Menée aux Etats-Unis à partir de données portant sur 12 340 patients ayant survécu au moins 5 ans à un cancer pédiatrique (âge moyen : 39 ans) et sur 2 395 témoins (âge moyen : 44,6 ans), cette étude de cohorte identifie les facteurs associés au risque de troubles du sommeil

Mechanisms of sleep disturbances in Long-Term cancer survivors: a childhood cancer survivor study report

Daniel, Lauren C ; Wang, Huiqi ; Brinkman, Tara M ; Ruble, Kathy ; Zhou, Eric S ; Palesh, Oxana ; Stremler, Robyn ; Howell, Rebecca ; Mulrooney, Daniel A ; Crabtree, Valerie M ; Mostoufi-Moab, Sogol ; Oeffinger, Kevin ; Neglia, Joseph ; Yasui, Yutaka ; Armstrong, Gregory T ; Krull, Kevin

Background: Sleep problems following childhood cancer treatment may persist into adulthood, exacerbating cancer-related late effects and putting survivors at risk for poor physical and psychosocial functioning. This study examines sleep in long-term survivors and their siblings to identify risk factors and disease correlates. Methods: Childhood cancer survivors (≥5 years from diagnosis; n = 12,340; 51.5% female; mean[SD] age = 39.4[9.6] years) and siblings (n = 2395; 57.1% female; [...]

A partir d'une revue systématique de la littérature (12 essais, 423 patients), cette méta-analyse évalue l'intérêt, pendant la phase de traitement et de réadaptation, des interventions comportant de l'activité physique pour réduire la fatigue, améliorer les capacités physiques (endurance, force musculaire, mobilité fonctionnelle, etc) et la qualité de vie des enfants atteints d'une leucémie lymphoblastique aiguë

Efficacy of physical exercise intervention on children with acute lymphoblastic leukemia during treatment and rehabilitation: a systematic review and meta-analysis

Liu, Hengxu ; Yin, Jingqi ; Wang, Kun ; Liu, Shiqi ; Yang, Yi ; Song, Ziyi ; Dong, Caiyun ; Zhang, Tingran ; Luo, Jiong

Objective: To systematically evaluate the impact of physical exercise intervention on children with acute lymphoblastic leukemia (ALL) during the treatment and rehabilitation consolidation periods. Method: Randomized controlled trials (RCTs) were retrieved from PubMed, Scopus, Web of Science, CNKI, and Cochrane databases, with a search time range from database establishment to September 1, 2023. The quality of the included RCTs was evaluated using the Cochrane risk assessment tool, and a [...]

A partir d'une revue systématique de la littérature (21 études, 824 patientes), cette méta-analyse évalue l'efficacité, du point de vue du taux de réponse complète dans les 12 mois et du taux de grossesse, d'une contraception par progestatif oral et d'un dispositif intra-utérin libérant du lévonorgestrel chez les femmes en âge de procréer et présentant des néoplasies intraépithéliales de l'endomètre

Levonorgestrel-releasing intrauterine device therapy versus oral progestin treatment for Reproductive-Aged patients with endometrial intraepithelial neoplasia: a systematic review and Meta-Analysis

Suzuki, Yukio ; Ferris, Jennifer S ; Chen, Ling ; Dioun, Shayan ; Usseglio, John ; Matsuo, Koji ; Xu, Xiao ; Hershman, Dawn L ; Wright, Jason D

Background: We conducted a systematic review and meta-analysis to examine outcomes of patients with endometrial intraepithelial neoplasia (EIN) treated with oral progestins or levonorgestrel-releasing intrauterine device (LNG-IUD). Methods: We conducted a systematic review across five databases to examine outcomes of progestational treatment (oral progestins or LNG-IUD) for patients with EIN. The primary outcome was the best complete response (CR) rate within twelve months of primary [...]

Menée au Royaume-Uni à partir de données 2016-2020 portant sur 119 patientes atteintes d'un cancer diagnostiqué pendant leur grossesse (âge médian au diagnostic : 33 ans), cette étude de cohorte rétrospective analyse les traitements reçus, l'issue des grossesses et la mortalité maternelle

CAnceR IN PreGnancy (CARING) – a retrospective study of cancer diagnosed during pregnancy in the United Kingdom

Baxter, M. A. ; Denholm, M. ; Kingdon, S. J. ; Kathirgamakarthigeyan, S. ; Parikh, S. ; Shakir, R. ; Johnson, R. ; Martin, H. ; Walton, M. ; Yao, W. ; Swan, A. ; Samuelson, C. ; Ren, X. ; Cooper, A. ; Gray, H. L. ; Clifton, S. ; Ball, J. ; Gullick, G. ; Anderson, M. ; Dodd, L. ; Hayhurst, H. ; Salama, M. ; Shotton, R. ; Britton, F. ; Christodoulou, T. ; Abdul-Hamid, A. ; Eichholz, A. ; Evans, R. M. ; Wallroth, P. ; Gibson, F. ; Poole, K. ; Rowe, M. ; Harris, J. ; National Oncology Trainees Collaborative for Healthcare, Research

Background: The incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population. Methods: In this retrospective study we report data from 119 patients diagnosed with cancer during pregnancy from 14 cancer centres in the UK across a five-year period (2016-2020). Results: Median age at diagnosis was 33 years, with breast, skin and haematological the most common [...]

Menée aux Etats-Unis à partir de données portant sur 1 836 adolescents et jeunes adultes décédés d'un cancer entre 2009 et 2019, cette étude de cohorte rétrospective analyse l'utilisation de thérapies ciblées, d'immunothérapies et de chimiothérapies dans les 90 derniers jours de vie

Use of Cancer-Directed therapy at the end of life among adolescents and young adults

Mack, Jennifer W ; Cernik, Colin ; Xu, Lanfang ; Laurent, Cecile A ; Fisher, Lauren ; Cannizzaro, Nancy ; Munneke, Julie ; Cooper, Robert M ; Lakin, Joshua R ; Schwartz, Corey M ; Casperson, Mallory ; Altschuler, Andrea ; Wiener, Lori ; Kushi, Lawrence H ; Chao, Chun R ; Uno, Hajime

Background: Adolescents and young adults (AYAs) frequently receive chemotherapy near death. We know less about use of targeted agents and immunotherapy or trends over time. Methods: We conducted a retrospective cohort study of 1,836 AYAs with cancer who died between 2009-2019 after receiving care at one of three sites (Dana-Farber Cancer Institute, Kaiser Permanente Northern California, and Kaiser Permanente Southern California). We reviewed electronic health data and medical records to examine [...]

A partir d'une revue systématique de la littérature (16 études), cette étude analyse, chez les patients atteints d'un cancer, la prévalence d'une dysesthésie buccale en lien avec les traitements reçus (radiothérapie, chimiothérapie et chimioradiothérapie)

Burning mouth in oncology care: a systematic review

Normando, Ana Gabriela Costa ; Santos-Silva, Alan Roger ; Epstein, Joel B.

Burning mouth, also referred to as oral dysesthesia, is an underreported condition among cancer patients that may represent an early symptom of cancer or an adverse effect of treatment. This review sought to characterize this symptom in oncology care where burning symptoms may occur. A systematic review of the literature was performed based on the PRISMA statement, and the protocol was registered at PROSPERO database. A structured search was done using eight databases. The process of study [...]

Menée à partir de données asiatiques, américaines et britanniques portant sur 33 793 patients atteints d'un cancer du poumon et n'ayant jamais fumé, cette étude analyse l'âge au diagnostic en fonction du sexe, de l'origine ethnique et du sous-type histologique de la maladie

Age at lung cancer diagnosis in females versus males who never smoke by race and ethnicity

Blechter, Batel ; Wong, Jason Y. Y. ; Chien, Li-Hsin ; Shiraishi, Kouya ; Shu, Xiao-Ou ; Cai, Qiuyin ; Zheng, Wei ; Ji, Bu-Tian ; Hu, Wei ; Rahman, Mohammad L. ; Jiang, Hsin-Fang ; Tsai, Fang-Yu ; Huang, Wen-Yi ; Gao, Yu-Tang ; Han, Xijing ; Steinwandel, Mark D. ; Yang, Gong ; Daida, Yihe G. ; Liang, Su-Ying ; Gomez, Scarlett L. ; DeRouen, Mindy C. ; Diver, W. Ryan ; Reddy, Ananya G. ; Patel, Alpa V. ; Le Marchand, Loic ; Haiman, Christopher ; Kohno, Takashi ; Cheng, Iona ; Chang, I. Shou ; Hsiung, Chao Agnes ; Rothman, Nathaniel ; Lan, Qing

Background : We characterized age at diagnosis and estimated sex differences for lung cancer and its histological subtypes among individuals who never smoke. Methods: We analyzed the distribution of age at lung cancer diagnosis in 33,793 individuals across 8 cohort studies and two national registries from East Asia, the United States (US) and the United Kingdom (UK). Student’s t-tests were used to assess the study population differences (  [...]

Menée à Singapour à partir de données portant sur 9 803 patients ayant survécu à un cancer de la tête et du cou (âge médian au diagnostic : 58 ans), cette étude transversale identifie les facteurs associés au risque d'accident vasculaire cérébral

Stroke Risk in Survivors of Head and Neck Cancer

Yip, Pui Lam ; Zheng, Huili ; Cheo, Timothy ; Tan, Teng Hwee ; Lee, Shing Fung ; Leong, Yiat Horng ; Wong, Lea Choung ; Tey, Jeremy ; Ho, Francis ; Soon, Yu Yang

Importance : Survivors of head and neck cancers (HNC) have increased risk of stroke. A comprehensive report using standardized methods is warranted to characterize the risk and to inform on survivorship strategy. Objective : To determine the stroke risk in subpopulations of survivors of HNC in Singapore. Design, Setting, and Participants : This national, registry-based, cross-sectional study aimed to estimate stroke risk in subgroups of the HNC population between January 2005 and December 2020. [...]

Menée par questionnaire auprès de 141 patients atteints d'un cancer du poumon traité par inihibiteurs de point de contrôle immunitaire, cette étude transversale analyse l'association entre leurs perceptions de la maladie, leurs besoins en soins de support et le soutien social

Comprehensive needs, social support, and disease perception in lung cancer patients treated with immune checkpoint inhibitors: a cross-sectional study

Luo, Xiaoyan ; Zhang, Ningning ; Guo, Lingru ; Zhou, Li ; Jiang, Haiying ; Cui, Ren-Shan

Purpose: The aim of this study was to investigate the comprehensive needs of lung cancer patients treated with immune checkpoint inhibitors and to explore the relationships between comprehensive needs and social support and disease perception, moreover, to analyse associated factors of comprehensive needs. Methods: The study was conducted in a teaching hospital in Jiaxing Province, China. A total of 141 patients with lung cancer completed a battery of self-report questionnaires, including the [...]

Menée aux Etats-Unis à partir de données portant sur 713 patients ayant survécu à un rhabdomyosarcome pédiatrique (âge moyen : 30,5 ans) et sur 706 témoins, cette étude identifie les facteurs associés au risque de déficience neurocognitive et de détresse psychique

Risk factors for neurocognitive impairment, emotional distress, and poor quality of life in survivors of pediatric rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study

van der Plas, Ellen ; Darji, Himani ; Srivastava, Deo K. ; Schapiro, Melissa ; Jeffe, Donna ; Perkins, Stephanie ; Howell, Rebecca ; Leisenring, Wendy ; Armstrong, Gregory T. ; Oeffinger, Kevin ; Krull, Kevin ; Edelstein, Kim ; Hayashi, Robert J.

Background: Prevalence and risk of poor psychological outcomes following rhabdomyosarcoma (RMS) are not well-established. Methods: Participants in this cross-sectional, case-control study (n = 713 survivors, 42.5% female; mean [SD] age, 30.5 [6.6] years; n = 706 siblings, 57.2% female; mean age, 32.8,[7.9] years) completed measures of neurocognition, emotional distress, and health-related quality of life (HRQOL). Multivariable logistic regression models identified treatments, health behaviors, [...]

Menée aux Etats-Unis à partir de données portant sur 4 089 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre la charge allostatique, le dynamisme socioéconomique du lieu de vie (transports, emploi, écoles, environnement, etc.) et la mortalité toutes causes confondues

Association Between Neighborhood Opportunity, Allostatic Load, and All-Cause Mortality in Patients With Breast Cancer

J.C. Chen ; Mohamed I. Elsaid ; Demond Handley ; Jesse J. Plascak ; Barbara L. Andersen ; William E. Carson ; Timothy M. Pawlik ; Naleef Fareed ; Samilia Obeng-Gyasi

PURPOSE: Adverse neighborhood contextual factors may affect breast cancer outcomes through environmental, psychosocial, and biological pathways. The objective of this study is to examine the relationship between allostatic load (AL), neighborhood opportunity, and all-cause mortality among patients with breast cancer. METHODS: Women age 18 years and older with newly diagnosed stage I-III breast cancer who received surgical treatment between January 1, 2012, and December 31, 2020, at a National [...]

Menée dans un contexte américain, cette étude analyse l'association entre les coûts liés au logement et la mortalité prématurée par cancer (avant 65 ans) en fonction de la couverture médicale Medicaid

Severe housing cost burden and premature mortality from cancer: Unaffordable housing and premature cancer mortality

Lawrence, Wayne R ; Freedman, Neal D ; McGee-Avila, Jennifer K ; Mason, Lee ; Chen, Yingxi ; Ewing, Aldenise P ; Shiels, Meredith S

Unaffordable housing has been associated with poor health. We investigated the relationship between severe housing cost burden(SHCB) and premature cancer mortality (death <65 years) overall and by Medicaid expansion status. County-level SHCB was measured by percentage of households that spend ≥50% of their income on housing. States were classified based on Medicaid expansion status (expanded, late-expanded, non-expanded). Adjusted-mortality rate ratios (aRRs) were estimated by cancer type [...]

Menée au Canada à partir de données portant sur 54 628 atteints d'un cancer de stade avancé, cette étude évalue l'intérêt d'un outil utilisant un système d'apprentissage automatique pour accroître l'accès précoce à des consultations en soins palliatifs pendant la phase des traitements

Machine Learning to Allocate Palliative Care Consultations During Cancer Treatment

Jiang Chen He ; Gordon Taylor Moffat ; Sho Podolsky ; Ferhana Khan ; Ning Liu ; Nathan Taback ; Steven Gallinger ; Breffni Hannon ; Monika K. Krzyzanowska ; Marzyeh Ghassemi ; Kelvin K.W. Chan ; Robert C. Grant

PURPOSE: For patients with advanced cancer, early consultations with palliative care (PC) specialists reduce costs, improve quality of life, and prolong survival. However, capacity limitations prevent all patients from receiving PC shortly after diagnosis. We evaluated whether a prognostic machine learning system could promote early PC, given existing capacity. METHODS: Using population-level administrative data in Ontario, Canada, we assembled a cohort of patients with incurable cancer who [...]