Menée à partir de données portant sur 9 885 patientes ayant survécu à un cancer pédiatrique (âge médian au diagnostic : 10 ans, durée médiane de suivi après l'âge de 18 ans : 11 ans) et auprès de témoins, cette étude analyse leur recours à des techniques de procréation médicalement assistée puis évalue le succès de ces dernières

Assisted reproductive technology use and outcomes in childhood cancer survivors

Keefe, Kimberly W. ; Lanes, Andrea ; Stratton, Kayla ; Green, Daniel M. ; Chow, Eric J. ; Oeffinger, Kevin C. ; Barton, Sara ; Diller, Lisa ; Yasui, Yutaka ; Leisenring, Wendy M. ; Armstrong, Gregory T. ; Ginsburg, Elizabeth S.

Background : Treatment exposures for childhood cancer reduce ovarian reserve. However, the success of c(ART) among female survivors is not well established. Methods: Five-year survivors of childhood cancer in the Childhood Cancer Survivor Study were linked to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System, which captures national ART outcomes. The authors assessed the live birth rate, the relative risk (RR) with 95% confidence intervals (95% CIs), and [...]

Menée à partir de données portant sur 6 318 patients ayant survécu à un cancer pédiatrique (âge médian lors de l'étude : 31 ans), cette étude analyse la présence de troubles auditifs (perte d'audition et acouphènes) puis évalue l'impact de ces troubles sur leur qualité de vie

Auditory complications among childhood cancer survivors and health-related quality of life: a PanCareLIFE study

Strebel, Sven ; Baust, Katja ; Grabow, Desiree ; Byrne, Julianne ; Langer, Thorsten ; am Zehnhoff-Dinnesen, Antoinette ; Kuonen, Rahel ; Weiss, Annette ; Kepak, Tomas ; Kruseova, Jarmila ; Berger, Claire ; Calaminus, Gabriele ; Sommer, Grit ; Kuehni, Claudia E. ; on behalf of the PanCare, Life Consortium

Purpose: Auditory complications are potential side effects from childhood cancer treatment. Yet, limited evidence exists about the impact of auditory complications—particularly tinnitus—on health-related quality of life (HRQoL) among childhood cancer survivors (CCS). We determined the prevalence of hearing loss and tinnitus in the European PanCareLIFE cohort of CCS and examined its effect on HRQoL. Methods: We included CCS from four European countries who were diagnosed at age   [...]

Menée à partir de données portant sur 162 patients atteints d'un cancer de l'estomac, cette étude rétrospective analyse l'impact, sur la survie, d'une sarcopénie et d'une obésité sarcopénique

The effect of sarcopenia and sarcopenic obesity on survival in gastric cancer

Şahin, Muzaffer Ece Hakan ; Akbaş, Feray ; Yardimci, Aytul Hande ; Şahin, Eren

Background: Sarcopenic obesity arises from increased muscle catabolism triggered by inflammation and inactivity. Its significance lies in its role in contributing to morbidity and mortality in gastric cancer. This study aims to explore the potential correlation between sarcopenia, sarcopenic obesity, and gastric cancer, as well as their effect on survival. Materials and methods: This retrospective study included 162 patients aged ≥ 18 years who were diagnosed with stomach cancer. Patient age, [...]

Menée à partir des données GLOBOCAN, cette étude estime, pour l'année 2018, l'incidence des cancers et la mortalité dans les pays arabes

Cancer incidence and mortality estimates in Arab countries in 2018: A GLOBOCAN data analysis

Al-Muftah, Mariam ; Al-Ejeh, Fares

Background: Arab countries are projecting increase in cancer incidence and mortality, however, there are limited studies that compare the epidemiology of cancer in Arab countries compared to other parts of the world. Methods: We used the 2018 Global Cancer Observatory data to compare the age-standardized incidence and mortality estimates in Arab-speaking countries to the rest of the world. Results: Rates for incidence and mortality for all cancers in Arab countries were lower than the world’s [...]

Menée à partir des données de l'Organisation Mondiale de la Santé concernant 31 pays européens, cette étude analyse l'évolution, sur la période 1990-2020, de la mortalité par cancer de l'ovaire et présente des projections jusqu'en 2025

European trends in ovarian cancer mortality, 1990-2020 and predictions to 2025

Wojtyła, Cezary ; Bertuccio, Paola ; Giermaziak, Wojciech ; Santucci, Claudia ; Odone, Anna ; Ciebiera, Michał ; Negri, Eva ; Wojtyła, Andrzej ; La Vecchia, Carlo

Introduction: Over the last decades ovarian cancer mortality in Europe has been decreasing, but disparities in trends were observed. In this paper, we analyzed ovarian cancer mortality trends in Europe over the period 1990-2020 and predicted the number of deaths and rates to 2025. Methods: We extracted population and death certification data from ovarian cancer in women for 31 European countries, between 1990 and 2020 from the World Health Organization database. We computed age-standardized [...]

Menée aux Etats-Unis à partir de données portant sur un total de 840 patients atteints d'un cancer du poumon non à petites cellules, cette étude de cohorte analyse la survie globale en fonction du type de maladie métastatique (de novo de stade IV ou de stade métastatique récidivante à distance)

Overall Survival Among Patients With De Novo Stage IV Metastatic and Distant Metastatic Recurrent Non–Small Cell Lung Cancer

Su, Chloe C. ; Wu, Julie T. ; Choi, Eunji ; Myall, Nathaniel J. ; Neal, Joel W. ; Kurian, Allison W. ; Stehr, Henning ; Wood, Douglas ; Henry, Solomon M. ; Backhus, Leah M. ; Leung, Ann N. ; Wakelee, Heather A. ; Han, Summer S.

Importance : Despite recent breakthroughs in therapy, advanced lung cancer still poses a therapeutic challenge. The survival profile of patients with metastatic lung cancer remains poorly understood by metastatic disease type (ie, de novo stage IV vs distant recurrence). Objective : To evaluate the association of metastatic disease type on overall survival (OS) among patients with non–small cell lung cancer (NSCLC) and to identify potential mechanisms underlying any survival difference. Design, [...]

Menée en Angleterre à partir de données portant sur des patients atteints d'un cancer colorectal diagnostiqué entre 2012 et 2016, cette étude analyse les inégalités dans l'accès aux traitements

Inequalities in treatment among patients with colon and rectal cancer: a multistate survival model using data from England national cancer registry 2012–2016

Ling, Suping ; Luque Fernandez, Miguel-Angel ; Quaresma, Manuela ; Belot, Aurélien ; Rachet, Bernard

Background: Individual and tumour factors only explain part of observed inequalities in colorectal cancer survival in England. This study aims to investigate inequalities in treatment in patients with colorectal cancer. Methods: All patients diagnosed with colorectal cancer in England between 2012 and 2016 were followed up from the date of diagnosis (state 1), to treatment (state 2), death (state 3) or censored at 1 year after the diagnosis. A multistate approach with flexible parametric model [...]

Menée en Angleterre à partir de données 2014-2019 portant sur 168 449 patientes atteintes d'un cancer invasif du sein, cette étude de cohorte analyse le respect des recommandations du "National Institute for Health and Clinical Excellence" (NICE) en matière d'utilisation des médicaments anticancéreux

Evidence into practice: a national cohort study of NICE-recommended oncological drug therapy utilisation among women diagnosed with invasive breast cancer in England

Gannon, Melissa Ruth ; Dodwell, David ; Aggarwal, Ajay ; Park, Min Hae ; Miller, Katie ; Horgan, Kieran ; Clements, Karen ; Medina, Jibby ; Cromwell, David Alan

Background: Multiple drug treatments are approved for invasive breast cancer (IBC). We investigated uptake of NICE-recommended oncological drugs and variation by age, comorbidity burden and geographical region. Methods: Women (aged 50+ years) diagnosed with IBC from 2014 to 2019, were identified from England Cancer Registry data and drug utilisation from Systemic Anti-Cancer Therapy data. Interrupted time series analysis assessed national-level changes in drug use after publication of NICE [...]

A partir d'une revue de la littérature (237 documents), cette étude analyse la prise en compte, dans les plans nationaux de lutte contre les cancers, des soins psychosociaux destinés aux patients ayant survécu à la maladie

Psychosocial care for cancer survivors: A global review of national cancer control plans

Mullen, Louise ; Signorelli, Christina ; Nekhlyudov, Larissa ; Jacobsen, Paul B. ; Gitonga, Isaiah ; Estapé, Tania ; Lim-Hoeg, Beverly ; Miles, Anne ; Sade, Cristina ; Mazariego, Carolyn ; Dégi, Csaba L. ; Howard, Fuchsia ; Manne, Sharon ; Travado, Luzia ; Jefford, Michael ; International Psycho-Oncology Society Survivorship Special Interest Group

Objective: National Cancer Control Plans (NCCPs) are high-level policy documents that prioritise actions to be taken to improve cancer control activities. As the number of cancer survivors grows globally, there is an urgent need to assess whether and how psychosocial care across the cancer care continuum is included in NCCPs. This review aimed to ascertain the extent to which NCCPs referenced psycho-oncology care for cancer survivors in the post-treatment phase. Methods: NCCPs were obtained [...]

Menée auprès de 98 dyades constituées de patientes atteintes d'un cancer et de leurs aidants, cette étude randomisée évalue l'effet, sur leur santé psychique et leur qualité de vie, d'une intervention de psychologie positive centrée sur la famille

Effects of family-centered positive psychological intervention on psychological health and quality of life in patients with breast cancer and their caregivers

Zhang, Yao ; Tang, Ruijin ; Bi, Liuna ; Wang, Dan ; Li, Xiaoxu ; Gu, Feng ; Han, Jing ; Shi, Ming

Purpose: Positive psychological intervention could improve individual’s psychological health and quality of life. This study aimed to examine the effectiveness of family-centered positive psychological intervention on resilience, hope, perceived benefits, and quality of life in breast cancer patients and their caregivers. Methods: A two-group, randomized controlled study, including 98 dyads of breast cancer patients and caregivers, was conducted. Dyads were randomly assigned to intervention [...]

Menée aux Pays-Bas à partir de données portant sur 924 patients atteints d'un lymphome (durée de suivi : 8 ans après le diagnostic), cette étude analyse l'évolution de leurs déficiences cognitives auto-déclarées et le lien entre ces déficiences et une fatigue ou une détresse psychologique

The course of self-perceived cognitive functioning among patients with lymphoma and the co-occurrence with fatigue and psychological distress

Ekels, Afke ; Oerlemans, Simone ; Schagen, Sanne B. ; Issa, Djamila E. ; Thielen, Noortje ; Nijziel, Marten R. ; van der Poel, Marjolein W. M. ; Arts, Lindy P. J. ; Posthuma, Eduardus F. M. ; van de Poll-Franse, Lonneke V.

Purpose: To investigate the proportion of patients with lymphoma with persistent clinically relevant cognitive impairment, and its relation to treatment, fatigue, and psychological distress. Methods: Patients with diffuse-large-B-cell-lymphoma (DLBCL), follicular-lymphoma (FL), and chronic-lymphocytic-leukemia (CLL)/small-lymphocytic-lymphoma (SLL), diagnosed between 2004–2010 or 2015–2019, were followed up to 8 years post-diagnosis. Sociodemographic and clinical data were obtained from the [...]