A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2023 (27 études, 22 319 participants), cette méta-analyse évalue l'association entre le type de tabac utilisé (cigarette, pipe, cigarette roulée), la quantité consommée et le risque de cancer de l'oesophage en Afrique

Uncovering Risks Associated with Smoking Types and Intensities in Esophageal Cancer within High-Prevalence Regions in Africa: A Comprehensive Meta-Analysis

Kamsu, Gabriel Tchuente. ; Ndebia, Eugene Jamot.

Tobacco is usually cited among the well-known risk factors of esophageal cancer, nevertheless, the extent of the contribution of the type of smoking and its intensity to the disease has not been comprehensively elucidated in Africa. We searched Medline/PubMed, Embase, Web of Science, Scopus, Cochrane Library, and African Journals Online studies published before September 2023. The quality of the studies was assessed using the Newcastle-Ottawa scale and the funnel plot was used for assessing [...]

A partir d'une revue de la littérature publiée jusqu'en janvier 2024 (10 revues systématiques), cette étude analyse l'association entre l'apport en protéines et le risque de cancer

Protein intake and cancer: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society

Kühn, Tilman ; Kalotai, Nicole ; Amini, Anna M. ; Haardt, Julia ; Lehmann, Andreas ; Schmidt, Annemarie ; Buyken, Anette E. ; Egert, Sarah ; Ellinger, Sabine ; Kroke, Anja ; Lorkowski, Stefan ; Louis, Sandrine ; Schulze, Matthias B. ; Schwingshackl, Lukas ; Siener, Roswitha ; Stangl, Gabriele I. ; Watzl, Bernhard ; Zittermann, Armin ; Nimptsch, Katharina ; on behalf of the German Nutrition, Society

Purpose: It has been proposed that a higher habitual protein intake may increase cancer risk, possibly via upregulated insulin-like growth factor signalling. Since a systematic evaluation of human studies on protein intake and cancer risk based on a standardised assessment of systematic reviews (SRs) is lacking, we carried out an umbrella review of SRs on protein intake in relation to risks of different types of cancer. Methods: Following a pre-specified protocol (PROSPERO: CRD42018082395), we [...]

Cette étude fait le point sur la recherche actuelle concernant le risque de cancer du poumon associé à une exposition au radon

Radon and Lung Cancer: Current Status and Future Prospects

Liu, Yan ; Xu, Yanqing ; Xu, Wei ; He, Zhengzhong ; Fu, Cong ; Du, Fen

Beyond tobacco smoking, radon takes its place as the second most significant contributor to lung cancer, excluding hereditary and other biologically related factors. Radon and its byproducts play a pivotal role in exposing humans to elevated levels of natural radiation. Approximately 10-20% of lung cancer cases worldwide can be attributed to radon exposure, leading to between 3% and 20% of all lung cancer-related deaths. Nevertheless, a knowledge gap persists regarding the association between [...]

Menée à l'aide de données de 20 études de l'"Asia Cohort Consortium" portant sur 968 738 personnes, cette méta-analyse évalue l'association entre un diabète et le risque de cancer du foie (5 654 cas) ainsi que la mortalité spécifique

Diabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium

Ho, Nhan Thi ; Abe, Sarah Krull ; Rahman, Md. Shafiur ; Islam, Rashedul ; Saito, Eiko ; Gupta, Prakash C. ; Pednekar, Mangesh S. ; Sawada, Norie ; Tsugane, Shoichiro ; Tamakoshi, Akiko ; Kimura, Takashi ; Shu, Xiao-Ou ; Gao, Yu-Tang ; Koh, Woon-Puay ; Cai, Hui ; Wen, Wanqing ; Sakata, Ritsu ; Tsuji, Ichiro ; Malekzadeh, Reza ; Pourshams, Akram ; Kanemura, Seiki ; Kim, Jeongseon ; Chen, Yu ; Ito, Hidemi ; Oze, Isao ; Nagata, Chisato ; Wada, Keiko ; Sugawara, Yumi ; Park, Sue K. ; Shin, Aesun ; Yuan, Jian-Min ; Wang, Renwei ; Kweon, Sun-Seog ; Shin, Min-Ho ; Poustchi, Hossein ; Vardanjani, Hossein Molavi ; Ahsan, Habibul ; Chia, Kee Seng ; Matsuo, Keitaro ; Qiao, You-Lin ; Rothman, Nathaniel ; Zheng, Wei ; Inoue, Manami ; Kang, Daehee ; Boffetta, Paolo

There has been growing evidence suggesting that diabetes may be associated with increased liver cancer risk. However, studies conducted in Asian countries are limited. This project considered data of 968,738 adults pooled from 20 cohort studies of Asia Cohort Consortium to examine the association between baseline diabetes and liver cancer incidence and mortality. Cox proportional hazard model and competing risk approach was used for pooled data. Two-stage meta-analysis across studies was also [...]

Menée à partir de données 1992-2019 du registre finlandais des cancers portant sur 45 533 patients ayant survécu à un cancer hématologique (âge : au moins 20 ans), cette étude analyse le risque de second cancer (6 076 cas)

Subsequent malignant neoplasms after primary hematological malignancy in adult patients

Rönkkö, Rosa M. ; Nevala, Aapeli O. ; Pitkäniemi, Janne M. ; Wartiovaara-Kautto, Ulla M. ; Malila, Nea K.

Patients with primary hematological malignancy (HM) are at an elevated risk of subsequent malignant neoplasms (SMNs), which is a common concern after treatment of primary cancer. We identified 45,533 patients aged ≥20 years and diagnosed with primary HM in Finland from 1992 to 2019 from the Finnish Cancer Registry and estimated standardized incidence ratios (SIR) and excess absolute risks per 1000 person-years (EAR) for SMNs. A total of 6076 SMNs were found (4604 solid and 1472 hematological [...]

Menée à partir de données 1986-2016 de la cohorte américaine "the Health Professionals Follow-Up Study" portant sur 49 104 hommes, cette étude analyse l'association entre une appendicectomie et le risque de cancer de la prostate (7 253 cas)

Appendectomy and risk of prostate cancer in the Health Professionals Follow-up Study

Zhang, Yiwen ; Feng, Xiaotong ; Giovannucci, Edward L.

Background: Appendectomy is a common surgical procedure to treat appendicitis. Limited studies examined its association on prostate cancer, with one large cohort study suggesting significant increased risk of overall and advanced prostate cancer, especially among younger men. Methods: A total of 49,104 men in the Health Professionals Follow-up Study were followed from 1986 to 2016. Cox proportional hazards models were applied to evaluate the association between self-reported history of [...]

Menée en Corée auprès de 2 427 978 femmes (durée moyenne de suivi : 8,3 ans ; âge : au moins 40 ans), cette étude analyse l'association entre l'hyperglycémie et le risque de cancer de l'estomac en fonction du statut ménopausique

Association between glycemic status and the risk of gastric cancer in pre-and postmenopausal women: A nationwide cohort study

Han, Kyung Hee ; Choi, Yoon Jin ; Il Kim, Tae ; Park, Noh Hyun ; Han, Kyung-Do ; Lee, Dong Ho

Purpose: This study aimed to assess the correlation between glycemic status (prediabetes and type 2 diabetes mellitus) and the risk of gastric cancer according to menopausal status. Methods: A total of 982,559 pre/peri-menopausal and 1,445,419 postmenopausal women aged ≥ 40, who underwent the Korean national health screening in 2009, were included and followed up until 2018. Hazard ratio (HR) and 95% confidence interval (CI) were calculated for development of gastric cancers according to [...]

Menée à l'aide de données portant sur 550 508 participants de l'"Asia Cohort Consortium" (durée moyenne de suivi : 15,6 ans), cette étude analyse l'association entre des antécédents familiaux de cancer gastrique et le risque de développer la maladie par sous-type (2 258 cas)

Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants

Huang, Dan ; Song, Minkyo ; Abe, Sarah Krull ; Rahman, Md Shafiur ; Islam, Md Rashedul ; Saito, Eiko ; De la Torre, Katherine ; Sawada, Norie ; Tamakoshi, Akiko ; Shu, Xiao-Ou ; Cai, Hui ; Hozawa, Atsushi ; Kanemura, Seiki ; Kim, Jeongseon ; Chen, Yu ; Ito, Hidemi ; Sugawara, Yumi ; Park, Sue K. ; Shin, Myung-Hee ; Hirabayashi, Mayo ; Kimura, Takashi ; Gao, Yu-Tang ; Wen, Wanqing ; Oze, Isao ; Shin, Aesun ; Ahn, Yoon-Ok ; Ahsan, Habibul ; Boffetta, Paolo ; Chia, Kee Seng ; Matsuo, Keitaro ; Qiao, You-Lin ; Rothman, Nathaniel ; Zheng, Wei ; Inoue, Manami ; Kang, Daehee

Background: The family history of gastric cancer holds important implications for cancer surveillance and prevention, yet existing evidence predominantly comes from case–control studies. We aimed to investigate the association between family history of gastric cancer and gastric cancer risk overall and by various subtypes in Asians in a prospective study. Methods: We included 12 prospective cohorts with 550,508 participants in the Asia Cohort Consortium. Cox proportional hazard regression was [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données européennes, cette étude identifie des facteurs génétiques influençant l'association entre une hépatite C chronique et le risque de lymphome à cellules B ou de leucémie lymphoïde chronique

Shared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma

Fu, Leihua ; Yu, Jieni ; Chen, Zhe ; Gao, Feidan ; Zhang, Zhijian ; Fu, Jiaping ; Feng, Weiying ; Hong, Pan ; Jin, Jing

Background: Epidemiological research and systematic meta-analyses indicate a higher risk of B-cell lymphomas in patients with chronic hepatitis C virus (HCV) compared to non-infected individuals. However, the genetic links between HCV and these lymphomas remain under-researched. Methods: Mendelian randomization analysis was employed to explore the association between chronic hepatitis C (CHC) and B-cell lymphomas as well as chronic lymphocytic leukemia (CLL). Approximate Bayes Factor (ABF) [...]

Menée à l'aide d'échantillons sanguins collectés auprès de 395 témoins et 395 patientes atteintes d'un cancer du poumon, cette étude analyse l'association entre des caractéristiques métaboliques individuelles et le risque de développer la maladie chez les femmes n'ayant jamais fumé

A nested case-control study of untargeted plasma metabolomics and lung cancer among never-smoking women within the prospective Shanghai Women's Health Study

Rahman, Mohammad L. ; Shu, Xiao-Ou ; Jones, Dean P. ; Hu, Wei ; Ji, Bu-Tian ; Blechter, Batel ; Wong, Jason Y. Y. ; Cai, Qiuyin ; Yang, Gong ; Gao, Yu-Tang ; Zheng, Wei ; Rothman, Nathaniel ; Walker, Douglas ; Lan, Qing

The etiology of lung cancer in never-smokers remains elusive, despite 15% of lung cancer cases in men and 53% in women worldwide being unrelated to smoking. Here, we aimed to enhance our understanding of lung cancer pathogenesis among never-smokers using untargeted metabolomics. This nested case-control study included 395 never-smoking women who developed lung cancer and 395 matched never-smoking cancer-free women from the prospective Shanghai Women's Health Study with 15,353 metabolic features [...]

Cette étude fait le point sur l'association entre le microbiote cervicovaginal, une infection persistante par le papillomavirus humain et le risque de cancer du col de l'utérus

Cervicovaginal microbiota: a promising direction for prevention and treatment in cervical cancer

Shen, Jie ; Sun, Hao ; Chu, Jing ; Gong, Xiaodi ; Liu, Xiaojun

Cervical cancer is a common malignancy in women, with high incidence rate and mortality. Persistent infection of high-risk human papillomavirus (HPV) is the most important risk factor for cervical cancer and precancerous lesions. Cervicovaginal microbiota (CVM) plays an essential role in the defense of HPV infections and prevention of subsequent lesions. Dominance of Lactobacillus is the key of CVM homeostasis, which can be regulated by host, exogenous and endogenous factors. Dysbiosis of CVM, [...]

Menée en France auprès de 229 témoins et 229 patients atteints d'un cancer colorectal, cette étude identifie des variants génétiques et des facteurs alimentaires impliqués dans l'association entre le métabolisme monocarboné induit par les folates et le risque de développer la maladie

Interactions between folate metabolism-related nutrients and polymorphisms on colorectal cancer risk: a case-control study in the Basque country

Corchero-Palacios, Sara ; Alegria-Lertxundi, Iker ; de Pancorbo, Marian M. ; Arroyo-Izaga, Marta

Folate-mediated one-carbon metabolism (FOCM) plays an important role in colorectal carcinogenesis. Previous studies have assessed the role of folate-mediated one-carbon metabolism (FOCM)-related gene-diet interaction in the aetiology of colorectal cancer (CRC), however, the results remained inconclusive. Thus, this study aimed to investigate dietary factors and genetic variants related to FOCM, as well as potential nutrient-gene and nutrient-lifestyle interactions, on CRC risk. This [...]