Menée à l'aide de données de la "UK Biobank" portant sur 375 998 personnes (durée médiane de suivi : 11,8 ans), cette étude analyse l'association entre un mode de vie sain et le risque de cancer de la vessie (880 cas) en fonction du score de risque polygénique

Genetic factors, adherence to healthy lifestyle behaviors, and risk of bladder cancer

He, Qiangsheng ; Wu, Siqing ; Zhou, Ying ; Liu, Yuchen ; Xia, Bin ; Li, Wenjing ; Zhao, Jinyu ; Mi, Ningning ; Xie, Peng ; Qin, Xiwen ; Yuan, Jinqiu ; Pan, Yihang

Background: Genetic and lifestyle factors both contribute to the pathogenesis of bladder cancer, but the extent to which the increased genetic risk can be mitigated by adhering to a healthy lifestyle remains unclear. We aimed to investigate the association of combined lifestyle factors with bladder cancer risk within genetic risk groups. Methods: We conducted a prospective study of 375 998 unrelated participants of European ancestry with genotype and lifestyle data and free of cancer from the [...]

Menée auprès de 172 patients ayant survécu à un cancer associé au syndrome de Lynch (durée médiane de suivi : 3 ans), cette étude analyse le risque de développer de nouvelles lésions précancéreuses après exposition aux inhibiteurs de points de contrôle immunitaire

Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockade

Harrold, Emily C. ; Foote, Michael B. ; Rousseau, Benoit ; Walch, Henry ; Kemel, Yelena ; Richards, Allison L. ; Keane, Fergus ; Cercek, Andrea ; Yaeger, Rona ; Rathkopf, Dana ; Segal, Neil H. ; Patel, Zalak ; Maio, Anna ; Borio, Matilde ; O’Reilly, Eileen M. ; Reidy, Diane ; Desai, Avni ; Janjigian, Yelena Y. ; Murciano-Goroff, Yonina R. ; Carlo, Maria I. ; Latham, Alicia ; Liu, Ying L. ; Walsh, Michael F. ; Ilson, David ; Rosenberg, Jonathan E. ; Markowitz, Arnold J. ; Weiser, Martin R. ; Rossi, Anthony M. ; Vanderbilt, Chad ; Mandelker, Diana ; Bandlamudi, Chaitanya ; Offit, Kenneth ; Berger, Michael F. ; Solit, David B. ; Saltz, Leonard ; Shia, Jinru ; Diaz, Luis A. ; Stadler, Zsofia K.

Metastatic and localized mismatch repair-deficient (dMMR) tumors are exquisitely sensitive to immune checkpoint blockade (ICB). The ability of ICB to prevent dMMR malignant or pre-malignant neoplasia development in patients with Lynch syndrome (LS) is unknown. Of 172 cancer-affected patients with LS who had received ≥1 ICB cycles, 21 (12%) developed subsequent malignancies after ICB exposure, 91% (29/32) of which were dMMR, with median time to development of 21 months (interquartile range, [...]

Menée sur la période 2019-2021 sur Twitter/X (1 122 397 tweets), cette étude analyse la prévalence et le contenu des informations concernant le risque de cancer associé à une consommation d'alcool à l'échelle internationale

Global prevalence and content of information about alcohol use as a cancer risk factor on twitter

King, Andy J. ; Dunbar, Natalie M. ; Margolin, Drew ; Chunara, Rumi ; Tong, Chau ; Jih-Vieira, Lea ; Matsen, Cindy B. ; Niederdeppe, Jeff

Objectives: Alcohol use is a major risk factor for several forms of cancer, though many people have limited knowledge of this link. Public health communicators and cancer advocates desire to increase awareness of this link with the long-term goal of reducing cancer burden. The current study is the first to examine the prevalence and content of information about alcohol use as a cancer risk on social media internationally. Methods: We used a three-phase process (hashtag search, dictionary-based [...]

A partir de données bibliométriques, cette étude fait le point sur la recherche concernant la prévention des cancers en Europe

Mapping the European cancer prevention research landscape: A case for more prevention research funding

Schmutz, A. ; Matta, M. ; Cairat, M. ; Espina, C. ; Schuz, J. ; Kampman, E. ; Ervik, M. ; Vineis, P. ; Kelm, O.

Despite the strong evidence of prevention as a prime defence against the disease, the majority of cancer research investment continues to be made in basic science and clinical translational research. Little quantitative data is available to guide decisions on the choice of research priorities or the allocation of research resources. The primary aim of the mapping of the European cancer prevention research landscape presented in this paper is to provide the evidence-base to inform future [...]

Menée en Australie auprès de 459 témoins et 666 patients atteints d'un lymphome folliculaire, cette étude analyse l'association entre l'exposition solaire au cours de la vie et le risque de développer la maladie

A population-based family case-control study of sun exposure and follicular lymphoma risk

Odutola, Michael K. ; van Leeuwen, Marina T. ; Bruinsma, Fiona ; Turner, Jennifer ; Hertzberg, Mark ; Seymour, John F. ; Prince, H Miles ; Trotman, Judith ; Verner, Emma ; Roncolato, Fernando ; Opat, Stephen ; Lindeman, Robert ; Tiley, Campbell ; Milliken, Samuel T. ; Underhill, Craig R. ; Benke, Geza ; Giles, Graham G. ; Vajdic, Claire M.

Background: Epidemiological evidence suggests an inverse association between sun exposure and follicular lymphoma (FL) risk. Methods: We conducted an Australian population-based family case-control study based on 666 cases and 459 controls (288 related, 171 unrelated). Participants completed a lifetime residence and work calendar and recalled outdoor hours on weekdays, weekends and holidays in the warmer and cooler months at ages 10, 20, 30, and 40 years, and clothing types worn in the warmer [...]