Menée auprès de 20 965 témoins et 16 901 patients atteints d'un cancer du poumon, cette étude internationale analyse l'association entre une multi-exposition professionnelle à 2 agents cancérogènes (amiante, silice cristalline, nickel, chrome-VI et hydrocarbures aromatiques polycycliques) et le risque de développer la maladie

Lung Cancer Risks Associated with Occupational Exposure to Pairs of Five Lung Carcinogens: Results from a Pooled Analysis of Case-Control Studies (SYNERGY)

Ann Olsson ; Liacine Bouaoun ; Joachim Schüz ; Roel Vermeulen ; Thomas Behrens ; Calvin Ge ; Hans Kromhout ; Jack Siemiatycki ; Per Gustavsson ; Paolo Boffetta ; Benjamin Kendzia ; Loredana Radoi ; Christine Barul ; Stefan Karrasch ; Heinz-Erich Wichmann ; Dario Consonni ; Maria Teresa Landi ; Neil E. Caporaso ; Franco Merletti ; Enrica Migliore ; Lorenzo Richiardi ; Karl-Heinz Jöckel ; Wolfgang Ahrens ; Hermann Pohlabeln ; Guillermo Fernandez-Tardon ; David Zaridze ; John K. Field ; Jolanta Lissowska ; Beata Świątkowska ; John R. McLaughlin ; Paul A. Demers ; Miriam Schejbalova ; Lenka Foretova ; Vladimir Janout ; Tamás Pándics ; Eleonora Fabianova ; Dana Mates ; Francesco Forastiere ; Kurt Straif ; Thomas Brüning ; Jelle Vlaanderen ; Susan Peters

Background: While much research has been done to identify individual workplace lung carcinogens, little is known about joint effects on risk when workers are exposed to multiple agents. Objectives: We investigated the pairwise joint effects of occupational exposures to asbestos, respirable crystalline silica, metals (i.e., nickel, chromium-VI), and polycyclic aromatic hydrocarbons (PAH) on lung cancer risk, overall and by major histologic subtype, while accounting for cigarette smoking. [...]

Menée à partir de données portant sur 449 patients traités pour un lymphome non hodgkinien à cellules B par immunothérapie à base de lymphocytes CAR-T ciblant CD19 (durée médiane de suivi : 10,3 mois), cette étude analyse le risque de second lymphome lié au traitement (16 cas)

T-cell Lymphoma and Secondary Primary Malignancy Risk After Commercial CAR T-cell Therapy

Ghilardi, Guido ; Fraietta, Joseph A. ; Gerson, James N. ; Van Deerlin, Vivianna M. ; Morrissette, Jennifer J. D. ; Caponetti, Gabriel C. ; Paruzzo, Luca ; Harris, Jaryse C. ; Chong, Elise A. ; Susanibar Adaniya, Sandra P. ; Svoboda, Jakub ; Nasta, Sunita D. ; Ugwuanyi, Ositadimma H. ; Landsburg, Daniel J. ; Fardella, Eugenio ; Waxman, Adam J. ; Chong, Emeline R. ; Patel, Vrutti ; Pajarillo, Raymone ; Kulikovskaya, Irina ; Lieberman, David B. ; Cohen, Adam D. ; Levine, Bruce L. ; Stadtmauer, Edward A. ; Frey, Noelle V. ; Vogl, Dan T. ; Hexner, Elizabeth O. ; Barta, Stefan K. ; Porter, David L. ; Garfall, Alfred L. ; Schuster, Stephen J. ; June, Carl H. ; Ruella, Marco

We report a T-cell lymphoma (TCL) occurring three months after anti-CD19 chimeric antigen receptor (CAR) T-cell immunotherapy for non-Hodgkin B-cell lymphoma. The TCL was diagnosed from a thoracic lymph node upon surgery for lung cancer. The TCL exhibited CD8+ cytotoxic phenotype and a JAK3 variant, while the CAR transgene was very low. The T-cell clone was identified at low levels in the blood before CART infusion and in the lung cancer. To assess the overall risk of secondary primary [...]

Menée à l'aide d'une méthode de randomisation mendélienne et notamment de données de la "UK Biobank" portant sur 372 184 personnes, cette étude pangénomique analyse l'association entre des caractéristiques des cellules NK et le risque de carcinome hépatocellulaire

The causality between CD8+NKT cells and CD16−CD56 on NK cells with hepatocellular carcinoma: a Mendelian randomization study

Lu, Zhengmei ; Chai, Xiaowei ; Pan, Yong ; Li, Shibo

Background: Hepatocellular carcinoma (HCC), which is featured with high morbidity and mortality worldwide, is a primary malignant tumor of the liver. Recently, there is a wealth of supporting evidence revealing that NK cell-related immune traits are strongly associated with the development of HCC, but the causality between them has not been proven. Methods: Two-sample Mendelian randomization (MR) study was performed to probe the causal correlation between NK cell-related immune traits and HCC. [...]

Menée à partir de données de séquençage de l'ADN de 14 192 témoins et 4 308 patients atteints d'un cancer colorectal, cette étude analyse l'effet génotoxique de la colibactine sur le risque de développer la maladie

Epidemiologic factors in relation to colorectal cancer risk and survival by genotoxic colibactin mutational signature

Thomas, Claire E. ; Georgeson, Peter ; Qu, Conghui ; Steinfelder, Robert S. ; Buchanan, Daniel D. ; Song, Mingyang ; Harrison, Tabitha A. ; Um, Caroline Y. ; Hullar, Meredith A. ; Jenkins, Mark A. ; Van Guelpen, Bethany ; Lynch, Brigid M. ; Melaku, Yohannes Adama ; Huyghe, Jeroen R. ; Aglago, Elom K. ; Berndt, Sonja I. ; Boardman, Lisa A. ; Campbell, Peter T. ; Cao, Yin ; Chan, Andrew T. ; Drew, David A. ; Figueiredo, Jane C. ; French, Amy J. ; Giannakis, Marios ; Goode, Ellen L. ; Gruber, Stephen B. ; Gsur, Andrea ; Gunter, Marc J. ; Hoffmeister, Michael ; Hsu, Li ; Huang, Wen-Yi ; Moreno, Víctor ; Murphy, Neil ; Newcomb, Polly A. ; Newton, Christina C. ; Nowak, Jonathan A. ; Obón-Santacana, Mireia ; Ogino, Shuji ; Sun, Wei ; Toland, Amanda E. ; Trinh, Quang M. ; Ugai, Tomotaka ; Zaidi, Syed H. ; Peters, Ulrike ; Phipps, Amanda I.

Background: The genotoxin colibactin causes a tumor single base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors association with colorectal cancer (CRC) risk and survival differ by SBS88. Methods: Within the Genetic Epidemiology of Colorectal Cancer Consortium and Colon Cancer Family Registry, we measured SBS88 in 4,308 microsatellite stable/microsatellite instability low tumors. Associations of epidemiologic factors with CRC risk by SBS88 were [...]

Menée à partir de données 2003-2020 de l'étude "the Sister Study" portant sur 50 884 Américaines, cette étude identifie les facteurs influençant l'association entre la présence d'un fibrome ou d'une endométriose et le risque de cancer du sein (4 419 cas)

Association of fibroids, endometriosis, and gynecologic surgeries with breast cancer incidence and hormone receptor subtypes

Zeldin, Jordan ; Sandler, Dale P. ; Ogunsina, Kemi ; O'Brien, Katie M.

Background: Fibroids and endometriosis are sex hormone-mediated and exhibit cancer-like behavior. Breast cancer may be more common in women who have had these conditions, but the literature is conflicting and does not always address factors like hysterectomy/oophorectomy status, race/ethnicity, menopause, and hormone receptor subtypes. Methods: Data are from the Sister Study, a cohort of 50,884 U.S. women enrolled in 2003-2009 and followed through 2020. Cox proportional hazards models with [...]

Menée à partir de données européennes portant sur 69 460 patients ayant survécu 5 ans à un cancer diagnostiqué pendant l'enfance, cette étude identifie des facteurs associés au risque de gliome ou de méningiome après 40 ans

Risk of subsequent gliomas and meningiomas among 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Heymer, Emma J. ; Hawkins, Michael M. ; Winter, David L. ; Teepen, Jop C. ; Sunguc, Ceren ; Ronckers, Cecile M. ; Allodji, Rodrigue S. ; Alessi, Daniela ; Sugden, Elaine ; Belle, Fabiën N. ; Bagnasco, Francesca ; Byrne, Julianne ; Bárdi, Edit ; Garwicz, Stanislaw ; Grabow, Desiree ; Jankovic, Momcilo ; Kaatsch, Peter ; Kaiser, Melanie ; Michel, Gisela ; Schindera, Christina ; Haddy, Nadia ; Journy, Neige ; Česen Mazić, Maja ; Skinner, Roderick ; Kok, Judith L. ; Gunnes, Maria W. ; Wiebe, Thomas ; Sacerdote, Carlotta ; Maule, Milena M. ; Terenziani, Monica ; Jakab, Zsuzsanna ; Winther, Jeanette F. ; Lähteenmäki, Päivi M. ; Zadravec Zaletel, Lorna ; Haupt, Riccardo ; Kuehni, Claudia E. ; Kremer, Leontien C. ; de Vathaire, Florent ; Hjorth, Lars ; Reulen, Raoul C.

Background: Childhood cancer survivors are at risk of subsequent gliomas and meningiomas, but the risks beyond age 40 years are uncertain. We quantified these risks in the largest ever cohort. Methods: Using data from 69,460 5-year childhood cancer survivors (diagnosed 1940–2008), across Europe, standardized incidence ratios (SIRs) and cumulative incidence were calculated. Results: In total, 279 glioma and 761 meningioma were identified. CNS tumour (SIR: 16.2, 95% CI: 13.7, 19.2) and leukaemia [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 30 657 personnes, cette étude analyse l'association entre 5 troubles psychiatriques (schizophrénie, trouble dépressif majeur, trouble bipolaire, trouble du spectre autistique et trouble panique) et le risque de gliome

Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis

Yang, Wenzhuo ; Han, Yu ; He, Changjia ; Zhong, Sheng ; Ren, Fei ; Chen, Zhongping ; Mou, Yonggao ; Sai, Ke

Background: Observational studies have explored the association of psychiatric disorders and the risk of brain cancers. However, the causal effect of specific mental illness on glioma remains elusive due to the lack of solid evidence. Methods: We performed a two-sample bidirectional Mendelian randomization (MR) analysis to explore the causal relationships between 5 common psychiatric disorders (schizophrenia, major depressive disorder, bipolar disorder, autism spectrum disorder, and panic [...]