Menée à l'aide de données 1993-2018 d'un registre italien portant sur 30 828 patients atteints d'un mésothéliome, cette étude analyse l'incidence précoce de la maladie (âge : jusqu'à 50 ans, 1 278 cas) puis identifie les facteurs d'exposition professionnelle ou environnementale à l'amiante

Incidence of mesothelioma in young people and causal exposure to asbestos in the Italian national mesothelioma registry (ReNaM)

Alessandro Marinaccio ; Davide Di Marzio ; Carolina Mensi ; Dario Consonni ; Carmela Gioscia ; Enrica Migliore ; Carlo Genova ; Roberta Rossetto Giaccherino ; Silvia Eccher ; Stefano Murano ; Vera Comiati ; Veronica Casotto ; Corrado Negro ; Lucia Mangone ; Lucia Miligi ; Sara Piro ; Alessia Angelini ; Iolanda Grappasonni ; Gabriella Madeo ; Ilaria Cozzi ; Laura Ancona ; Tommaso Staniscia ; Francesco Carrozza ; Domenica Cavone ; Luigi Vimercati ; Michele Labianca ; Federico Tallarigo ; Giuseppe Cascone ; Massimo Melis ; Michela Bonafede ; Alberto Scarselli ; Alessandra Binazzi

Introduction: The epidemiological surveillance of mesothelioma incidence is a crucial key for investigating the occupational and environmental sources of asbestos exposure. The median age at diagnosis is generally high, according to the long latency of the disease. The purposes of this study are to analyse the incidence of mesothelioma in young people and to evaluate the modalities of asbestos exposure. Methods: Incident malignant mesothelioma (MM) cases in the period 1993–2018 were retrieved [...]

Menée à l'aide de données multicentriques portant sur 4 693 patients atteints d'une hépatite B chronique en cours de traitement (durée médiane de suivi : 7,6 ans), cette étude analyse l'association entre la charge virale avant le traitement et le risque de carcinome hépatocellulaire

Non-linear association of baseline viral load with on-treatment hepatocellular carcinoma risk in chronic hepatitis B

Won-Mook Choi ; Gi-Ae Kim ; Jonggi Choi ; Gwang Hyeon Choi ; Yun Bin Lee ; Dong Hyun Sinn ; Young-Suk Lim

Objective: The association between baseline pretreatment serum HBV DNA levels and on-treatment hepatocellular carcinoma (HCC) risk remains controversial in patients with chronic hepatitis B (CHB). We aimed to investigate the association between baseline HBV viral load and on-treatment HCC risk in CHB patients without cirrhosis. Design: Using a multicentre historical cohort study including 4693 hepatitis B e antigen (HBeAg)-negative and HBeAg-positive, adult CHB patients without cirrhosis who [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données pangénomiques portant sur 25 806 patients atteints d'une maladie inflammatoire de l'intestin (MICI) ou d'une colite ulcéreuse, cette méta-analyse évalue l'association entre ces maladies et le risque de cancer extracolique (32 localisations)

Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study

Gao, Hui ; Zheng, Shuhao ; Yuan, Xin ; Xie, Jiarong ; Xu, Lei

Background: The risk of extracolonic cancer is increased in inflammatory bowel disease (IBD) patients, but it is not clear whether there is a causal relationship. We aimed to systematically estimate the causal relationship between IBD and extracolonic cancers. Methods: Independent genetic variants strongly associated with IBD were extracted as instrumental variables from genome-wide association study (GWAS) conducted by the International IBD Genetics Consortium including 12,882 IBD patients, [...]

Menée en Chine auprès de 7 940 femmes infectées par le papillomavirus humain HPV16/18 (âge médian : 40 ans), cette étude analyse l'association entre une co-infection par d'autres génotypes de HPV et le risque de néoplasie cervicale intraépithéliale de grade 3 ou plus (CIN 3+)

Risk of cervical intraepithelial neoplasia grade 3 or more diagnoses for human papillomavirus16/18-positive women by cytology and co-infection status

Ao, Mengyin ; Yao, Xiaoxi ; Zheng, Danxi ; Gu, Xuesai ; Xi, Mingrong

Background: Human papillomavirus (HPV) 16 and 18 cause approximately 70% of cervical cancer cases. The aim of this study was to evaluate whether co-infected with other HPV genotypes will affect the risk of cervical carcinogenesis in HPV16/18 positive-women. Methods: In this cross-sectional study, cervical cytology and histological classifications from women who tested positive for HPV 16/18 and underwent colposcopy within 6 months, between January 2010 and May 2021 were obtained from West China [...]

Menée en Corée à l'aide de données portant sur 51 899 personnes souffrant de polyarthrite rhumatoïde (durée de suivi : 4,5 ans), cette étude analyse le risque de cancer du poumon associé à cette maladie, en fonction du sexe, du statut tabagique et de l'âge

Rheumatoid arthritis and risk of lung cancer: a nationwide cohort study

Cho, Mi Hee ; Cho, Jong Ho ; Eun, Yeonghee ; Han, Kyungdo ; Jung, Jinhyoung ; Cho, In Young ; Yoo, Jung Eun ; Lee, Hyun ; Kim, Hyungjin ; Park, Seong Yong ; Shin, Dong Wook

Introduction: There has been increasing interest in the risk of lung cancer related to rheumatoid arthritis (RA). We investigated the association between RA and the risk of lung cancer with consideration of key confounding factors, including RA serostatus and smoking status. Methods: Using a nationwide database, we identified 51,899 patients with newly diagnosed RA between 2010 and 2017, which were matched by sex and age at a 1:5 ratio with 259,495 non-RA population. The association of lung [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données sur le génome entier portant sur 488 témoins et 304 patients atteints d'un cancer primitif du foie, cette étude analyse l'association entre la graisse hépatique, le tissu adipeux viscéral ou l'indice de masse corporelle et le risque de développer la maladie

Visceral and ectopic fat are more predictively associated with primary liver cancer than overall obesity from genetic sights: A Mendelian randomization study

Xu, Fei-Qi ; Xu, Qing-Yun ; Zhu, Zhang-Ji ; Jin, Lei ; Ye, Tai-Wei ; Du, Cheng-Fei ; Gao, Zhen-Yu ; Huang, Xiao-Kun ; Zhang, Zhe ; Jin, Li-Ming ; Yao, Wei-Feng

Several observational studies have reported an association between obesity and primary liver cancer (PLC), while the causality behind this association and the comparison of the risk effects of different obesity indicators on PLC remain unclear. In this study, we performed two-sample Mendelian randomization (MR) analyses to assess the associations of genetically determined liver fat, visceral adipose tissue (VAT), and body mass index (BMI) with the risk of PLC. The summary statistics of [...]

Menée en Suède sur la période 1995-2018 auprès de 4 998 patientes atteintes de tumeurs ovariennes à la limite de la malignité (âge moyen : 55,7 ans), cette étude analyse le risque de cancer (hors ovaire) associé à la maladie par rapport à la population générale

Risks of non-ovarian cancers in women with borderline ovarian tumor: a national cohort study in Sweden

Dobilas, Arturas ; Jansåker, Filip ; Li, Xinjun ; Sundquist, Kristina ; Borgfeldt, Christer

Background: Associations between different cancer types are known. The affirmation of the risk for non-ovarian cancer after ovarian borderline tumors (BOT) is, however, sparse. Aim: To analyze the risk of subsequent or simultaneous cancers in women with BOTs compared with the general female Swedish population. Methods: An open cohort study (1995–2018) was conducted where a diagnosis of BOTs as well as subsequent or simultaneous cancer diagnoses were obtained from the Swedish Cancer Register and [...]

Menée en Chine auprès de 12 518 femmes présentant un risque moyen de cancer du sein (âge : 45-64 ans), cette étude identifie des facteurs modifiant l'association entre la densité mammaire et le risque de cancer du sein

Breast cancer risk factors and mammographic density among 12518 average-risk women in rural China

Yan, Huijiao ; Ren, Wenhui ; Jia, Mengmeng ; Xue, Peng ; Li, Zhifang ; Zhang, Shaokai ; He, Lichun ; Qiao, Youlin

Background: Mammographic density (MD) is a strong risk factor for breast cancer. We aimed to evaluate the association between MD and breast cancer related risk factors among average-risk women in rural China. Methods: This is a population-based screening study. 12518 women aged 45–64 years with complete MD data from three maternal and childcare hospitals in China were included in the final analysis. ORs and 95%CIs were estimated using generalized logit model by comparing each higher MD (BI-RADS [...]

Menée à l'aide d'échantillons sanguins collectés auprès de 168 témoins et 84 patients atteints d'un cancer de la vésicule biliaire, cette étude analyse l'association entre des adduits aflatoxineB1-lysine-albumine et le risque de développer la maladie

Association of aflatoxin with gallbladder cancer in a case-control study nested within a Chinese cohort

Koshiol, Jill ; Zhu, Bin ; Wang, Renwei ; Hildesheim, Allan ; Gao, Yu-Tang ; Egner, Patricia A. ; Yuan, Jian-Min ; Groopman, John D.

We evaluated whether aflatoxin B1 (AFB1) exposure was associated with later risk of developing gallbladder cancer (GBC). We measured AFB1-lysine albumin adducts in baseline samples from the Shanghai Cohort Study of 18 244 men aged 45 to 64 years (recruited 1986-1989). We included 84 GBC cases with sufficient serum and 168 controls matched on age at sample collection, date of blood draw and residence. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for detectable [...]