Mené en Suisse sur 151 adultes ayant survécu à un cancer pédiatrique, cet essai randomisé évalue l'effet, sur leur fatigue et leur détresse psychique, d'une intervention comportant des exercices physiques et dispensée pendant 1 an

Effect of a 1-year physical activity intervention on quality of life, fatigue, and distress in adult childhood cancer survivors—A randomized controlled trial (SURfit)

Deng, Wei H. ; Zürcher, Simeon J. ; Schindera, Christina ; Jung, Ruedi ; Hebestreit, Helge ; Bänteli, Iris ; Bologna, Katja ; von der Weid, Nicolas X. ; Kriemler, Susi ; Rueegg, Corina S.

Introduction: Childhood cancer survivors (CCS) are at risk of experiencing lower quality-of-life, fatigue, and depression. Few randomized controlled trials have studied the effect of physical activity (PA) on these in adult long-term CCS. This study investigated the effect of a 1-year individualized PA intervention on health-related quality-of-life (HRQOL), fatigue, and distress symptoms in adult CCS. Methods: The SURfit trial randomized 151 CCS ≥16 years old, <16 at diagnosis and ≥5 years [...]

Menée aux Pays-Bas à partir de données portant sur 3 569 adultes ayant survécu à un cancer diagnostiqué entre l'âge de 18 et de 39 ans (1 457 hommes, 2 112 femmes ; âge moyen : 43 et 45 ans ; durée de suivi depuis le diagnostic : 5-22 ans), cette étude analyse leur utilisation de consultations liées à la préservation de la fertilité et leur recours à la cryopréservation et aux technologies de procréation assistée

Pre-treatment fertility preservation and post-treatment reproduction in long-term survivors of adolescent and young adult (AYA) cancer

Lehmann, Vicky ; Vlooswijk, Carla ; van der Graaf, Winette T. A. ; Bijlsma, Rhodé ; Kaal, Suzanne E. J. ; Kerst, Jan Martijn ; Tromp, Jacqueline M. ; Bos, Monique E. M. M. ; van der Hulle, Tom ; Lalisang, Roy I. ; Nuver, Janine ; Kouwenhoven, Mathilde C. M. ; Lok, Christianne A. R. ; Beerendonk, Catharina C. M. ; Dinkelman-Smit, Marij ; Husson, Olga

Purpose: To describe recall of fertility-related consultations and cryopreservation and to examine reproductive goals and reproduction post-treatment in long-term survivors of adolescent and young adult (AYA) (age, 18–39 years) cancer. Methods: This study included n = 1457 male and n = 2112 female long-term survivors (Mage = 43–45 years; 5–22 years from diagnosis) who provided self-report. Clinical data were supplied by the Netherlands Cancer Registry. Results: Most male survivors (72.7%) [...]

A partir d'une revue systématique de la littérature (121 études, 13 806 patients), cette méta-analyse évalue l'effet de l'activité physique sur la douleur des patients atteints d'un cancer ou ayant survécu à la maladie

Physical activity and pain in people with cancer: a systematic review and meta-analysis

Peters, Mitchell ; Butson, Grace ; Mizrahi, David ; Denehy, Linda ; Lynch, Brigid M. ; Swain, Christopher T. V.

Purpose: Physical activity can provide analgesic benefit but its effect on cancer-related pain is unclear. This review synthesised and appraised the evidence for the effect of physical activity on pain in people living with or beyond cancer. Methods: A systematic search of Ovid Medline and Embase was performed to identify randomised controlled trials (RCTs), randomised cross-over studies (RXTs), and prospective observational studies that examined physical activity and pain outcomes in adults [...]

Menée à partir de données portant sur 302 patients ayant survécu à une leucémie lymphoblastique aiguë pendant l'enfance et sur 256 témoins, cette étude de cohorte identife les facteurs affectant l'efficacité de leurs mouvements

Movement efficiency in survivors of childhood acute lymphoblastic leukemia: a report from the St. Jude lifetime cohort study

Onerup, Aron ; Mirzaei S, Sedigheh ; Wogksch, Matthew D. ; Goodenough, Chelsea G. ; Lambert, Genevieve ; Sapkota, Yadav ; Mulrooney, Daniel A. ; Hudson, Melissa M. ; Jacola, Lisa M. ; Ness, Kirsten K.

Purpose: Movement efficiency, a measure of neuromuscular biomechanics, may be modified by physical activity. We aimed to assess the risk of and risk factors for low movement efficiency in survivors of childhood acute lymphoblastic leukemia (ALL). Methods: Participants underwent an assessment of activity energy expenditure (AEE) with actigraphy, and the gold standard doubly labeled water, where the differences between elimination rates of oxygen and hydrogen from body water are evaluated over a [...]

A partir d'une revue systématique de la littérature (18 études), cette étude analyse l'utilisation, aux Etats-Unis, des tests génomiques chez les patients atteints d'un cancer du poumon, en fonction de l'origine ethnique

Racial and ethnic disparities in genomic testing among lung cancer patients: a systematic review

Meernik, Clare ; Raveendran, Yadurshini ; Kolarova, Michaela ; Rahman, Fariha ; Olunuga, Ebunoluwa ; Hammond, Emmery ; Shivaramakrishnan, Akhilesh ; Hendren, Steph ; Bosworth, Hayden B ; Check, Devon K ; Green, Michelle ; Strickler, John H ; Akinyemiju, Tomi

Introduction: Racial and ethnic disparities in genomic testing could exacerbate disparities in access to precision cancer therapies and survival—particularly in the context of lung cancer, where genomic testing has been recommended for the past decade. However, prior studies assessing disparities in genomic testing have yielded mixed results. Methods: We conducted a systemic review to examine racial and ethnic disparities in the use of genomic testing among lung cancer patients in the U.S. Two [...]

Menée à partir de données 1990-2019 portant sur 204 pays et territoires, cette étude estime la prévalence du cancer du poumon associé à une exposition domestique aux particules fines

Global burden of lung cancer attributable to household fine particulate matter pollution in 204 countries and territories, 1990-2019

Zhou, Run-Xuan ; Liao, Hong-Jin ; Hu, Jun-Jie ; Xiong, Hua ; Cai, Xiu-Yu ; Ye, Da-Wei

Introduction: Household Particulate matter (PM) air pollution is significantly associated with lung cancer. Nevertheless, the global burden of lung cancer attributable to household PM2.5 is still uncertain. Methods: In this study, data from the Global Burden and Disease Study (GBD) 2019 are used to thoroughly assess the burden of lung cancer associated with household PM2.5. Results: The number of deaths and disability-adjusted life years (DALYs) attributable to household PM2.5 was found to be [...]

Menée au Japon à partir de données portant sur 271 patients atteints d'un cancer de stade avancé et présentant des symptômes d'agitation et de délire, cette étude multicentrique prospective analyse l'efficacité de médicaments antipsychotiques

Effectiveness of antipsychotics for managing agitated delirium in patients with advanced cancer: a secondary analysis of a multicenter prospective observational study in Japan (Phase-R)

Kurisu, Ken ; Inada, Shuji ; Maeda, Isseki ; Nobata, Hiroyuki ; Ogawa, Asao ; Iwase, Satoru ; Uchida, Megumi ; Akechi, Tatsuo ; Amano, Koji ; Nakajima, Nobuhisa ; Morita, Tatsuya ; Sumitani, Masahiko ; Yoshiuchi, Kazuhiro

Purpose: Delirium is a common and serious comorbidity in patients with advanced cancer, necessitating effective management. Nonetheless, effective drugs for managing agitated delirium in patients with advanced cancer remain unclear in real-world settings. Thus, the present study aimed to explore an effective pharmacotherapy for this condition. Methods: We conducted a secondary analysis of a multicenter prospective observational study in Japan. The analysis included patients with advanced cancer [...]

A partir d'une revue systématique de la littérature (20 études, 1 440 patients), cette méta-analyse évalue l'effet d'une hormonothérapie sur les fonctions cognitives des patients atteints d'un cancer de la prostate

Does hormone therapy impact cognition in patients with prostate cancer? A systematic review and meta-analysis

Boué, Antoine ; Joly, Florence ; Lequesne, Justine ; Lange, Marie

Background: Hormone therapy, which is widely prescribed for prostate cancer, might induce cognitive impairment and affect the autonomy of elderly patients. However, previous studies provided conflicting results. The aim of this systematic review and meta-analysis was to synthesize the longitudinal impact of hormone therapy on objective (cognitive tests) and subjective (questionnaires) cognition. Methods: A search was performed of the PubMed, Web of Science, and PsycINFO databases. Studies that [...]

A partir d'une revue systématique de la littérature (44 études), cette étude analyse les expériences des hommes après le diagnostic d'un cancer du sein (adhésion aux traitements, effet psychosocial de la maladie, besoins en soins de support et de réadaptation, etc.)

Experiences and perceptions of men following breast cancer diagnosis: a mixed method systematic review

Abboah-Offei, Mary ; Bayuo, Jonathan ; Salifu, Yakubu ; Afolabi, Oladayo ; Akudjedu, Theophilus N.

Background: Men with breast cancer experience unique physical and emotional challenges. However, a thorough understanding of these experiences including the psychosocial effects and supportive care needs have received less attention. In some settings, men with breast cancer experience stigma within the healthcare system and their care needs are not prioritised. This influences the level of professional support offered, consequently worsening their health and well-being outcomes. This review [...]

Menée auprès de 65 patientes ayant survécu à un cancer du col de l'utérus et de 70 témoins, cette étude analyse la concordance entre la fréquence ou la sévérité des déficiences cognitives auto-déclarées et celles mesurées objectivement

Cognitive impairment in cervical cancer survivors—Exploring the discrepancy between subjective and objective assessment

Areklett, Elisabeth Wang ; Andersson, S. ; Fagereng, E. ; Bruheim, K. ; Stubberud, J. ; Lindemann, K.

Objective: Cancer-related cognitive impairment has severe implications for the quality of life and societal participation of cervical cancer survivors (CCS). However, there is no research on the association between subjective and objective cognitive impairment (CI) in cervical cancer. This cross-sectional study aimed to examine the frequency and severity of objective CI in CCS reporting significant subjective CI and explore the discrepancy between subjective and objective CI. Methods: [...]