Mené sur 52 patients atteints d'un cancer thoracique, cet essai multicentrique de phase II évalue l'efficacité, du point de vue du taux de réponse complète, et la toxicité d'un traitement combinant mirtazapine, granisétron et dexaméthasone pour prévenir les nausées et vomissements induits par le carboplatine

Mirtazapine plus granisetron and dexamethasone for carboplatin-induced nausea and vomiting in patients with thoracic cancers: A prospective multicenter phase II trial

Iihara, Hirotoshi ; Iwai, Masamichi ; Morita, Ryo ; Fujita, Yukiyoshi ; Ohgino, Keiko ; Ishihara, Takuma ; Hirose, Chiemi ; Suzuki, Yasuyuki ; Masubuchi, Ken ; Kawazoe, Hitoshi ; Kawae, Daisuke ; Aihara, Kanako ; Endo, Satoshi ; Fukunaga, Koichi ; Yamazaki, Mizuki ; Tamura, Takuya ; Kitamura, Yu ; Fukui, Shin ; Endo, Junki ; Suzuki, Akio

Background: Mirtazapine blocks 5-hydroxytryptamine type (5-HT)2A, 5-HT2C, 5-HT3 and histamine H1 receptors, similarly to olanzapine. This study aimed to investigate the efficacy and safety of mirtazapine plus granisetron and dexamethasone for carboplatin (CBDCA)-induced nausea and vomiting in patients with thoracic cancers. Methods: We conducted a prospective, open‐label, single‐arm, multicenter, phase II trial in four institutions in Japan. Registered patients were moderately to highly [...]

Menée dans un contexte américain, cette étude rétrospective analyse l'effet, sur l'utilisation de soins médicaux et les coûts associés, de soins de support dédiés aux patients atteints d'un cancer de stade avancé

The impact of outpatient supportive oncology on cancer care cost and utilization

Worster, Brooke ; Zhu, Yifan ; Garber, Gregory ; Kieffer, Sawyer ; Smith-McLallen, Aaron

Background: Supportive oncology (SO) care reduces symptom severity, admissions, and costs in patients with advanced cancer. This study examines the impact of SO care on utilization and costs. Methods: Retrospective analysis of utilization and costs comparing patients enrolled in SO versus three comparison cohorts who did not receive SO. Using claims, the authors estimated differences in health care utilization and cost between the treatment group and comparison cohorts. The treatment group [...]

Mené sur 358 adultes en surpoids ou obèses, ayant survécu à une leucémie lymphoblastique aiguë diagnostiquée pendant l'enfance et présentant un risque de décès par maladie cardiovasculaire (âge médian : 37 ans), cet essai randomisé évalue l'efficacité d'une intervention destinée à la perte de poids

Exercise and QUality diet After Leukemia (EQUAL): A randomized weight loss trial among adult survivors of childhood leukemia in the Childhood Cancer Survivor Study

Friedman, Danielle Novetsky. ; Chou, Joanne F. ; Clark, Jeanne M. ; Moskowitz, Chaya S. ; Ford, Jennifer S. ; Armstrong, Gregory T. ; Mubdi, Nidha Z. ; McDonald, Aaron ; Nathan, Paul C. ; Sklar, Charles A. ; Ramanathan, Lakshmi V. ; Robison, Leslie L. ; Oeffinger, Kevin C. ; Tonorezos, Emily S.

Background: Obesity is prevalent in childhood cancer survivors and interacts with cancer treatments to potentiate risk for cardiovascular (CV) death. We tested a remote weight-loss intervention that was effective among adults with CV risk factors in a cohort of adult survivors of childhood acute lymphoblastic leukemia (ALL) with overweight/obesity. Methods: In this phase 3 efficacy trial, survivors of ALL enrolled in the Childhood Cancer Survivor Study with body mass index (BMI)≥25 kg/m2 were [...]

Menée aux Etats-Unis à partir de données portant sur 2 781 patientes ayant survécu à un cancer du sein, cette étude analyse leur bien-être émotionnel et fonctionnel

Emotional and functional well-being in long-term breast cancer survivorship

Ren, Yumeng ; Maselko, Joanna ; Tan, Xianming ; Olshan, Andrew F. ; Stover, Angela M. ; Bennett, Antonia V. ; Reeder-Hayes, Katherine E. ; Edwards, Jessie K. ; Reeve, Bryce B. ; Troester, Melissa A. ; Emerson, Marc A.

Purpose: Emotional and functional well-being (EWB and FWB) are important components of mental health and quality of life. This study aims to evaluate long-term EWB and FWB in breast cancer (BC) survivors. Methods: The Carolina Breast Cancer Study Phase 3 oversampled Black and younger (< 50 years in age) women so that they each represent approximately 50% of the study population and assessed participants’ EWB and FWB with the Functional Assessment of Cancer Therapy—Breast (FACT-B) at 5- [...]

Menée aux Pays-Bas à partir de données portant sur 2 253 patients ayant survécu à un cancer pédiatrique et 906 témoins, cette étude identifie les facteurs associés à un surpoids ou une obésité et aux comportements de santé à risque (consommation excessive d'alcool, tabagisme, consommation de drogues,...)

Unhealthy lifestyle behaviors, overweight, and obesity among childhood cancer survivors in the Netherlands: A DCCSS LATER study

Bouwman, Eline ; Penson, Adriaan ; de Valk, Maud ; van den Oever, Selina R. ; van der Pal, Helena J. H. ; van Dulmen-den Broeder, Eline ; Blijlevens, Nicole M. A. ; Bresters, Dorine ; Feijen, Elizabeth A. M. ; van den Heuvel-Eibrink, Marry M. ; van der Heiden-van der Loo, Margriet ; Michel, Gisela ; Ronckers, Cecile M. ; Teepen, Jop C. ; Tissing, Wim J. E. ; Versluys, Birgitta A. B. ; Kremer, Leontien C. M. ; Pluijm, Saskia M. F. ; Loonen, Jacqueline J. ; the Dutch LATER Study Group ; the PanCareFollowUp Consortium

Background: The objective of this study was to examine the prevalence of unhealthy lifestyle behaviors, overweight, and obesity in Dutch childhood cancer survivors (CCSs) compared with sibling controls and the Dutch general population. Other aims were to assess associated factors of unhealthy lifestyle behaviors, overweight, and obesity and to identify subgroups of CCSs at risk for these unhealthy statuses. Methods: The authors included 2253 CCSs and 906 siblings from the Dutch Childhood Cancer [...]

Menée à Hong Kong à partir de données portant sur 12 649 patients atteints d'un cancer (durée médiane de suivi : 8,7 ans), cette étude analyse l'association entre la présence d'un prédiabète (3 997 cas) et le risque d'événements indésirables de nature cardiaque en lien avec un traitement anticancéreux par anthracyclines

Prediabetes is associated with increased cardiac events in patients with cancer who are prescribed anthracyclines

Cheang, Iokfai ; Zhu, Xu ; Huang, Jia-Yi ; Tse, Yi-Kei ; Li, Hang-Long ; Ren, Qing-Wen ; Wu, Mei-Zhen ; Chan, Yap-Hang ; Xu, Xin ; Tse, Hung-Fat ; Gue, Ying ; Lip, Gregory Y. H. ; LI, XINLI ; Yiu, Kai-Hang

Background: Prediabetes, which is a precedent of overt diabetes, is a known risk factor for adverse cardiovascular outcomes. Its impact on adverse cardiovascular outcomes in patients with cancer who are prescribed anthracycline-containing chemotherapy (ACT) is uncertain. The objective of this study was to evaluate the association of prediabetes with cardiovascular events in patients with cancer who are prescribed ACT. Methods: The authors identified patients with cancer who received ACT from [...]

Menée aux Etats-Unis à partir de données portant sur 5 032 patients ayant survécu à un cancer (âge moyen : 62,5 ans), cette étude analyse l'association entre une insécurité alimentaire et la mortalité

Association of food insecurity with overall and disease-specific mortality among cancer survivors in the US

Hong, Young-Rock ; Wang, Ruixuan ; Case, Stuart ; Jo, Ara ; Turner, Kea ; Ross, Kathryn M.

Purpose: To investigate the association of food insecurity with overall and disease-specific mortality among US cancer survivors. Methods: Data from the National Health and Nutrition Examination Survey (NHANES 1999–2018) were used to examine the impact of food insecurity on mortality risks among cancer survivors in the US. Study participants aged ≥ 20 years who had a history of cancer and completed the Adult Food Security Survey Module were included. Mortality data [all-cause, cancer, and [...]

Menée à partir de données d'études d'association sur le génome entier puis répliquée sur des données portant sur 5 965 patients ayant survécu à un cancer pédiatrique, cette étude identifie des loci de susceptibilité au diabète de type 2 induit par les traitements anticancéreux, en fonction de l'origine ethnique

Trans-Ancestral Genetic Risk Factors for Treatment-Related Type 2 Diabetes Mellitus in Survivors of Childhood Cancer

Cindy Im ; Achal Neupane ; Jessica L. Baedke ; Brian Lenny ; Angela Delaney ; Stephanie B. Dixon ; Eric J. Chow ; Sogol Mostoufi-Moab ; Tianzhong Yang ; Melissa A. Richard ; M. Monica Gramatges ; Philip J. Lupo ; Noha Sharafeldin ; Smita Bhatia ; Gregory T. Armstrong ; Melissa M. Hudson ; Kirsten K. Ness ; Leslie L. Robison ; Yutaka Yasui ; Carmen L. Wilson ; Yadav Sapkota

Purpose: Type 2 diabetes mellitus (T2D) is a prevalent long-term complication of treatment in survivors of childhood cancer, with marked racial/ethnic differences in burden. In this study, we investigated trans-ancestral genetic risks for treatment-related T2D. Patients and Methods: Leveraging whole-genome sequencing data from the St Jude Lifetime Cohort (N = 3,676, 304 clinically ascertained cases), we conducted ancestry-specific genome-wide association studies among survivors of African and [...]

Menée à partir de données portant sur 1 104 patientes atteintes d'un cancer du sein et 814 témoins, cette étude analyse l'association entre le niveau d'acides gras polyinsaturés dans les globules rouges et la mortalité (290 décès par cancer du sein)

Red Blood Cell Polyunsaturated Fatty Acids and Mortality Following Breast Cancer

Parada, Humberto ; Wu, Tianying ; Hoh, Eunha ; Rock, Cheryl L. ; Martinez, Maria Elena.

Background: Intake of polyunsaturated fatty acids (PUFAs) may impact mortality following breast cancer (BC); however, epidemiological studies have relied on self-reported assessment of PUFA intake. Herein, we examined the associations between red blood cell (RBC) PUFAs and mortality. Methods: This nested case-control study included 1,104 women from, the Women’s Healthy Eating and Living Study, a multi-site randomized controlled trial. Cases (n=290) were women who died from 1995-2006. Matched [...]

Menée au Royaume-Uni à partir de données portant sur 903 patientes atteintes d'un cancer du sein de survenue précoce et présentant des variants constitutionnels BRCA1/2 (âge moyen : 34,7 ans ; durée moyenne de suivi : 10,8 ans), cette étude de cohorte prospective analyse l'effet, sur la mortalité, du délai entre le dernier accouchement et le diagnostic de la maladie

Postpartum Breast Cancer and Survival in Women With Germline BRCA Pathogenic Variants

Zhang, Zhenzhen ; Ye, Shangyuan ; Bernhardt, Sarah M. ; Nelson, Heidi D. ; Velie, Ellen M. ; Borges, Virginia F. ; Woodward, Emma R. ; Evans, D. Gareth R. ; Schedin, Pepper J.

Importance : In young-onset breast cancer (YOBC), a diagnosis within 5 to 10 years of childbirth is associated with increased mortality. Women with germline BRCA1/2 pathogenic variants (PVs) are more likely to be diagnosed with BC at younger ages, but the impact of childbirth on mortality is unknown. Objective : To determine whether time between most recent childbirth and BC diagnosis is associated with mortality among patients with YOBC and germline BRCA1/2 PVs. Design, Setting, and [...]

Menée en France par questionnaire auprès de 203 aidants de patients atteints d'un cancer (112 cas de cancer gastro-intestinal, 91 cas de cancer hématologique), cette étude transversale analyse l'association entre leurs compétences émotionnelles, leurs symptômes psychiques (anxiété, dépression) et leurs besoins en soins de support au début des traitements anticancéreux

Association between emotional competence and risk of unmet supportive care needs in caregivers of cancer patients at the beginning of care

Baudry, Anne-Sophie ; Delpuech, Marion ; Charton, Emilie ; Hivert, Benedicte ; Carnot, Aurelien ; Ceban, Tatiana ; Dominguez, Sophie ; Lemaire, Antoine ; Aelbrecht-Meurisse, Capucine ; Anota, Amelie ; Christophe, Véronique

Purpose: This cross-sectional study explored the associations between intrapersonal and interpersonal emotional competence (EC) and the unmet supportive care needs (SCN), anxiety, and depression of informal caregivers at the beginning of gastrointestinal or haematological cancer care, i.e. during chemotherapy and within 6 months after diagnosis. Methods: The participants completed a self-reported questionnaire, comprising the Short Profile of Emotional Competence (S-PEC), the SCN survey for [...]

Mené sur 80 patientes atteintes d'un cancer du sein de stade I à III, cet essai randomisé évalue l'intérêt d'une intervention de psychothérapie de groupe pour diminuer leur peur de la récidive de la maladie et améliorer leur qualité de vie

A randomized clinical trial: Efficacy of group-based acceptance and commitment therapy program for breast cancer patients with high fear of progression

Hassani Alimolk, Fatemeh ; McDonald, Fiona Elizabeth Jean ; Asghari-Jafarabadi, Mohammad ; Ahmadi, Farzane ; Zenoozian, Saeedeh ; Lashkari, Marzieh ; Patterson, Pandora

Background: Fear of progression (FOP) is a common and significant concern among cancer patients, encompassing worries about cancer progression during active treatment. Elevated levels of FOP can be dysfunctional. This study aims to assess the efficacy of an Acceptance and Commitment Therapy (ACT)-based intervention on FOP, anxiety sensitivity (AS), and quality of life (QOL) in breast cancer patients. Methods: A clinical trial was conducted involving 80 stage I-III active-treatment breast cancer [...]

Mené sur 52 patients ayant survécu à un lymphome hodgkinien, cet essai randomisé évalue l'intérêt d'une intervention pédagogique en ligne pour améliorer leurs connaissances des risques de second cancer liés à la radiothérapie et développer leurs comportements de dépistage

A pilot randomized controlled trial of an online intervention for Hodgkin lymphoma survivors to increase knowledge about late effects and recommended screening

Rick, Tara J. ; Sagaram, Smitha ; Jewett, Patricia I. ; Lee, Hee Yun ; Sadak, Karim T. ; Turcotte, Lucie M. ; Vogel, Rachel I. ; Blaes, Anne

Background: Hodgkin lymphoma (HL) survivors who received chest radiotherapy are at risk for breast cancer and cardiovascular disease, but screening adherence is low. We assessed the acceptability/feasibility of a web-based educational intervention and its impact on knowledge of health risks and screening. Methods: HL survivors were randomized to either an interactive online educational intervention or handouts only. Surveys were completed at baseline and 3 months post-intervention. We described [...]

Menée en France à partir de données portant sur 149 patients atteints d'un cancer du poumon non à petites cellules, cette étude de cohorte observationnelle analyse l'intégration des soins palliatifs dans les soins dispensés en fin de vie

Palliative care integration and end-of-life care intensity for patients with NSCLC

Martin, A. ; Carton, M. ; Thery, L. ; Burnod, A. ; Daniel, C. ; Du Rusquec, P. ; Girard, N. ; Bouleuc, C.

Background: Non-small cell lung cancer (NSCLC) without oncogenic driver mutations is considered to have a poor prognosis, although recent therapeutic progress. This study aims to assess the real-life integration of palliative care (PC) and the intensity of end-of-life (EOL) care for this population. Methods: This was an observational cohort study of decedent patients from metastatic NSCLC without oncogenic driver mutations over the period 01/2018 to 12/2022, treated in first line with [...]

Cet article présente les succès en matière de lutte contre les cancers au Rwanda, en Inde et au Brésil, et met en évidence l'intérêt des collaborations statégiques pour améliorer les soins contre le cancer à l'échelle mondiale

Growing the global cancer care system: success stories from around the world and lessons for the future

Dee, Edward Christopher ; Pramesh, C S ; Booth, Christopher M ; Rubagumya, Fidel ; Mutebi, Miriam ; Feliciano, Erin Jay G ; Eala, Michelle Ann B ; Cerri, Giovanni G ; Ginsburg, Ophira ; Gyawali, Bishal ; Ynoe de Moraes, Fabio

Despite significant biomedical advancements in various realms of oncology, the benefits of these developments are not equitably distributed, particularly in under-resourced settings. While much work has described the challenges and systemic barriers in global cancer control, in this essay we focus on success stories. This piece describes clinical care delivered at Rwanda’s Butaro Cancer Center of Excellence, the cancer research collaborations under India’s National Cancer Grid, and the efforts [...]