Menée à l'aide d'une méthode de randomisation mendélienne et de données pangénomiques portant sur 217 602 personnes, cette étude analyse l'association entre la consommation de thé vert et le risque de cancers digestifs (estomac, colon-rectum, foie, pancréas, oesophage)

Association between green tea intake and digestive system cancer risk in European and East Asian populations: a Mendelian randomization study

Nie, Duorui ; He, Xiaoyu ; Zheng, Hao ; Deng, Deyu ; He, Fanghui ; Li, Ruyi ; Ni, Xiaoting ; Li, Shunxiang ; Xu, Fei

Purpose: Previous observational studies have shown that green tea consumption is associated with a reduced incidence of digestive system cancers (DSCs). However, the observed association could be due to confounding factors. Therefore, we used a two-sample Mendelian randomization (MR) approach to assess the causal effect of green tea intake on the risk of five common DSCs. Methods: Independent genetic variants strongly associated with green tea consumption in European and East Asian populations [...]

Menée à partir de données du "National Statistics Institute" au Portugal et de la base "Global Burden of Disease", cette étude analyse l'association entre la consommation d'aliments ultra-transformés et le risque de maladie non transmissible comme le cancer

Trends in ultra-processed food availability and its association with diet-related non-communicable disease health indicators in the Portuguese population

Afonso, Cláudia ; Pereira de Araújo, Taissa ; Rodrigues, Sara Simões Pereira ; de Moraes, Milena Miranda

Broad variations in dietary and physical activity patterns are part of nutritional transition concept. An additional nutritional transition has as main characteristic the change of consumption of processed foods for ultra-processed foods (UPF). This study aims to evaluate trends of UPF availability in Portuguese population and its association with diet-related non-communicable diseases (NCD) health indicators. This ecological study used data from the Household Budget Surveys conducted by the [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données d'études d'association pangénomiques, cette étude analyse l'association entre une endométriose et le risque de cancer (34 localisations)

Causal effects of endometriosis on cancer risk: A Mendelian randomization study

Tang, Tianyou ; Yu, Huilin ; Xu, Sipei ; Zhong, Yi ; Ma, Jie ; Zhao, Tingting

Endometriosis has been reported in epidemiological studies to be associated with certain types of cancer. However, the presence of reverse causality and residual confounding due to common risk factors introduces uncertainty regarding the extent to which endometriosis itself contributes to the development of cancer. We performed the Mendelian randomization (MR) to investigate the causal associations between endometriosis and 34 different types of cancers. The results of the [...]

Menée à l'aide des données de cinq études de l'"Ovarian Cancer Association Consortium" incluant 4 926 patientes atteintes d'un cancer de l'ovaire, cette étude analyse l'influence de facteurs reproductifs, hormonaux ou comportementaux sur le risque de développer la maladie, en fonction du statut mutationnel de BRCA

Risk factors for ovarian cancer by BRCA status: a collaborative case-only analysis

Gersekowski, Kate ; Na, Renhua ; Alsop, Kathryn ; Delahunty, Rachel ; Goode, Ellen L. ; Cunningham, Julie M. ; Winham, Stacey J. ; Pharoah, Paul D P. ; Song, Honglin ; Webb, Penelope M.

Background: Women with an inherited pathogenic variant in BRCA1 or BRCA2 have a greatly increased risk of developing ovarian cancer, but the importance of behavioral factors is less clear. We used a case-only design to compare the magnitude of associations with established reproductive, hormonal and lifestyle risk factors between BRCA mutation carriers and non-carriers. Methods: We pooled data from five studies from the Ovarian Cancer Association Consortium including 637 BRCA carriers and 4289 [...]