Menée à partir de données de la "UK Biobank" portant sur 234 598 personnes (durée moyenne de suivi : 13,4 ans), cette étude analyse l'association entre les niveaux sériques d'acides gras polyinsaturés n-3 et le risque de cancer colorectal (2 602 cas)

Plasma n-3 polyunsaturated fatty acid levels and colorectal cancer risk in the UK Biobank: Evidence of non-linearity, as well as tumour site- and sex-specificity

Aldoori, Joanna ; Zulyniak, Michael A. ; Toogood, Giles J. ; Hull, Mark A.

Background: The relationship between n-3 polyunsaturated fatty acid (PUFA) intake and colorectal cancer (CRC) risk is unclear. Blood n-3 PUFA concentration is a biomarker of dietary n-3 PUFA intake. We examined the relationship between plasma n-3 PUFA concentrations and CRC risk in UK Biobank (UKBB) participants. Methods: We analysed the relationship between tertiles (T) of plasma total n-3 PUFAs and n-3 PUFA docosahexaenoic acid (DHA) levels, and overall CRC (also stratified by tumour location [...]

Menée à partir de données chinoises portant sur 343 966 patients atteints de diabète de type 2 (durée médiane de suivi : 10,5 ans), cette étude analyse l'association entre une utilisation d'aspirine et le risque de cancer du pancréas (1 224 cas)

Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus

Tan, Jing Tong ; Mao, Xianhua ; Cheng, Ho-Ming ; Seto, Wai-Kay ; Leung, Wai-K ; Cheung, Ka-Shing

Background: Patients with type 2 diabetes mellitus (T2DM) have higher pancreatic cancer (PC) risk. While aspirin has chemopreventive effects on digestive cancers, its effect on PC among patients with T2DM is unclear. Methods: This retrospective cohort study identified newly diagnosed adult patients with T2DM in Hong Kong between 2001 and 2015 from a territory-wide healthcare registry. Exclusion criteria were history of PC, pancreatic cyst, IgG4 disease, or pancreatectomy. To address reverse [...]

Menée auprès de 2,2 millions de Suédoises âgées de 10 à 35 ans, cette étude évalue l'efficacité du vaccin quadrivalent anti papillomavirus humain contre les lésions cervicales de haut grade, en fonction de l'âge au moment de la vaccination et du nombre de doses reçues

Effectiveness of quadrivalent human papillomavirus vaccination against high-grade cervical lesions by age and doses: a population-based cohort study

Wu, Shiqiang ; Ploner, Alexander ; Astorga Alsina, Ana Martina ; Deng, Yunyang ; Ask Schollin, Lina ; Lei, Jiayao

Background: One or two-dose schedule for human papillomavirus (HPV) vaccination has been recommended by the World Health Organization and used in many vaccination programs. We aimed to comprehensively evaluate the effectiveness of quadrivalent HPV vaccine against high-grade cervical lesions by age at vaccination and number of doses received. Methods: This cohort study included 2,200,495 females aged 10–35 years old who were residents of Sweden between 2006 and 2022, with 584,676 (26.6%) [...]

Menée à partir de données suédoises 2008-2021 portant sur 1 237 femmes présentant un variant pathogène de BRCA, cette étude analyse leur recours à la mastectomie prophylactique puis évalue l'incidence des cancers du sein après l'intervention en fonction du type de mutation (BRCA1 ou BRCA2)

Risk reducing mastectomy in Norwegian BRCA1/2 carriers

Hyldebrandt, Hanne Kjensli ; Stormorken, Astrid Tenden ; Vitelli, Valeria ; Mæhle, Lovise ; Schlichting, Ellen ; Grindedal, Eli Marie

Background: Risk reducing mastectomy (RRM) is an option for women with pathogenic germline variants in BRCA1 or BRCA2 (BRCA1/2). This study investigates and compares RRM-uptake among Norwegian BRCA1/2 carriers from 2008 to 2021, temporal trends, and incidence of breast cancer (BC) after surgery. Methods: BRCA1/2 carriers without prior breast or ovarian cancer, tested at Oslo University Hospital between January 1st 2008 and December 31st 2021 were included in the study. Data on RRM was obtained [...]