Mené sur 275 patients atteints d'une tumeur solide, cet essai randomisé de phase III évalue l'intérêt, du point de vue de la prévention des nausées et vomissements induits par une chimiothérapie hautement émétisante, de faibles doses d'olanzapine (2,5 mg) par rapport à la dose standard (10 mg)

Low-dose versus standard-dose olanzapine with triple antiemetic therapy for prevention of highly emetogenic chemotherapy-induced nausea and vomiting in patients with solid tumours: a single-centre, open-label, non-inferiority, randomised, controlled, phase 3 trial

Bajpai, Jyoti ; Kapu, Venkatesh ; Rath, Sushmita ; Kumar, Sravan ; Sekar, Anbarasan ; Patil, Priyanka ; Siddiqui, Altaf ; Anne, Srikanth ; Pawar, Akash ; Srinivas, Sujay ; Bhargava, Prabhat ; Gulia, Seema ; Noronha, Vanita ; Joshi, Amit ; Prabhash, Kumar ; Banavali, Shripad ; Sarin, Rajiv ; Badwe, Rajendra ; Gupta, Sudeep

Background: Olanzapine is an effective antiemetic agent but it results in substantial daytime somnolence when administered at the standard dose. Our aim was to compare the efficacy of low-dose versus standard-dose olanzapine after highly emetogenic chemotherapy in patients with solid tumours. Methods: This was a single-centre, open-label, non-inferiority, randomised, controlled, phase 3 trial done in a tertiary care referral centre in India (Tata Memorial Centre, Homi Bhabha National Institute, [...]

Menée aux Etats-Unis par enquête auprès de patients atteints d'un cancer (5 523 répondants), cette étude analyse l'association entre une utilisation de cannabis et la gestion de la douleur liée à la maladie

Current cannabis use and pain management among US cancer patients

Krok-Schoen, Jessica L. ; Plascak, Jesse J. ; Newton, Alison M. ; Strassels, Scott A. ; Adib, Anita ; Adley, Neema C. ; Hays, John L. ; Wagener, Theodore L. ; Stevens, Erin E. ; Brasky, Theodore M.

Background: National studies reporting the prevalence of cannabis use have focused on individuals with a history of cancer without distinction by their treatment status, which can impact symptom burden. While pain is a primary motivation to use cannabis in cancer, the magnitude of its association with cannabis use remains understudied. Methods: We examined cannabis use and pain management among 5523 respondents of the Behavioral Risk Factor Surveillance System with a cancer history. [...]

Mené sur 86 patients atteints d'un cancer du poumon non à petites cellules et souffrant d'anorexie (âge moyen : 63,5 ans), cet essai randomisé évalue l'effet de la mirtazapine pour stimuler l'appétit

Mirtazapine as Appetite Stimulant in Patients With Non–Small Cell Lung Cancer and Anorexia: A Randomized Clinical Trial

Arrieta, Oscar ; Cárdenas-Fernández, Daniela ; Rodriguez-Mayoral, Oscar ; Gutierrez-Torres, Salvador ; Castañares, Diana ; Flores-Estrada, Diana ; Reyes, Edgar ; López, Dennis ; Barragán, Pablo ; Soberanis Pina, Pamela ; Cardona, Andrés F. ; Turcott, Jenny G.

Importance : Currently there is no standard therapy to improve cancer-related anorexia, hampering survival. Mirtazapine has been suggested as a feasible option in this context. Objectives : To assess the effect of mirtazapine on appetite and energy consumption in patients with advanced non–small cell lung cancer (NSCLC). Design, Setting, and Participants : This randomized, double-blind, placebo-controlled clinical trial including adults was performed in a tertiary cancer care center from August [...]

A partir d'une revue systématique de la littérature (10 essais), cette méta-analyse évalue l'intérêt, pour réduire l'incontinence fécale et améliorer la qualité de vie, d'interventions de kinésithérapie chez les patients atteints d'un cancer colorectal traité par chirurgie

The effectiveness of physiotherapy interventions on fecal incontinence and quality of life following colorectal surgery: a systematic review and meta-analysis of randomized controlled trials

Pun, Ming Yan ; Leung, Pak Ho ; Chan, Tsz Ching ; Pang, Chunn ; Chan, Kin Hei ; Kannan, Priya

Purpose: To investigate the effectiveness of physiotherapy interventions compared to control conditions on fecal incontinence (FI) and quality of life (QoL) following colorectal surgery. Methods: Electronic searches in English-language (Scopus, Web of Science, Embase, AMED, CENTRAL, CINAHL, MEDLINE, Ovid, and PEDro) and Chinese-language (CNKI, Wanfang Data) databases were conducted. Trials comparing physiotherapy interventions against control conditions and assessing FI and QoL outcomes were [...]

Menée en France à partir de données portant sur 74 patients présentant des métastases gastro-intestinales provenant d'un carcinome à cellules rénales (âge médian au diagnostic des métastases : 69 ans), cette étude multicentrique rétrospective analyse les caractéristiques des métastases et des patients, les stratégies thérapeutiques et le pronostic associé

Gastrointestinal metastases in renal cell carcinoma: a retrospective multicenter GETUG (Groupe d’Étude des Tumeurs Uro-Génitales) study

Carneiro, F. ; Vinceneux, A. ; Larroquette, M. ; Rony, M. ; Carril, L. ; Laguerre, B. ; Blazevic, I. ; Bartelemy, P. ; Teyssonneau, D. ; Goujon, M. ; Linassier, C. ; Thiery-Vuillemin, A. ; Roubaud, G. ; Chevreau, C. ; Albiges, L. ; Gravis, G. ; Gross Goupil, M. ; Cancel, M.

Background: Among patients with renal cell carcinoma (RCC), bone and visceral metastases have a poor prognosis, while endocrine gland metastases have a more favorable prognosis. Gastrointestinal metastases (GIMs) are rare, and their prognosis is still poorly understood. Objectives: To report clinical presentations, patient characteristics, therapeutic strategies, and prognosis of GIMs from RCC. Methods: We retrospectively collected data from RCC patients presenting GIMs, in 10 French GETUG [...]

Menée aux Etats-Unis à partir de données portant sur 6 101 adultes ayant survécu à un cancer, cette étude transversale analyse la prévalence de troubles liés à l'utilisation de substances psychoactives en fonction du type de cancer

Substance Use Disorders Among US Adult Cancer Survivors

Jones, Katie F. ; Osazuwa-Peters, Oyomoare L. ; Des Marais, Andrea ; Merlin, Jessica S. ; Check, Devon K.

Importance : Some individuals are predisposed to cancer based on their substance use history, and others may use substances to manage cancer-related symptoms. Yet the intersection of substance use disorder (SUD) and cancer is understudied. Because SUD may affect and be affected by cancer care, it is important to identify cancer populations with a high prevalence of SUD, with the goal of guiding attention and resources toward groups and settings where interventions may be needed. Objective : To [...]

Cette étude présente une estimation, pour la période 1990-2019, de l'incidence de la leucémie lymphoïde aiguë et de la mortalité spécifique chez les adolescents et jeunes adultes dans 25 États et Territoires de la Région du Pacifique occidental (Chine, Malaisie, Australie, Japon, etc.)

The burden of acute lymphoid leukemia among adolescents and young adults in the Western Pacific Region: evidence from Global Burden Disease 2019

Yang, Fan ; Zhang, Bo ; Lodder, Paul ; Guo, Jing

Purpose: Acute lymphoblastic leukemia (ALL) is a type of blood cancer that affects white blood cells. Here, we use data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, to estimate the burden and incidence rate changes in adolescents and young adults (AYA) ALL in the Western Pacific Region and to reveal potential risk factors of incidence- and mortality rates. Methods: The GBD 2019 study data was stratified by sex, age, country, and territory. We calculated the [...]

A partir d'une revue systématique de la littérature (11 études, 2 881 patientes), cette étude analyse l'effet, sur la toxicité des chimiothérapies, de la composition corporelle des patientes atteintes d'un cancer du sein

Body composition and chemotherapy toxicities in breast cancer: a systematic review of the literature

Lewis, Lori ; Thompson, Belinda ; Stellmaker, Rhiannon ; Koelmeyer, Louise

Purpose: Breast cancer is the most diagnosed cancer in women with chemotherapy being a common treatment. Toxicities due to chemotherapy can result in dose reduction, delay, and early cessation of treatment, which along with causing distress for individuals during their cancer treatment might also reduce the therapeutic effect. The purpose of this systematic review is to examine the role of body composition on chemotherapy toxicities in women with breast cancer. Methods: A systematic search of [...]

A partir d'une revue systématique de la littérature publiée entre 2001 et 2023 (35 études), cette étude analyse l'intérêt des outils de communication permettant aux patients atteints d'un cancer d'échanger avec les professionnels de santé au sujet des changements dans leur intimité et leur sexualité

Feasibility and effectiveness of communication tools for addressing intimacy and sexuality in patients with cancer: a systematic review

Arends, Susanne A. M. ; van Rossum, Carlijn E. ; Eeltink, Corien M. ; Robertus, Jantien E. ; Schoonmade, Linda J. ; Francke, Anneke L. ; Jongerden, Irene P.

Purpose: Patients diagnosed with cancer might experience changes in intimacy and sexuality due to the illness itself, treatment, or psychological and social factors. Healthcare professionals (HCPs) often feel reluctant to discuss these changes. This study aimed to provide an overview of the feasibility and effectiveness of communication tools that support communication regarding changes in intimacy or sexuality among patients with cancer. Methods: This is a systematic review. Databases are [...]