Mené sur 147 patients atteints d'un cancer, cet essai randomisé de phase II/III évalue l'efficacité d'un traitement à base d'extraits de cannabis (tétrahydrocannabinol et cannabidiol) pour prévenir les nausées et vomissements induits par la chimiothérapie et réfractaires aux traitements antiémétiques standards

Oral Cannabis Extract for Secondary Prevention of Chemotherapy-Induced Nausea and Vomiting: Final Results of a Randomized, Placebo-Controlled, Phase II/III Trial

Peter Grimison ; Antony Mersiades ; Adrienne Kirby ; Annette Tognela ; Ian Olver ; Rachael L. Morton ; Paul Haber ; Anna Walsh ; Yvonne Lee ; Ehtesham Abdi ; Stephen Della-Fiorentina ; Morteza Aghmesheh ; Peter Fox ; Karen Briscoe ; Jasotha Sanmugarajah ; Gavin Marx ; Ganessan Kichenadasse ; Helen Wheeler ; Matthew Chan ; Jenny Shannon ; Craig Gedye ; Stephen Begbie ; R. John Simes ; Martin R. Stockler

Purpose: The aim of this randomized, placebo-controlled, two-stage, phase II/III trial was to determine the efficacy of an oral cannabis extract in adults with refractory nausea and/or vomiting during moderately or highly emetogenic, intravenous chemotherapy despite guideline-consistent antiemetic prophylaxis. Here, we report results of the prespecified combined analysis including the initial phase II and subsequent phase III components. Patients and Methods: Study treatment consisted of oral [...]

A partir d'une revue de la littérature d'essais randomisés (16 études, 954 patients), cette méta-analyse évalue l'intérêt des interventions nutritionnelles dédiées aux patients atteints d'un cancer et recevant une chimioradiothérapie néoadjuvante

Effects of nutritional interventions on cancer patients receiving neoadjuvant chemoradiotherapy: a meta-analysis of randomized controlled trials

Li, Chunrong ; Zhang, Shu ; Liu, Yan ; Hu, Ti ; Wang, Chunyan

Background: Malnutrition commonly occurs in cancer patients, impacting their quality of life and survival duration. The objective of this meta-analysis and systematic review is to assess the effects of nutritional interventions on patients undergoing neoadjuvant chemoradiotherapy. Methods: A comprehensive search was conducted in PubMed, Embase, and the Cochrane Library databases to obtain randomized controlled trials of nutritional interventions in patients with neoadjuvant chemoradiotherapy. [...]

A partir d'une revue systématique de la littérature (7 essais, 561 participants), cette méta-analyse évalue l'intérêt, pendant la chimiothérapie, d'exercices physiques de résistance pour réduire la fatigue, améliorer la qualité de vie et la force musculaire des patients atteints d'un cancer

Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis

Metcalfe, James W. ; Orange, Samuel T. ; Madden, Leigh A. ; Marshall, Phil ; Vince, Rebecca V.

Purpose: To systematically review and meta-analyse the efficacy of resistance training on quality of life (QOL), fatigue, physical function, and muscular strength in people diagnosed with cancer undergoing chemotherapy. Methods: Electronic databases PubMed, Cochrane Central, CINAHL, SCOPUS and Web of Science were systematically searched for randomised controlled trials (RCTs) that compared the effects of resistance training to control on QOL, fatigue, physical function, and lower-body and [...]

Mené sur 247 patients atteints d'un cancer du poumon non à petites cellules de stade avancé (âge médian : 66,1 ans), cet essai randomisé évalue l'intérêt d'une intervention comportementale menée par des infirmières (techniques de respiration, positions posturales, thérapie par ventilation pulmonaire) pour soulager une dyspnée

Randomized Controlled Trial of a Nurse-Led Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer

Joseph A. Greer ; Kathryn E. Post ; Reena Chabria ; Seetha Aribindi ; Natalie Brennan ; Ijeoma Julie Eche-Ugwu ; Barbara Halpenny ; Erica Fox ; Stephen Lo ; Lauren P. Waldman ; Kedie Pintro ; Dustin J. Rabideau ; William F. Pirl ; Mary E. Cooley ; Jennifer S. Temel

PURPOSE: In patients with lung cancer, dyspnea is one of the most prevalent and disabling symptoms, for which effective treatments are lacking. We examined the efficacy of a nurse-led brief behavioral intervention to improve dyspnea in patients with advanced lung cancer. METHODS: Patients with advanced lung cancer reporting at least moderate breathlessness (n = 247) were enrolled in a randomized trial of a nurse-led two-session intervention (focused on breathing techniques, postural positions, [...]

Menée à partir des données GLOBOCAN 2022 dans 185 pays et territoires, cette étude analyse l'incidence des cancers chez les hommes (30 localisations) et la mortalité associée puis présente des projections jusqu'en 2050

Burden of 30 cancers among men: Global statistics in 2022 and projections for 2050 using population-based estimates

Bizuayehu, Habtamu Mellie ; Dadi, Abel F. ; Ahmed, Kedir Y. ; Tegegne, Teketo Kassaw ; Hassen, Tahir Ahmed ; Kibret, Getiye Dejenu ; Ketema, Daniel Bekele ; Bore, Meless G. ; Thapa, Subash ; Odo, Daniel Bogale ; Kassa, Zemenu Y. ; Shifti, Desalegn Markos ; Amsalu, Erkihun ; Sarich, Peter ; Venchiarutti, Rebecca L. ; Melaku, Yohannes Adama ; Kibret, Kelemu Tilahun ; Habte, Aklilu ; Mefsin, Yonatan M. ; Seid, Abdulbasit ; Belachew, Sewunet Admasu

Background: Men exhibit higher prevalence of modifiable risk factors, such as smoking and alcohol consumption, leading to greater cancer incidence and lower survival rates. Comprehensive evidence on global cancer burden among men, including disparities by age group and country, is sparse. To address this, the authors analyzed 30 cancer types among men in 2022, with projections estimated for 2050. Methods: The 2022 GLOBOCAN estimates were used to describe cancer statistics for men in 185 [...]

Menée sur la période 1990-2019 à partir de données de 238 pays et territoires, cette étude internationale examine le rôle des décès par cancers féminins dans la différence d'espérance de vie entre hommes et femmes

Deciphering the Sex gap in global life expectancy: the impact of female-specific cancers 1990–2019

Trias-Llimós, Sergi ; Renteria, Elisenda ; Rutigliano, Roberta ; Aggarwal, Ajay ; Moodley, Jennifer ; Unger-Saldaña, Karla ; Soerjomataram, Isabelle

Background: Females live longer than males, which results in a sex gap in life expectancy. This study examines the contribution of female cancers to this differential by world region and country 1990-2019 with special focus to the 15-69 age group. Methods: Cause-specific mortality data for 30 cancers, including four female-specific cancers from 238 countries and territories was retrieved from the Global Burden of Disease Study 2019. Using life table techniques and demographic decomposition [...]

Menée à partir des données GLOBOCAN 2020, cette étude analyse l'incidence de 11 types de cancer et la survie associée pour 56 pays du Commonwealth

Cancer incidence and survival for 11 cancers in the Commonwealth: a simulation-based modelling study

Ward, Zachary J. ; Gaba, Qassi ; Atun, Rifat

Background: The number of new cancer cases in Commonwealth countries rose by 35% between 2008 and 2018, but progress in cancer control has been slow in many low-income and lower-middle-income member states. We aimed to examine cancer outcomes and priority areas in the Commonwealth to provide insight and guidance on prioritisation of efforts to improve cancer survival and make the best use of scarce resources. Methods: We adapted a previously developed microsimulation model of global cancer [...]

Menée aux Etats-Unis sur la période 1999-2020, cette étude analyse l'évolution de la mortalité par cancer du pancréas

Trends in pancreatic cancer mortality in the United States 1999–2020: a CDC database population-based study

Didier, Alexander J. ; Nandwani, Swamroop ; Fahoury, Alan M. ; Craig, Daniel J. ; Watkins, Dean ; Campbell, Andrew ; Spencer, Caleb T. ; Batten, Macelyn ; Vijendra, Divya ; Sutton, Jeffrey M.

Introduction: Pancreatic cancer is a significant public health concern and a leading cause of cancer-related deaths worldwide. This study aimed to investigate pancreatic cancer mortality trends and disparities in the United States (US) from 1999 to 2020. Methods: Data were obtained from the Centers for Disease Control (CDC) Wide-Ranging Online Data for Epidemiologic Research database. Mortality rates were age-adjusted and standardized to the year 2000 US population. Joinpoint regression was [...]

Menée en Autriche à partir de données 2000-2020 portant sur 639 patientes atteintes d'un cancer du sein et présentant des métastases osseuses, cette étude multicentrique rétrospective analyse le risque d'ostéonécrose de la mâchoire en lien avec un traitement par dénosumab ou biphosphonates

Incidence of Medication-Related Osteonecrosis of the Jaw in Patients With Breast Cancer During a 20-Year Follow-Up: A Population-Based Multicenter Retrospective Study

Christine Brunner ; Marjan Arvandi ; Christian Marth ; Daniel Egle ; Florentina Baumgart ; Miriam Emmelheinz ; Benjamin Walch ; Johanna Lercher ; Claudia Iannetti ; Ewald Wöll ; Agnes Pechlaner ; August Zabernigg ; Birgit Volgger ; Maria Castellan ; Oliver Tibor Andraschofsky ; Alice Markl ; Michael Hubalek ; Michael Schnallinger ; Sibylle Puntscher ; Uwe Siebert ; Sebastian Schönherr ; Lukas Forer ; Emanuel Bruckmoser ; Johannes Laimer

Purpose: Medication-related osteonecrosis of the jaw (MRONJ) is one of the most important toxicities of antiresorptive therapy, which is standard practice for patients with breast cancer and bone metastases. However, the population-based incidence of MRONJ is not well established. We therefore performed a retrospective multicenter study to assess the incidence for a whole Austrian federal state (Tyrol). Materials and Methods: This retrospective multicenter study was conducted between 2000 and [...]

A partir d'une revue de la littérature (30 études), cette étude analyse la prévalence de dysfonctionnements sexuels après traitements chez les patients atteints d'un cancer de la prostate et identifie les facteurs entravant ou facilitant leur capacité à discuter de ces dysfonctionnements avec les professionnels de santé

Prostate Cancer Related Sexual Dysfunction and Barriers to Help Seeking: A Scoping Review

Charlick, Megan ; Tiruye, Tenaw ; Ettridge, Kerry ; O’Callaghan, Michael ; Sara, Sally ; Jay, Alexander ; Beckmann, Kerri

Objective: Despite available support, sexuality needs are the most frequently reported unmet need among men with prostate cancer, which may be due to low help-seeking rates. Using the Ecological Systems Framework as a theoretical foundation, we conducted a scoping review of the available literature to understand what factors impact help-seeking behaviour for sexual issues after prostate cancer treatment among men who had received treatment. Methods: Following PRISMA guidelines, a systematic [...]

Menée auprès de 216 patientes âgées ayant survécu à un cancer du sein et auprès de 216 témoins, cette étude longitudinale évalue l'effet d'une activité physique, modérée ou intense, sur leurs fonctions cognitives

Physical Activity and Cognition: Longitudinal findings from the Thinking and Living with Cancer Study

Artese, Ashley L ; Zhou, Xingtao ; Tometich, Danielle B ; Small, Brent J ; Ahles, Tim A ; Ahn, Jaeil ; Bethea, Traci N ; Breen, Elizabeth C ; Cohen, Harvey J ; Extermann, Martine ; Graham, Deena ; Isaacs, Claudine ; Jim, Heather S L ; McDonald, Brenna C ; Nakamura, Zev M ; Patel, Sunita K ; Rentscher, Kelly E ; Root, James C ; Saykin, Andrew J ; Van Dyk, Kathleen ; Zhai, Wanting ; Carroll, Judith E ; Mandelblatt, Jeanne

Background: Physical activity can improve cognition; however, little is known regarding the relationships between longitudinal objectively-measured physical activity, cognition, and inflammation in older breast cancer survivors. Methods: Older (≥60 yrs) breast cancer survivors (n = 216) and frequency-matched non-cancer controls (n = 216) were assessed at baseline (pre-systemic therapy for survivors) and annually for up to five years. Assessments included hip-worn ActiGraphs worn for seven days, [...]

Menée dans un contexte canadien et à partir de données portant sur 1 040 patients traités pour un cancer, cette étude analyse le rapport coût-efficacité d'aides systématiques au sevrage tabagique pour chaque patient fumeur

Cost-effectiveness of point of care smoking cessation interventions in oncology clinics

Mullen, Kerri A. ; Hurley, Kelly ; Hewitson, Shelley ; Scoville, Joshua ; Grant, Alyssa ; Thavorn, Kednapa ; Kumar, Eshwar ; Warren, Graham W.

Background: We examined the cost-effectiveness of providing systematic smoking cessation interventions to oncology patients at point-of-care. Methods: A decision analytic model was completed from the healthcare payer’s perspective and included all incident cancer cases involving patients who smoke in New Brunswick, Canada (n = 1040), cancer site stratifications, and risks of mortality, continued smoking, and cancer treatment failure over one year. Usual care (no cessation support) was compared [...]

Menée dans un contexte américain et un contexte chinois, cette étude compare le rapport coût-efficacité du datopotamab déruxtécan et du docétaxel pour traiter un cancer du poumon non à petites cellules de stade avancé ou métastatique

Datopotamab deruxtecan versus docetaxel in previously treated advanced or metastatic non-small cell lung cancer: A cost-effectiveness analysis

Tan, Chenfeng ; Han, Jiaqi ; Zeng, Bin ; Xiang, Zhongzheng ; Zeng, Yuanyuan ; Wang, Jun ; Wei, Xiaoyuan ; Dai, Zelei ; Xu, Ningyue ; Xiong, Wenju ; Liu, Lei

Objectives: The TROPION-Lung-01 trial demonstrated that datopotamab deruxtecan (Dato-DXd) produced significantly longer progression-free survival (PFS) than docetaxel (DXT) in previously treated advanced/metastatic non-small cell lung cancer (NSCLC). Dato-DXd will be the first novel trophoblast cell surface antigen 2 (TROP-2) directed antibody-drug conjugate approved for NSCLC. Nevertheless, its expensive pricing may impose a significant financial burden on patients and healthcare systems [...]

Menée dans un contexte américain à partir de données portant sur 15 407 patients atteints d'un carcinome rénal de stade métastatique diagnostiqué sur la période 2015-2019, cette étude rétrospective analyse les coûts associés à l'utilisation des immunothérapies et des agents anticancéreux dispensés par voie orale

Cost trends of Metastatic Renal Cell Carcinoma Therapy: the impact of oral anticancer agents and immunotherapy

Forman, Rebecca ; Long, Jessica B ; Westvold, Sarah J ; Agnish, Khushi ; McManus, Hannah D ; Leapman, Michael S ; Hurwitz, Michael E ; Spees, Lisa P ; Wheeler, Stephanie B ; Gross, Cary P ; Dinan, Michaela A

Background: Immunotherapy (IO) and oral anticancer agents (OAA) have improved outcomes for metastatic renal cell carcinoma (mRCC) but there is a need to understand real-world costs from the perspective of payers and patients. Methods: We used retrospective fee-for-service Medicare 100% claims data to study patients diagnosed with mRCC in 2015-2019. We identified initial treatment type and costs (the year after diagnosis) and analyzed differences in monthly and 12-month costs over time and [...]