Menée à l'aide de données portant sur 20 010 témoins et 4 002 patients atteints d'un cancer du poumon, cette étude analyse l'association entre un score de risque polygénique et le risque de développer un cancer du poumon lié au tabagisme

Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort

Boumtje, Véronique ; Manikpurage, Hasanga D. ; Li, Zhonglin ; Gaudreault, Nathalie ; Armero, Victoria Saavedra ; Boudreau, Dominique K. ; Renaut, Sébastien ; Henry, Cyndi ; Racine, Christine ; Eslami, Aida ; Bougeard, Stéphanie ; Vigneau, Evelyne ; Morissette, Mathieu ; Arsenault, Benoit J. ; Labbe, Catherine ; Laliberté, Anne-Sophie ; Martel, Simon ; Maltais, François ; Couture, Christian ; Desmeules, Patrice ; Mathieu, Patrick ; Thériault, Sébastien ; Joubert, Philippe ; Bosse, Yohan

Background: The most near-term clinical application of genome-wide association studies in lung cancer is a polygenic risk score (PRS). Methods: A case-control dataset was generated consisting of 4002 lung cancer cases from the LORD project and 20,010 ethnically matched controls from CARTaGENE. A genome-wide PRS including >1.1 million genetic variants was derived and validated in UK Biobank (n = 5419 lung cancer cases). The predictive ability and diagnostic discrimination performance of the PRS [...]

Menée à partir de données portant sur 2 264 hommes employés pendant au moins 1 an dans une raffinerie de pétrole suédoise, cette étude analyse l'association entre une exposition faible à modérée au benzène et le risque de cancer (258 cas)

Cancer incidence in Swedish oil refinery workers exposed to benzene

Andersson, E. M. ; Barregard, L. ; Akerstrom, M. ; Sallsten, G. ; Järvholm, B. ; Nilsson, R. I.

Background: Oil refinery workers are exposed to benzene, which is a well-known cause of leukaemia, but results on leukaemia in oil refinery workers have been mixed, and the data on workers’ exposure is limited. Oil refinery workers are also exposed to asbestos and several studies have shown increased risk of mesothelioma. Aim: The objective was to investigate cancer incidence, especially leukaemia, at low to moderate exposure to benzene in an update of a previous study of employees at three [...]

Menée à partir de données brésiliennes 2000-2019, cette étude analyse l'association entre une exposition à l'ozone ambiant et la mortalité par cancer en fonction de la localisation (3 459 826 décès par cancer)

Short-term ozone exposure and cancer mortality in Brazil: A nationwide case-crossover study

Yu, Pei ; Xu, Rongbin ; Huang, Wenzhong ; Yang, Zhengyu ; Coelho, Micheline S. Z. S. ; Saldiva, Paulo H. N. ; Wen, Bo ; Wu, Yao ; Ye, Tingting ; Zhang, Yiwen ; Sun, Haitong Z. ; Abramson, Michael J. ; Li, Shanshan ; Guo, Yuming

Exposure to ambient ozone (O3) is linked to increased mortality risks from various diseases, but epidemiological investigations delving into its potential implications for cancer mortality are limited. We aimed to examine the association between short-term O3 exposure and site-specific cancer mortality and investigate vulnerable subgroups in Brazil. In total 3,459,826 cancer death records from 5570 Brazilian municipalities between 2000 and 2019, were included. Municipal average daily O3 [...]

Menée à l'aide des données d'une étude canadienne portant sur 242 témoins et 465 patientes atteintes d'un cancer du sein (âge : 18-45 ans), cette étude analyse l'association entre une exposition résidentielle aux particules fines ambiantes (PM2.5) et/ou au dioxyde d'azote (NO2) et le risque de développer la maladie

Residential exposure to ambient fine particulate matter (PM2.5) and nitrogen dioxide (NO2) and incident breast cancer among young women in Ontario, Canada

Le Provost, Blandine ; Parent, Marie-Élise ; Villeneuve, Paul J. ; Waddingham, Claudia M. ; Brook, Jeffrey R. ; Lavigne, Eric ; Dugandzic, Rose ; Harris, Shelley A.

Background: Air pollution has been classified as a human carcinogen based largely on findings for respiratory cancers. Emerging, but limited, evidence suggests that it increases the risk of breast cancer, particularly among younger women. We characterized associations between residential exposure to ambient fine particulate matter (PM2.5) and nitrogen dioxide (NO2) and breast cancer. Analyses were performed using data collected in the Ontario Environmental Health Study (OEHS). Methods: The [...]

Cet article passe en revue les données concernant le rôle du lactate dans le développement d'un carcinome hépatocellulaire lié au virus de l'hépatite B

Understanding lactate in the development of Hepatitis B virus-related hepatocellular carcinoma

Sheikhrobat, Sheida Behzadi ; Mahmoudvand, Shahab ; Kazemipour-Khabbazi, Salva ; Ramezannia, Zahra ; Baghi, Hossein Bannazadeh ; Shokri, Somayeh

Hepatitis B Virus (HBV) is a hepatotropic virus that can establish a persistent and chronic infection in humans. Chronic hepatitis B (CHB) infection is associated with an increased risk of hepatic decompensation, cirrhosis, and hepatocellular carcinoma (HCC). Lactate level, as the end product of glycolysis, plays a substantial role in metabolism beyond energy production. Emerging studies indicate that lactate is linked to patient mortality rates, and HBV increases overall glucose consumption [...]

Cet article passe en revue les informations concernant les mécanismes biologiques et moléculaires impliqués dans l'association entre le stress psychosocial et l'incidence et/ou la progression d'un cancer du sein

Mechanisms of stress-attributed breast cancer incidence and progression

Reznik, Elizabeth ; Torjani, Ava

Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths in women, with psychosocial stress commonly cited by patients as one of its causes. While there is conflicting epidemiological evidence investigating the association between psychosocial stress and breast cancer incidence and progression, there is reason to believe that interventions aimed at reducing stress pharmacologically or psychologically may improve breast cancer outcomes. The aim of this [...]

Menée à partir de données portant sur 1 019 patients atteints d'un adénocarcinome gastrique, cette étude analyse le taux d'amplification de ERBB2/HER2 en fonction de l'origine ethnique

ERBB2 amplification in gastric cancer: a genomic insight into ethnic disparities

Mirza, Muhammad Bilal ; Choi, Jungyoon ; Marincola Smith, Paula ; Baechle, Jordan J ; Padmanabhan, Chandrasekhar ; Holowatyj, Andreana N ; Shah, Shailja C ; Guo, Xingyi ; Idrees, Kamran

Overall, gastric adenocarcinoma (GC) incidence rates have declined in recent years, but racial and ethnic disparities persist. Individuals who identify as Hispanic/Spanish/Latino are diagnosed with GC at younger ages and have poorer outcomes than non-Hispanic individuals. However, our understanding of GC biology across racial/ethnic groups remains limited. We assessed tumor genomic patterns by race/ethnicity among 1019 patients with primary GC in the American Association for Cancer Research [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2023 (20 études), cette méta-analyse évalue l'association entre le diabète et le risque de mélanome

Melanoma risk, tumour stage, and melanoma-specific mortality in individuals with diabetes: a systematic review and meta-analysis

Tønder, Jens Ejrnæs ; Bønnelykke-Behrndtz, Marie Louise ; Laurberg, Tinne ; Røssell, Eeva-Liisa ; Sollie, Martin

Background: Cancer has become the leading diabetes-related cause of death in high-income countries, and more knowledge is needed to clarify the impact of diabetes on site-specific cancers. The purpose of this study is to assess the association between diabetes and malignant melanoma by conducting a comprehensive systematic review and meta-analysis. Methods: Using predefined eligibility criteria, PubMed, The Cochrane Library and Web of Science were systematically searched up to February 22, [...]

Menée notamment à partir de données transcriptomiques portant sur 67 523 témoins et 8 803 patients atteints d'un adénocarcinome du pancréas, cette étude identifie 16 gènes de susceptibilité à la maladie et met en évidence des associations entre le cancer du pancréas, le diabète de type 2 et la thromboembolie veineuse

Transcriptome-wide association study and Mendelian randomization in pancreatic cancer identifies susceptibility genes and causal relationships with type 2 diabetes and venous thromboembolism

Tan, Marcus C. B. ; Isom, Chelsea A. ; Liu, Yangzi ; Trégouët, David-Alexandre ; Lindström, Sara ; Wang, Lu ; Smith, Erin ; Gordon, William ; Van Hylckama Vlieg, Astrid ; de Andrade, Mariza ; Brody, Jennifer ; Pattee, Jack ; Haessler, Jeffrey ; Brumpton, Ben ; Chasman, Daniel ; Suchon, Pierre ; Chen, Ming-Huei ; Turman, Constance ; Germain, Marine ; Wiggins, Kerri ; Macdonald, James ; Braekkan, Sigrid ; Armasu, Sebastian ; Pankratz, Nathan ; Jackson, Rabecca ; Nielsen, Jonas ; Giulianini, Franco ; Puurunen, Marja ; Ibrahim, Manal ; Heckbert, Susan ; Bammler, Theo ; Frazer, Kelly ; McCauley, Bryan ; Taylor, Kent ; Pankow, James ; Reiner, Alexander ; Gabrielsen, Maiken ; Deleuze, Jean-Francois ; O'Donnell, Chris ; Kim, Jihye ; McKnight, Barbara ; Kraft, Peter ; Hansen, John-Bjarne ; Rosendaal, Frits ; Heit, John ; Psaty, Bruce ; Tang, Weihong ; Kooperberg, Charles ; Hveem, Kristian ; Ridker, Paul ; Morange, Pierre-Emmanuel ; Johnson, Andrew ; Kabrhel, Christopher ; Smith, Nicholas ; Wu, Lang ; Zhou, Dan ; Gamazon, Eric R.

Background: Two important questions regarding the genetics of pancreatic adenocarcinoma (PDAC) are 1. Which germline genetic variants influence the incidence of this cancer; and 2. Whether PDAC causally predisposes to associated non-malignant phenotypes, such as type 2 diabetes (T2D) and venous thromboembolism (VTE). Methods: In this study of 8803 patients with PDAC and 67,523 controls, we first performed a large-scale transcriptome-wide association study to investigate the association between [...]

Menée en Suède à l'aide de données mammographiques 2011-2013 portant sur 70 877 femmes et à partir de données du registre des cancers, cette étude analyse l'association entre la densité des tissus mammaires et le risque de cancer du sein

Studying the association Between longitudinal non-dense breast tissue and breast cancer risk: a joint modelling approach

Illipse, Maya ; Gasparini, Alessandro ; Christoffersen, Benjamin ; Hall, Per ; Czene, Kamila ; Humphreys, Keith

Conflicting results have appeared in the literature on whether the amount of non-dense, adipose tissue in the breast is a risk factor or a protective factor for breast cancer, and biological hypotheses supporting both have been proposed. We suggest here that limitations in study design and statistical methodology could potentially explain the inconsistent results. Specifically, we exploit recent advances in methodology and software developed for the joint analysis of multiple longitudinal [...]