Menée auprès de 38 262 participants à l'étude "EPIC-Espagne" (durée moyenne de suivi : 16,7 ans), cette étude analyse l'association entre la consommation de nitrosylhème ou de fer héminique et le risque de cancer colorectal (577 cas)

Nitrosyl-heme and heme iron intake from processed meats and risk of colorectal cancer in the EPIC-Spain cohort

Rizzolo-Brime, Lucía ; Luján-Barroso, Leila ; Farran-Codina, Andreu ; Bou, Ricard ; Lasheras, Cristina ; Amiano, Pilar ; Aizpurua, Amaia ; Sánchez, María-José ; Molina-Montes, Esther ; Guevara, Marcela ; Moreno-Iribas, Conchi ; Gasque, Alba ; Chirlaque-López, María Dolores. ; Colorado-Yohar, Sandra M. ; Huerta, José María ; Zamora-Ros, Raul ; Agudo, Antonio ; Jakszyn, Paula

Background: The International Agency for Research on Cancer classified processed meats (PMs) as “carcinogenic” and red meat as “probably carcinogenic” for humans. The possible relationship between colorectal cancer (CRC) risk and the mechanisms involved in the carcinogenesis of PMs have not been established yet. Nitrosyl-heme and heme iron have been proposed as potential-related compounds. The aim of this study was to determine the association between nitrosyl-heme and heme iron intake and CRC [...]

Menée auprès de 437 937 Américains ayant travaillé sur des chantiers navals nucléaires entre 1957 et 2004, cette étude analyse l'association entre une exposition professionnelle aux rayonnements et le risque de tumeur solide ainsi que la mortalité spécifique

Low-Dose Radiation Associated Mortality Risks of Site-Specific Solid Tumors in U.S. Shipyard Workers

Tao, Xuguang ; Curriero, Frank C. ; Mahesh, Mahadevappa

Background: U.S. nuclear capable shipyard workers have increased potential for occupational radiation exposure. Objective: to examine solid tumor mortality risks at low doses. Method: 437,937 workers working from 1957 to 2004 at eight U.S. shipyards were studied. Results: Radiation workers with a median life-time dose at 0.82 mSv had a significantly lower solid tumor mortality risk [Relative risk (RR): 0.96, 95% confidence interval (CI): 0.94-0.98] than non-radiation workers. Among 153,930 [...]

A partir d'une revue systématique de la littérature (40 études, 748 188 participants), cette méta-analyse analyse l'association entre la dose d'exposition aux substances perfluoroalkylées et polyfluoroalkylées (PFAS) et le risque de cancer

Perfluoroalkyl and polyfluoroalkyl substances and Cancer risk: results from a does-response Meta-analysis

Yang, Jingxuan ; Zhang, Kui ; Shi, Jingyi ; Li, Zhuo ; Dai, Hao ; Yang, Wenxing

Background: Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are persistent organic pollutants in the environment. While some studies suggest that PFASs may contribute to cancer development, the link between PFAS exposure and cancer risk remains debated. Methods: This dose-response meta-analysis explores the relationship between PFASs and cancer. It employs odds ratio (OR) and standardized mean difference (SMD), along with their 95% confidence interval (CI), to assess the effects of PFASs [...]

Menée à l'aide de données portant sur 28 486 femmes ménopausées, cette étude évalue l'effet d'un score de risque polygénique sur l'association entre un traitement hormonal substitutif et le risque de cancer colorectal

Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk

Tian, Yu ; Lin, Yi ; Qu, Conghui ; Arndt, Volker ; Baurley, James W. ; Berndt, Sonja I. ; Bien, Stephanie A. ; Bishop, D. Timothy ; Brenner, Hermann ; Buchanan, Daniel D. ; Budiarto, Arif ; Campbell, Peter T. ; Carreras-Torres, Robert ; Casey, Graham ; Chan, Andrew T. ; Chen, Rui ; Chen, Xuechen ; Conti, David V. ; Díez-Obrero, Virginia ; Dimou, Niki ; Drew, David A. ; Figueiredo, Jane C. ; Gallinger, steven ; Giles, Graham G. ; Gruber, Stephen B. ; Gunter, Marc J. ; Harlid, Sophia ; Harrison, Tabitha A. ; Hidaka, Akihisa ; Hoffmeister, Michael ; Huyghe, Jeroen R. ; Jenkins, Mark A. ; Jordahl, Kristina M. ; Joshi, Amit D. ; Keku, Temitope O. ; Kawaguchi, Eric ; Kim, Andre E. ; Kundaje, Anshul ; Larsson, Susanna C. ; Marchand, Loïc Le ; Lewinger, Juan Pablo ; Li, Li ; Moreno, Víctor ; Morrison, John ; Murphy, Neil ; Nan, Hongmei ; Nassir, Rami ; Newcomb, Polly A. ; Obón-Santacana, Mireia ; Ogino, Shuji ; Ose, Jennifer ; Pardamean, Bens ; Pellatt, Andrew J. ; Peoples, Anita R. ; Platz, Elizabeth A. ; Potter, John D. ; Prentice, Ross L. ; Rennert, Gad ; Ruiz-Narváez, Edward A. ; Sakoda, Lori C. ; Schoen, Robert E. ; Shcherbina, Anna ; Stern, Mariana C. ; Su, Yu-Ru ; Thibodeau, Stephen N. ; Thomas, Duncan C. ; Tsilidis, Konstantinos K. ; van Duijnhoven, Fränzel J. B. ; Van Guelpen, Bethany ; Visvanathan, Kala ; White, Emily ; Wolk, Alicja ; Woods, Michael O. ; Wu, Anna H. ; Peters, Ulrike ; Gauderman, W. James ; Hsu, Li ; Chang-Claude, Jenny

Background: Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC risk prediction and MHT risk-benefit assessment, we aimed to evaluate the joint association of a polygenic risk score (PRS) for CRC and MHT on CRC risk. Methods: We used data from 28,486 postmenopausal women (11,519 cases and 16,967 controls) of European descent. A PRS based on 141 CRC-associated genetic variants was modeled [...]

Menée à partir de données des cohortes américaines "the Nurses’ Health Studies" portant sur 185 181 femmes, cette étude analyse l'association entre une utilisation de metformine ou d'autres médicaments antidiabétiques et l'incidence du cancer du sein (9 192 cas)

Metformin and other anti-diabetic medication use and breast cancer incidence in the Nurses' Health Studies

Wang, Tengteng ; Chai, Boyang ; Chen, Wendy Y. ; Holmes, Michelle D. ; Erdrich, Jennifer ; Hu, Frank B. ; Rosner, Bernard A. ; Tamimi, Rulla M. ; Willett, Walter C. ; Kang, Jae H. ; Eliassen, A. Heather

We aimed to examine the association between the use of metformin and other anti-diabetic medications and breast cancer incidence within two large prospective cohort studies. We followed 185,181 women who participated in the Nurses' Health Study (NHS; 1994–2016) and the NHSII (1995–2017), with baseline corresponding to the date metformin was approved for type 2 diabetes (T2D) treatment in the US Information on T2D diagnosis, anti-diabetes medications, and other covariates was self-reported at [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données génomiques portant sur des patients atteints d'une maladie inflammatoire de l'intestin (MICI), de la maladie de Crohn ou d'une colite ulcéreuse, cette méta-analyse évalue l'association entre ces maladies et le risque de cancer

Association between inflammatory bowel disease and cancer risk: evidence triangulation from genetic correlation, Mendelian randomization, and colocalization analyses across East Asian and European populations

Liu, Di ; Cao, Meiling ; Wang, Haotian ; Cao, Weijie ; Zheng, Chenguang ; Li, Yun ; Wang, Youxin

Background: Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have been inconsistent and may face the bias of confounding and reverse causality. The potential causal relationships between IBD and the risk of cancers remain largely unclear. Methods: We performed genome-wide linkage disequilibrium score regression (LDSC), standard two-sample [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données européennes portant sur 400 210 personnes, 3 254 témoins et 1 627 patients atteints d'un neuroblastome, cette étude analyse l'association entre le niveau sanguin de globuline de liaison des hormones sexuelles et le risque de développer la maladie, en fonction du sexe

Causal relationship between sex hormone-binding globulin and risk of neuroblastoma: A bidirectional two-sample Mendelian randomization study

Wu, Han ; Ding, Miao ; Zhu, Jiabei ; Mao, Siwei ; Tang, Xiaochen ; Fang, Sijia ; Liu, Li ; Pan, Qiuhui ; Yue, Chaoyan

Background: The causal relationship between sex hormone-binding globulin (SHBG) and neuroblastoma (NB) remains unknown. This study aimed to explore the causality between SHBG and the risk of NB using bidirectional two-sample Mendelian randomization (MR) study. Methods: Instrumental variables associated with SHBG were obtained from the genome-wide association study (GWAS) of European containing 214,989 females and 185,221 males from the UK Biobank. Summary-level data for NB were derived from the [...]

Menée à l'aide de données de 29 études portant au total sur 42 239 témoins et 15 631 patientes atteintes d'un cancer de l'endomètre, cette étude analyse l'association entre une hypertension et le risque de développer la maladie

Hypertension and risk of endometrial cancer: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Habeshian, Talar S. ; Peeri, Noah C. ; De Vivo, Immaculata ; Schouten, Leo J. ; Shu, Xiao-Ou ; Coté, Michele L. ; Bertrand, Kimberly A. ; Chen, Yu ; Clarke, Megan A. ; Clendenen, Tess V. ; Cook, Linda S. ; Costas, Laura ; Dal Maso, Luigino ; Freudenheim, Jo L. ; Friedenreich, Christine M. ; Gallagher, Grace ; Gierach, Gretchen L. ; Goodman, Marc T. ; Jordan, Susan J. ; La Vecchia, Carlo ; Lacey, James V. ; Levi, Fabio ; Liao, Linda M. ; Lipworth, Loren ; Lu, Lingeng ; Matias-Guiu, Xavier ; Moysich, Kirsten B. ; Mutter, George L. ; Na, Renhua ; Naduparambil, Jeffin ; Negri, Eva ; O'Connell, Kelli ; O'Mara, Tracy A. ; Onieva Hernández, Irene ; Palmer, Julie R. ; Parazzini, Fabio ; Patel, Alpa V. ; Penney, Kathryn L. ; Prizment, Anna E. ; Ricceri, Fulvio ; Risch, Harvey A. ; Sacerdote, Carlotta ; Sandin, Sven ; Stolzenberg-Solomon, Rachael Z. ; van den Brandt, Piet A. ; Webb, Penelope M. ; Wentzensen, Nicolas ; Wijayabahu, Akemi T. ; Wilkens, Lynne R. ; Xu, Wanghong ; Yu, Herbert ; Zeleniuch-Jacquotte, Anne ; Zheng, Wei ; Du, Mengmeng ; Setiawan, Veronica Wendy.

Background: The incidence rates of endometrial cancer (EC) are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for EC. Hypertension, another component of metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it may be associated with the development of certain cancers. The role of hypertension independent of other components of metabolic syndrome in the etiology of EC remains unclear. In this study we [...]