Menée en France à partir de données de questionnaires portant sur 3 047 patients atteints d'un lymphome non hodgkinien et 875 patients atteints d'un lymphome de Hodgkin, cette étude analyse leur qualité de vie liée à la santé au moment du diagnostic de la maladie

Health-related quality of life profile of newly diagnosed patients with Hodgkin and non-Hodgkin lymphomas: a real-world study including 3,922 patients from the French REALYSA cohort

Anota, Amelie ; Basset, Mathurine ; Charton, Emilie ; Bommier, Côme ; Efficace, Fabio ; Dupuis, Jehan ; Cottone, Francesco ; Bouabdallah, Krimo K. ; Mollevi, Caroline ; Ysebaert, Loic ; Winter, Audrey ; Bijou, Fontanet ; Préau, Marie ; Chauchet, Adrien ; Bernier, Adeline ; Fornecker, Luc-Matthieu ; Hafirassou, Hadia ; Carras, Sylvain ; Lachenal, Florence ; Lionne-Huyghe, Pauline ; Detourmignies, Laurence ; Leyronnas, Cécile ; Drénou, Bernard ; Peyrou, Sandra Le Guyader ; Abraham, Julie ; Monnereau, Alain ; Fouillet, Ludovic ; Morschhauser, Franck ; Rossi, Cédric ; Belot, Aurélien ; Ghesquieres, Herve

Introduction: Considering the notable advances made in the treatment of lymphoma, assessment of health-related quality of life (HRQoL) of lymphoma patients has become a critical aspect to consider both in clinical research and routine practice. However, there is paucity of information about lymphoma specific HRQoL profile at diagnosis. Patients and methods: HRQoL at diagnosis was assessed for 3,922 adult patients with newly diagnosed high-grade (HG) (n=1,994), low-grade (LG) (n=1,053) [...]

Menée aux Etats-Unis à partir de données statistiques 2003-2020 et de données de registres des cancers, cette étude analyse, chez les enfants et chez les adultes, l'incidence du carcinome hépatocellulaire et la survie

Incidence and survival of pediatric and adult hepatocellular carcinoma, United States, 2001–2020

Arnett, Azlann ; Siegel, David A. ; Dai, Shifan ; Thompson, Trevor D. ; Foster, Jennifer ; di Pierro, Erika J. ; Momin, Behnoosh ; Lupo, Philip J. ; Heczey, Andras

Background: Hepatocellular carcinoma accounts for approximately 80 % of liver neoplasms. Globally, hepatocellular carcinoma ranks as the third most lethal cancer, with the number of deaths expected to further increase by 2040. In adults, disparities in incidence and survival are well described while pediatric epidemiology is not well characterized. We describe incidence and survival for pediatric (ages 0–19 years) hepatocellular carcinoma cases and compare these measures to adults (ages ≥ 20 [...]

Menée aux Etats-Unis auprès de 1 777 enfants âgés de 3 à 11 ans, cette étude analyse l'absorption nicotinique, mesurée par le niveau sérique de cotinine, en fonction de leur exposition à la fumée de tabac et/ou à la vapeur de cigarette électronique

Secondhand Nicotine Absorption From E-Cigarette Vapor vs Tobacco Smoke in Children

Tattan-Birch, Harry ; Brown, Jamie ; Jackson, Sarah E. ; Jarvis, Martin J. ; Shahab, Lion

With the prevalence of e-cigarette use (vaping) increasing worldwide, there are concerns about children’s exposure to secondhand vapor.To compare nicotine absorption among children who are (1) exposed to secondhand tobacco smoke only or (2) exposed to secondhand vapor only with (3) those exposed to neither.The US Continuous National Health and Nutrition Examination Survey (NHANES) is a repeat cross-sectional survey. Participants are interviewed in their homes and, several days after, visit a [...]

Menée à l'aide d'une projection et de données statistiques et des registres américains des cancers, cette étude analyse les tendances de la survie à long terme des patients ayant des antécédents de cancer et les conséquences en matière de santé publique

Prevalence of cancer survivors in the United States

Tonorezos, Emily ; Devasia, Theresa ; Mariotto, Angela B ; Mollica, Michelle A ; Gallicchio, Lisa ; Green, Paige ; Doose, Michelle ; Brick, Rachelle ; Streck, Brennan ; Reed, Crystal ; de Moor, Janet S

With aging of the population and improvements in diagnosis, treatment, and supportive care, the number of cancer survivors in the United States (US) has increased; updated prevalence estimates are needed.Cancer prevalence on January 1, 2022 was estimated using the Prevalence Incidence Approach Model, utilizing incidence, survival, and mortality. Prevalence by age decade, sex, and time from diagnosis were calculated. The percentage of cancer survivors in the projected US population by age and [...]

Menée à l'aide d'un nouveau modèle de simulation et de données de "EUROCARE-6" portant sur les patients atteints d'un cancer de la tête et du cou, du côlon-rectum ou du sein diagnostiqué sur la période 1998-2002 (âge : 40-79 ans), cette étude estime la survie nette et la proportion de patients guéris

Estimating cure and risk of death from other causes of cancer patients: EUROCARE-6 data on Head & Neck, Colorectal, and Breast cancers

Botta, Laura ; Capocaccia, Riccardo ; Bernasconi, Alice ; Rossi, Silvia ; Galceran, Jaume ; Maso, Luigino Dal ; Lepage, Come ; Molinié, Florence ; Bouvier, Anne-Marie ; Gragera, Rafael Marcos ; Vener, Claudia ; Guevara, Marcela ; Murray, Deirdre ; Ragusa, Rosalia ; Gatta, Gemma ; Jooste, Valérie

Background: To estimate net survival and cancer cure fraction (CF), i.e. the proportion of patients no longer at risk of dying from cancer progression/relapse, a clear distinction needs to be made between mortality from cancer and from other causes. Conventionally, CF is estimated assuming no excess mortality compared to the general population. Methods: A new modelling approach, that corrects for patients’ extra risk of dying (RR) from causes other than the diagnosed cancer, was considered to [...]

Menée aux Etats-Unis à l'aide de données nationales sur l'incidence et la mortalité du cancer, cette étude estime la part des cancers et des décès attribuables à des facteurs de risque modifiables (30 localisations)

Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, 2019

Islami, Farhad ; Marlow, Emily C. ; Thomson, Blake ; McCullough, Marjorie L. ; Rumgay, Harriet ; Gapstur, Susan M. ; Patel, Alpa V. ; Soerjomataram, Isabelle ; Jemal, Ahmedin

In 2018, the authors reported estimates of the number and proportion of cancers attributable to potentially modifiable risk factors in 2014 in the United States. These data are useful for advocating for and informing cancer prevention and control. Herein, based on up-to-date relative risk and cancer occurrence data, the authors estimated the proportion and number of invasive cancer cases (excluding nonmelanoma skin cancers) and deaths, overall and for 30 cancer types among adults who were aged [...]

Menée à partir de données vietnamiennes 2007-2019 portant sur 39 401 personnes (âge moyen : 40,4 ans ; 52,3 % de femmes), cette étude analyse la corrélation entre le narguilé, utilisé seul ou avec du tabac, et la mortalité par cancer (554 cas)

Waterpipe Tobacco Smoking and Risk of Cancer Mortality

Le, Ngoan Tran ; Phan, Can Van ; Pham, Yen Thi-Hai ; Le, Phuoc Hong ; Dao, Hang Viet ; Nguyen, Long Cong ; Yuan, Jian-Min ; Luu, Hung N.

There has been an increasing trend of using noncigarette products, including waterpipe tobacco (WTP), worldwide. While cigarette smoking is a well-established risk factor for numerous cancers, little is known about the association between WTP smoking and cancer mortality.To assess the association between WTP smoking and risk of cancer mortality in Vietnam.This cohort study was based on data from the Hanoi Prospective Cohort Study, an ongoing study with a median (range) follow-up of 11.0 [...]

Menée en Italie à partir de données de mortalité 2000-2018, cette étude évalue la part des décès par cancer de l'ovaire attribuable à une exposition à l'amiante (10 468 décès)

Ovarian cancer deaths attributable to asbestos exposure in Lombardy (Italy) in 2000–2018

Stoppa, Giorgia ; Mensi, Carolina ; Fazzo, Lucia ; Minelli, Giada ; Manno, Valerio ; Marinaccio, Alessandro ; Consonni, Dario ; Biggeri, Annibale ; Catelan, Dolores

Objectives: We aimed to estimate the fraction of deaths from ovarian cancer attributable to asbestos exposure in Lombardy Region, Italy, using a novel approach that exploits the fact that ovarian cancer asbestos exposure is associated with pleural cancer and other risk factors for breast cancer. Methods: This ecological study is based on the Italian National Institute of Statistics mortality data. We formulate a trivariate Bayesian joint disease model to estimate the attributable fraction (AF) [...]

Menée à l'aide de données 2022 portant sur 73 869 adultes âgés de 45 à 75 ans, cette étude analyse l'association entre des antécédents de cancer, le soutien social et un dépistage récent du cancer colorectal, en fonction de l'origine ethnique

Cancer History and Social Support Impact Colorectal Cancer Screening Utilization by Race/Ethnicity

Tsai, Meng-Han ; Lee, Minjee ; Coughlin, Steven S. ; Eberth, Jan M. ; Rogers, Charles R.

This study examined the association between cancer history, social support, and up to date colorectal cancer (CRC) screening among four racial/ethnic groups. We conducted a cross-sectional analysis using data on respondents aged 45-75 years from the 2022 Behavioral Risk Factor Surveillance System. Our outcome of interest was CRC screening and exposures of interest were race/ethnicity, cancer history, and social support. Weighted multivariable logistic regression was performed. Among 73,869 [...]

Menée à partir de données du registre néerlandais des cancers portant sur 842 jeunes patients atteints d'un sarcome d'Ewing, cette étude compare la survie des enfants (0-17 ans) et celle des adolescents ou jeunes adultes (18-39 ans) atteints de la maladie sur la période 1990-2018, en fonction de la période de diagnostic, du site de la tumeur et du stade de la maladie

The survival disparity between children and adolescents and young adults (AYAs) with Ewing sarcoma in the Netherlands did not change since the 1990s despite improved survival: A population-based study

Schulpen, Maya ; Haveman, Lianne M. ; van der Heijden, Lizz ; Kaal, Suzanne E. J. ; Bramer, Jos A. M. ; Fajardo, Raquel Dávila ; de Haan, Jacco J. ; Hiemcke-Jiwa, Laura S. ; ter Horst, Simone A. J. ; Jutte, Paul C. ; Schreuder, Hendrik W. B. ; Tromp, Jacqueline M. ; van der Graaf, Winette T. A. ; van de Sande, Michiel A. J. ; Gelderblom, Hans ; Merks, Johannes H. M. ; Karim-Kos, Henrike E.

Background: Adolescents and young adults (AYAs) with Ewing sarcoma have a worse prognosis than children. Population-based survival evaluations stratifying findings by important clinical factors are, however, limited. This Dutch population study comprehensively compared survival of children and AYAs with Ewing sarcoma over three decades considering diagnostic period, tissue of origin, tumor site, and disease stage. Methods: Data on all children (0-17 years, N=463) and AYAs (18-39 years, N=379) [...]

Menée notamment à l'aide de données du registre anglais des cancers portant sur 36 985 patientes atteintes d'un cancer du sein HER2+ invasif, cette étude identifie des facteurs sociodémographiques facilitant ou entravant l'accès à un traitement par trastuzumab

Socio-demographic disparities in HER2+ breast cancer trastuzumab receipt: An English population-based study

Norris, Ruth P. ; Dew, Rosie ; Greystoke, Alastair ; Cresti, Nicola ; Cain, Henry ; Todd, Adam ; Sharp, Linda

Background: Socio-demographic disparities in traditional breast cancer treatment receipt in non-publicly funded healthcare systems are well documented. This study investigated trastuzumab receipt by socio-demographic factors within a female, HER2+ breast cancer population in England’s publicly funded National Health Service. Methods: The English national population-based cancer registry and linked Systemic Anti-Cancer Therapy (SACT) database identified 36,985 women with HER2+ invasive breast [...]

Menée à partir de données portant sur 2 653 femmes ayant bénéficié d'une greffe de rein entre 2001 et 2017 (âge : 20-65 ans), cette étude analyse leur participation aux examens de dépistage du cancer du col de l'utérus

Cervical cancer screening utilization among kidney transplant recipients, 2001-2018

Hsu, Christine D. ; Yu, Xiaoying ; Guo, Fangjian ; Adekanmbi, Victor ; Kuo, Yong-Fang ; Westra, Jordan ; Berenson, Abbey B.

Background: Kidney transplant recipients (KTRs) have elevated risks of cervical pre-cancers and cancers, and guidelines recommend more frequent cervical cancer screening exams. However, little is known about current trends in cervical cancer screening in this unique population. We described patterns in the uptake of cervical cancer screening exams among female KTRs and identified factors associated with screening utilization. Methods: This retrospective cohort study included female KTRs between [...]

Cette étude passe en revue les essais cliniques concernant le traitement des cancers de l'ovaire et du testicule et enregistrés sur le site ClinicalTrials.gov jusqu'en juillet 2022

Trials of interventions for ovarian and testicular germ cell tumors registered in ClinicalTrials.gov: a cross-sectional study

Puljak, Livia ; Bojcic, Ruzica ; Botic, Monika Cikes ; Odak, Zdravko ; Riva, Nicoletta ; Gold, Vienna R. ; Tabone, Ylenia ; Squizzato, Alessandro ; Calleja-Agius, Jean

Introduction: There is unmet need in the treatment of ovarian and testicular germ cell tumors (GCTs). This study analyzed registered trials of interventions for GCTs. Materials and methods: We included trials of interventions for GCTs registered on ClinicalTrials.gov by July 29, 2022. We analyzed their interventions, outcome measures and study design. Results: We included 142 trials registrations; 42 (30%) for ovarian GCTs, 50 (35 for testicular GCTs, and 50 (35%) trials for both. The majority [...]