496 cas et 3 179 témoins), cette méta-analyse évalue l'association entre une consommation de boissons sucrées et le risque de cancer du pancréas

Sweetened Beverages Consumption and Pancreatic Cancer: A Meta-Analysis

Milajerdi, Alireza ; Larijani, Bagher ; Esmaillzadeh, Ahmad

No study has summarized earlier findings on the association of sweetened beverages (SBs) consumption and risk of Pancreatic Cancer (PC). This systematic review and meta-analysis was conducted to systematically review available observational studies that examined the association of SB consumption with risk of PC. Relevant papers published up to December 2017 were searched through PubMed, MEDLINE, SCOPUS, EMBASE, and Google Scholar databases, using relevant keywords. Cohort and case?control [...]

Menée aux Etats-Unis à partir de données portant sur 6 528 hommes sans antécédent de cancer, cette étude évalue l'association entre une supplémentation nutritionnelle en choline et en bétaïne, le risque de cancer de la prostate et le risque de cancer létal

Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study

Han, Peijin ; Bidulescu, Aurelian ; Barber, John R. ; Zeisel, Steven H. ; Joshu, Corinne E. ; Prizment, Anna E. ; Vitolins, Mara Z. ; Platz, Elizabeth A.

Purpose : Two prior cohort studies suggested that choline, but not betaine intake, is associated with an increased risk of advanced prostate cancer (PCa). Given that evidence remains limited, we evaluated whether intakes of choline and derivative betaine are associated with total and lethal PCa risk and PCa death in men with PCa. Methods : We included 6,528 men (24.4% African American) without a cancer diagnosis at baseline (1987–1989) followed through 2012. Dietary intake was assessed using a [...]

Menée aux Pays-Bas auprès de 3 209 femmes âgées d'au moins 55 ans (durée médiane de suivi : 17 ans), cette étude de cohorte évalue l'association entre la consommation d'aliments d'origine animale et le risque de cancer du sein après la ménopause (199 cas)

Animal foods and postmenopausal breast cancer risk: a prospective cohort study

Marcondes, Larissa Hansen ; Franco, Oscar H. ; Ruiter, Rikje ; Ikram, Mohammad Arfan ; Mulder, Marlies ; Stricker, Bruno H. ; Kiefte-de Jong, Jessica C.

The role of diet on breast cancer risk is not well elucidated but animal food sources may play a role through, for example, the pathway of the insulin-like growth factor 1 system or cholesterol metabolism. The aim of this study was to evaluate the association between animal foods and the risk of postmenopausal breast cancer. This study was embedded in the Rotterdam Study, a population-based prospective cohort study of subjects aged 55 years and over (61 % female). Dietary intake of different [...]

Menée en France auprès de 76 442 participantes âgées de plus de 50 ans (durée moyenne de suivi : 11,2 ans), cette étude analyse, en fonction du statut ménopausique, l'association entre une supplémentation en isoflavones de soja et le risque de cancer du sein (3 608 cas) par statut des récepteurs ER

Use of dietary supplements containing soy isoflavones and breast cancer risk among women aged >50 y: a prospective study

Touillaud, Marina ; Fournier, Agnès ; Gelot, Amandine ; Clavel-Chapelon, Françoise ; Mesrine, Sylvie ; Boutron-Ruault, Marie-Christine ; Arveux, Patrick ; Bonnet, Fabrice ; Bennetau-Pelissero, Catherine ; Gunter, Marc

Background : Soy-based dietary supplements have been promoted as natural alternatives to menopausal hormone therapy, but their potential effect on breast cancer development is controversial. Objectives : We examined the relation between the consumption of soy supplements and the risk of breast cancer, overall and by tumor hormone receptor status, among women aged >50 y. Methods : In total, 76,442 women from the Etude Epidemiologique aupres de Femmes de la Mutuelle Generale de l’Education [...]

Menée au Canada à partir de données portant sur 496 patientes atteintes d'un cancer épithélial de l'ovaire et sur 906 témoins, cette étude évalue l'association entre le travail posté, le chronotype auto-déclaré et le risque de développer la maladie

Shift Work Patterns, Chronotype, and Epithelial Ovarian Cancer Risk

Leung, Lisa ; Grundy, Anne ; Siemiatycki, Jack ; Arseneau, Jocelyne ; Gilbert, Lucy ; Gotlieb, Walter H ; Provencher, Diane M. ; Aronson, Kristan J ; Koushik, Anita

Background: Shift work causing circadian disruption is classified as a 'probable carcinogen' and may contribute to the pathogenesis of hormone-sensitive cancers. This study investigated shift work exposure in relation to epithelial ovarian cancer (EOC) risk. Methods: In a population-based case-control study with 496 EOC cases and 906 controls, lifetime occupational histories were collected and used to calculate cumulative years of shift work exposure, average number of night shifts per month, [...]

Menée en France à partir de données portant sur 4 059 patientes atteintes d'un cancer du sein et sur 4 059 témoins, cette étude évalue l'association entre une expostion à long terme à une pollution atmosphérique au cadmium et le risque de développer la maladie en fonction du sous-type moléculaire

Chronic long-term exposure to cadmium air pollution and breast cancer risk in the French E3N cohort

Amadou, Amina ; Praud, Delphine ; Coudon, Thomas ; Danjou, Aurélie M N ; Faure, Elodie ; Leffondre, Karen ; Le Romancer, Muriel ; Severi, Gianluca ; Salizzoni, Pietro ; Mancini, Francesca Romana ; Fervers, Beatrice

Cadmium, due to its estrogen like activity, has been suspected to increase the risk of breast cancer, however epidemiological studies have reported inconsistent findings. We conducted a case-control study (4,059 cases and 4,059 matched controls) nested within the E3N French cohort study to estimate the risk of breast cancer associated with long-term exposure to airborne cadmium pollution, and its effect according to molecular subtype of breast cancer (estrogen receptor negative/positive [...]

Menée en Europe et au Japon auprès de 50 patients atteints de stéatose hépatique ou d'une hépatite C ou B (6 témoins) et à l'aide d'un modèle murin de foie infecté par le virus de l'hépatite C, cette étude identifie des altérations épigénétiques causées par le virus et associées au risque de carcinome hépatocellulaire après un traitement antiviral d'action directe

HCV-induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Hamdane, Nourdine ; Juhling, Frank ; Crouchet, Emilie ; El Saghire, Houssein ; Thumann, Christine ; Oudot, Marine A. ; Bandiera, Simonetta ; Saviano, Antonio ; Ponsolles, Clara ; Roca Suarez, Armando Andres ; Li, Shen ; Fujiwara, Naoto ; Ono, Atsushi ; Davidson, Irwin ; Bardeesy, Nabeel ; Schmidl, Christian ; Bock, Christoph ; Schuster, Catherine ; Lupberger, Joachim ; Habersetzer, Francois ; Doffoël, Michel ; Piardi, Tullio ; Sommacale, Daniele ; Imamura, Michio ; Uchida, Takuro ; Ohdan, Hideki ; Aikata, Hiroshi ; Chayama, Kazuaki ; Boldanova, Tujana ; Pessaux, Patrick ; Fuchs, Bryan C. ; Hoshida, Yujin ; Zeisel, Mirjam B. ; Duong, François H. T. ; Baumert, Thomas F.

Background and Aims : Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is reduced but not eliminated following a sustained virologic response (SVR) to direct-acting antiviral (DAA) agents, and risk is higher in patients with advanced fibrosis. We investigated HCV-induced epigenetic alterations that might affect risk for HCC after DAA treatment in patients and mice with humanized [...]

A partir des données de 272 registres des cancers de 76 pays, cette étude compare, en fonction du sexe, l'incidence des cancers pédiatriques (de 0 à 14 ans) à l'échelle mondiale et par types

Enigmatic gender difference in cancer incidence: evidences from childhood cancers

Liu, Zhenqiu ; Jin, Li ; Chen, Xingdong ; Cai, Ning ; Yang, Qin ; Zhang, Tiejun

We aimed to investigate the differences in cancer incidence between boys and girls. The incidence data for pediatric cancer were retrieved from the International Incidence of Childhood Cancer. Poisson regression was applied to detect the gender differences in cancer incidence at global and regional levels. Boys were more susceptible to childhood cancers than girls, with a global boy−to−girl incidence rate ratio (IRR) of 1.27 (95% confidence intervals [CI] 1.26−1.28) for leukaemia, 1.48 (95% CI [...]

Menée en Suède auprès de 37 663 hommes, cette étude évalue l'association entre l'indice de masse corporelle à l'âge de 8 ans et de 20 ans et le risque de cancer colorectal à l'âge adulte (257 cas de cancer du côlon, 159 cas de cancer du rectum)

Childhood Body Mass Index is associated with risk of adult colon cancer in men - an association modulated by pubertal change in Body Mass Index

Celind, Jimmy ; Ohlsson, Claes ; Bygdell, Maria ; Nethander, Maria ; Kindblom, Jenny M

Background : The relative contribution of childhood and pubertal BMI for the risk of adult colorectal cancer is not known. The aim of this study was to evaluate the independent associations for childhood BMI and pubertal BMI change with risk of colorectal cancer in men. Materials and Methods : We included 37 663 men born 1946-1961 who had weight and height measured at age 8 (childhood) and 20 (young adult age) years of age available from the BMI Epidemiology Study (BEST). Information on [...]

Menée à partir des données de deux études d'association sur le génome entier (une étude chinoise incluant 2 248 patients et 3 173 témoins, une étude européenne incluant 4 461 patients et 4 140 témoins), cette étude analyse l'association entre 58 polymorphismes de gènes et le risque de cancer colorectal dans les deux populations

Combinations of Single Nucleotide Polymorphisms Identified in Genome-wide Association Studies Determine Risk for Colorectal Cancer

Xin, Junyi ; Du, Mulong ; Gu, Dongying ; Ge, Yuqiu ; Li, Shuwei ; Chu, Haiyan ; Meng, Yixuan ; Shen, Hongbing ; Zhang, Zhengdong ; Wang, Meilin

Genome-wide association studies (GWASs) have identified single nucleotide polymorphisms (SNPs) associated with colorectal cancer (CRC) risk, but whether these SNPs have additive effects on the risk of CRC remains unclear. We performed a systematic analysis of GWAS-identified SNPs using GWAS datasets from China (2,248 patients and 3,173 controls) and Europe (4,461 patients and 4,140 controls). We analyzed 58 independent variants from DNA samples from Chinese populations and found 19 SNPs that [...]

Menée à Taïwan auprès de 659 hommes atteints d'un cancer de la tête et du cou et auprès de 659 témoins (durée médiane de suivi : 47,13 mois), cette étude analyse la relation entre des polymorphismes de gènes impliqués dans le métabolisme de l'alcool (ADH1B, ADH1C et ALDH2) et le risque de second cancer primitif, puis identifie des génotypes à haut-risque

Alcohol Metabolizing Enzymes Gene Polymorphisms and Susceptibility to Multiple Head and Neck Cancers

Chien, Huei-Tzu ; Young, Chi-Kuang ; Chen, Tzu-Ping ; Liao, Chun-Ta ; Wang, Hung-Ming ; Cheng, Sou-De ; Huang, Shiang-Fu

Multiple primary tumors (MPTs), especially in the hypopharynx and esophagus, are challenging in head and neck cancer (HNC) patients. Alcohol and alcohol-metabolizing genes were reported to be related to upper digestive tract cancers. Here, we investigated whether the genotypes of alcohol-metabolizing enzymes (ADH1B, ADH1C and ALDH2) affected patients' susceptibility to developing MPTs. We recruited 659 male HNC patients between March 1996 and February 2017. Age and gender-matched controls were [...]