Menée à l'aide de données de la "UK Biobank" portant sur 259 435 femmes, cette étude analyse l'influence du niveau d'inflammation systémique sur l'association entre un mode de vie sain et le risque de cancer du sein (8 889 cas)

Healthy lifestyles, systemic inflammation and breast cancer risk: a mediation analysis

Zhang, Yanyu ; Song, Mengjie ; Yang, Zixuan ; Huang, Xiaoxi ; Lin, Yuxiang ; Yang, Haomin

Background: Despite the known association between healthy lifestyles and reduced risk of breast cancer, it remains unclear whether systemic inflammation, as a consequence of unhealthy lifestyles, may mediate the association. Methods: A cohort study of 259,435 female participants in the UK Biobank was conducted to estimate hazard ratio (HR) for breast cancer according to 9 inflammation markers using Cox regression models. We further estimated the percentage of total association between healthy [...]

A partir d'une revue systématique de la littérature publiée entre 1987 et 2023 (40 études), cette méta-analyse évalue l'association entre une exposition professionnelle à la silice cristalline et le risque de cancer gastro-intestinal

Occupational exposure to silica and risk of gastrointestinal cancers: a systematic review and meta-analysis of cohort studies

Shao, Jiyuan ; Fu, Pengfei ; Wang, Shengchun ; Cheng, Hong ; Zhang, Xin

Background: Although silica is a proven lung carcinogen, there is no convincing evidence linking crystalline silica to gastrointestinal malignancies. Methods: We detailedly searched studies on the link between gastrointestinal malignancies and occupational silica exposure. Studies published between 1987 and 2023 were found by searching PubMed, Scopus, Cochrane Library, and Web of Science databases. Further studies were included from reference searching. We conducted a meta-analysis of the [...]

Menée à l'aide d'une matrice emploi-exposition et de données portant sur 1 408 témoins et 1 182 patients atteints d'un cancer de la vessie, cette étude analyse l'association entre une exposition professionnelle aux solvants et le risque de développer la maladie

Occupational exposure to organic solvents and risk of bladder cancer

Xie, Shuai ; Friesen, Melissa C. ; Baris, Dalsu ; Schwenn, Molly ; Rothman, Nathaniel ; Johnson, Alison ; Karagas, Margaret R. ; Silverman, Debra T. ; Koutros, Stella

Background: Bladder cancer has been linked to several occupations that involve the use of solvents, including those used in the dry-cleaning industry. Objectives: We evaluated exposure to solvents and risk of bladder cancer in 1182 incident cases and 1408 controls from a population-based study. Methods: Exposure to solvents was quantitatively assessed using a job-exposure matrix (CANJEM). Exposure to benzene, toluene and xylene often co-occur. Therefore, we created two additional sets of [...]

Menée à l'aide de données portant sur 2 894 patients, cette étude analyse les facteurs génétiques et environnementaux associés au risque de développer plusieurs cancers primitifs (au moins 3 cancers, 31 cas)

Triple Primary Cancers: An Analysis of Genetic and Environmental Factors

Borja, Nicholas A. ; Silva-Smith, Rachel ; Calfa, Carmen ; Sussman, Daniel A. ; Tekin, Mustafa

The occurrence of multiple primary cancers (MPC) is thought to reflect increased cancer susceptibility in patients due to a combination of genetic and environmental factors. Here we conducted a retrospective review of 2,894 consecutive patients evaluated at a single institution and identified 31 (1.14%) individuals with a history of three or more primary cancers, then analyzed the genetic and environmental influences associated with their propensity for developing malignancies. We found that [...]

Menée à partir d'échantillons sanguins collectés auprès de 7 236 adultes, cette étude analyse l'association entre les concentrations de 7 métaux lourds (cadmium, manganèse, plomb, mercure, sélénium, cuivre et zinc) et le risque de maladie comme le cancer

Associations between patterns of blood heavy metal exposure and health outcomes: insights from NHANES 2011–2016

Wang, Xiangyu ; Han, Xinhao ; GUO, Shufang ; Ma, Yujie ; ZHANG, Yafeng

Background: Extensive research has explored the association between heavy metal exposure and various health outcomes, including malignant neoplasms, hypertension, diabetes, and heart diseases. This study aimed to investigate the relationship between patterns of exposure to a mixture of seven heavy metals and these health outcomes. Methods: Blood samples from 7,236 adults in the NHANES 2011–2016 studies were analyzed for levels of cadmium, manganese, lead, mercury, selenium, copper, and zinc. [...]

Menée au Texas à partir de données 1995-2011 portant sur 109 762 témoins et 6 101 patients atteints d'un cancer pédiatrique (âge : 0-16 ans), cette étude analyse l'association entre une exposition aux particules fines (PM2,5), l'indice de végétation et le risque de développer la maladie

PM2.5, vegetation density, and childhood cancer: a case-control registry-based study from Texas 1995-2011

Williams, Lindsay A ; Haynes, David ; Sample, Jeannette M ; Lu, Zhanni ; Hossaini, Ali ; McGuinn, Laura A ; Hoang, Thanh T ; Lupo, Philip J ; Scheurer, Michael E

Air pollution is positively associated with some childhood cancers while greenness is inversely associated with some adult cancers. The interplay between air pollution and greenness in childhood cancer etiology is unclear. We estimated the association between early life air pollution and greenness exposure and childhood cancer in Texas (1995-2011).We included 6,101 cancer cases and 109,762 controls (aged 0-16 years). We linked residential birth address to census tract annual average particulate [...]

Menée à Los Angeles auprès d'une cohorte multi-ethnique de 71 387 personnes (durée moyenne de suivi : 16,4 ans), cette étude analyse l'association entre une exposition à long terme aux particules ultra-fines liées aux aéroports et le risque de cancer du poumon

Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study

Bookstein, Arthur ; Po, Justine ; Tseng, Chiuchen ; Larson, Timothy V. ; Yang, Juan ; Park, Sung-shim L. ; Wu, Jun ; Shariff-Marco, Salma ; Inamdar, Pushkar P. ; Ihenacho, Ugonna ; Setiawan, Veronica Wendy. ; DeRouen, Mindy C. ; Le Marchand, Loic ; Stram, Daniel O. ; Samet, Jonathan ; Ritz, Beate ; Fruin, Scott ; Wu, Anna H. ; Cheng, Iona

Background: Ultrafine particles (UFPs) are unregulated air pollutants abundant in aviation exhaust. Emerging evidence suggests that UFPs may impact lung health due to their high surface area-to-mass ratio and deep penetration into airways. This study aimed to assess long-term exposure to airport-related UFPs and lung cancer incidence in a multiethnic population in Los Angeles County. Methods: Within the California Multiethnic Cohort, we examined the association between long-term exposure to [...]

Menée à partir de données 1992-2016 des registres américains des cancers portant sur les personnes âgées de 30 à 49 ans, cette étude identifie les facteurs environnementaux susceptibles d'être à l'origine de l'augmentation de l'incidence du cancer colorectal de survenue précoce

Environmental drivers of the rising incidence of early-onset colorectal cancer in the United States

Chen, Jianjiu ; Terry, Mary Beth ; Dalerba, Piero ; Hur, Chin ; Hu, Jianhua ; Yang, Wan

Incidence of early-onset (diagnosed before age 50) colorectal cancer (EOCRC) has increased alarmingly since the 1990s in the United States. This study investigated what environmental exposures may have driven this increase. We obtained EOCRC incidence data from the Surveillance, Epidemiology, and End Results Program, and data for 11 exposures, for example, body mass index (BMI), from long-term national surveys. We aggregated these data for 30 to 49-year-olds during 1992 to 2016 by population [...]

A partir d'une revue systématique de la littérature publiée jusqu'en août 2023 (13 études, 58 006 patients), cette méta-analyse évalue l'association entre une infection par le virus de l'hépatite B et le risque de cancer de la tête et du cou

The association of HBV infection and head and neck cancer: a systematic review and meta-analysis

Tan, Rukeng ; Zhu, Xinyu ; Sun, Yutong ; Yang, Shihao ; Peng, Chao ; Feng, Xinkai ; Chen, Zengyu ; Yimamu, Yiliyaer ; Liao, Guiqing ; Yang, Le

Background: Hepatitis B virus (HBV) infections is an important public health problem worldwide and closely affect extrahepatic cancer. Several recent studies have investigated the relationship between HBV infection and head and neck cancer (HNC), but their findings were inconsistent.In order to address the limitations of small sample sizes, we conducted a meta-analysis to assess the association between HBV and HNC. Methods: We systematically searched PubMed, Web of Science, Embase, Scopus, [...]

Menée aux Pays-Bas auprès de 1 964 femmes ayant survécu 5 ans à un lymphome de Hodgkin (âge lors du traitement : 15-50 ans ; durée médiane de suivi : 21,6 ans), cette étude analyse l'association entre un traitement à base de doxorubicine et le risque de cancer du sein (252 cas)

Doxorubicin Exposure and Breast Cancer Risk in Survivors of Adolescent and Adult Hodgkin Lymphoma

Neppelenbroek, Suzanne I. M. ; Geurts, Yvonne M. ; Aleman, Berthe M. P. ; Lugtenburg, Pieternella J. ; Rademakers, Saskia E. ; de Weijer, Roel J. ; Schippers, Maaike G. A. ; Ta, Bastiaan D. P. ; Plattel, Wouter J. ; Zijlstra, Josée M. ; van der Maazen, Richard W. M. ; Nijziel, Marten R. ; Ong, Francisca ; Schimmel, Erik C. ; Posthuma, Eduardus F. M. ; Kersten, Marie Jose ; Böhmer, Lara H. ; Muller, Karin ; Koene, Harry R. ; te Boome, Liane C. J. ; Bilgin, Yavuz M. ; de Jongh, Eva ; Janus, Cécile P. M. ; van Leeuwen, Flora E. ; Schaapveld, Michael

PURPOSE: Female Hodgkin lymphoma (HL) survivors treated with chest radiotherapy (RT) at a young age have a strongly increased risk of breast cancer (BC). Studies in childhood cancer survivors have shown that doxorubicin exposure may also increase BC risk. Although doxorubicin is the cornerstone of HL chemotherapy, the association between doxorubicin and BC risk has not been examined in HL survivors treated at adult ages. METHODS: We assessed BC risk in a cohort of 1,964 female 5-year HL [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2023 (12 études, 31 055 patients), cette méta-analyse évalue l'association entre les taux sériques de cholestérol total, de triglycérides, de lipoprotéines de haute ou basse densité et le risque de cancer du foie

Association between blood lipid levels and the risk of liver cancer: a systematic review and meta-analysis

Zhang, Zhihui ; Xu, Shicong ; Song, Meixuan ; Huang, Weirong ; Yan, Manlin ; Li, Xianrong

Purpose: The association between blood lipid levels and the risk of developing liver cancer remains a subject of ongoing debate. To elucidate this association, we conducted a meta-analysis by systematically incorporating data from all relevant prospective cohort studies. Methods: We conducted a systematic search of the PubMed, Embase, Web of Science, and Cochrane Library databases covering studies published from database inception through July 2023. This study included prospective cohort [...]

Menée à l'aide de données portant sur 308 949 femmes asiatiques (durée moyenne de suivi : 16,4 ans), cette étude analyse l'association entre des facteurs reproductifs et le risque de cancer du poumon (3 119 cas)

Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia cohort consortium

Yin, Xin ; Kishida, Rie ; Abe, Sarah Krull ; Islam, Md. Rashedul ; Rahman, Md. Shafiur ; Saito, Eiko ; Lan, Qing ; Blechter, Batel ; Merritt, Melissa ; Choi, Ji-Yeob ; Shin, Aesun ; Katagiri, Ryoko ; Shu, Xiao-Ou ; Sawada, Norie ; Tamakoshi, Akiko ; Koh, Woon-Puay ; Tsuji, Ichiro ; Nagata, Chisato ; Park, Sue K. ; Kweon, Sun-Seog ; Gao, Yu-Tang ; Tsugane, Shoichiro ; Kimura, Takashi ; Yuan, Jian-Min ; Lu, Yukai ; Kanemura, Seiki ; Sugawara, Yumi ; Wada, Keiko ; Shin, Min-Ho ; Ahsan, Habibul ; Boffetta, Paolo ; Chia, Kee Seng ; Matsuo, Keitaro ; Qiao, You-Lin ; Rothman, Nathaniel ; Zheng, Wei ; Inoue, Manami ; Kang, Daehee ; Seow, Wei Jie

Previous studies have investigated the association between reproductive factors and lung cancer risk; however, findings have been inconsistent. In order to assess this association among Asian women, a total of 308,949 female participants from 11 prospective cohorts and four Asian countries (Japan, Korea, China, and Singapore) were included. Cox proportional hazards regression models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CIs). A total of 3,119 primary lung [...]

Menée en Chine sur la période 2011-2020 auprès de 43 516 personnes, cette étude analyse l'association entre un syndrome métabolique et le risque de cancer colorectal en fonction du sexe

Association between metabolic syndrome and the risk of colorectal cancer: a prospective study in China

Wang, zhongge ; Chen, Ruirui ; Zhang, Lizhen ; Chen, Yarong ; Li, Jing ; Li, Siyu ; Xu, Lulu ; Hu, Yujia ; Bai, Yana

Objective: To evaluate the correlation between metabolic syndrome (MetS) and its components on the incidence of colorectal cancer (CRC) based on data from Jinchang Cohort. Methods: This is a large prospective cohort study. Between 2011 and 2020, a total of 43 516 individuals from Jinchang Cohort were included for this study. Hazard ratios (HRs) with 95% confidence intervals (CIs) for CRC according to MetS were calculated with the Cox proportional hazard models. The restricted cubic spine models [...]

Menée à partir de données australiennes portant sur 1 208 femmes, cette étude analyse l'association entre les concentrations plasmatiques des hormones stéroïdes sexuelles et le risque de cancer du sein ER+ chez les femmes ménopausées

Sex-steroid hormones and risk of postmenopausal estrogen receptor-positive breast cancer: a case–cohort analysis

Albers, Frances E. M. ; Lou, Makayla W. C. ; Dashti, S. Ghazaleh ; Swain, Christopher T. V. ; Rinaldi, Sabina ; Viallon, Vivian ; Karahalios, Amalia ; Brown, Kristy A. ; Gunter, Marc J. ; Milne, Roger L. ; English, Dallas R. ; Lynch, Brigid M.

Purpose: Sex-steroid hormones are associated with postmenopausal breast cancer but potential confounding from other biological pathways is rarely considered. We estimated risk ratios for sex-steroid hormone biomarkers in relation to postmenopausal estrogen receptor (ER)-positive breast cancer, while accounting for biomarkers from insulin/insulin-like growth factor-signaling and inflammatory pathways. Methods: This analysis included 1208 women from a case–cohort study of postmenopausal breast [...]

Menée à l'aide de données portant sur 609 880 femmes (âge : 45-55 ans ; durée médiane de suivi : 5 ans), cette étude analyse l'association entre un indice de masse corporelle élevé et le risque de cancer du sein en fonction de l'âge et du statut ménopausique

BMI and breast cancer risk around age at menopause

Von Holle, Ann ; Adami, Hans-Olov ; Baglietto, Laura ; Berrington, Amy ; Bertrand, Kimberly A. ; Blot, William ; Chen, Yu ; DeHart, Jessica Clague ; Dossus, Laure ; Eliassen, A. Heather ; Fournier, Agnès ; Garcia-Closas, Montse ; Giles, Graham ; Guevara, Marcela ; Hankinson, Susan E. ; Heath, Alicia ; Jones, Michael E. ; Joshu, Corinne E. ; Kaaks, Rudolf ; Kirsh, Victoria A. ; Kitahara, Cari M. ; Koh, Woon-Puay ; Linet, Martha S. ; Park, Hannah Lui ; Masala, Giovanna ; Mellemkjaer, Lene ; Milne, Roger L. ; O'Brien, Katie M. ; Palmer, Julie R. ; Riboli, Elio ; Rohan, Thomas E. ; Shrubsole, Martha J. ; Sund, Malin ; Tamimi, Rulla ; Tin Tin, Sandar ; Visvanathan, Kala ; Vermeulen, Roel C. H. ; Weiderpass, Elisabete ; Willett, Walter C. ; Yuan, Jian-Min ; Zeleniuch-Jacquotte, Anne ; Nichols, Hazel B. ; Sandler, Dale P. ; Swerdlow, Anthony J. ; Schoemaker, Minouk J. ; Weinberg, Clarice R.

Background: A high body mass index (BMI, kg/m2) is associated with decreased risk of breast cancer before menopause, but increased risk after menopause. Exactly when this reversal occurs in relation to menopause is unclear. Locating that change point could provide insight into the role of adiposity in breast cancer etiology. Methods: We examined the association between BMI and breast cancer risk in the Premenopausal Breast Cancer Collaborative Group, from age 45 up to breast cancer diagnosis, [...]

Menée à l'aide de données de la cohorte européenne "EPIC" portant sur 706 témoins et 333 patients atteints d'un cancer différencié de la thyroïde, cette étude analyse l'association entre les taux sériques des hormones stéroïdes sexuelles ou de la globuline de liaison des hormones sexuelles et le risque de développer la maladie, en fonction du sexe et du statut ménopausique

Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women

Rinaldi, Sabina ; Dossus, Laure ; Keski-Rahkonen, Pekka ; Kiss, Agneta ; Navionis, Anne-Sophie ; Biessy, Carine ; Travis, Ruth ; Weiderpass, Elisabete ; Romieu, Isabelle ; Eriksen, Anne Kirstine ; Tjonneland, Anne ; Kvaskoff, Marina ; Canonico, Marianne ; Truong, Thérèse ; Katzke, Verena ; Kaaks, Rudolf ; Catalano, Alberto ; Panico, Salvatore ; Masala, Giovanna ; Tumino, Rosario ; Lukic, Marko ; Olsen, Karina Standahl ; Zamora-Ros, Raul ; Santiuste, Carmen ; Aizpurua Atxega, Amaia ; Guevara, Marcela ; Rodriguez-Barranco, Miguel ; Sandström, Maria ; Hennings, Joakim ; Almquist, Martin ; Aglago Kouassivi, Elom ; Christakoudi, Sofia ; Gunter, Marc ; Franceschi, Silvia

Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in [...]