A partir d'une revue systématique de la littérature publiée jusqu'en mai 2022 (15 articles), cette étude analyse le risque de cancer et la mortalité après un diagnostic de cancer chez les consommateurs exclusifs de snus suédois

A systematic review of cancer risk among users of smokeless tobacco (Swedish snus) exclusively, compared with no use of tobacco

Valen, Håkon ; Becher, Rune ; Vist, Gunn Elisabeth ; Holme, Jørn Andreas ; Mdala, Ibrahimu ; Elvsaas, Ida-Kristin Ørjasæter ; Alexander, Jan ; Underland, Vigdis ; Brinchmann, Bendik Christian ; Grimsrud, Tom Kristian

The main objective of this systematic review was to assess cancer risk, and mortality after cancer diagnosis, for exclusive users of Swedish snus, compared with non-users of tobacco. We followed international standards for systematic reviews and graded our confidence in the risk estimates using the GRADE approach. Our search gave 2450 articles, of which 67 were assessed in full text against our inclusion criteria. Of these, 14 cohort-studies and one case-control study were included in the [...]

Menée à partir de données 2006-2022 de la "UK Biobank" portant sur 113 256 personnes, cette étude analyse l'association entre une utilisation longue ou répétée d'antibiotiques pendant l'enfance ou l'adolescence et le risque de survenue précoce d'un adénome (719 cas) ou d'un cancer colorectal (165 cas), en fonction du polymorphisme du gène FUT2

Association between antibiotic use during early life and early-onset colorectal cancer risk overall and according to polygenic risk and FUT2 genotypes

Jiang, Fangyuan ; Boakye, Daniel ; Sun, Jing ; Wang, Lijuan ; Yu, Lili ; Zhou, Xuan ; Zhao, Jianhui ; Bian, Zilong ; Song, Peige ; He, Yazhou ; Zhu, Yingshuang ; Chen, Jie ; Yuan, Shuai ; Song, Mingyang ; Larsson, Susanna C. ; Giovannucci, Edward L ; Theodoratou, Evropi ; Ding, Kefeng ; Li, Xue

Early-onset colorectal cancer (EOCRC) has been increasing worldwide. Potential risk factors may have occurred in childhood or adolescence. We investigated the associations between early-life factors and EOCRC risk, with a particular focus on long-term or recurrent antibiotic use (LRAU) and its interaction with genetic factors. Data on the UK Biobank participants recruited between 2006 and 2010 and followed up to February 2022 were used. We used logistic regression to estimate adjusted odds [...]

Menée à partir de données 1973-2015 du registre suédois des naissances portant sur 4 173 108 enfants (durée médiane de suivi : 20 ans), cette étude analyse l'association entre un syndrome neurocutané, des facteurs périnataux et le risque de cancer pédiatrique

Neurocutaneous Syndromes, Perinatal Factors, and the Risk of Childhood Cancer in Sweden

Kampitsi, Christina-Evmorfia ; Nordgren, Ann ; Mogensen, Hanna ; Pontén, Emeli ; Feychting, Maria ; Tettamanti, Giorgio

Neurocutaneous syndromes are associated with cancer predisposition and sometimes associated with perinatal factors. A better understanding of the association between neurocutaneous syndromes, perinatal factors, and childhood cancer is key for earlier cancer detection.To evaluate the association of neurocutaneous syndromes and perinatal factors with childhood cancer risk in a cohort of Swedish children.In this nationwide cohort study, all children and adolescents up to age 20 years, from 1973 to [...]

Menée auprès de 25 073 personnes (âge moyen : 50 ans ; 32 % de femmes ; durée médiane de suivi : 9 ans), cette étude analyse l'association entre le débit de filtration glomérulaire et le risque de cancer (2 045 cas)

Baseline renal function and the risk of cancer among apparently healthy middle-aged adults

Moshkovits, Yonatan ; Goldman, Adam ; Beckerman, Pazit ; Tiosano, Shmuel ; Kaplan, Alon ; Kalstein, Maia ; Bayshtok, Gabriella ; Segev, Shlomo ; Grossman, Ehud ; Segev, Amit ; Maor, Elad

Background: The association between mildly impaired renal function with all-site and site-specific cancer risk is not established. We aim to explore this association among apparently healthy adults. Methods: We followed 25,073 men and women, aged 40–79 years, free of cancer or cardiovascular disease at baseline who were screened annually in preventive healthcare settings. The estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration equation (CKD-EPI) [...]

Menée auprès de 1 509 témoins et 776 patientes atteintes d'un cancer épithélial de l'ovaire ou du péritoine, cette étude analyse l'association entre des mutations constitutionnelles de 12 gènes et le risque de développer la maladie

Germline mutations in 12 genes and risk of ovarian cancer in three population-based cohorts

Kotsopoulos, Joanne ; Hathaway, Cassandra A. ; Narod, Steven A. ; Teras, Lauren R. ; Patel, Alpa V. ; Hu, Chunling ; Yadav, Siddhartha ; Couch, Fergus J. ; Tworoger, Shelley S.

Background: With the widespread use of multigene panel genetic testing, population-based studies are necessary to accurately assess penetrance in unselected individuals. We evaluated the prevalence of germline pathogenic or likely pathogenic variants (mutations) in 12 cancer-predisposition genes and associations with ovarian cancer risk in three population-based prospective studies (Nurses’ Health Study [NHS], NHSII, Cancer Prevention Study II). Methods: We included women with epithelial [...]

Menée auprès de 74 714 hommes âgés d'au moins 45 ans, cette étude analyse l'association entre des affections allergiques atopiques et le risque de cancer de la prostate (8 697 cas) ainsi que la mortalité (1 170 décès) en fonction de l'origine ethnique

Atopic allergic conditions and prostate cancer risk and survival in the Multiethnic Cohort study

Wang, Anqi ; Wan, Peggy ; Hebert, James R. ; Le Marchand, Loic ; Wilkens, Lynne R. ; Haiman, Christopher A.

Background: Previous studies investigating relationship between atopic allergic conditions (AACs)—a highly reactive immune state—and prostate cancer (PCa) risk were inconclusive, and few have studied diverse racial/ethnic populations. Methods: We analysed 74,714 men aged  [...]