Nota Bene Cancer
Nota Bene Cancer est un bulletin hebdomadaire de veille bibliographique. En libre accès, Nota Bene Cancer permet à ses abonnés de gagner du temps pour se tenir informé de l’actualité scientifique et médicale dans les divers domaines de la recherche sur les cancers.
Rechercher des publications
Pour retrouver les publications signalées par Nota Bene Cancer (archives indexées à partir du n°127 du 1" mars 2012) :
Sommaire du n° 573 du 1 août 2023
Lutte contre les cancers
Qualité de vie, soins de support (1)
Menée à partir de données portant sur 192 patients atteints d'un cancer de la prostate de stade avancé, cette étude analyse la prévalence de comorbidités et évalue l'impact de celles-ci sur la qualité de vie
Comorbidity burden and health-related quality of life in men with advanced prostate cancer
Menée à partir de données portant sur 192 patients atteints d'un cancer de la prostate de stade avancé, cette étude analyse la prévalence de comorbidités et évalue l'impact de celles-ci sur la qualité de vie
Comorbidity burden and health-related quality of life in men with advanced prostate cancer
Benzo, Roberto M. ; Moreno, Patricia I. ; Fox, Rina S. ; Silvera, Carlos A. ; Walsh, Emily A. ; Yanez, Betina ; Balise, Raymond R. ; Oswald, Laura B. ; Penedo, Frank J.
Purpose: Identifying clinically relevant comorbidities and their effect on health-related quality of life (HRQoL) outcomes among men with advanced prostate cancer (APC) can inform patient care and improve outcomes; however, this is poorly understood. The aim of this observational study was to examine the prevalence of comorbidities, and the relationship of comorbidity burden to HRQoL and other patient-reported outcomes (PROs) among men with APC. Methods: Participants were 192 men (average age [...]
Observation (8)
A partir d'une revue systématique de la littérature publiée entre 2010 et 2021 (501 études incluant un total de 68 351 patients pédiatriques), cette méta-analyse évalue la mortalité liée aux traitements anticancéreux chez des enfants atteints d'un cancer dans les pays à faible ou moyen revenu
Treatment-related mortality in children with cancer in low-income and middle-income countries: a systematic review and meta-analysis
A partir d'une revue systématique de la littérature publiée entre 2010 et 2021 (501 études incluant un total de 68 351 patients pédiatriques), cette méta-analyse évalue la mortalité liée aux traitements anticancéreux chez des enfants atteints d'un cancer dans les pays à faible ou moyen revenu
Treatment-related mortality in children with cancer in low-income and middle-income countries: a systematic review and meta-analysis
Ehrlich, Bella S. ; McNeil, Michael J. ; Pham, Linh T. D. ; Chen, Yichen ; Rivera, Jocelyn ; Acuna, Carlos ; Sniderman, Liz ; Sakaan, Firas M. ; Aceituno, Alejandra Mendez ; Villegas, Cesar A. ; Force, Lisa M. ; Bolous, Nancy S. ; Wiphatphumiprates, Parima P. ; Slone, Jeremy S. ; Carrillo, Angela K. ; Gillipelli, Srinithya R. ; Duffy, Caitlyn ; Arias, Anita V. ; Devidas, Meenakshi ; Rodriguez-Galindo, Carlos ; Mukkada, Sheena ; Agulnik, Asya
Background: Approximately 90% of children with cancer live in low-income and middle-income countries (LMICs), where 5-year survival is lower than 20%. Treatment-related mortality in high-income countries is approximately 3–5%; however, in LMICs, treatment-related mortality has been reported in up to 45% of children with cancer. This study aimed to systematically explore the burden of treatment-related mortality in children with cancer in LMICs and to explore the association between country [...]
Menée à partir de données portant sur des patients atteints d'un cancer et souffrant d'une thrombose veineuse profonde distale isolée (886 cas) ou d'une thrombose veineuse profonde proximale (5 196 cas), cette étude compare, chez ces deux populations, la survenue d'événements indésirables (décès, récidive d'une maladie thromboembolique veineuse, saignements importants)
Clinical Presentation and Outcomes of Patients With Cancer-Associated Isolated Distal Deep Vein Thrombosis
Menée à partir de données portant sur des patients atteints d'un cancer et souffrant d'une thrombose veineuse profonde distale isolée (886 cas) ou d'une thrombose veineuse profonde proximale (5 196 cas), cette étude compare, chez ces deux populations, la survenue d'événements indésirables (décès, récidive d'une maladie thromboembolique veineuse, saignements importants)
Clinical Presentation and Outcomes of Patients With Cancer-Associated Isolated Distal Deep Vein Thrombosis
Jean-Philippe Galanaud ; Javier Trujillo-Santos ; Behnood Bikdeli ; Laurent Bertoletti ; Pierpaolo Di Micco ; Géraldine Poénou ; Conxita Falgá ; Marija Zdraveska ; Jorge Lima ; Francisco Rivera-Civico ; Josefa Fernández Muixi ; Manuel Monreal ; on behalf of the RIETE Investigators
PURPOSE: Patients with isolated distal deep vein thrombosis (DVT) have lower rates of adverse outcomes (death, venous thromboembolism [VTE] recurrence or major bleeding) than those with proximal DVT. It is uncertain if such findings are also observed in patients with cancer. METHODS: Using data from the international Registro Informatizado de la Enfermedad TromboEmbolica venosa registry, we compared the risks of adverse outcomes at 90 days (adjusted odds ratio [aOR]; 95% CI) and 1 year [...]
Menée à partir de données portant sur 5 100 patients atteints d'une maladie veineuse thrombombolique associée à un cancer (âge moyen : 66,3 ans), cette étude de cohorte rétrospective analyse les facteurs associés à une utilisation d'anticoagulants puis évalue l'efficacité de ces derniers
Comparative Effectiveness of Anticoagulants in Patients With Cancer-Associated Thrombosis
Menée à partir de données portant sur 5 100 patients atteints d'une maladie veineuse thrombombolique associée à un cancer (âge moyen : 66,3 ans), cette étude de cohorte rétrospective analyse les facteurs associés à une utilisation d'anticoagulants puis évalue l'efficacité de ces derniers
Comparative Effectiveness of Anticoagulants in Patients With Cancer-Associated Thrombosis
Riaz, Irbaz Bin ; Fuentes, Harry ; Deng, Yihong ; Naqvi, Syed Arsalan Ahmed ; Yao, Xiaoxi ; Sangaralingham, Lindsey R. ; Houghton, Damon E. ; Padrnos, Leslie J. ; Shamoun, Fadi E. ; Wysokinski, Waldemar E. ; McBane, Robert D., II
Importance : Patterns of clinical utilization and comparative effectiveness of anticoagulants for cancer-associated thrombosis (CAT) remain largely unexplored. Objectives : To assess patterns of and factors associated with anticoagulant use and to evaluate the comparative effectiveness of contemporary anticoagulants in patients with active cancer in a clinical setting. Design, Setting, and Participants : This retrospective cohort study obtained deidentified OptumLabs electronic health record [...]
Menée aux Etats-Unis sur la période 2017-2022, cette étude analyse les disparités ethniques dans la participation des patients atteints d'un cancer à des essais cliniques
Racial and Ethnic Inequities in US Oncology Clinical Trial Participation From 2017 to 2022
Menée aux Etats-Unis sur la période 2017-2022, cette étude analyse les disparités ethniques dans la participation des patients atteints d'un cancer à des essais cliniques
Racial and Ethnic Inequities in US Oncology Clinical Trial Participation From 2017 to 2022
Pittell, Harlan ; Calip, Gregory S. ; Pierre, Amy ; Ryals, Cleo A. ; Altomare, Ivy ; Royce, Trevor J. ; Guadamuz, Jenny S.
There is increasing recognition from regulatory agencies that racial and ethnic representation in clinical trials is inadequate and linked to health inequities. The extent of racial inequities in clinical trial participation is unclear because prior studies have synthesized enrollment data from published trials, which often do not report participant race and ethnicity.To evaluate racial and ethnic inequities in oncology clinical trial participation in a contemporary cohort of patients with [...]
A Ground’s-Eye View on Racial and Ethnic Disparities in Cancer Clinical Trial Participation
Menée aux Etats-Unis sur la période 2017-2022, cette étude analyse les disparités ethniques dans la participation des patients atteints d'un cancer à des essais cliniques
A Ground’s-Eye View on Racial and Ethnic Disparities in Cancer Clinical Trial Participation
Unger, Joseph M.
The conduct of clinical trials is vital for developing new therapies for patients with cancer. It is sometimes forgotten that the entire clinical trial system hinges on the availability of patients who participate. Yet few adult patients with cancer participate in clinical treatment trials. Therefore, research that aims to improve understanding about barriers to trial participation and disparities in access to trials is critical.A 2019 study by Unger et al delineated the structural, clinical, [...]
Menée en Suède à partir de données 2005-2020 portant sur 47 303 patients atteints d'un cancer colorectal, cette étude de cohorte analyse l'association entre une utilisation d'antibiotiques prescrits avant le diagnostic de cancer et la survie
Prediagnostic prescription antibiotics use and survival in colorectal cancer patients: A Swedish national register-based study
Menée en Suède à partir de données 2005-2020 portant sur 47 303 patients atteints d'un cancer colorectal, cette étude de cohorte analyse l'association entre une utilisation d'antibiotiques prescrits avant le diagnostic de cancer et la survie
Prediagnostic prescription antibiotics use and survival in colorectal cancer patients: A Swedish national register-based study
Lu, Sai San Moon ; Rutegård, Martin ; Ahmed, Maghfoor ; Häggström, Christel ; Gylfe, Åsa ; Harlid, Sophia ; Van Guelpen, Bethany
Background: Antibiotics use is associated with higher colorectal cancer risk, but little is known regarding any potential effects on survival. Methods: We conducted a nationwide cohort study, using complete-population data from Swedish national registers between 2005 and 2020, to investigate prediagnostic prescription antibiotics use in relation to survival in colorectal cancer patients. Results: We identified 36 061 stage I-III and 11 242 stage IV colorectal cancer cases diagnosed between 2010 [...]
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19
Direct and indirect effects of COVID-19 on short-term mortality of breast cancer patients
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19
Direct and indirect effects of COVID-19 on short-term mortality of breast cancer patients
Di Cosimo, Serena ; Ljevar, Silva ; Trama, Annalisa ; Bernasconi, Alice ; Lasalvia, Paolo ; De Santis, Maria Carmen ; Cappelletti, Vera ; Miceli, Rosalba ; Apolone, Giovanni
We studied the COVID-19 impact in newly-diagnosed breast cancer (7,349 patients in 2019, and 5,563 in 2020). In 2020 there were two diagnostic drops: −37.2% (March–May), −15.8% (October–December). Early-stage at presentation (76.4% vs. 74.4%, p = 0.0013), conserving surgery (71.0% vs. 67.0%, p < 0.0001), chemotherapy (86.2% vs. 53.4%, p < 0.0001), and radiotherapy (65.7% vs. 42.1%, p < 0.0001) decreased in 2020 compared to 2019. COVID-19 occurred in 250 patients (4.49%). The time-dependent [...]
Impact of the COVID-19 Pandemic on Outcomes for Patients with Lung Cancer Receiving Curative-intent Radiotherapy in the UK
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19
Impact of the COVID-19 Pandemic on Outcomes for Patients with Lung Cancer Receiving Curative-intent Radiotherapy in the UK
Fornacon-Wood, I. ; Banfill, K. ; Ahmad, S. ; Britten, A. ; Carson, C. ; Dorey, N. ; Hatton, M. ; Hiley, C. ; Thippu Jayaprakash, K. ; Jegannathen, A. ; Kidd, A. C. ; Koh, P. ; Panakis, N. ; Peedell, C. ; Peters, A. ; Pope, A. ; Powell, C. ; Stilwell, C. ; Thomas, B. ; Toy, E. ; Wicks, K. ; Wood, V. ; Yahya, S. ; Price, G. ; Faivre-Finn, C.
Aims: Previous work found that during the first wave of the COVID-19 pandemic, 34% of patients with lung cancer treated with curative-intent radiotherapy in the UK had a change to their centre’s usual standard of care treatment (Banfill et al. Clin Oncol 2022;34:19–27). We present the impact of these changes on patient outcomes. Materials and methods: The COVID-RT Lung database was a prospective multicentre UK cohort study including patients with stage I–III lung cancer referred for and/or [...]
Impact of COVID-19 control on lung, breast, and colorectal pathological cancer diagnoses. A comparison between the Netherlands, Aotearoa New Zealan...
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19
Impact of COVID-19 control on lung, breast, and colorectal pathological cancer diagnoses. A comparison between the Netherlands, Aotearoa New Zealand, and Northern Ireland
Mitchell, Helen ; McLean, Jennifer ; Gavin, Anna T. ; Visser, Otto ; Millar, Elinor ; Luff, Tessa ; Bennett, Damien
Background: The COVID-19 pandemic was managed in Aotearoa New Zealand (NZ) by a COVID-19 elimination policy, involving border closure and an initial national lockdown. This was different to most other countries including Northern Ireland (NI) and the Netherlands (NED). We quantify the effect of these policies on the diagnosis of three major cancers, comparing NZ with these two European countries. Method: Data from NED, NZ and NI population-based cancer registries were used to assess trends in [...]
Engaging the community served: a U.S. Cancer Center’s Facebook live cancer awareness campaign for Spanish-speaking Latinos during COVID-19
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19
Engaging the community served: a U.S. Cancer Center’s Facebook live cancer awareness campaign for Spanish-speaking Latinos during COVID-19
Mora, Javier ; Romo, Raul ; Dempsey, Sandra ; Silva, Betzaida ; Nevels, Debra ; Leone, Gustavo W. ; Stolley, Melinda
Cancer is the leading cause of mortality in U.S. Latino adults, a group with limited access to screening, higher rates of advanced disease, and prone to online misinformation. Our project created a Facebook Live social media video campaign on general cancer prevention, screening, risk, information, and resources, targeting Spanish-monolingual Latinos during the COVID-19 pandemic. Content was delivered in Spanish by fluent, ethnically concordant topic experts and cancer center staff. Four [...]
Impact of the COVID-19 pandemic on paediatric renal tumour presentation and management, a SIOP renal tumour study group study
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19
Impact of the COVID-19 pandemic on paediatric renal tumour presentation and management, a SIOP renal tumour study group study
Roy, Prakriti ; van Peer, Sophie E. ; Dandis, Rana ; Duncan, Catriona ; de Aguirre-Neto, Joaquim Caetano ; Verschuur, Arnauld ; de Camargo, Beatriz ; Karim-Kos, Henrike E. ; Boschetti, Luna ; Spreafico, Filippo ; Ramírez-Villar, Gema L. ; Graf, Norbert ; van Tinteren, Harm ; Pritchard-Jones, Kathy ; van den Heuvel-Eibrink, Marry M.
Background: The COVID-19 pandemic had global catastrophic effects on the management of non-communicable diseases including paediatric cancers. Restrictions during the start of 2020 complicated timely referrals of patients to specialized centres. We aimed to evaluate the pandemic’s impact on the number of new diagnoses, disease characteristics and management delay for paediatric renal tumour patients included in the SIOP-RTSG-UMBRELLA study, as compared with data from a historical SIOP-RTSG [...]
Telemedicine in Care of Sarcoma Patients beyond the COVID-19 Pandemic: Challenges and Opportunities
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19
Telemedicine in Care of Sarcoma Patients beyond the COVID-19 Pandemic: Challenges and Opportunities
Tsagkaris, Christos ; Trygonis, Nikolaos ; Spyrou, Vasiliki ; Koulouris, Andreas
Background: The COVID-19 pandemic has created a challenging environment for sarcoma patients. Most oncology societies published guidelines or recommendations prioritizing sarcoma patients and established telehealth as an efficient method of approaching them. The aim of this review is the assessment of current evidence regarding the utilization of telemedicine in diagnosis, treatment modalities, telerehabilitation and satisfaction among sarcoma patients and healthcare providers (HP). Methods: [...]
Potential global loss of life expected due to COVID-19 disruptions to organised colorectal cancer screening
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19
Potential global loss of life expected due to COVID-19 disruptions to organised colorectal cancer screening
Worthington, Joachim ; van Wifferen, Francine ; Sun, Zhuolu ; de Jonge, Lucie ; Lew, Jie-Bin ; Greuter, Marjolein J. E. ; van den Puttelaar, Rosita ; Feletto, Eleonora ; Lansdorp-Vogelaar, Iris ; Coupe, Veerle M. H. ; Ein Yong, Jean Hai ; Canfell, Karen
Background: Screening for colorectal cancer (CRC) decreases cancer burden through removal of precancerous lesions and early detection of cancer. The COVID-19 pandemic has disrupted organised CRC screening programs worldwide, with some programs completely suspending screening and others experiencing significant decreases in participation and diagnostic follow-up. This study estimated the global impact of screening disruptions on CRC outcomes, and potential effects of catch-up screening. Methods: [...]
Menée à partir de données d'un registre suédois, cette étude analyse l'incidence et le pronostic du cancer du sein métastatique de novo en fonction du sexe
De Novo metastatic breast cancer in males versus females: a Swedish, population-based cohort study
Menée à partir de données d'un registre suédois, cette étude analyse l'incidence et le pronostic du cancer du sein métastatique de novo en fonction du sexe
De Novo metastatic breast cancer in males versus females: a Swedish, population-based cohort study
Schiza, Aglaia ; Fredriksson, Irma ; Sund, Malin ; Valachis, Antonios
Current evidence on de novo metastatic breast cancer (dnMBC) is based on data from women. This Swedish, population-based cohort study compared the incidence over time and prognosis of dnMBC between sexes using data from the National Quality register for Breast Cancer. Joinpoint regression analysis was used to compare incidence trends in all stages (104,733 women, 648 men) and multivariate Cox regression analysis to investigate potential sex disparities in dnMBC prognosis (6005 women, 41 men). [...]
Menée à partir de données 2000-2019 des registres américains des cancers, cette étude analyse les tendances de l'incidence du cancer de la thyroïde en fonction de caractéristiques démographiques et tumorales au moment du diagnostic
Trends in the incidence of thyroid cancer among US persons from 2000 to 2019
Menée à partir de données 2000-2019 des registres américains des cancers, cette étude analyse les tendances de l'incidence du cancer de la thyroïde en fonction de caractéristiques démographiques et tumorales au moment du diagnostic
Trends in the incidence of thyroid cancer among US persons from 2000 to 2019
Yu, Juebo
Background: The incidence of thyroid cancer is increasing by 3% annually; however, the analysis was restricted to the period from 1973 to 2013, which could be changed in incidence trends over time. This study is to analyze trends in thyroid cancer incidence based on demographic and tumor characteristics at diagnosis using recent database. Methods: We used the Surveillance, Epidemiology, and End Results database to assess thyroid cancer incidence rates and trends from 2000 to 2019. We compared [...]
Approches psycho-sociales (2)
A partir d'une revue systématique de la littérature (44 articles), cette étude identifie les facteurs associés à l'isolement social chez les jeunes adultes ayant survécu à un cancer (âge : 18-39 ans) puis analyse l'impact de cet isolement sur leur santé psychique
Social isolation and social connectedness among young adult cancer survivors: A systematic review
A partir d'une revue systématique de la littérature (44 articles), cette étude identifie les facteurs associés à l'isolement social chez les jeunes adultes ayant survécu à un cancer (âge : 18-39 ans) puis analyse l'impact de cet isolement sur leur santé psychique
Social isolation and social connectedness among young adult cancer survivors: A systematic review
Fox, Rina S. ; Armstrong, Grace E. ; Gaumond, Julia S. ; Vigoureux, Taylor F. D. ; Miller, Corinne H. ; Sanford, Stacy D. ; Salsman, John M. ; Katsanis, Emmanuel ; Badger, Terry A. ; Reed, Damon R. ; Gonzalez, Brian D. ; Jim, Heather S. L. ; Warner, Echo L. ; Victorson, David E. ; Oswald, Laura B.
Background: Social isolation and connectedness are social determinants of health that have demonstrated effects on cancer-related outcomes. These constructs have been systematically evaluated among pediatric and older adult cancer populations. In this review, the authors evaluated the prevalence, correlates, and psychosocial implications of social isolation and connectedness among young adult (YA) cancer survivors aged 18–39 years. Methods: Peer-reviewed articles published in English before [...]
Mené sur 85 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'intérêt d'une psychothérapie dispensée en ligne et en groupe pour réduire la peur de la récidive de la maladie
ConquerFear-Group: A randomized controlled trial of an online-delivered group-based psychological intervention for fear of cancer recurrence in bre...
Mené sur 85 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'intérêt d'une psychothérapie dispensée en ligne et en groupe pour réduire la peur de la récidive de la maladie
ConquerFear-Group: A randomized controlled trial of an online-delivered group-based psychological intervention for fear of cancer recurrence in breast cancer survivors
Tauber, Nina M. ; O’Toole, Mia S. ; Jensen, Anders B. ; Butow, Phyllis N. ; Thewes, Belinda ; Elkjær, Emma ; Knutzen, Sofie ; von Heymann, Annika ; Johansen, Christoffer ; Zachariae, Robert
Objective: Fear of cancer recurrence (FCR) is a distressing concern among cancer survivors. Interventions to address FCR need to be effective but also accessible and low cost. This randomized controlled trial evaluated the efficacy of an online group-based psychological intervention for FCR (ConquerFear-Group). Methods: Eligible breast cancer (BC) survivors had completed primary treatment 3 months–5 years previously, were ≥18 years, and scored ≥22 on the Fear of Cancer Recurrence [...]
Analyses économiques et systèmes de soins (2)
Menée dans un contexte américain, cette étude rétrospective estime les coûts associés au gaspillage de pilules lié à la modification des doses et à l'arrêt de 22 anticancéreux oraux approuvés par la "Food and Drug Administration" entre 2020 et 2022 ou couramment prescrits
Cost of Drug Wastage From Dose Modification and Discontinuation of Oral Anticancer Drugs
Menée dans un contexte américain, cette étude rétrospective estime les coûts associés au gaspillage de pilules lié à la modification des doses et à l'arrêt de 22 anticancéreux oraux approuvés par la "Food and Drug Administration" entre 2020 et 2022 ou couramment prescrits
Cost of Drug Wastage From Dose Modification and Discontinuation of Oral Anticancer Drugs
Lam, Michael ; Olivier, Timothée ; Haslam, Alyson ; Tuia, Jordan ; Prasad, Vinay
Importance : Oral chemotherapy is often dispensed to patients as a 1-month supply, with pill dose and package size predetermined by the drug manufacturer; thus, changing the patient dosage may waste the remaining initial drug supply. The cost of pills wasted due to dose modification and discontinuation is often unreported. Objective : To estimate the cost of pill wastage due to dose modification and discontinuation for oral anticancer drugs that were recently approved by the US Food and Drug [...]
Discarded Targeted Oral Anticancer Medication—A Hard Pill to Swallow?
Menée dans un contexte américain, cette étude rétrospective estime les coûts associés au gaspillage de pilules lié à la modification des doses et à l'arrêt de 22 anticancéreux oraux approuvés par la "Food and Drug Administration" entre 2020 et 2022 ou couramment prescrits
Discarded Targeted Oral Anticancer Medication—A Hard Pill to Swallow?
Bradley, Cathy J. ; Yabroff, K. Robin ; Shih, Ya-Chen Tina
Oral targeted agents for cancer are among the most expensive outpatient prescription drugs dispensed in the US. These drugs, often distributed as specialty drugs, can cost more than $170 000 per patient per year. Patients in the US pay a greater share of their health care costs than patients living in other developed countries. As a result, terms such as “financial burden,” “financial hardship,” and “financial toxicity” have risen, especially in the US, to describe the untenable phenomenon [...]
Menée dans un contexte français, cette étude analyse le rapport coût-efficacité de l'atézolizumab en traitement adjuvant chez des patients atteints d'un cancer du poumon non à petites cellules de stade II-IIIA et surexprimant PD-L1
Cost-effectiveness analysis of atezolizumab as adjuvant treatment of patients with stage II-IIIA non-small cell lung cancer, PD-L1+
Menée dans un contexte français, cette étude analyse le rapport coût-efficacité de l'atézolizumab en traitement adjuvant chez des patients atteints d'un cancer du poumon non à petites cellules de stade II-IIIA et surexprimant PD-L1
Cost-effectiveness analysis of atezolizumab as adjuvant treatment of patients with stage II-IIIA non-small cell lung cancer, PD-L1+
Plessala, Ingrid ; Cawston, Hélène ; Cortes, Justine ; Ajjouri, Roula ; Le Lay, Katell ; Souquet, Pierre-Jean ; Chouaid, Christos
Introduction: The objective of this study was to assess the cost-effectiveness of atezolizumab versus best supportive care (BSC) as adjuvant treatment following resection and platinum-based chemotherapy for patients with stage II-IIIA non-small cell lung cancer (NSCLC) whose tumours have a programmed death-ligand 1 (PD-L1) expression
Ressources et infrastructures (Lutte contre les cancers) (3)
Cet article souligne les progrès réalisés et les efforts nécessaires pour augmenter la qualité et la quantité d'années de vie gagnées des patients ayant survécu à un cancer pédiatrique au 21ème siècle
Improving quality and quantity of life for childhood cancer survivors globally in the twenty-first century
Cet article souligne les progrès réalisés et les efforts nécessaires pour augmenter la qualité et la quantité d'années de vie gagnées des patients ayant survécu à un cancer pédiatrique au 21ème siècle
Improving quality and quantity of life for childhood cancer survivors globally in the twenty-first century
Ehrhardt, Matthew J. ; Krull, Kevin R. ; Bhakta, Nickhill ; Liu, Qi ; Yasui, Yutaka ; Robison, Leslie L. ; Hudson, Melissa M.
The contributions of cooperative groups to performing large-cohort clinical trials and long-term survivorship studies have facilitated advances in treatment, supportive care and, ultimately, survival for patients with paediatric cancers. As a result, the number of childhood cancer survivors in the USA alone is expected to reach almost 580,000 by 2040. Despite these substantial improvements, childhood cancer survivors continue to have an elevated burden of chronic disease and an excess risk of [...]
Cet article propose des pistes de réflexion pour développer le rôle des 70 centres américains de lutte contre le cancer dans la protection des populations vulnérables face aux crises climatiques
Protecting Vulnerable Patient Populations from Climate Hazards: The Role of the Nations’ Cancer Centers
Cet article propose des pistes de réflexion pour développer le rôle des 70 centres américains de lutte contre le cancer dans la protection des populations vulnérables face aux crises climatiques
Protecting Vulnerable Patient Populations from Climate Hazards: The Role of the Nations’ Cancer Centers
Espinel, Zelde ; Shultz, James M ; Aubry, Vanina Pavia ; Abraham, Omar Muñoz ; Fan, Qinjin ; Crane, Tracy E ; Sahar, Liora ; Nogueira, Leticia M
Individuals diagnosed with cancer are a vulnerable population during disasters. Emergency preparedness efforts are crucial for meeting the health and safety needs of patients, providers, healthcare facilities, and communities before, during, and after a disaster. Recognizing the importance of advancing emergency preparedness expertise to cancer control efforts nationwide, especially in the era of climate change, we searched National Cancer Institute (NCI)-designated Cancer Centers’ websites to [...]
Cet article passe en revue les données sur les facteurs associés au risque de cancer du poumon, l'incidence de la maladie et la mortalité spécifique puis présente les politiques internationales de dépistage de la maladie
The global burden of lung cancer: current status and future trends
Cet article passe en revue les données sur les facteurs associés au risque de cancer du poumon, l'incidence de la maladie et la mortalité spécifique puis présente les politiques internationales de dépistage de la maladie
The global burden of lung cancer: current status and future trends
Leiter, Amanda ; Veluswamy, Rajwanth R. ; Wisnivesky, Juan P.
Lung cancer is the leading cause of cancer-related death worldwide. However, lung cancer incidence and mortality rates differ substantially across the world, reflecting varying patterns of tobacco smoking, exposure to environmental risk factors and genetics. Tobacco smoking is the leading risk factor for lung cancer. Lung cancer incidence largely reflects trends in smoking patterns, which generally vary by sex and economic development. For this reason, tobacco control campaigns are a central [...]
