Menée à l'aide de données de la cohorte européenne "EPIC" portant sur 295 865 personnes (durée médiane de suivi : 7,8 ans), cette étude analyse l'effet d'une modification des habitudes de vie vers 50 ans (tabagisme, consommation d'alcool, indice de masse corporelle et activité physique) sur le risque de cancer (14 933 cas)

Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition

Botteri, Edoardo ; Peveri, Giulia ; Berstad, Paula ; Bagnardi, Vincenzo ; Hoff, Geir ; Heath, Alicia K. ; Cross, Amanda J. ; Vineis, Paolo ; Dossus, Laure ; Johansson, Mattias ; Freisling, Heinz ; Matta, Komodo ; Huybrechts, Inge ; Chen, Sairah L. F. ; B. Borch, Kristin ; Sandanger, Torkjel M. ; H. Nøst, Therese ; Dahm, Christina C. ; Antoniussen, Christian S. ; Tin Tin, Sandar ; Fournier, Agnès ; Marques, Chloé ; Artaud, Fanny ; Sánchez, María-José ; Guevara, Marcela ; Santiuste, Carmen ; Agudo, Antonio ; Bajracharya, Rashmita ; Katzke, Verena ; Ricceri, Fulvio ; Agnoli, Claudia ; Bergmann, Manuela M. ; Schulze, Matthias B. ; Panico, Salvatore ; Masala, Giovanna ; Tjønneland, Anne ; Olsen, Anja ; Stocks, Tanja ; Manjer, Jonas ; Aizpurua-Atxega, Amaia ; Weiderpass, Elisabete ; Riboli, Elio ; Gunter, Marc J. ; Ferrari, Pietro

In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI ranged from 0 (most unfavourable) to 16 (most favourable). We estimated the association between HLI [...]

Menée au Brésil à partir de données 2017-2021 portant sur 194 témoins et 193 patients atteints d'un cancer de l'estomac, cette étude analyse l'association entre la consommation de polyphénols et le risque de développer la maladie

Polyphenol intake and gastric cancer: A case-control study in the Brazilian Amazon region

de Araújo Fagundes, Marcela ; Alves Carnauba, Renata ; Fernandes, Gisele Aparecida ; Pimentel de Assumpção, Paulo ; Curado, Maria Paula

Background: Polyphenol intake has been associated with a decreased risk of some types of cancer, including gastric cancer (GC). However, few studies address this topic in the Latin American population. In the present study, we evaluated the association between polyphenol intake and the risk of GC in the Brazilian Amazon region. Methods: A case-control study was conducted in Belém (Amazon region) from July 2017 to February 2021. A total of 193 GC cases and 194 controls of both sexes, between 18 [...]

A partir d'une revue systématique de la littérature publiée jusqu'en octobre 2022 (16 études, 529 917 participants), cette méta-analyse évalue l'association entre le niveau sérique de 25-hydroxyvitamine D et le risque de cancer du pancréas

The association between circulating 25-hydroxyvitamin D and pancreatic cancer: a systematic review and meta-analysis of observational studies

Shen, Yajing ; Xia, Junfen ; Yi, Chuncheng ; Li, Tiandong ; Wang, Peng ; Dai, Liping ; Shi, Jianxiang ; Wang, Keyan ; Sun, Changqing ; Ye, Hua

Purpose: The relationship between circulating 25-hydroxyvitamin D [25(OH)D] and pancreatic cancer has been well studied but remains unclear. The purpose of this study was to elucidate the association between circulating 25(OH)D and pancreatic cancer by using a meta-analytic approach. Methods: PubMed, Embase, and Wed of Science databases were searched through October 15, 2022. A random or fixed-effects model was used to estimate the pooled odds ratio (OR), risk ratio (RR), hazard ratio (HR) and [...]

Cette étude passe en revue les données scientifiques sur les stratégies visant à accélérer l'élimination du cancer du col de l'utérus et du papillomavirus humain

Scientific approaches toward improving cervical cancer elimination strategies

Lehtinen, Matti ; Bruni, Laia ; Elfstrom, Miriam ; Gray, Penelope ; Logel, Margaret ; Mariz, Filipe Colaço ; Baussano, Iacopo ; Vänskä, Simopekka ; Franco, Eduardo L. ; Dillner, Joakim

At the 2023 EUROGIN workshop scientific basis for strategies to accelerate the elimination of cervical cancer and its causative agent, human papillomavirus (HPV) were reviewed. Although some countries have reached key performance indicators toward elimination (>90% of girls HPV vaccinated and >70% of women HPV screened), most are yet to reach these targets, implying a need for improved strategies. Gender-neutral vaccination, even with moderate vaccination coverage was highlighted as a strategy [...]

Menée à l'aide d'une microsimulation et de données françaises, néerlandaises et roumaines, cette étude estime l'effet, sur la morbidité et l'incidence du cancer du foie, de 7 programmes de prévention sur la période 2022-2030 (restriction du marketing alimentaire, taxes sur l'alcool et les boissons sucrées/édulcorées)

Preventing liver disease with policy measures to tackle alcohol consumption and obesity: the HEPAHEALTH II study

Retat, Lise ; Webber, Laura ; Jepsen, Peter ; Martin, Alexander ; Cortez-Pinto, Helena ; Lazarus, Jeffrey V. ; Negro, Francesco ; Mitchyn, Markiyan ; Guzek, John ; Card-Gowers, Joshua ; Graff, Hannah ; Nahon, Pierre ; Sheron, Nick ; Sagi, Shira Zelber ; Buti, Maria

Background and aims: Chronic liver disease (CLD) causes 1.8% of all deaths in Europe, many of them from liver cancer. We estimated the impact of several policy interventions the Netherlands, and Romania. Methods: We used a validated microsimulation model to assess seven different policy scenarios in 2022–2030: a Minimum Unit Pricing (MUP) on alcohol of €0.70, an MUP of €1, a volumetric alcohol tax, a sugar-sweetened beverages (SSB) tax, food marketing restrictions, plus two different [...]

Menée à partir de données de la "UK Biobank" portant sur 393 042 personnes, cette étude analyse l'association entre une exposition non professionnelle à long terme à de faibles concentrations de benzène dans l'air ambiant et la mortalité afin de règlementer cette pollution

Long-Term Exposure to Low-Level Ambient Benzene and Mortality in a National English Cohort

Jianing Wang ; Yudiyang Ma ; Linxi Tang ; Dankang Li ; Junqing Xie ; Yu Sun ; Yaohua Tian

Background: Benzene affects human health through environmental exposure in addition to occupational contact. However, few studies have examined the associations between long-term exposure to low-level ambient benzene and mortality risks in non-occupational settings. Methods: This prospective cohort study consists of 393,042 participants without stroke, myocardial infarction, or cancer at baseline from the UK Biobank. Annual average concentrations of benzene for each year during follow-up were [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2022 (44 études), cette méta-analyse évalue l'efficacité d'interventions de santé en ligne pour le sevrage tabagique

Efficacy of e-health interventions for smoking cessation management in smokers: a systematic review and meta-analysis

Li, Shen ; Qu, Zhan ; Li, Yiyang ; Ma, Xuelei

Background: Smoking is one of the major risk factors for shortened lifespan and disability, while smoking cessation is currently the only guaranteed method to reduce the harm caused by smoking. E-health is a field that utilizes information and communication technology to support the health status of its users. The emergence of this digital health approach has provided a new way of smoking cessation support for smokers seeking help, and an increasing number of researchers are attempting to use [...]