Menée à partir de données 1993-2017 portant sur 115 patients atteints d'une tumeur des cellules germinales traitée par de hautes doses de carboplatine (âge médian : 32 ans), cette étude analyse la sévérité et les caractéristiques de déficiences auditives liées au traitement

Ototoxicity associated with high-dose carboplatin for patients with previously treated germ cell tumors

Funt, Samuel A. ; Knezevic, Andrea ; Wilson, Kaamilah ; Bromberg, Maria ; Budnick, Amy ; O’Connor, Kerri L. ; McHugh, Deaglan J. ; Larsen, Erik ; Bajorin, Dean F. ; Motzer, Robert J. ; Tonorezos, Emily S. ; Patil, Sujata ; Feldman, Darren R.

Background: High-dose carboplatin is an essential part of curative high-dose chemotherapy (HDCT) for patients with previously treated germ cell tumors (GCTs). Although hearing loss (HL) is a known side effect of HDCT, data on its severity and characteristics are limited. Methods: Eligible patients received HDCT for GCTs from 1993 to 2017 and had audiograms before and after HDCT. HL severity was classified by American Speech-Language-Hearing Association criteria, and mean change in hearing [...]

Menée en Australie par questionnaire auprès de 16 053 patients ayant survécu à un cancer et de 106 345 témoins, cette étude analyse la présence de douleurs et l'impact de celles-ci sur les activités de la vie quotidienne

Pain and its interference with daily living in relation to cancer: a comparative population-based study of 16,053 cancer survivors and 106,345 people without cancer

Joshy, Grace ; Khalatbari-Soltani, Saman ; Soga, Kay ; Butow, Phyllis ; Laidsaar-Powell, Rebekah ; Koczwara, Bogda ; Rankin, Nicole M. ; Brown, Sinan ; Weber, Marianne ; Mazariego, Carolyn ; Grogan, Paul ; Stubbs, John ; Thottunkal, Stefan ; Canfell, Karen ; Blyth, Fiona M. ; Banks, Emily

Background: Pain is a common, debilitating, and feared symptom, including among cancer survivors. However, large-scale population-based evidence on pain and its impact in cancer survivors is limited. We quantified the prevalence of pain in community-dwelling people with and without cancer, and its relation to physical functioning, psychological distress, and quality of life (QoL). Methods: Questionnaire data from participants in the 45 and Up Study (Wave 2, n = 122,398, 2012–2015, mean [...]

A partir d'une revue systématique de la littérature (45 études incluant un total 7 797 participants âgés de 0 à 21 ans), cette étude analyse la présence de cardiotoxicités aiguës de survenue précoce chez des enfants et adolescents atteints d'un cancer traité par anthracyclines, mitoxantrone ou radiothérapie impliquant le coeur puis identifie les facteurs de risque associés

Acute and early-onset cardiotoxicity in children and adolescents with cancer: a systematic review

Kouwenberg, Theodorus W. ; van Dalen, Elvira C. ; Feijen, Elizabeth A. M. ; Netea, Stejara A. ; Bolier, Melissa ; Slieker, Martijn G. ; Hoesein, Firdaus A. A. Mohamed ; Kremer, Leontien C. M. ; Grotenhuis, Heynric B. ; Mavinkurve-Groothuis, Annelies M. C.

Background: Cardiotoxicity is among the most important adverse effects of childhood cancer treatment. Anthracyclines, mitoxantrone and radiotherapy involving the heart are its main causes. Subclinical cardiac dysfunction may over time progress to clinical heart failure. The majority of previous studies have focused on late-onset cardiotoxicity. In this systematic review, we discuss the prevalence and risk factors for acute and early-onset cardiotoxicity in children and adolescents with cancer [...]

Menée en Chine à partir de données portant sur 469 enfants atteints d'une leucémie aiguë, cette étude analyse les relations entre les différents symptômes pendant la chimiothérapie

Exploring core symptoms and interrelationships among symptoms in children with acute leukemia during chemotherapy: A network analysis

Fang, Jia ; Xu, Li-Ling ; Liu, Chun-Qin ; Zhu, Zheng ; Wang, Mei-Xiang ; Liu, Xia ; Liu, Qiong ; Huang, Hai-Ying ; Lin, Yan

Purpose: Children with acute leukemia have suffered from a considerable symptom burden during chemotherapy. However, few studies have focused on exploring the mechanisms among symptoms in children with acute leukemia. Our study aims to explore core symptoms and describe the interrelationships among symptoms in children with acute leukemia during chemotherapy. Methods: From January 2021 to March 2023, 469 children with acute leukemia were recruited from 20 Chinese cities. The Memorial Symptom [...]

Menée aux Etats-Unis, cette étude transversale analyse les disparités ethniques dans l'association entre une exposition aux phénols, parabens et substances per- et polyfluoroalkylées et un diagnostic de cancer (mélanome, thyroïde, sein, ovaire, utérus, prostate)

Exploratory profiles of phenols, parabens, and per- and poly-fluoroalkyl substances among NHANES study participants in association with previous cancer diagnoses

Cathey, Amber L. ; Nguyen, Vy K. ; Colacino, Justin A. ; Woodruff, Tracey J. ; Reynolds, Peggy ; Aung, Max T.

Background: Some hormonally active cancers have low survival rates, but a large proportion of their incidence remains unexplained. Endocrine disrupting chemicals may affect hormone pathways in the pathology of these cancers. Objective: To evaluate cross-sectional associations between per- and polyfluoroalkyl substances (PFAS), phenols, and parabens and self-reported previous cancer diagnoses in the National Health and Nutrition Examination Survey (NHANES). Methods: We extracted concentrations [...]

Menée aux Etats-Unis à partir de données 2011-2022 portant sur 291 419 patients atteints d'un cancer (20 localisations ; âge médian : 68 ans), cette étude de cohorte rétrospective analyse l'influence du statut socioéconomique sur les traitements anticancéreux et la survie

Socioeconomic Status and Inequities In Treatment Initiation and Survival Among Patients With Cancer, 2011-2022

Guadamuz, Jenny S ; Wang, Xiaoliang ; Ryals, Cleo A ; Miksad, Rebecca A ; Snider, Jeremy ; Walters, James ; Calip, Gregory S

Lower neighborhood socioeconomic status (SES) is associated with suboptimal cancer care and reduced survival. However, most studies examining cancer inequities across area-level SES tend to use less granular/unidimensional measures and pre-date the coronavirus disease (COVID-19) pandemic. Here we examined the association of area-level SES on real-world treatment initiation and overall survival (rwOS) among adults with 20 common cancers.Retrospective cohort study using electronic health [...]

Menée à partir de données 2007-2017 du registre texan des cancers et de la base Medicare, cette étude analyse l'impact des stratégies thérapeutiques d'un mélanome cutané sur la mortalité spécifique et sur la mortalité toutes causes confondues en fonction de l'origine ethnique

Effects of treatment methods on cutaneous melanoma related mortality and all-cause mortality in Texas: TCR-Medicare 2007–2017 database

Ramirez, Fabiola ; Riva, Hannah ; Digbeu, Biai ; Samaniego, Michelle ; Fernandez, Lorena ; Mansour, Sara ; Vasquez, Rebecca ; Lopez, David S. ; Chacon, Jessica

Purpose: The incidence of cutaneous melanoma is rising, and Melanoma related deaths are highest among people aged 65–74. Herein, we aim to understand the impact of novel and established melanoma treatment methods on CM related mortality and all-cause mortality. We further compared these effects among Hispanic and non-Hispanic Whites (NHW). Methods: The data was extracted from the Texas Cancer Registry from 2007 to 2017. A Cox Proportional Hazard regression analysis was performed to assess [...]

Menée à partir de données portant sur 1 135 patients atteints d'un cancer métastatique de novo de la prostate, cette étude analyse l'impact, sur la survie globale et la mortalité spécifique, d'une utilisation de médicaments courants (metformine, statines, inhibiteurs de la pompe à protons, inhibiteurs de COX-2, aspirine, paracétamol, anti-inflammatoires non stéroïdiens) pendant un traitement anticancéreux (acétate d'abiratérone, prednisone, thérapie anti-androgénique)

Effect of Concomitant Medications on Treatment Response and Survival in De Novo Metastatic Prostate Cancer: Secondary Analysis of the LATITUDE Study

Roy, Soumyajit ; Saad, Fred ; Wallis, Christopher J. D. ; Sun, Yilun ; Spratt, Daniel E. ; Akilla, Rishav ; Kishan, Amar U. ; Malone, Shawn ; Morgan, Scott C.

Purpose: It is unclear whether exposure to commonly prescribed medications influences survival and treatment response in patients with de novo high risk metastatic prostate cancer (mPCa) treated with androgen receptor pathway inhibitors (ARPIs). Methods: We performed a secondary analysis of the LATITUDE trial to determine whether receipt of concomitant medications influenced the effect of abiraterone acetate and prednisone, in addition to androgen deprivation therapy (ADT), on overall survival [...]

Menée en France à partir de données portant sur 14 353 patientes atteintes d'un cancer du sein diagnostiqué sur la période 2008-2015, cette étude analyse les disparités socioéconomiques et géographiques dans l'incidence de la maladie en fonction du stade au diagnostic

Socioeconomic and geographic disparities of breast cancer incidence according to stage at diagnosis in France

Delacôte, Claire ; Ariza, Juan Manuel ; Delacour-Billon, Solenne ; Ayrault-Piault, Stéphanie ; Borghi, Giulio ; Menanteau, Katia ; Bouron, Aurélie ; Métais, Magali ; Cowppli-Bony, Anne ; Molinié, Florence

Purpose: Low socioeconomic background (SB) has been associated with lower breast cancer (BC) incidence and higher BC mortality. One explanation of this paradox is the higher frequency of advanced BC observed in deprived women. However, it is still unclear if SB affects similarly BC incidence. This study investigated the link between SB and early/advanced BC incidence from Loire-Atlantique/Vendee Cancer registry data (France). Materials and methods: Fourteen thousand three hundred fifty three [...]

Menée à partir de données d'un centre médical universitaire américain portant sur 26 476 femmes âgées de 40 à 74 ans, cette étude analyse, en fonction de l'origine ethnique (africaine ou caucasienne), le taux de mammographies réalisées

Racial disparities in the screening mammography continuum within a heterogeneous health care system

Ganguly, Anisha P. ; Baker, Kelsey K. ; Redman, Mary W. ; McClintock, Adelaide H. ; Yung, Rachel L.

Background : Decreased mammography drives breast cancer disparities. Black women have lower rates of mammography completion than White women, and this contributes to disparities in outcomes. Points of disparity along the continuum for screening mammography remain underresearched. Methods : The authors compared mammography referrals for Black and White women aged 40–74 years at a heterogeneous academic medical center. Completion of steps of the screening mammography continuum was compared [...]

Menée à partir de données portant sur 2 449 patients atteints d'un carcinome épidermoïde de la tête et du cou, cette étude analyse l'association entre la santé buccale et la survie

Poor oral health influences head and neck cancer patient survival: an International Head and Neck Cancer Epidemiology Consortium pooled analysis

Tasoulas, Jason ; Farquhar, Douglas R ; Sheth, Siddharth ; Hackman, Trevor ; Yarbrough, Wendell G ; Agala, Chris B ; Koric, Alzina ; Giraldi, Luca ; Fabianova, Eleonora ; Lissowska, Jolanta ; Swiatkowska, Beata ; Vilensky, Marta ; Wünsch-Filho, Victor ; de Carvalho, Marcos Brasilino ; López, Rossana Verónica Mendoza ; Holcatova, Ivana ; Serraino, Diego ; Polesel, Jerry ; Canova, Cristina ; Richiardi, Lorenzo ; Zevallos, Jose P ; Ness, Andy ; Pring, Miranda ; Thomas, Steve J ; Dudding, Tom ; Lee, Yuan-Chin Amy ; Hashibe, Mia ; Boffetta, Paolo ; Olshan, Andrew F ; Divaris, Kimon ; Amelio, Antonio L

Background: Poor oral health has been identified as a prognostic factor potentially affecting the survival of patients with head and neck squamous cell carcinoma. However, evidence to date supporting this association has emanated from studies based on single cohorts with small-to-modest sample sizes. Methods: Pooled analysis of 2449 head and neck squamous cell carcinoma participants from 4 studies of the International Head and Neck Cancer Epidemiology Consortium included data on periodontal [...]

Menée au Danemark à partir de données portant sur 1 538 patients ayant survécu à un cancer, cette étude analyse l'association entre leur peur de la récidive de la maladie et l'utilisation des soins (de 18 à 30 mois avant et après le diagnostic de cancer)

Healthcare use and fear of recurrence in adult cancer survivors at 2.5 years after a cancer diagnosis: a nationwide register study in Denmark

Rasmussen, Linda Aagaard ; Jensen, Henry ; Pedersen, Anette Fischer ; Vedsted, Peter

Purpose: To investigate the association between fear of cancer recurrence (FCR) and healthcare use in general practice among cancer survivors. Methods: We linked nationwide register data to survey data on FCR in cancer survivors at 2.5 years after a cancer diagnosis. Multiple regression models were used to analyse the association between high FCR level and quartiles of healthcare use at 18–30 months before the cancer diagnosis (habitual healthcare use) and between high FCR level and healthcare [...]

Menée en Australie par questionnaires auprès de parents d'enfants atteints d'un cancer et auprès de patients pédiatriques, cette étude analyse leur expérience après la participation de l'enfant à un essai clinique effectué dans le cadre d'une médecine de précision

Hopes, concerns, satisfaction and regret in a precision medicine trial for childhood cancer: a mixed-methods study of parent and patient perspectives

Wakefield, Claire E. ; Hetherington, Kate ; Robertson, Eden G. ; Donoghoe, Mark W. ; Hunter, Jacqueline D. ; Vetsch, Janine ; Marron, Jonathan M. ; Tucker, Katherine M. ; Marshall, Glenn M. ; Broom, Alexander ; Haber, Michelle ; Tyrrell, Vanessa ; Malkin, David ; Lau, Loretta ; Mateos, Marion K. ; O’Brien, Tracey A. ; Ziegler, David S.

Background: Paediatric precision oncology aims to match therapeutic agents to driver gene targets. We investigated whether parents and patients regret participation in precision medicine trials, particularly when their hopes are unfulfilled. Methods: Parents and adolescent patients completed questionnaires at trial enrolment (T0) and after receiving results (T1). Parents opted-in to an interview at T1. Bereaved parents completed a questionnaire 6-months post-bereavement (T1B). We analysed [...]

Menée en France, en Autriche et en Allemagne, cette étude analyse le rapport coût-efficacité d'une utilisation prophylaxique primaire et secondaire de facteurs de stimulation des colonies de granulocytes (filgrastim, pegfilgrastim et leurs biosimilaires) chez les patients atteints d'un cancer à risque intermédiaire de neutropénie fébrile

Cost-effectiveness of granulocyte colony-stimulating factors (G-CSFs) for the prevention of febrile neutropenia (FN) in patients with cancer

Aapro, Matti S. ; Chaplin, Stephen ; Cornes, Paul ; Howe, Sebastian ; Link, Hartmut ; Koptelova, Natalia ; Mehl, Andrea ; Di Palma, Mario ; Schroader, Bridgette Kanz ; Terkola, Robert

Purpose: Clinical practice guidelines recommend the use of all approved granulocyte colony-stimulating factors (G-CSFs), including filgrastim and pegfilgrastim, as primary febrile neutropenia (FN) prophylaxis in patients receiving high- or intermediate-risk regimens (in those with additional patient risk factors). Previous studies have examined G-CSF cost-effectiveness by cancer type in patients with a high baseline risk of FN. This study evaluated patients with breast cancer (BC), non-small [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2023 (17 essais randomisés), cette méta-analyse évalue l'intérêt et le rapport coût-efficacité de l'évaluation gériatrique et de la prise en charge des patients âgés atteints d'un cancer (âge : 72-80 ans)

Effectiveness of geriatric assessment and management in older cancer patients: a systematic review and meta-analysis

Anwar, Mohammed Rashidul ; Yeretzian, Shant Torkom ; Ayala, Ana Patricia ; Matosyan, Emma ; Breunis, Henriette ; Bote, Kathyrin ; Puts, Martine ; Habib, Mohammed Hassan ; Li, Qixuan ; Sahakyan, Yeva ; Alibhai, Shabbir M H ; Abrahamyan, Lusine

Background: Frailty and multimorbidity among older cancer patients affect treatment tolerance and efficacy. Comprehensive Geriatric Assessment (CGA) and management is recommended to optimize cancer treatment but its effect on various outcomes remains uncertain. Objective: To conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) and cost-effectiveness studies comparing CGA (with or without implementation of recommendations) to usual care in older cancer patients. [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2021 (23 études), cette étude analyse l'intérêt des applications sur smartphone destinées aux patients ayant survécu à un cancer et évalue l'impact de leur utilisation sur la qualité de vie

A systematic review of smartphone applications for cancer survivors

Changrani, Krisha ; Chima, Sophie ; Sharma, Arun ; Han, Gil-Gyu ; Sharma, Anushka ; McNamara, Mairead ; Jefford, Michael ; Emery, Jon ; Druce, Paige

Purpose: Mobile phone applications are positioned to support, educate, and empower cancer survivors during post-treatment care. We undertook a review to assess the utility of such smartphone applications; determine whether their use correlates with improved quality of life and other self-reported outcomes; and understand the feasibility of integrating mobile apps into routine follow-up care. Methods: MEDLINE, EMBASE, Emcare, and PsycINFO databases were searched for studies evaluating apps that [...]

Menée aux Etats-Unis, cette étude décrit les processus d'identification des aidants de patients atteints d'un cancer ainsi que les pratiques de détection et de prise en charge de la détresse psychologique des aidants et des patients

Processes for Identifying Caregivers and Screening for Caregiver and Patient Distress in Community Oncology: Results from WF-1803CD

Nightingale, Chandylen L ; Snavely, Anna C ; McLouth, Laurie E ; Dressler, Emily V ; Kent, Erin E ; Adonizio, Christian S ; Danhauer, Suzanne C ; Cannady, Rachel ; Hopkins, Judith O ; Kehn, Heather ; Weaver, Kathryn E ; Sterba, Katherine R

Background: Despite their vital roles, informal caregivers of adult cancer patients are commonly overlooked in cancer care. This study describes processes for identifying cancer caregivers and processes for distress screening and management among caregivers and patients in the understudied community oncology setting. Methods: Supportive care leaders (SCLs) from NCI Community Oncology Research Program (NCORP) practices completed online survey questions regarding caregiver identification, [...]