Menée aux Etats-Unis par enquête auprès de 186 professionnels de santé, cette étude analyse leurs pratiques de prescription d'opioïdes pour soulager la douleur chronique des patients atteints d'un cancer

Healthcare provider perceptions and reported practices regarding opioid prescription for patients with chronic cancer pain

Arthur, Joseph ; Edwards, Tonya ; Lu, Zhanni ; Amoateng, Magdelene Doris ; Koom-Dadzie, Kwame ; Zhu, Hongxu ; Long, James ; Do, Kim-Anh ; Bruera, Eduardo

Purpose: Data indicates that clinicians might be under-prescribing opioids for patients with chronic cancer pain, and this could impact adequate pain management. Few studies have sought to understand healthcare provider (HCP) perceptions and practices regarding the prescription of opioids for chronic cancer pain. We assessed HCP perceptions and practices regarding opioid prescription for patients with chronic cancer pain since the onset of the COVID-19 pandemic. Methods: An anonymous [...]

Mené sur 58 patients pédiatriques ayant survécu à une leucémie lymphoblastique aiguë (âge moyen : 13,7 ans), cet essai randomisé évalue l'intérêt, pour améliorer leur fonction cardio-pulmonaire et leurs performances physiques, d'ajouter une intervention à base d'exercices aérobiques pratiqués de façon progressive à une rééducation traditionnelle

Effectiveness of a dose-graded aerobic exercise regimen on cardiopulmonary fitness and physical performance in pediatric survivors of acute lymphoblastic leukemia: a randomized clinical trial

Elnaggar, Ragab K. ; Osailan, Ahmad M. ; Elbanna, Mohammed F. ; Abd-Elmonem, Amira M.

Purpose: To determine whether a 12-week supervised dose-graded aerobic exercise (D-GAE) training, when implemented in conjunction with traditional rehabilitation, could help pediatric survivors of acute lymphoblastic leukemia (ALL) enhance their cardiopulmonary capacity and improve their physical performance. Methods: Fifty-eight pediatric survivors of ALL (age 13.78 ± 2.47 years; boys 60.34%) were assigned at random to either undergo the D-GAE in addition to the traditional physical [...]

A partir d'une revue systématique de la littérature publiée entre 2012 et 2022 (15 études, 320 686 patients), cette méta-analyse évalue les traitements reçus par les patients atteints d'un carcinome hépatocellulaire en fonction de l'origine ethnique

Racial and Ethnic Disparities in Hepatocellular Carcinoma Treatment Receipt in the United States: A Systematic Review and Meta-Analysis

Wagle, Nikita Sandeep ; Park, Sulki ; Washburn, David ; Ohsfeldt, Robert ; Kum, Hye-Chung ; Singal, Amit G.

Background: Racial and ethnic disparities in hepatocellular carcinoma (HCC) prognosis exist, partly related to differential failures along the cancer care continuum. We characterized racial and ethnic disparities in treatment receipt among patients with HCC in the United States. Methods: We searched Medline, Embase, and CINAHL databases to identify studies published between January 2012 and March 2022 reporting HCC treatment receipt among adult patients with HCC, stratified by race or [...]

Menée aux Etats-Unis à partir de données portant sur 3 322 patients ayant survécu à un cancer pédiatrique (âge moyen : 31 ans), cette étude de cohorte analyse l'association entre une consommation de végétaux (fruits et légumes) et le risque de vieillissement prématuré

Plant Foods Intake and Risk of Premature Aging in Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort (SJLIFE)

Mei Wang ; Tuo Lan ; Annalynn M. Williams ; Matthew J. Ehrhardt ; Jennifer Q. Lanctot ; Shu Jiang ; Kevin R. Krull ; Gregory T. Armstrong ; Melissa M. Hudson ; Graham A. Colditz ; Leslie L. Robison ; Kirsten K. Ness ; Yikyung Park

Purpose: To identify dietary factors that are related to premature aging in adult survivors of childhood cancer, we examined the associations between plant food intakes and age-related deficit accumulation. Methods: A total of 3,322 childhood cancer survivors (age 18-65 years, mean = 31, standard deviation = 8.4) in the St Jude Lifetime Cohort had total fruit, total vegetables and subgroups, whole grains, refined grains, nuts/seeds, and nutrients intake assessed using a food frequency [...]

Menée aux Etats-Unis à partir de données portant sur 157 474 professionnels de santé (âge médian : 62 ans), cette étude de cohorte prospective analyse le taux de cancers diagnostiqués dans les 12 mois suivant la perte de poids

Cancer Diagnoses After Recent Weight Loss

Wang, Qiao-Li ; Babic, Ana ; Rosenthal, Michael H. ; Lee, Alice A. ; Zhang, Yin ; Zhang, Xuehong ; Song, Mingyang ; Rezende, Leandro F. M. ; Lee, Dong Hoon ; Biller, Leah ; Ng, Kimmie ; Giannakis, Marios ; Chan, Andrew T. ; Meyerhardt, Jeffrey A. ; Fuchs, Charles S. ; Eliassen, A. Heather ; Birmann, Brenda M. ; Stampfer, Meir J. ; Giovannucci, Edward L. ; Kraft, Peter ; Nowak, Jonathan A. ; Yuan, Chen ; Wolpin, Brian M.

Importance : Weight loss is common in primary care. Among individuals with recent weight loss, the rates of cancer during the subsequent 12 months are unclear compared with those without recent weight loss. Objective : To determine the rates of subsequent cancer diagnoses over 12 months among health professionals with weight loss during the prior 2 years compared with those without recent weight loss. Design, Setting, and Participants : Prospective cohort analysis of females aged 40 years or [...]

Menée en Russie à partir de données portant sur 30 445 personnes ayant travaillé dans des mines ou dans l'industrie du chrysotile entre 1975 et 2010 (durée de suivi : 721 312 personnes-années), cette étude de cohorte analyse le risque de décès par cancer

Cancer mortality in chrysotile miners and millers, Russian Federation: main results (Asbest Chrysotile Cohort-Study)

Schüz, Joachim ; Kovalevskiy, Evgeny ; Olsson, Ann ; Moissonnier, Monika ; Ostroumova, Evgenia ; Ferro, Gilles ; Feletto, Eleonora ; Schonfeld, Sara J ; Byrnes, Graham ; Tskhomariia, Iraklii ; Straif, Kurt ; Morozova, Tatiana ; Kromhout, Hans ; Bukhtiyarov, Igor

Background: We investigated mortality in workers of the world’s largest chrysotile mine and enrichment factories located in the town of Asbest, Russian Federation. Methods: This historical cohort study included all workers employed for at least 1 year between 1975 and 2010 and follow-up until the end of 2015. Cumulative exposure to dust was estimated based on workers’ complete occupational history linked to dust measurements systematically collected from the 1950s. Exposure to chrysotile fibers [...]

Menée à partir de données portant sur 700 000 adolescents et jeunes adultes atteints d'un cancer (âge : 15-39 ans), cette étude estime, pour 29 pays européens, la survie relative à 5 ans

Survival of European adolescents and young adults diagnosed with cancer in 2010-2014

Trama, Annalisa ; Botta, Laura ; Stiller, Charles ; Visser, Otto ; Cañete-Nieto, Adela ; Spycher, Ben ; Bielska-Lasota, Magdalena ; Katalinic, Alexander ; Vener, Claudia ; Innos, Kaire ; Marcos-Gragera, Rafael ; Paapsi, Keiu ; Guevara, Marcela ; Demuru, Elena ; Mousavi, Seyed Mohsen ; Blum, Marcel ; Eberle, Andrea ; Ferrari, Andrea ; Bernasconi, Alice ; Lasalvia, Paolo

Background: We used the comprehensive definition of AYA (age 15 to 39 years) to update 5-year relative survival (RS) estimates for AYAs in Europe and across countries and to evaluate improvements in survival over time. Methods: We used data from EUROCARE6. We analysed 700,000 AYAs with cancer diagnosed in 2000-2013 (follow-up to 2014). We focused the analyses on the 12 most common cancers in AYA. We used period analysis to estimate 5-year RS in Europe and 5-year RS differences in 29 countries [...]

Cet article analyse le risque de second cancer chez des patients atteints d'un cancer traité par immunothérapie à base de lymphocytes CAR-T

Secondary Cancers after Chimeric Antigen Receptor T-Cell Therapy

Verdun, Nicole ; Marks, Peter

As of December 31, 2023, the FDA had become aware of 22 cases of T-cell cancers that occurred after treatment with CAR-T products. For now, such cancers appear to be relatively rare adverse events.

Menée aux Pays-Bas auprès de 81 patients atteints d'un cancer, cette étude évalue la possibilité d'intégrer, en psycho-oncologie, une intervention destinée à réduire la peur de la récidive de la maladie

Toward implementation of an evidence-based intervention for fear of cancer recurrence: Feasibility in real-world psycho-oncology practice

Deuning-Smit, Esther ; Custers, José A. E. ; Braam, Cheyenne I. W. ; Hermens, Rosella P. M. G. ; Prins, Judith B.

Objective: Few evidence-based interventions addressing high levels of fear of cancer recurrence (FCR) have been implemented. Understanding how these might be implemented is crucial to bridge the research-practice gap. This study investigated the feasibility of implementing the blended Survivors' Worries of Recurrent Disease (SWORD) intervention in real-world psycho-oncology practice. Methods: SWORD was offered for 15 months (2021–2022) as the standard care for clinical FCR in a university [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2023 (63 articles), cette étude détermine le moment optimal pour une conversation médecin-patient sur le pronostic d'un cancer de stade avancé

Timing of prognostic discussions in people with advanced cancer: a systematic review

Nahm, Sharon H. ; Subramaniam, Shalini ; Stockler, Martin R. ; Kiely, Belinda E.

Purpose: Many people with cancer (patients) want to know their prognosis (a quantitative estimate of their life expectancy) but this is often not discussed or poorly communicated. The optimal timing of prognostic discussions with people with advanced cancer is highly personalised and complex. We aimed to find, organise, and summarise research regarding the timing of discussions of prognosis with people with advanced cancer. Methods: We conducted a systematic review of publications from [...]